期刊
BIOMOLECULES
卷 9, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biom9120850
关键词
diabetes; NLRP3; Glucose tolerance; insulin resistance; gut microbes
资金
- National Natural Science Foundation of China [31672457, 31772642]
- Ministry of Agricultural of the People's Republic of China [2015-Z64, 2016-X47]
- Hunan Provincial Science and Technology Department [2016NK2101, 2017NK2322, 2016WK2008, 2016TP2005]
- China Postdoctoral Science Foundation [2018M632963, 2019T120705]
The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1 beta, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual's gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据