Article
Biochemistry & Molecular Biology
Hongcai Zhang, Tingting Qiu, Yifei Bai, Bin Chen, Juan Yan, Jianxiong Xu
Summary: In this study, cellulose nanocrystals were used to stabilize Lysozyme encapsulated in quaternary ammonium chitosan nanoparticles. The CNC stabilized Lys loaded QC NPs showed potential implications in the food industry for food preservation and packaging, as well as demonstrated good antibacterial activity against Staphylococcus aureus and Vibrio parahaemolyticus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Yingqi Mi, Yuan Chen, Wenqiang Tan, Jingjing Zhang, Qing Li, Zhanyong Guo
Summary: In this study, different chitosan derivatives were synthesized by ion exchange of glyoxylate bearing Schiff base with chitosan quaternary ammonium salts. The results showed that glyoxylate bearing Schiff base significantly improved the bioactivity of chitosan derivatives, with good antioxidant and antifungal activities.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Li-Yuan Huang, Wen Li, Nan Du, Hai-Qin Lu, Li-Dan Meng, Ke-Yu Huang, Kai Li
Summary: In this study, novel green in situ quaternary-ammonium-functionalized magnetic chitosan microspheres (IQMCM) were synthesized and characterized. The IQMCMs showed spherical morphology, superior thermal stability, magnetic properties, and surface charges. The adsorption capacities of the IQMCM microspheres to Congo red dye were high, and the adsorption process was spontaneous, endothermic, and monolayer chemisorption. The magnetic adsorbent could be easily separated and reused with little capacity loss, indicating the potential application of IQMCMs in wastewater treatment.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Wanjing Zou, Jingwei Gu, Jianna Li, Yuanfang Wang, Shiguo Chen
Summary: The study successfully synthesized IQAS and ISB derivatives and systematically investigated the effects of their substitution degree, carbon chain length, and content ratio on water solubility, antibacterial activity, and cytotoxicity of CS derivatives, suggesting that the properties of CS derivatives can be tailored by adjusting the amount of grafted antibacterial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Zonghua Tian, Xia Wu, Li Peng, Na Yu, Guojing Gou, Wenbao Zuo, Jianhong Yang
Summary: In this study, pH-responsive bufadienolides nanocrystals decorated by chitosan quaternary ammonium salt (HE BU NCs) were successfully constructed to improve the bioavailability, release characteristics, and intestinal transport ability of bufadienolides. In vitro studies showed that HE BU NCs could improve the internalization of bufadienolides, induce apoptosis, decrease mitochondrial membrane potential, and increase ROS levels in tumor cells. In vivo experiments demonstrated that HE BU NCs effectively targeted intestinal sites, increased retention time, and exerted antitumor activity through Caspase-3 and Bax/Bcl-2 ratio pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Liqiu Chu, Zhiyu Zhou, Zhipan Feng, Xinqi Zhao, Huimin Tan, Yu Chen
Summary: In this study, HTCC/Fe3O4/CdTe magnetic fluorescent nanoparticles (MFCNPs) that can be well dispersed in water were prepared via electrostatic interaction. The nanoparticles showed good biocompatibility and their properties were mainly influenced by the relative ratios of different components. The chitosan-based magnetic fluorescent composite may be a promising delivery carrier candidate.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Polymer Science
Baiqing Song, Tianyi Zhang, Xinfeng Li, Kaili Yang, Jinyu Shan, Yunzhi Dang, Jianhua Ma
Summary: Smart and controllable antibacterial fabrics have great potential in textile, medical, and healthcare fields. In this study, a composite antimicrobial fiber with thermally responsive properties was created by synthesizing nano zinc oxide (ZnO) and combining it with quaternary ammonium chitosan (QAC). The addition of a copper sulphide (CuS) layer further enhanced the antibacterial properties of the materials. These smart responsive composite fibers show promise in medical dressings, special textiles, and healthcare materials.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Tao Lin, Dandan Chen, Yan Geng, Jiayu Li, Yanghui Ou, Zhijun Zeng, Canqiang Yin, Xudong Qian, Xiang Qiu, Gang Li, Yali Zhang, Wen Guan, Mengjie Li, Xiaojia Cai, Jiaqiang Wu, Wen-Hua Chen, Yan-Qing Guan, Hongliang Yao
Summary: In this study, a compound with anti-inflammatory activity, 3J, was synthesized and incorporated into an intelligent composite hydrogel for the treatment of oral ulcers. The hydrogel exhibited a dense honeycomb structure for effective drug loading and wound ventilation, as well as biodegradability. It showed antibacterial effects, reduced inflammatory cytokine levels, and had excellent swelling and water retention properties, making it a promising treatment for oral ulcers.
