Article
Chemistry, Applied
Lei Wang, Dong Xiang, Conga Li, Weimin Zhang, Xinpeng Bai
Summary: Studies have shown that low temperature significantly affects the conformation and properties of xanthan molecules, leading to an increase in the double-helix portion and changes in properties such as interfacial tension and hydrophobicity.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Fatih Ozbas, Elif Tuzun, Ahmet Yildiz, Selcan Karakus
Summary: An optimized method was developed for the synthesis of biological macromolecule blend supported iron oxide nanoparticles in this study. The synthesized nanoparticles were characterized and optimized to determine the effect of the biopolymer blend matrix on morphology, size, stability, and thermal properties. Optimization analysis confirmed that sonication played a role in size distribution and stability of nanoparticles with the optimum mixture ratio of the binary biopolymer matrix.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Dongling Qiao, Wenjuan Shi, Man Luo, Wanting Hu, Yuchun Huang, Fatang Jiang, Fengwei Xie, Binjia Zhang
Summary: This study reveals how the addition of xanthan gum (XG) adjusts the performance of an agar/konjac glucomannan (KGM) system. The results show that increasing the XG content can strengthen the chain entanglement, increase viscosity, sol-gel transition point, and gel hardness, as well as improve hydrogen bonding and tensile strength.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Xiliang Yu, Yue Wang, Wenyu Zhao, Shouwei Li, Jinfeng Pan, Sangeeta Prakash, Xiuping Dong
Summary: The effects of different KGM/XG ratios on the properties of cooked sturgeon pastes were investigated. The pastes demonstrated shear-thinning behavior and viscoelasticity, making them suitable for 3D printing. The texture properties of the pastes were significantly improved with different KGM/XG ratios and met the requirements for transitional foods in the IDDSI framework. Cross-linking between proteins through hydrogen bonding was promoted by the addition of KGM/XG, strengthening the network structure.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Hiroyuki Takeno, Mao Nishino, Wen -Chuan Hsieh
Summary: The study examined the properties of freeze-thawed konjac glucomannan (GM) gels prepared using sodium carbonate as a solidifying agent. The freezing-thawing treatment enhanced the compressive stress and crystallization of GM gels. Three additives, curdlan (CUD), antifreeze glycoprotein (AFGP), and tremella fuciformis polysaccharide (TFP), were added to the GM gels prepared at pH = 8.5. The CUD-added gels showed unchanged compressive stress but lower water-holding capacity (WHC) after the FT treatment. The AFGP and TFP gels had increased compressive stress and high WHC after FT treatment.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Dongling Qiao, Man Luo, Yishen Li, Fatang Jiang, Binjia Zhang
Summary: Combined with rheology and micro-DSC methods, atomic force microscopy revealed the syner-gistic binding ways of KGM and xanthan in high pyruvate group content composites. Type A binding was associated with the interactions of KGM and helical structures of xanthan, while Type B binding involved the interactions of KGM and disordered xanthan molecules. This study contributes to the comprehensive understanding of the binding ways between KGM and xanthan and provides valuable insights for exploring the binding ways of food hydrocolloids.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Zhu Tao Han, Wen Min Long, Tie Hua Zhang, Zhou Yong Dong, Jia Xin Yan
Summary: The effects of xanthan gum, konjac gum, and mixed gum of xanthan gum and konjac gum on the gel properties of Oviductus Ranae were studied. The addition of xanthan gum and mixed gum increased the hardness, water-holding capacity, and energy storage modulus of the gel, while the addition of konjac gum had the opposite effect. When the mass ratio of xanthan gum to konjac gum was 1:1, the gel exhibited maximum hardness, springiness, and chewiness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yan Chen, Xuefeng Gao, Bin Li, Jing Tian
Summary: The study investigated the effects of the interaction between konjac glucomannan (KGM) and dihydromyricetin (DMY) on KGM's viscosity, hydration capacity, and DMY's thermal stability. Contrary to most reports, adding DMY to KGM increased viscosity and hydration capacity and improved DMY's retention and radical scavenging capacity under heating conditions. The KGM-DMY complex was characterized as a non-covalent compound connected by hydrogen bonds. This study is beneficial for the development of polyphenol-enriched nutrition based on KGM, particularly in terms of satiety, appetite regulation, and glucose regulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xinli Ran, Hongshun Yang
