Article
Cardiac & Cardiovascular Systems
Andrei C. Sposito, Ikaro Breder, Joaquim Barreto, Jessica Breder, Isabella Bonilha, Marcus Lima, Alessandra Oliveira, Vaneza Wolf, Beatriz Luchiari, Helison R. do Carmo, Daniel Munhoz, Daniela Oliveira, Otavio R. Coelho-Filho, Otavio R. Coelho, Jose Roberto Matos-Souza, Filipe A. Moura, Luiz Sergio F. de Carvalho, Wilson Nadruz, Thiago Quinaglia, Sheila T. Kimura-Medorima
Summary: The addition of evolocumab to empagliflozin in individuals with T2D improves endothelial function, leading to better vascular function.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Sport Sciences
Francisco Javier Soto-Rodriguez, Eva Isidoro Cabanas, Jose Manuel Perez-Marmol
Summary: Prolonged sitting can affect endothelial function, and strategies that interrupt sitting have shown significant improvements in shear rate, flow-mediated dilation, and blood flow, thus playing a crucial role in preventing endothelial dysfunction.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Physiology
Andrea Tryfonos, Joseph Mills, Daniel J. Green, Anton J. M. Wagenmakers, Ellen A. Dawson, Matthew Cocks
Summary: This study examined the relationships between in vivo measures of vascular function and the expression of atherogenic risk-modulating proteins in endothelial cells (ECs) isolated from the radial artery of CAD patients. The results revealed a difference in the regulation of endothelium-dependent vasodilation measured in vivo between patients with CAD compared to previously reported data in subjects without a clinical diagnosis, suggesting that eNOS Ser(1177) phosphorylation may be the key to maintain vasodilation in CAD patients.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Rheumatology
Kavita Poonia, Mala Bhalla, Kanika Dogar, Anita Malhotra, Kajal Aggarwal
Summary: Flow-mediated dilatation (FMD) testing can assess macrovascular dysfunction in systemic sclerosis (SS) and correlate FMD values with disease severity. Lower FMD values were observed in SS patients compared to healthy controls. Lung manifestations in SS patients were associated with lower FMD values.
CLINICAL RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Woo-Young Chung
Summary: This study investigated the prognostic value of reactive hyperemia index (RHI), a measure of endothelial function, in patients with heart failure (HF). The findings suggest that a lower RHI value is associated with an increased risk of adverse clinical outcomes in HF, indicating that endothelial dysfunction may be an important prognostic marker in HF patients.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Christos Chatzakis, Nikolaos Koletsos, Maria Tirta, Konstantinos Dinas, Eugenia Gkaliagkousi, Alexandros Sotiriadis
Summary: This meta-analysis compared endothelial dysfunction between women with and without gestational diabetes mellitus (GDM) during pregnancy and post-partum. The results indicated that pregnant women with GDM had lower flow-mediated dilation (FMD) compared to those without GDM. Additionally, women with previous GDM showed lower FMD in the immediate post-partum period, but there was no significant difference in the late post-partum period (more than 4 years).
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Peripheral Vascular Disease
Theresa Herbrand, Hans-Veit Coester, Roberto Sansone, Annelie Fischer, Christian Heiss, Tim Heise, Malte Kelm, Hans J. DeVries
Summary: The study found that assessing FMD using the maximum dilatory peak (MDP) was more accurate and precise than the traditional 60-second method in both healthy subjects and those with type 2 diabetes mellitus (T2DM), leading to a significant reduction in necessary sample size.
Article
Endocrinology & Metabolism
Li-ying Hou, Xiao Li, Guo-qiang Zhang, Chuang Xi, Chen-tian Shen, Hong-jun Song, Wen-kun Bai, Zhong-ling Qiu, Quan-yong Luo
Summary: The purpose of this study was to assess the impact of short-term hypothyroidism on endothelial function and metabolic changes in patients with differentiated thyroid cancer during radioiodine therapy. The results showed that endothelial function was impaired during short-term hypothyroidism, but immediately returned to normal after restoring thyroid stimulating hormone suppression therapy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Sheung Yin San, Jennifer. M. F. Wan, Jimmy Chun Yu Louie
Summary: This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction. The results showed that salt reduction may still be the most effective strategy to improve vascular health.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Peripheral Vascular Disease
Keishi Ichikawa, Toru Miyoshi, Yuko Ohno, Kazuhiro Osawa, Mitsutaka Nakashima, Takahiro Nishihara, Takashi Miki, Hironobu Toda, Masatoki Yoshida, Hiroshi Ito
Summary: This study found that there is an association between high PCAT attenuation and endothelial dysfunction assessed using FMD in patients with suspected coronary artery disease. These results suggest that endothelial dysfunction may be one of the pathophysiological mechanisms linking pericoronary inflammation to cardiac mortality.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Enrique Garcia-Sayan, Miryoung Lee, James R. Stone, Danielle M. Stone, Beverly Smulevitz, David D. McPherson, Susan P. Fisher-Hoch, Joseph B. McCormick, Susan T. Laing
