Methanogenesis involves direct hydride transfer from H2 to an organic substrate

The bacterial [Fe]-hydrogenase paralog uses tetrahydrofolate derivatives as substrates

(2019) Tomohiro Watanabe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Methyl (Alkyl)-Coenzyme M Reductases: Nickel F-430-Containing Enzymes Involved in Anaerobic Methane Formation and in Anaerobic Oxidation of Methane or of Short Chain Alkanes

(2019) Rudolf K. Thauer   BIOCHEMISTRY

A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor

(2019) Hui-Jie Pan et al.   Nature Chemistry

The atomic-resolution crystal structure of activated [Fe]-hydrogenase

(2019) Gangfeng Huang et al.   Nature Catalysis

Functional Hydride Transfer by a Thiolate-Containing Model of Mono-Iron Hydrogenase featuring an Anthracene Scaffold

(2018) Spencer A. Kerns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dioxygen Sensitivity of [Fe]-Hydrogenase in the Presence of Reducing Substrates

(2018) Gangfeng Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Mimics of the [Fe]-Hydrogenase: A Complete Set for Group VIII Metals

(2018) Chandan Kr Barik et al.   INORGANIC CHEMISTRY

Effects of Thiolate Ligation in Monoiron Hydrogenase (Hmd): Stability of the {Fe(CO)2}2+ Core with NNS Ligands

(2018) Zhu-Lin Xie et al.   INORGANIC CHEMISTRY

Molybdenum- and tungsten-containing formate dehydrogenases and formylmethanofuran dehydrogenases: structure, mechanism and cofactor insertion

(2018) Dimitri Niks et al.   PROTEIN SCIENCE

Direct Observation of an Iron-Bound Terminal Hydride in [FeFe]-Hydrogenase by Nuclear Resonance Vibrational Spectroscopy

(2017) Edward J. Reijerse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and functional synthetic model of mono-iron hydrogenase featuring an anthracene scaffold

(2017) Junhyeok Seo et al.   Nature Chemistry

Structural basis of the redox switches in the NAD+-reducing soluble [NiFe]-hydrogenase

(2017) Y. Shomura et al.   SCIENCE

Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction

(2017) Tristan Wagner et al.   SCIENCE

Accumulating the hydride state in the catalytic cycle of [FeFe]-hydrogenases

(2017) Martin Winkler et al.   Nature Communications

A Functional Model of [Fe]-Hydrogenase

(2016) Tao Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methane production from coal by a single methanogen

(2016) D. Mayumi et al.   SCIENCE

The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters

(2016) T. Wagner et al.   SCIENCE

The radical mechanism of biological methane synthesis by methyl-coenzyme M reductase

(2016) T. Wongnate et al.   SCIENCE

MtrA of the sodium ion pumping methyltransferase binds cobalamin in a unique mode

(2016) Tristan Wagner et al.   Scientific Reports

Mononuclear Iron(II) Dicarbonyls Derived from NNS Ligands - Structural Models Related to a “Pre-Acyl” Active Site of Mono-Iron (Hmd) Hydrogenase

(2015) Keren A. Thomas Muthiah et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Iron Hydride Detection and Intramolecular Hydride Transfer in a Synthetic Model of Mono-Iron Hydrogenase with a CNS Chelate

(2015) Gummadi Durgaprasad et al.   INORGANIC CHEMISTRY

Hydrogens detected by subatomic resolution protein crystallography in a [NiFe] hydrogenase

(2015) Hideaki Ogata et al.   NATURE

Mechanism of hydrogen activation by [NiFe] hydrogenases

(2015) Rhiannon M Evans et al.   Nature Chemical Biology

Reconstitution of [Fe]-hydrogenase using model complexes

(2015) Seigo Shima et al.   Nature Chemistry

Hydride bridge in [NiFe]-hydrogenase observed by nuclear resonance vibrational spectroscopy

(2015) Hideaki Ogata et al.   Nature Communications

New Mode of Energy Metabolism in the Seventh Order of Methanogens as Revealed by Comparative Genome Analysis of “Candidatus Methanoplasma termitum”

(2014) Kristina Lang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Hydrogenases

(2014) Wolfgang Lubitz et al.   CHEMICAL REVIEWS

Synthesis, structural characterization, and some properties of 2-acylmethyl-6-ester group-difunctionalized pyridine-containing iron complexes related to the active site of [Fe]-hydrogenase

(2014) Li-Cheng Song et al.   DALTON TRANSACTIONS

The F420-Reducing [NiFe]-Hydrogenase Complex from Methanothermobacter marburgensis, the First X-ray Structure of a Group 3 Family Member

(2014) Stella Vitt et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structures of [Fe]-Hydrogenase in Complex with Inhibitory Isocyanides: Implications for the H2-Activation Site

(2013) Haruka Tamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioenergetics and anaerobic respiratory chains of aceticlastic methanogens

(2013) Cornelia Welte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

[Fe]-Hydrogenase and Models that Contain IronAcyl Ligation

(2013) Katherine M. Schultz et al.   Chemistry-An Asian Journal

Biomimetic assembly and activation of [FeFe]-hydrogenases

(2013) G. Berggren et al.   NATURE

De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy

(2013) Deryck J Mills et al.   eLife

Reversible Protonation of a Thiolate Ligand in an [Fe]-Hydrogenase Model Complex

(2012) Dafa Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Pyridinol Acyl Cofactor in the Active Site of [Fe]-hydrogenase Evidenced by the Reactivity of Model Complexes

(2012) Bowen Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Five-Coordinate Iron Center in the Active Site of [Fe]-Hydrogenase: Hints from a Model Study

(2011) Dafa Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insight into the Mechanism of Dihydrogen-Heterolysis at Cyclopentadienone Iron Complexes and Subsequent CX Hydrogenation

(2011) Adrian von der Höh et al.   ChemCatChem

Evidence for acyl–iron ligation in the active site of [Fe]-hydrogenase provided by mass spectrometry and infrared spectroscopy

(2011) Seigo Shima et al.   DALTON TRANSACTIONS

Synthesis and Characterization of a Series of Model Complexes of the Active Site of [Fe]-Hydrogenase (Hmd)

(2011) Dafa Chen et al.   INORGANIC CHEMISTRY

Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea

(2011) A.-K. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

[Fe]-Hydrogenase Models Featuring Acylmethylpyridinyl Ligands

(2010) Dafa Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Third Hydrogenase: A Ferracyclic Carbamoyl with Close Structural Analogy to the Active Site of Hmd

(2010) Peter J. Turrell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrogenases from Methanogenic Archaea, Nickel, a Novel Cofactor, and H2Storage

(2010) Rudolf K. Thauer et al.   Annual Review of Biochemistry

Analysis of a Pentacoordinate Iron Dicarbonyl as Synthetic Analogue of the Hmd or Mono-Iron Hydrogenase Active Site

(2010) Tianbiao Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure and Function of [Fe]-Hydrogenase and its Iron-Guanylylpyridinol (FeGP) Cofactor

(2010) Seigo Shima et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Iron Acyl Thiolato Carbonyls: Structural Models for the Active Site of the [Fe]-Hydrogenase (Hmd)

(2010) Aaron M. Royer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Density Functional Theory Calculations on the Mononuclear Non-Heme Iron Active Site of Hmd Hydrogenase: Role of the Internal Ligands in Tuning External Ligand Binding and Driving H2Heterolysis

(2010) Abhishek Dey   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Crystal Structure of an [Fe]-Hydrogenase-Substrate Complex Reveals the Framework for H2Activation

(2009) Takeshi Hiromoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Basis of the Hydride Transfer Mechanism in F420-Dependent Methylenetetrahydromethanopterin Dehydrogenase

(2009) Katharina Ceh et al.   BIOCHEMISTRY

The crystal structure of C176A mutated [Fe]-hydrogenase suggests an acyl-iron ligation in the active site iron complex

(2009) Takeshi Hiromoto et al.   FEBS LETTERS

An Iron Carbonyl Pyridonate Complex Related to the Active Site of the [Fe]-Hydrogenase (Hmd)

(2009) Blaise V. Obrist et al.   INORGANIC CHEMISTRY

Synthesis and Reactivity of Iron Acyl Complexes Modeling the Active Site of [Fe]-Hydrogenase

(2009) Dafa Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Addition of Thioesters to Iron(0): Active-Site Models for Hmd, Nature’s Third Hydrogenase

(2009) Aaron M. Royer et al.   ORGANOMETALLICS

The iron centre of the cluster-free hydrogenase (Hmd): low-spin Fe(ii) or low-spin Fe(0)?

(2008) Xiufeng Wang et al.   CHEMICAL COMMUNICATIONS

Characterization of the Fe Site in Iron−Sulfur Cluster-Free Hydrogenase (Hmd) and of a Model Compound via Nuclear Resonance Vibrational Spectroscopy (NRVS)

(2008) Yisong Guo et al.   INORGANIC CHEMISTRY

Methanogenic archaea: ecologically relevant differences in energy conservation

(2008) Rudolf K. Thauer et al.   NATURE REVIEWS MICROBIOLOGY

The Crystal Structure of [Fe]-Hydrogenase Reveals the Geometry of the Active Site

(2008) S. Shima et al.   SCIENCE

Coordination Chemistry of a Model for the GP Cofactor in the Hmd Hydrogenase:  Hydrogen-Bonding and Hydrogen-Transfer Catalysis

(2007) Aaron M. Royer et al.   INORGANIC CHEMISTRY