Article
Biochemistry & Molecular Biology
Wanjing Zou, Jingwei Gu, Jianna Li, Yuanfang Wang, Shiguo Chen
Summary: The study successfully synthesized IQAS and ISB derivatives and systematically investigated the effects of their substitution degree, carbon chain length, and content ratio on water solubility, antibacterial activity, and cytotoxicity of CS derivatives, suggesting that the properties of CS derivatives can be tailored by adjusting the amount of grafted antibacterial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Chemistry, Physical
Maria Jose G. de Araujo, Francivandi C. Barbosa, Marcus Vinicius L. Fook, Suedina Maria L. Silva, Itamara F. Leite
Summary: In this study, an antimicrobial packaging material was successfully developed by melt processing blends of high-density polyethylene (HDPE) and chitosan (CS). The effect of chitosan content (up to 40%) and the addition of quaternary ammonium salt functionalized chitosan (CS-CTAB) as an additive were evaluated. The results showed that HDPE/CS composites with 10% and 20% chitosan exhibited better elongation values and higher thermal stability, and the additive acted as an antimicrobial agent, making the composites suitable for food packaging.
Article
Environmental Sciences
Wenxin Song, Zhimin Gao, Chengsi Hou, Xiaoxiang Cheng, Jinchuan Lian, Tao Yang, Zhiwei Zhou, Daoji Wu, Heng Liang
Summary: A strategy of pre-oxidation with sodium percarbonate (SPC) enhanced by chitosan quaternary ammonium salt (HTCC) coagulation was proposed to improve the performance of ultrafiltration (UF) for algae removal. The results showed that the SPC-HTCC treatment had a significant effect on the removal of algal pollutants, reducing their concentration and alleviating membrane fouling.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nanoscience & Nanotechnology
Qingyan Chen, Kai Zhao, Guoping Li, Jiyue Luo, Xin Li, Yingjie Zeng, Xiao-mao Wang
Summary: Given the increasing demand for drinking water purifiers, researchers have successfully developed highly permeable membranes with strong antimicrobial properties. These membranes, created through chemical grafting of quaternary ammonium salt molecules onto biodegradable polylactic acid substrates, exhibit excellent antimicrobial efficiency and high water filtration rates.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Zonghua Tian, Xia Wu, Li Peng, Na Yu, Guojing Gou, Wenbao Zuo, Jianhong Yang
Summary: In this study, pH-responsive bufadienolides nanocrystals decorated by chitosan quaternary ammonium salt (HE BU NCs) were successfully constructed to improve the bioavailability, release characteristics, and intestinal transport ability of bufadienolides. In vitro studies showed that HE BU NCs could improve the internalization of bufadienolides, induce apoptosis, decrease mitochondrial membrane potential, and increase ROS levels in tumor cells. In vivo experiments demonstrated that HE BU NCs effectively targeted intestinal sites, increased retention time, and exerted antitumor activity through Caspase-3 and Bax/Bcl-2 ratio pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Abolfazl Heydari, Eva Dusicka, Matej Micusik, Marian Sedlak, Igor Lacik
Summary: In this study, the characteristics of N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan salt (HTCS) were investigated, revealing a significant exchange of chloride counterions during synthesis, with the true degree of quaternization determined by NMR spectroscopy. This phenomenon of counterion exchange was further validated by XPS and shown for quaternized dextran, highlighting the importance of considering counterion type in applications of polyelectrolytes.
Article
Environmental Sciences
Huaicheng Zhang, Shudi Zhao, Aimin Li, Kaiqin Bian, Shanqi Shen, Meng Tao, Peng Shi
Summary: The researchers systematically studied the structure-dependent antimicrobial mechanism of QARs and synthesized a new resin, Ac-81, with a surficial antibacterial design, which exhibited better antimicrobial efficiency and higher contaminant removal potential. Ac-81 showed remarkable broad-spectrum antibacterial effects against various bacteria in simulated and actual water, significantly improving water quality by reducing contaminants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Polymer Science
Tao Lin, Dandan Chen, Yan Geng, Jiayu Li, Yanghui Ou, Zhijun Zeng, Canqiang Yin, Xudong Qian, Xiang Qiu, Gang Li, Yali Zhang, Wen Guan, Mengjie Li, Xiaojia Cai, Jiaqiang Wu, Wen-Hua Chen, Yan-Qing Guan, Hongliang Yao
Summary: In this study, a compound with anti-inflammatory activity, 3J, was synthesized and incorporated into an intelligent composite hydrogel for the treatment of oral ulcers. The hydrogel exhibited a dense honeycomb structure for effective drug loading and wound ventilation, as well as biodegradability. It showed antibacterial effects, reduced inflammatory cytokine levels, and had excellent swelling and water retention properties, making it a promising treatment for oral ulcers.
