ClpG Provides Increased Heat Resistance by Acting as Superior Disaggregase

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

(2019) Célia Deville et al.   Cell Reports

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

(2018) Yingying Pu et al.   MOLECULAR CELL

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria

(2017) Changhan Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

Turn Up the Heat—Food and Clinical Escherichia coli Isolates Feature Two Transferrable Loci of Heat Resistance

(2017) Erik J. Boll et al.   Frontiers in Microbiology

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

(2017) Célia Deville et al.   Science Advances

Protein homeostasis — more than resisting a hot bath

(2016) Changhan Lee et al.   CURRENT OPINION IN MICROBIOLOGY

Short communication: Heat-resistant Escherichia coli as potential persistent reservoir of extended-spectrum β-lactamases and Shiga toxin-encoding phages in dairy

(2016) Roger Marti et al.   JOURNAL OF DAIRY SCIENCE

Heat resistance in extended-spectrum beta-lactamase-producing Escherichia coli may favor environmental survival in a hospital setting

(2016) Erik J. Boll et al.   RESEARCH IN MICROBIOLOGY

Some Like It Hot: Heat Resistance of Escherichia coli in Food

(2016) Hui Li et al.   Frontiers in Microbiology

A novel protein quality control mechanism contributes to heat shock resistance of worldwide-distributedPseudomonas aeruginosaclone C strains

(2015) Changhan Lee et al.   ENVIRONMENTAL MICROBIOLOGY

Genetic determinants of heat resistance in Escherichia coli

(2015) Ryan G. Mercer et al.   Frontiers in Microbiology

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation

(2014) Marta Carroni et al.   eLife

Coordination of Translational Control and Protein Homeostasis during Severe Heat Stress

(2013) Valeria Cherkasov et al.   CURRENT BIOLOGY

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

Concurrent emergence of multidrug resistance and heat resistance by CTX-M-15-encoding conjugative plasmids in Klebsiella pneumoniae

(2012) Martin S. Bojer et al.   APMIS

Disruption of Ionic Interactions between the Nucleotide Binding Domain 1 (NBD1) and Middle (M) Domain in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70

(2012) Natalia Lipińska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces

(2012) Fabian Seyffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A tightly regulated molecular toggle controls AAA+ disaggregase

(2012) Yuki Oguchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae

(2012) Martin Saxtorph Bojer et al.   RESEARCH IN MICROBIOLOGY

Heat Resistance Mediated by a New Plasmid Encoded Clp ATPase, ClpK, as a Possible Novel Mechanism for Nosocomial Persistence of Klebsiella pneumoniae

(2010) Martin Saxtorph Bojer et al.   PLoS One

DnaK-mediated association of ClpB to protein aggregates. A bichaperone network at the aggregate surface

(2009) Sergio P. Acebrón et al.   FEBS LETTERS

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments

(2008) Tobias Haslberger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY