Article
Microbiology
Chaoyue Wen, Siyu Li, Jiaojiao Wang, Yimin Zhu, Xin Zong, Yizhen Wang, Mingliang Jin
Summary: Heat stress disrupts the homeostatic balance of intestinal microbiota in mice and induces significant alterations in intestinal metabolites. This research provides a basis for treating intestinal disorders caused by elevated temperature in humans and animals and formulating nutritional countermeasures to reduce heat stress-induced damage.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pernille Baumann Toft, Hiroaki Yashiro, Derek M. Erion, Matthew Paul Gillum, Fredrik Backhed, Tulika Arora
Summary: Depletion of gut microbiota affects dietary protein metabolism and regulates GLP-1-mediated intestinal transit, playing an important role in host physiology.
Article
Environmental Sciences
Guoxia Zhang, Fengmin Ma, Ziwei Zhang, Zenghua Qi, Meiqiong Luo, Yingxin Yu
Summary: This study focused on the gut microbiome and fecal metabolome of female rats and their offspring exposed to DBDPE. The results showed that maternal DBDPE exposure increased the alpha-diversity of gut microbiota in immature offspring and decreased the abundance of certain bacteria in adult offspring. The changes in gut microbiota led to alterations in fecal metabolites. This study provides new insights into the long-term effects of DBDPE exposure on human health.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Engineering, Environmental
Jo De Vrieze, Robert Heyer, Ruben Props, Lieven Van Meulebroek, Karen Gille, Lynn Vanhaecke, Dirk Benndorf, Nico Boon
Summary: This study compared four different microbial community fingerprinting methods for characterizing the full-scale anaerobic digestion microbiome, with cytometric fingerprinting through flow cytometry proving to be a reliable, fast method for holistic monitoring. The complementary identification of key features through other methods could give rise to a direct interpretation of anaerobic digestion process performance.
Article
Cell Biology
Kenneth J. O'Riordan, Michael K. Collins, Gerard M. Moloney, Emily G. Knox, Maria R. Aburto, Christine Fulling, Shane J. Morley, Gerard Clarke, Harriet Schellekens, John F. Cryan
Summary: The role of the intestinal microbiota in regulating gut-brain axis signaling has gained attention in recent years. Understanding the relationship between the gut microbiota, its metabolites, and the brain is crucial for developing new therapeutic approaches, including identifying psychobiotics. Current research focuses on the effects of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, on brain function, behavior, and physiology, and how these SCFAs enter the systemic circulation and can potentially impact the brain.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Cell Biology
Yuanyuan Shao, Weiwei Qi, Xiaomei Zhang, Ningyuan Ran, Chunyan Liu, Rong Fu, Zonghong Shao
Summary: Patients with severe aplastic anemia (SAA) show abnormalities in both their plasma metabolomes and intestinal microbial compositions, which might reflect the molecular mechanisms involved in the defective immunity that characterizes SAA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Maria Munoz-Benavent, Ana Elena Perez-Cobas, Carlos Garcia-Ferris, Andres Moya, Amparo Latorre
Summary: The study of insect-associated microbial communities is crucial in agriculture due to the role insects play as pests. Recent focus on insect gut microbiome highlights their potential in biotechnology and biomedicine, with functional approaches providing insights into their metabolic capabilities. Understanding these microbial communities is essential for their exploitation and future perspectives in this field.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Nutrition & Dietetics
Jing Cong, Ping Zhou, Ruiyan Zhang
Summary: Intestinal microbiota plays a crucial role in human physiology by producing metabolites, such as short chain fatty acids (SCFAs), which regulate colon physiology and influence the intestinal environment. Recent research has shown that SCFAs not only affect the gut's signal transduction pathway but also reach tissues and organs outside of the gut through the bloodstream. The level of SCFAs is increasingly recognized as important for maintaining health and preventing disease. This review provides a systematic theoretical basis for studying the mechanisms and precise intake levels of SCFAs to promote human health.