Article
Energy & Fuels
Chenglong Li, Geng Liu, Shuang Wang, Di Wang, Fengxiang Liu, Yinghe Cui, Dan Liang, Xiaodong Wang, Zhipeng Yong, Yue Chi
Summary: A hydrogel electrolyte with excellent electrochemical and sensing performance was prepared. The hydrogel is composed of a highly cross-linked network formed by quaternary ammonium side chain chitosan and polyvinyl alcohol, and the device is assembled with activated carbon electrodes. After 5000 charge/discharge cycles, the capacitance retention rate of the supercapacitor device remained as high as 92.5%. Additionally, the gel exhibited outstanding sensing ability, with a sensing factor of 0.995 and a response time of 180 ms, which could still be maintained after multiple cycles.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Applied
Bing Ma, Jingjing Zhang, Yingqi Mi, Qin Miao, Wenqiang Tan, Zhanyong Guo
Summary: In this study, imidazole acids grafted chitosan derivatives were synthesized and characterized by FT-IR and 1H NMR. The chitosan derivatives exhibited improved antioxidant, antibacterial, and cytotoxic activities compared to chitosan. The derivatives also showed potential as carrier materials in drug delivery systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Samantha E. Mackay, Francois Malherbe, Daniel S. Eldridge
Summary: Phosphate contamination from agricultural runoff is a major global issue that has severe environmental effects. This study presents a synthesized biopolymer that can effectively remediate phosphate in the environment. The modified-chitosan not only demonstrates a high adsorption capacity but also shows remarkable regenerability.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Biochemistry & Molecular Biology
Lin Wang, Meihua Xin, Mingchun Li, Wenfeng Liu, Yangfan Mao
Summary: In this study, three new chitosan quaternary phosphonium compounds were synthesized and characterized. Their antibacterial activities against Escherichia coli and Staphylococcus aureus, as well as their antibiofilm activities, were investigated. The results showed that the chitosan quaternary phosphonium salts exhibited stronger antibacterial and antibiofilm activities compared to chitosan quaternary ammonium salt.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Sandeep Goyal, Ketul V. Patel, Yadav Nagare, Digambar B. Raykar, Santosh S. Raikar, Atul Dolas, Princy Khurana, Rajath Cyriac, Sharad Sarak, Mukesh Gangar, Anil K. Agarwal, Aditya Kulkarni
Summary: This study describes the design, optimization, and evaluation of novel non-peptidic acylguanidine based small molecule inhibitors of Cathepsin D, leading to the identification of an optimized lead 24e with improved microsomal stability and potency. This compound could serve as a potential candidate for further preclinical studies against diseases where Cathepsin D plays a key role.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jieun Lee, Hye Soo Park, Hee Jin Jung, Yu Jung Park, Min Kyung Kang, Hye Jin Kim, Dahye Yoon, Sultan Ullah, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Summary: Ten 2-mercaptobenzimidazole analogs were synthesized and found to be potent tyrosinase inhibitors and antioxidants. They effectively delayed browning of apple slices and could be potential anti-browning agents in foods.
