Article
Cell & Tissue Engineering
Li-Li Zhang, Yu-Yan Xiong, Yue-Jin Yang
Summary: Acute myocardial infarction (AMI) is a condition of ischemic myocardial necrosis caused by acute coronary artery occlusion, with treatment focusing on reperfusion therapy and promoting angiogenesis. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have shown potential in promoting angiogenesis to improve cardiac function post-AMI, providing a basis for developing improved MSC-based methods in clinical treatment. Identifying the mechanisms behind MSCs and their derived EVs in promoting angiogenesis can pave the way for novel approaches utilizing MSCs to enhance angiogenesis capability in treating AMI.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Qingjie Wang, Le Zhang, Zhiqin Sun, Boyu Chi, Ailin Zou, Lipeng Mao, Xu Xiong, JianGuang Jiang, Ling Sun, Wenwu Zhu, Yuan Ji
Summary: EVs derived from HIF-1α-engineered MSCs can promote angiogenesis of endothelial cells and apoptosis of cardiomyocytes through upregulating the expression of miR-221-3p. Additionally, RGD hydrogels can enhance the therapeutic efficacy of these EVs.
MATERIALS TODAY BIO
(2021)
Review
Cell & Tissue Engineering
Si-Jia Sun, Rui Wei, Fei Li, Song-Yan Liao, Hung-Fat Tse
Summary: MSC-derived exosomes show promising potential in cardiac regeneration and repair due to their trophic and immunomodulatory effects. Compared to parent stem cells, they offer lower tumorigenic risk and superior stability.
Article
Cell Biology
Dong Mei Xie, Yang Chen, Yan Liao, Wanwen Lin, Gang Dai, Di Han Lu, Shuanghua Zhu, Ke Yang, Bingyuan Wu, Zhihong Chen, Chaoquan Peng, Mei Hua Jiang
Summary: The study found that CD51 can serve as a marker for resident cardiac MSCs, and CD51(+)cMSC therapy enhances cardiac repair through promoting angiogenesis and a mechanism mediated by SCF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Yang Liu, Xing Lyu, Shengy Tan, Xiangyu Zhang
Summary: This review summarizes the origins and functions of exosomes, as well as the role of exosomal non-coding RNAs in pathological cardiac remodeling.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Oncology
Ping Sun, Chao Wang, Ge Mang, Xiangli Xu, Shuai Fu, Jianfeng Chen, Xiaoqi Wang, Weiwei Wang, Hairu Li, Peng Zhao, Yifei Li, Qi Chen, Naixin Wang, Zhonghua Tong, Xin Fu, Ying Lang, Shasha Duan, Dongmei Liu, Maomao Zhang, Jiawei Tian
Summary: Mounting evidence suggests that extracellular vesicles (EVs) play an important role in cardiac physiology and pathology. This study found that EVs induced by acute myocardial infarction (AMI) can impair cardiomyocyte survival and worsen cardiac injury. The mechanism involves the EV-encapsulated miR-503 directly targeting PGC-1β and SIRT3, leading to mitochondrial metabolic dysfunction and cardiomyocyte death. Endothelial cells were identified as the primary source of miR-503 in EVs after AMI.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Paula Gil-Cabrerizo, Laura Saludas, Felipe Prosper, Gloria Abizanda, Miguel Echanove-Gonzalez de Anleo, Adrian Ruiz-Villalba, Elisa Garbayo, Maria J. Blanco-Prieto
Summary: In this study, a novel injectable hydrogel (HG) based on alginate and collagen was developed as a delivery vehicle for extracellular vesicles (EVs) in cardiac repair. The HG exhibited good injectability, internal gel structure, and low viscosity, allowing for long-term retention in the heart and sustained release of EVs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Marta Monguio-Tortajada, Cristina Prat-Vidal, Daina Martinez-Falguera, Albert Teis, Carolina Soler-Botija, Yvan Courageux, Micaela Munizaga-Larroude, Miriam Moron-Font, Antoni Bayes-Genis, Francesc E. Borras, Santiago Roura, Carolina Galvez-Monton
Summary: This study demonstrates the preclinical efficacy of locally delivering cATMSC-EV in an acute myocardial infarction (MI) pig model, showing improved cardiac function and reduced myocardial remodeling.
Article
Medicine, General & Internal
Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin, Yuejin Yang
Summary: This study found that MSCATV-EV, derived from ATV-treated MSCs, has a good cardiac repair effect on acute myocardial infarction. The results showed that MSCATV-EV alleviated inflammation in the infarct region by regulating macrophage polarization. Additionally, the study identified the miR-139-3p/Stat1 pathway as the mechanism underlying the promotion of macrophage polarization by MSCATV-EV.