Article
Biochemistry & Molecular Biology
Sander Wuyts, Renato Alves, Maria Zimmermann-Kogadeeva, Suguru Nishijima, Sonja Blasche, Marja Driessen, Philipp E. Geyer, Rajna Hercog, Ece Kartal, Lisa Maier, Johannes B. Mueller, Sarela Garcia Santamarina, Thomas Sebastian B. Schmidt, Daniel C. Sevin, Anja Telzerow, Peter Treit, Tobias Wenzel, Athanasios Typas, Kiran R. Patil, Matthias Mann, Michael Kuhn, Peer Bork
Summary: Multi-omics analyses were used to study the molecular changes in microbial communities under different conditions. Using five omics layers, the study mapped the molecular response of a synthetic community of gut bacteria to three non-antibiotic drugs. The results showed that the omics methods were consistent in estimating relative species abundances and complemented each other in capturing functional changes.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Immunology
Shuai Li, Xiaolu Wen, Xuefen Yang, Li Wang, Kaiguo Gao, Xingwei Liang, Hao Xiao
Summary: This study investigated the effects of glutamine supplementation on the intestinal microbiota and microbial metabolites. The results showed no significant changes in the microbiota, but differences were observed in the metabolites. Metabolomics analysis revealed alterations in various metabolic pathways and differential metabolites, which are beneficial for intestinal development and immunity. Overall, glutamine supplementation may maintain intestinal homeostasis and improve intestinal immunity through the modulation of intestinal microbial metabolites.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Li Wu, Yuqiu Han, Zhipeng Zheng, Guoping Peng, Ping Liu, Siqing Yue, Shuai Zhu, Jun Chen, Hanying Lv, Lifang Shao, Yan Sheng, Yulan Wang, Liang Li, Lanjuan Li, Baohong Wang
Summary: The study revealed differences in gut microbiota between patients with pre-onset amnestic mild cognitive impairment and Alzheimer's disease, with significant variances in tryptophan metabolites, short-chain fatty acids, and other metabolites between Alzheimer's disease and healthy controls. These findings suggest an association between fecal-based gut microbial signatures and the presence and progression of Alzheimer's disease, potentially providing a target for microbiota or dietary intervention in Alzheimer's disease prevention.
Article
Microbiology
Jianlong Yan, Yanbin Pan, Wenming Shao, Caiping Wang, Rongning Wang, Yaqiong He, Min Zhang, Yongshun Wang, Tangzhiming Li, Zhefeng Wang, Wenxing Liu, Zhenmin Wang, Xin Sun, Shaohong Dong
Summary: This study found that propionate can improve vascular calcification by regulating the intestinal microbiota. The results of the observational cohort study showed that the levels of propionate in both blood and faecal samples were negatively correlated with vascular calcification. Animal experiments confirmed that propionate supplementation can reshape the intestinal microbiota, increase SCFA production, improve intestinal barrier function, alleviate inflammation, and ultimately ameliorate vascular calcification.
Article
Multidisciplinary Sciences
Sarah K. Munyoki, Julie P. Goff, Antonija Kolobaric, Armari Long, Steven J. Mullett, Jennifer K. Burns, Aaron K. Jenkins, Lauren DePoy, Stacy G. Wendell, Colleen A. McClung, Kathleen E. Morrison, Eldin Jasarevic
Summary: This study investigates the role of sex-specific intestinal microbial circadian rhythms in host metabolism and reveals that the sex differences in these rhythms depend on oscillations in microbiota, microbial metabolic functions, and microbial metabolites. Moreover, the dietary intake can also affect these rhythms and subsequently influence the severity of sex differences.
Review
Agriculture, Dairy & Animal Science
Jiayu Ma, Xiangshu Piao, Shad Mahfuz, Shenfei Long, Jian Wang
Summary: The interaction between gut microbiota and the host gut is crucial for maintaining the homeostasis of the organism, with short chain fatty acids playing a vital role in regulating intestinal community homeostasis and influencing the host gut barriers.
Article
Nutrition & Dietetics
Longying Pei, Wei Liu, Luping Liu, Xiaoyu Wang, Luxi Jiang, Zhaohui Chen, Qiquan Wang, Peng Wang, Heng Xu
Summary: This study investigated the effects of morel mushroom supplementation on the gut bacterial microbiota and short-chain fatty acids in healthy mice. The results showed that morel intervention altered the bacterial community composition, increased short-chain fatty acids levels, and was associated with weight loss. These findings contribute to the development of prebiotics for improving health and reducing obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Lei Zhang, Marina Toplak, Raspudin Saleem-Batcha, Lars Hoeing, Roman Jakob, Nico Jehmlich, Martin von Bergen, Timm Maier, Robin Teufel
Summary: Antimicrobial resistance is a serious threat to human health, and understanding the underlying mechanisms is crucial. This study discovered and characterized oxidoreductases that inactivate the broad-spectrum antibiotic chloramphenicol through dual oxidation of the C3-hydroxyl group. These enzymes also enable the inactivation of related compounds but not the fluorinated derivative. Phylogenetic analyses suggest that distinct isofunctional enzymes evolved independently in Gram-positive and Gram-negative bacteria. Mechanistic and structural studies provide insights into the catalytic mechanisms of these enzymes, which have both negative and positive impacts on antibiotic resistance and chloramphenicol bioremediation.
Article
Engineering, Environmental
Zishu Liu, Yuxiang Zhao, Baofeng Zhang, Jiaqi Wang, Lizhong Zhu, Baolan Hu
Summary: Soil is the major reservoir of antibiotic resistance genes (ARGs), particularly multidrug efflux pump genes, which have raised concerns due to their high prevalence in natural soil ecosystems. This study examined the influence of soil pH on the selection and composition of multidrug efflux pump genes in soil resistomes. The findings indicate that acidic soil environments significantly enrich multidrug efflux pump genes, reflecting the benefits of high soil proton activity on these genes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Ecology
Nelson Khan, Edward Muge, Francis J. Mulaa, Benson Wamalwa, Martin von Bergen, Nico Jehmlich, Lukas Y. Wick
Summary: Fungi play a crucial role in the biodegradation of soil organochlorine pesticides by facilitating bacterial dispersal and nutrient release. Experimental results indicate that the transfer of nutrients from fungi to bacteria can enhance the degradation of organic pollutants, highlighting the importance of fungal-bacterial interactions.
Article
Environmental Sciences
Lin Zhu, Yuxiang Zhao, Meng Zhou, Wenji Li, Zishu Liu, Baolan Hu
Summary: Inoculation can effectively improve the recycling level of organic waste in composting process. By adding commercial microbial agents, the high temperature maintenance time was extended by 33% and the humic acid content was increased by 42%. Inoculation significantly improved the degree of directional humification and microbial community interaction.
Article
Biochemistry & Molecular Biology
Katie O'Rourke, Beatrice Engelmann, Rolf Altenburger, Ulrike Rolle-Kampczyk, Konstantinos Grintzalis
Summary: Pharmaceutical compounds, along with pesticides, heavy metals, and personal care products, are emerging contaminants that pose a major concern for aquatic ecosystems. The presence of pharmaceuticals can affect both freshwater organisms and human health through non-target effects and contamination of drinking water sources. This study explored the molecular and phenotypic alterations of commonly found pharmaceuticals in aquatic environments in daphnids, finding changes in enzyme activities and metabolic perturbations. Chronic exposure to low concentrations of pharmaceuticals resulted in significant alterations in metabolic and physiological endpoints.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Ecology
Markus Krueger, Narendrakumar Chaudhari, Bo Thamdrup, Will A. Overholt, Laura A. Bristow, Martin Taubert, Kirsten Kuesel, Nico Jehmlich, Martin von Bergen, Martina Herrmann
Summary: The study reveals that complete ammonia-oxidizing bacteria (CMX) of the genus Nitrospira have a competitive advantage over ammonia-oxidizing bacteria (AOB) and archaea (AOA) in oligotrophic carbonate rock aquifers, due to their ecophysiological characteristics and wide occurrence in groundwater. However, their specific contribution to nitrification processes has been unclear. The research aimed to unravel the contribution of CMX, AOA, and AOB to nitrification and identify the environmental drivers of their niche differentiation in oligotrophic carbonate rock aquifers.