Article
Chemistry, Multidisciplinary
Zhihua Yu, Jichao Zhang, Shuhui Li, Zhijuan Zhou, Ziqi Qin, Hui Liu, Yuekun Lai, Shaohai Fu
Summary: In this study, a bio-inspired fog harvesting device with a switchable 2D-3D structure made of copper is reported. The device can efficiently capture and transport fog water, and it can dynamically transform its structure in response to humidity changes, enabling effective fog harvesting and water storage.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Xuanfei Xu, Tianxue Zhu, Weiwei Zheng, Caiyun Xian, Jianying Huang, Zhong Chen, Weilong Cai, Weiying Zhang, Yuekun Lai
Summary: In this study, a scraping technique was used to coat antifogging films on a substrate by utilizing a solution containing nanoparticles. The resulting hydrophilic coating showed excellent antifogging and self-healing properties, and it could withstand prolonged exposure to heat, ultraviolet radiation, sand impact, and solvent soaking. The simple construction approach could also be applied to various flexible and rigid substrates.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Xuerui Zang, Xuewen Cao, Weiwei Zheng, Tianxue Zhu, Yonggang Lei, Jianying Huang, Zhong Chen, Lin Teng, Jiang Bian, Yuekun Lai
Summary: Inspired by human meniscus, a superhydrophobic inner pipeline coating has been developed to mitigate the erosion and corrosion damages to gas transportation pipeline. The erosion resistance of the coating is significantly improved by optimizing the filler type and buffer layer thickness. The experiment results show that the fiber filler can greatly enhance the erosion resistance of the material.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Yonggang Lei, Kim Hoong Ng, Yucheng Zhu, Yingzhen Zhang, Zengxing Li, Shen Xu, Jianying Huang, Jun Hu, Zhong Chen, Weilong Cai, Yuekun Lai
Summary: In this study, a new cocatalyst design and synthesis approach was proposed. By activating VC with Mo, the hydrogen generation activity of CdS was significantly improved. The CdS/Mo(0.38)-VC(5 wt%) photocatalyst exhibited excellent photocatalytic hydrogen production rate, hydrogen production quantum efficiency, stability, and recyclability. This work provides an economic alternative for solar-derived hydrogen production by replacing precious metals.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Tianxue Zhu, Yimeng Ni, Gill M. Biesold, Yan Cheng, Mingzheng Ge, Huaqiong Li, Jianying Huang, Zhiqun Lin, Yuekun Lai
Summary: This review explores the recent advances in multifunctional conductive hydrogels for electronic devices, including their different components and functionalities. The applications of hydrogels in flexible devices are illustrated, and the current challenges and future development prospects are discussed.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Nanoscience & Nanotechnology
Fang Guo, Yueping Bao, Jiajun Mao, Yu Xie, Jianying Huang, Xiao Hu, Yuekun Lai
Summary: In this study, carboxyl-modified graphene oxide (GO-COOH) was prepared and deposited into flexible superwettable patterned cotton (SPC) for humidity sensing. The morphology of the as-prepared electronic-SPC (ESPC) was characterized, and the carboxylation process was investigated. The ESPC showed high sensitivity for humidity sensing, with a short response time and the output current increased with increasing relative humidity. The ESPC also exhibited high stability and durability, retaining its performance even after overnight washing and bending cycles. Additionally, it showed potential for wearable health monitoring.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Tianxue Zhu, Lexin Liu, Jianying Huang, Shuhui Li, Yonggang Lei, Weilong Cai, Yuekun Lai, Huaqiong Li
Summary: This study successfully prepared a hydrophobic and conductive fabric-based strain sensor for smart fabric, which can be used as a strain sensor and wearable heater. The sensor exhibited a fast electrical response, excellent stability, and satisfactory electro-thermal and photo-thermal performances. It shows great potential for applications in medical monitoring and personal care.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Chemical
Yukui Gou, Yuanye Hao, Weilong Cai, Jianying Huang, Yuekun Lai
Summary: Particulate matter (PM) poses a significant threat to the environment and human health. Traditional air filters are not effective in harsh environments. This study provides a new design concept for three-dimensional high-efficiency air filters that can adapt to harsh conditions. The composite sponge made of PDMS sponge and ZIF-8 material efficiently removes particulate matter and demonstrates stable filtration performance and good adaptability.
Article
Engineering, Chemical
Weiwei Zheng, Shujing Lin, Yimeng Ni, Yukui Gou, Jianying Huang, Yuekun Lai
Summary: Transparent photothermal coatings play an increasingly important role in preventing icing in various fields. Previous research focused too much on achieving high photothermal performance at the expense of transparency. In this study, a liquid-like anti/deicing coating with excellent transparency was prepared using a unique combination of materials. This coating shows promise in anti/deicing scenarios where transparency is required.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Review
Chemistry, Physical
Xuzheng Ji, Jianying Huang, Lin Teng, Shuhui Li, Xiao Li, Weilong Cai, Zhong Chen, Yuekun Lai
Summary: Airborne pollutants in particulate matter (PM) pose a significant threat to human health and effective virus filtration is crucial during the COVID-19 pandemic. This review provides an overview of PM, including its source, classification, filtration mechanisms, and evaluation parameters. Advanced filtration materials, such as polymers and MOFs, and their antibacterial performance are discussed. The application of PM filtration is divided into end-of-pipe treatment and source control, and future research prospects are presented in the conclusion.
GREEN ENERGY & ENVIRONMENT
(2023)
Article
Engineering, Environmental
Jiajun Chen, Yimeng Ni, Yukui Gou, Tianxue Zhu, Lan Sun, Zhong Chen, Jianying Huang, Dapeng Yang, Yuekun Lai
Summary: Organogels have shown wide application prospects as adsorbent materials in the field of oil-water separation, with the ability to effectively treat oily wastewater in complex environments and high adsorption capacity and recyclability.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Physical
Zhibin Zhang, Xi Wang, Hongyan Li, Gengchen Liu, Kaiying Zhao, Yajun Wang, Zheng Li, Jianying Huang, Zhiwei Xu, Yuekun Lai, Xiaoming Qian, Songnan Zhang
Summary: In this study, an innovative atmospheric water harvester combining hydrogel and 3D raised-fabric was developed, which exhibited excellent photothermal conversion performance and adsorption capacity, making it effective for water collection and storage.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Chemistry, Multidisciplinary
Yikun Liu, Yongju Gao, Beom Jin Kim, Meili Xia, Yunlong Zhou, Yongjing Zhang, Yang Li, Jianying Huang, Duxia Cao, Songfang Zhao, Jong-Hyun Ahn, Yuekun Lai
Summary: This study developed a stretchable bioinspired interactive platform that can quantitatively sense applied strains through variations in digital electrical resistance and visual fluorescence intensity. The platform exhibited excellent strain-sensing performance, stability, and sensitivity to mechanical stimuli. The fusion of digital data and visual images enabled important applications such as pulse detection, human motion tracking, and information encryption.
Article
Chemistry, Physical
Yingzhen Zhang, Denglong Ma, Yonggang Lei, Tianxue Zhu, Jun Hu, Yu Tang, Zhong Chen, Jianying Huang, Yuekun Lai, Zhiqun Lin
Summary: This study reports the substitution of oxygen evolution reaction (OER) with ammonia oxidation reaction (AOR) to enhance hydrogen evolution reaction (HER) efficiency. The experimental results demonstrate the important role of AOR in enhancing interfacial charge transfer and promoting active species generation. Compared to traditional OER-HER water splitting, the AOR-HER system shows a significant increase in hydrogen production.
Article
Engineering, Environmental
Fengjuan Xiong, Xi Wang, Yuanqian Liu, Zhibin Zhang, Tong Zhang, Hanchao Gao, Hiroshi Fu, Jianying Huang, Xiaoming Qian, Yuekun Lai, Songnan Zhang
Summary: The removal of oil mist is crucial for industrial processes and worker safety. A sustainable sandwich structure filter was developed, which showed high efficiency and low resistance. Results demonstrated that the filter maintained its ultra-high filtration efficiency even after continuous use for 50 and 100 cycles.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