Summary: This research investigated the effect of konjac glucomannan (KGM) concentrations on the molecular interactions, gelation behaviors, and viscoelastic properties of a soy protein - konjac glucomannan complex gel. The results showed that increasing KGM concentration enhanced the strain-hardening effect and promoted protein denaturation and aggregation. The gel strength and crystalline index of the complex gel improved significantly with increased KGM incorporation. This study provides fundamental support for the potential application of the KGM-protein complex in plant-based seafood alternatives.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Physical
Keerti Chauhan, Amit Raj Singh, Sanjay Kumar, Rony Granek
Summary: This research investigates the kinetics of DNA sequence melting using molecular dynamic simulations and the Gaussian binding energy model. Two major partial denaturation states are identified, and their influence on the dynamics of base pair opening and closing is analyzed. The study demonstrates that multi-step relaxation can be observed by tagging specific base pairs at certain temperatures. It also suggests which base pairs should be tagged in order to observe this behavior. The results show that the Gaussian binding energy model can reliably predict the dynamics of long DNA sequences, where molecular dynamic simulations may be limited.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Materials Science, Multidisciplinary
Ning Li, Yuheng Lei, Ziyuan Song, Lichen Yin
Summary: Polypeptides obtained from N-carboxyanhydrides' ring-opening polymerization have attracted broad interests as synthetic analogues of natural proteins. They form ordered secondary structures like alpha-helices and 8-sheets, offering unique conformation-specific functions and potential biomedical applications.
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mohammed A. Abosheasha, Toru Itagaki, Yoshihiro Ito, Motoki Ueda
Summary: The LxxxLxxxL sequence is crucial for nanotube self-assembly, as evidenced by the formation of nanotubes with different diameters and the fabrication of double-layer nanotubes by combining two types of nanotubes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Eloise Masquelier, Sheng-Ping Liang, Lior Sepunaru, Daniel E. Morse, Michael J. Gordon
Summary: The reversible electrochemical triggering of polylysine conformational transition was achieved at a Pt electrode, allowing for easy distinction of different reduction processes. In situ UV absorbance and circular dichroism spectroscopies were used to track the evolution of alpha-helix formation, while isotope experiments confirmed direct electroreduction as the cause of subsequent alpha-helix formation. The site-selective electrochemistry and optical methodologies present potential for studying and controlling dynamic structural evolution in biomolecular systems.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Applied
Said Elmarhoum, Komla Ako, Claire D. Munialo, Yahya Rharbi
Summary: The polysaccharide in solution forms a nano hydrogel (nHG) at the critical concentration Cc (g/L). The temperature at which the kappacarrageenan (kappa-Car) nHG swells the most is 20 +/- 2 degrees C with Cc = 0.55 +/- 0.05 g/L. In the presence of KCl, the minimum deswelling temperature is found to be 30 +/- 2 degrees C for 5 mM with Cc = 1.15 +/- 0.05 g/L, but it is not measurable above 100 degrees C for 10 mM with Cc = 1.3 +/- 0.05 g/L. The viscosity of the nHG increases with time at a logarithmic scale, and the relative increment of viscosity per unit concentration (Rv) should increase with increasing polysaccharide concentration. However, Rv decreases for kappa-Car samples above 3.5 +/- 0.5 g/L in the presence of 10 mM KCl under steady shear 15 s-1, indicating a decrease in the helicity degree of kappa-Car.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Yu-Chieh Lan, Lih-Shiuh Lai
Summary: Water caltrop starch isolated from dehydrated water caltrop has higher protein and ash content compared to starch from fresh water caltrop, resulting in slightly lower starch purity. The addition of gums to the starch system increases the pasting temperature, peak viscosity, and final viscosity. Konjac glucomannan has the most pronounced effect on viscosity, followed by guar gum and xanthan gum. All WCS/gum mixed systems demonstrate shear thinning and thixotropic behavior.
FOOD HYDROCOLLOIDS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)