Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening

The small non-coding RNA RsaE influences extracellular matrix composition in Staphylococcus epidermidis biofilm communities

(2019) Sonja M. K. Schoenfelder et al.   PLoS Pathogens

A decade of antimicrobial resistance in Staphylococcus aureus: A single center experience

(2019) Claudia P. Vicetti Miguel et al.   PLoS One

New Strategy on Antimicrobial-resistance: Inhibitors of DNA Replication Enzymes

(2019) Lanhua Yi et al.   CURRENT MEDICINAL CHEMISTRY

Bioactive Brominated Oxindole Alkaloids from the Red Sea Sponge Callyspongia siphonella

(2019) Seham S. El-Hawary et al.   Marine Drugs

Synthesis and Evaluation of N -Phenylpyrrolamides as DNA Gyrase B Inhibitors

(2018) Martina Durcik et al.   ChemMedChem

Increasing Clindamycin and Trimethoprim-Sulfamethoxazole Resistance in Pediatric Staphylococcus aureus Infections

(2018) Dina F Khamash et al.   Journal of the Pediatric Infectious Diseases Society

Epigenetic Modifiers Induce Bioactive Phenolic Metabolites in the Marine-Derived Fungus Penicillium brevicompactum

(2018) Seham El-Hawary et al.   Marine Drugs

New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes

(2018) Seham S. El-Hawary et al.   Frontiers in Chemistry

Permeability rules for antibiotic design

(2017) Susan Jones   NATURE BIOTECHNOLOGY

Search for New Bioactive Marine Natural Products and Application to Drug Development

(2016) Jun’ichi Kobayashi   CHEMICAL & PHARMACEUTICAL BULLETIN

Design and Biological Evaluation of Furan/Pyrrole/Thiophene-2-carboxamide Derivatives as Efficient DNA GyraseB Inhibitors ofStaphylococcus aureus

(2015) Renuka Janupally et al.   Chemical Biology & Drug Design

Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase

(2015) Mardia Telep El-Sayed et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site

(2015) Tihomir Tomašič et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

(2014) Nag S. Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In Staphylococcus aureus the regulation of pyruvate kinase activity by serine/threonine protein kinase favors biofilm formation

(2014) D. Vasu et al.   3 Biotech

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

(2012) Leslie W. Tari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cheminformatics-Driven Discovery of Selective, Nanomolar Inhibitors for Staphylococcal Pyruvate Kinase

(2011) Peter Axerio-Cilies et al.   ACS Chemical Biology

Methicillin-resistantStaphylococcus aureus(MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities

(2011) Roya Zoraghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase

(2010) Steven M. Ronkin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impact of the Staphylococcus epidermidis LytSR two-component regulatory system on murein hydrolase activity, pyruvate utilization and global transcriptional profile

(2010) Tao Zhu et al.   BMC MICROBIOLOGY

Crystal Structure of Pyruvate Kinase from Geobacillus stearothermophilus

(2008) K. Suzuki et al.   JOURNAL OF BIOCHEMISTRY