Summary: Endothelial dysfunction assessed by impaired brachial flow-mediated dilation (FMD) predicts incident cardiovascular disease (CVD). This study aimed to assess determinants of impaired FMD response (%FMD), an earlier marker of atherosclerosis, in a population-based sample of asymptomatic Mexican Americans. The results showed age-dependent associations between cardiometabolic biomarkers and an FMD response in a sample composed of Mexican Americans without previous CVD.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Georgios Mavraganis, Maria-Angeliki Dimopoulou, Dimitrios Delialis, Dimitrios Bampatsias, Raphael Patras, Alexandros Sianis, Eleni Maneta, Kimon Stamatelopoulos, Georgios Georgiopoulos
Summary: Research suggests that endothelial dysfunction and increased arterial stiffness are associated with the severity and prognosis of COVID-19. These vascular impairments may play a crucial role in the clinical manifestations of COVID-19 and can be used for risk stratification.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Joshua I. Barzilay, Petra Buzkova, Howard A. Fink, Jane A. Cauley, Laura Carbone, Rachel Elam, John A. Robbins, Phyllis Stein, Kerry Sheets, Diana Jalal, Kenneth J. Mukamal
Summary: Endothelial dysfunction, which is associated with atherosclerotic vascular disease, was not found to have a significant association with hip fracture risk in older adults based on the examination of two markers of endothelial dysfunction.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Environmental Sciences
Szymon Mucka, Martyna Miodonska, Grzegorz K. Jakubiak, Monika Starzak, Grzegorz Cieslar, Agata Stanek
Summary: Assessment of endothelial function, particularly using the non-invasive method of flow-mediated dilation (FMD), is crucial in predicting the risk of cardiovascular diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Cody Juguilon, Zhiyuan Wang, Yang Wang, Molly Enrick, Anurag Jamaiyar, Yanyong Xu, James Gadd, Chwen-Lih W. Chen, Autumn Pu, Chris Kolz, Vahagn Ohanyan, Yeong-Renn Chen, James Hardwick, Yanqiao Zhang, William M. Chilian, Liya Yin
Summary: This study reveals the mechanism of coronary microvascular dysfunction in patients with diabetes, identifying the switch from NO to H2O2 and confirming its association with upregulation of miR-21.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Salik Nazir, Keerat R. Ahuja, Anthony Donato, Robert D. Grande, Khalid Changal, Mohamed M. Gad, Anas Saad, Beni R. Verma, Mubasshar A. Syed, Mujeeb Sheikh, Samir Kapadia, P. Kasi Ramanathan
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Salik Nazir, Keerat R. Ahuja, Hafeez U. H. Virk, Ahmed Elzanaty, Tayyab A. Waheed, Khalid H. Changal, Kevin Wohlfarth, Vladimir Lakhter, Robert D. Grande, Ehab A. Eltahawy
Summary: In patients with acute coronary syndrome (ACS), genotype-guided initiation of P2Y(12) inhibitors was associated with lower rates of major adverse cardiovascular events (MACE) and similar bleeding risk compared to standard care treatment. This treatment approach may have potential benefits for ACS patients.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Sameer Saleem, Mubbasher Syed, Ahmed M. Elzanaty, Salik Nazir, Khalid Changal, Sajjad Gul, Mujeeb Sheikh
CORONARY ARTERY DISEASE
(2020)
Letter
Cardiac & Cardiovascular Systems
Khalid Changal, Mitra Patel, Tanveer Mir, Ahmed Elzanaty, Salik Nazir, Ehab Eltahawy
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Khalid Changal, Saqib Masroor, Salik Nazir, Sadik Khuder, Ehab Eltahawy
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Khalid Changal, Mitra Patel, F. N. U. Salman, Salik Nazir, Rajesh Gupta
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Khalid Changal, Saqib Masroor, Ahmed Elzanaty, Mitra Patel, Tanveer Mir, Shayan Khan, Salik Nazir, Ronak Soni, Carson Oostra, Sadik Khuder, Ehab Eltahawy
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Khalid Changal
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Khalid Changal, Mubbasher Ameer Syed, Ealla Atari, Salik Nazir, Sameer Saleem, Sajjad Gul, F. N. U. Salman, Asad Inayat, Ehab Eltahawy
Summary: The study assessed current training preferences, expertise, and comfort with transfemoral access (TFA) and transradial access (TRA) among cardiovascular training fellows and teaching faculty in the United States. Results showed significant differences between trainees and trainers in comfort and preference for TFA and TRA, with concerns regarding training in TFA and the shift to radial access.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Khalid Changal, Tanveer Mir, Rachel Royfman, Pratyush Pavan Devarasetty, Rohit Vyas, Mohammed M. Uddin, Waseem Farooq, Mujeeb Sheikh, Ehab Eltahawy
Summary: This study aimed to investigate group differences in ST-elevation myocardial infarction (STEMI) patients with or without associated coronary artery aneurysms (CAA). The study found significant differences between patients with and without CAA, including patient characteristics, risk of coronary dissection, treatment, and mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Muhammad Asif Mangi, Chandramohan Meenakshisundaram, Mubbasher Ameer Syed, Khalid Hamid Changal, Mohammed Alyosif, Mark W. Burket, Mujeeb A. Sheikh
JOURNAL OF INVASIVE CARDIOLOGY
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Salik Nazir, Keerat Rai Ahuja, Mubbasher A. Syed, Khalid Changal, Mohammed Gad, Anas Saad, Robert Grande, Mujeeb Sheikh, Kasi Ramanathan
JACC-CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Medicine, General & Internal
Muhammad S. Khan, Rahil Kasmani, Ghazal Khan, Khalid Changal, Hemindermeet Singh
CUREUS JOURNAL OF MEDICAL SCIENCE
(2019)
Meeting Abstract
Hematology
Ronak G. Soni, Smit Patel, Mohit Pahuja, Khalid Changal, Mujeeb Sheikh
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)