Article
Engineering, Environmental
Goksu Celik, Stefan Stolte, Susann Muller, Florian Schattenberg, Marta Markiewicz
Summary: This study investigated the biodegradability of heterocyclic PAHs and found that nine compounds were non-readily biodegradable. After one year of adaptation, the bacterial community developed the ability to mineralize carbazole but became more sensitive to the toxic effects of benzo[c]carbazole. The results were partially consistent with in silico models regarding biodegradation and sorption. This study provides valuable insights into the persistence of heterocyclic PAHs in aquatic environments.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Beatrix M. Heinze, Kirsten Kuesel, Nico Jehmlich, Martin von Bergen, Martin Taubert
Summary: High rates of CO2 fixation and the genetic potential of various groundwater microbes for autotrophic activity have shown that primary production is an important source of organic C in groundwater ecosystems. However, the contribution of specific chemolithoautotrophic groups such as S-oxidizing bacteria (SOB) to groundwater primary production and their adaptation strategies remain largely unknown.
Article
Multidisciplinary Sciences
Yuxiang Zhao, Zishu Liu, Baofeng Zhang, Jingjie Cai, Xiangwu Yao, Meng Zhang, Ye Deng, Baolan Hu
Summary: Research shows that high temperature can promote mutualism and reduce competition among microbial communities. Genomic analysis and culturing experiments in a composting system with temperature variation (20°C-70°C) reveal that temperature selects for stress-tolerant strains (Thermobifida fusca and Saccharomonospora viridis), and mutualistic interactions emerge between them and other strains through the sharing of cobalamin.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Ana Ramos-Nascimento, Lucia Grenga, Sven-Bastiaan Haange, Alexandra Himmelmann, Franca Sabine Arndt, Yen-Tran Ly, Guylaine Miotello, Olivier Pible, Nico Jehmlich, Beatrice Engelmann, Martin von Bergen, Edwin Mulder, Petra Frings-Meuthen, Christine Elisabeth Hellweg, Jens Jordan, Ulrike Rolle-Kampczyk, Jean Armengaud, Ralf Moeller
Summary: The AGBRESA study examined the effect of simulated weightlessness on the human body and explored the potential benefits of artificial gravity. The study found that simulated microgravity had a mild impact on the gut microbiome, but countermeasure protocols increased the abundance of beneficial short-chain fatty acids. Monitoring the gut microbiome and metabolite profiling can provide valuable information about health disturbances and the outcome of countermeasure protocols.
Article
Biochemistry & Molecular Biology
Zhipeng Wang, Sven-Bastiaan Haange, Volker Haake, Maike Huisinga, Hennicke Kamp, Roland Buesen, Kristin Schubert, Sebastian Canzler, Joerg Hackermueller, Ulrike Rolle-Kampczyk, Martin von Bergen
Summary: Thyroid hormones play a crucial role in regulating various physiological mechanisms in mammals. The therapeutic drugs PTU and phenytoin have been found to induce hypothyroidism and decrease blood thyroid hormone levels. This study aimed to analyze the impact of these drugs on systemic metabolism by investigating the metabolome of thyroid and liver tissue, as well as blood plasma, in a rat model.
Article
Biotechnology & Applied Microbiology
Vedran Vucic, Hauke Harms, Susann Mueller
Summary: This study applied the latest advances in phosphorus recovery to a pilot-scale and full-scale wastewater treatment plant. The most feasible process streams for phosphorus recovery were identified based on economic feasibility and the German Sewage Sludge Ordinance thresholds. A three-stage process was established for phosphorus recovery, demonstrating a novel pilot-scale process for the production of bio-based phosphorus-rich fertilizer.
ENGINEERING IN LIFE SCIENCES
(2023)
Article
Environmental Sciences
Ambra Maddalon, Arkadiusz Pierzchalski, Jannike Lea Krause, Mario Bauer, Saskia Finckh, Werner Brack, Ana C. Zenclussen, Marina Marinovich, Emanuela Corsini, Martin Krauss, Gunda Herberth
Summary: This study investigated the effect of extracts from wastewater treatment plant effluents on human primary immune cell activation. The results showed that these extracts, containing a mixture of chemicals, significantly reduced the activation of human lymphocytes, mainly affecting T helper and mucosal-associated invariant T cells. Basophil activation was also altered. Additionally, changes in mRNA expression of immune-related genes were observed.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