Article
Biotechnology & Applied Microbiology
Xiaoting Liang, Yuelin Zhang, Fang Lin, Mimi Li, Xin Li, Yu Chen, Jing Liu, Qingshu Meng, Xiaoxue Ma, Enhao Wang, Lu Wei, Zhiying He, Huimin Fan, Xiaohui Zhou, Yue Ding, Zhongmin Liu
Summary: Direct transplantation of mitochondria derived from mesenchymal stem cells (MSC-mt) can enhance blood vessel density, inhibit cardiac remodeling and apoptosis, thus improving heart function. MSC-mt also has protective effects on endothelial cells.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Rafael Sanchez-Sanchez, Marta Gomez-Ferrer, Ignacio Reinal, Marc Buigues, Estela Villanueva-Badenas, Imelda Ontoria-Oviedo, Amparo Hernandiz, Hernan Gonzalez-King, Esteban Peiro-Molina, Akaitz Dorronsoro, Pilar Sepulveda
Summary: Extracellular vesicles derived from mesenchymal stromal cells (MSCs) and containing miR-4732-3p microRNA show potential for cardioprotection, with miR-4732-3p being regulated by hypoxia and exerting protective actions against ischemic insult.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Min Jiang, Xupin Jiang, Hongmei Li, Can Zhang, Ze Zhang, Chao Wu, Junhui Zhang, Jiongyu Hu, Jiaping Zhang
Summary: Diabetic foot is a common complication of diabetes and often leads to amputation. Previous studies have shown that stem cell transplantation can promote the healing of chronic diabetic wounds, but safety concerns have limited its clinical application. Recently, it has been discovered that mesenchymal stem cell-derived extracellular vesicles (EVs) have similar therapeutic effects and offer advantages such as safety and reduced immune response. This paper summarizes the current understanding of mesenchymal stem cell-derived EVs in accelerating the healing of diabetic wounds and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yijin Wu, Wenying Peng, Miaoxian Fang, Meifen Wu, Min Wu
Summary: This study reveals that EVs released from MSCs containing miR-212-5p can attenuate myocardial infarction-induced cardiac fibrosis by suppressing NLRC5.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Kashif Khan, Georges Makhoul, Bin Yu, Ghulam Jalani, Ida Derish, Alissa K. Rutman, Marta Cerruti, Adel Schwertani, Renzo Cecere
Summary: The study demonstrated that inserting human amniotic stromal mesenchymal stem cells (ASMCs) in a chitosan and hyaluronic acid (C/HA) based hydrogel significantly increased cardiac function and promoted new vessel formation in a rat myocardial infarction model. Proteomic profiling revealed that extracellular vesicles released from hypoxia-preconditioned ASMCs contained proteins involved in cytoprotection and angiogenesis.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xuan Wei, Bing Wu, Jing Zhao, Zhi Zeng, Wanling Xuan, Shiping Cao, Xiaobo Huang, Masanori Asakura, Dingli Xu, Jianping Bin, Masafumi Kitakaze, Yulin Liao
Article
Oncology
Huixin Hao, Xixian Li, Qingman Li, Hairuo Lin, Zhenhuan Chen, Jiahe Xie, Wanling Xuan, Wangjun Liao, Jianping Bin, Xiaobo Huang, Masafumi Kitakaze, Yulin Liao
Article
Cardiac & Cardiovascular Systems
Wanling Xuan, Weixing Huang, Ruijie Wang, Chang Chen, Yequn Chen, Yan Wang, Xuerui Tan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Critical Care Medicine
Wanling Xuan, Yan Wang, Yaoliang Tang, Ailia Ali, Hong Hu, Mark Maienschein-Cline, Muhammad Ashraf
Article
Cardiac & Cardiovascular Systems
Yi Yan, Yulin Liao, Li Yang, Juefei Wu, Jing Du, Wanling Xuan, Lijing Ji, Qiaobing Huang, Yili Liu, Jianping Bin
CARDIOVASCULAR RESEARCH
(2011)
Article
Cardiac & Cardiovascular Systems
Jiajia Xie, Yulin Liao, Li Yang, Juefei Wu, Cheng Liu, Wanling Xuan, Mingyan Li, Lin Zhang, Yili Liu, Pingsheng Wu, Jianping Bin
CARDIOVASCULAR RESEARCH
(2011)
Article
Cardiac & Cardiovascular Systems
Wanling Xuan, Yulin Liao, Baihe Chen, Qiaobing Huang, Dingli Xu, Yili Liu, Jianping Bin, Masafumi Kitakaze
CARDIOVASCULAR RESEARCH
(2011)
Article
Critical Care Medicine
Wanling Xuan, Bing Wu, Ci Chen, Baihe Chen, Wenqing Zhang, Dingli Xu, Jianping Bin, Yulin Liao
CRITICAL CARE MEDICINE
(2012)
Article
Cardiac & Cardiovascular Systems
Yulin Liao, Jianping Bin, Masanori Asakura, Wanling Xuan, Baihe Chen, Qiaobing Huang, Dingli Xu, Catherine Ledent, Seiji Takashima, Masafumi Kitakaze
EUROPEAN HEART JOURNAL
(2012)
Article
Multidisciplinary Sciences
Ci Chen, Liang Shen, Shiping Cao, Xixian Li, Wanling Xuan, Jingwen Zhang, Xiaobo Huang, Jianping Bin, Dingli Xu, Guofeng Li, Masafumi Kitakaze, Yulin Liao
Article
Cell & Tissue Engineering
Wanling Xuan, Lei Wang, Meifeng Xu, Neal L. Weintraub, Muhammad Ashraf
STEM CELLS INTERNATIONAL
(2019)
Article
Materials Science, Biomaterials
Jian Shen, Yongli Ji, Mingjun Xie, Haiming Zhao, Wanling Xuan, Li Yin, Xiaohua Yu, Fangfang Xu, Shengan Su, Jing Nie, Yao Xie, Qing Gao, Hong Ma, Xueying Ke, Zhenyu Shi, Jianzhong Fu, Zhenjie Liu, Yong He, Meixiang Xiang
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Cell & Tissue Engineering
Wanling Xuan, Mahmood Khan, Muhammad Ashraf
Summary: Reprogramming hiPSCs into MPC using givinostat effectively repaired injured muscles and restored dystrophin with anti-oxidative, anti-inflammatory, and muscle gene-promoting properties.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Muhammad Ashraf, Srinivas M. Tipparaju, Joung Woul Kim, Wanling Xuan
Summary: The failure of muscle repair in aging may lead to muscle mass loss. Muscle progenitor cells (MPCs) were generated from human iPSC cell lines using small molecules. It was found that ITGA4, heavily expressed in Givi-MPCs, plays a role in directing MPC migration to the injury site.