Article
Polymer Science
Chaitany Jayprakash Raorane, Yeseul Kim, Thirukumaran Periyasamy, Jin-Hyung Lee, Selvakumari Ulagesan, Taek-Jeong Nam, Seong-Cheol Kim, Jintae Lee
Summary: The development of antimicrobial and antibiofilm materials for treating bacterial pathogens is attracting attention. A novel copolymer with dual functions was synthesized in this study. The copolymer exhibited high-efficient antimicrobial and antibiofilm properties, making it a potential antimicrobial agent in biomedical applications.
Article
Materials Science, Textiles
Muhammad Asad Saleem, Liujun Pei, Muhammad Faizan Saleem, Sumaira Shahid, Jiping Wang
Summary: A novel sustainable approach was used to combine dyeing and antimicrobial finishing for nylon fabric in a non-aqueous media dyeing system. The results showed that the D5 non-aqueous media dyeing system achieved uniformly dyed samples with high color strength and excellent colorfastness. After multiple washing cycles, the treated samples still exhibited good antibacterial activity.
TEXTILE RESEARCH JOURNAL
(2023)
Article
Electrochemistry
F. N. Jumaah, N. M. Mustafa, N. N. Mobarak, N. H. Hassan, S. A. M. Noor, N. A. Ludin, K. H. Badri, A. Ahmad, M. Yoshizawa-Fujita, M. S. Su'ait
Summary: Conventional ionic liquids have been widely used in various applications due to their unique properties and significant potential. In this preliminary study, a bio-based quaternary ammonium salt (QAS) ionic liquid crystals (ILC) was synthesized using lauric acid as an alternative and renewable feedstock. The chemical structure, ionic conductivity, and solid-solid transitions of the ILC were investigated. The findings suggest that the bio-based QAS has promising potential as an electrolyte for dye-sensitized solar cells.
ELECTROCHIMICA ACTA
(2023)
Article
Polymer Science
Jianjian Jiao, Chi Ma, Linlin Zhang, Fan Li, Tianxu Gao, Lei Wang, Lee Tin Sin
Summary: A hexameric quaternary ammonium salt surfactant with a rigid triazine spacer and six ammonium groups (Tz-6C(12)QC) was synthesized. The self-assembly behavior of Tz-6C(12)QC at different concentrations and its effects on the rheological behavior of the polyacrylamide system were investigated. The results showed that Tz-6C(12)QC exhibited excellent surface activity and had the ability to reduce the viscosity of polyacrylamide. The study also revealed the different structures formed by Tz-6C(12)QC at varying concentrations.
Article
Biochemistry & Molecular Biology
Linyu Nian, Yao Xie, Xiaoyang Sun, Mengjun Wang, Chongjiang Cao
Summary: In this study, a multifunctional packaging biopolymer-based film (CMCGF) was developed using a modified metal-organic framework (MOF) and a blended matrix of chitosan quaternary ammonium salt (CQAS)/gelatin. The CMCGF film showed improved physicochemical properties and had a higher ethylene adsorption performance compared to the control film (CGF). The release of Cu ions from CMCGF resulted in bacterial death, with an antibacterial efficiency of 97-100% against E. coli and 98-100% against S. aureus. Postharvest storage experiments confirmed the high-efficiency preservation effect of CMCGF packaging on tomato and winter jujube. Therefore, CMCGF provides a multifunctional approach to extend the shelf-life of perishable products and reduce food wastage.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Li Zhang, Xue-Zhen Feng, Zhuan-Quan Xiao, Guo-Rong Fan, Shang-Xing Chen, Sheng-Liang Liao, Hai Luo, Zong-De Wang
Summary: Beta-pinene quaternary ammonium salts were synthesized and evaluated for their antifungal, antibacterial, and anticancer activities, with compound 4a showing remarkable effectiveness. These findings suggest the potential of beta-PQA salts as novel antimicrobial and anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)