Article
Plant Sciences
Li Tan, Jianfeng Xu, Michael Held, Derek T. A. Lamport, Marcia Kieliszewski
Summary: This study found that Hyp-O-polysaccharides isolated from transgenic Arabidopsis suspension culture have similar structural features to AGPs isolated from tobacco. It also confirmed the presence of a previously identified β-1,6-linkage on the galactan backbone in AGP fusion glycoproteins expressed in tobacco. Furthermore, AGPs expressed in Arabidopsis suspension culture have differences in terminal-rhamnosyl residues and glucuronosylation compared to those expressed in tobacco suspension culture, suggesting the presence of distinct glycosyl transferases and minimum AG structures for type II AG functional features.
Article
Chemistry, Applied
Brock Kuhlman, Jose Luis Aleixandre-Tudo, John P. Moore, Wessel du Toit
Summary: This study investigated the relationship between astringency in wine and salivary protein precipitation. Results showed that wine polysaccharides compete with tannins for salivary proteins as ligand partners, and enzyme-treated polysaccharides changed astringency perception at a lower concentration.
Article
Biochemistry & Molecular Biology
Sergey Popov, Nikita Paderin, Daria Khramova, Elizaveta Kvashninova, Olga Patova, Fedor Vityazev
Summary: The study aimed to develop gel beads with improved functional properties and biocompatibility from hogweed (HS) pectin. The HS4 gel beads showed higher swelling degree, lower hardness, lower serum protein adsorption, lower hemolysis, and complement activation compared to the apple pectin (AP) gel beads (AP4). Additionally, HS4 gel beads exhibited an inhibitory effect on the inflammatory response of macrophages, while AP4 gel beads stimulated the inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaojun Li, Qi Chen, Guoku Liu, Hairong Xu, Xue Zhang
Summary: In this study, polysaccharides were isolated from Polygonatum sibiricum and characterized for their chemical structure and activities, showing potential as natural antioxidants. The polysaccharides exhibited different antioxidant activities depending on their molecular weight and chemical structure, indicating the diversity in their biological functions. Overall, Polygonatum sibiricum polysaccharides have the potential to be developed as natural antioxidants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Anna V. Tsyganova, Elena V. Seliverstova, Viktor E. Tsyganov
Summary: Different components of the symbiotic interface, such as pectins, xyloglucans, and cell wall proteins, play a crucial role in rhizobial infection and nodule development. The distribution and localization of these components were studied in the nodules of Pisum sativum and Medicago truncatula, revealing species-specific features in the symbiotic interface. The differences observed between wild-type and mutant nodules could be attributed to defense reactions or premature senescence in mutants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Siqi Yang, Guofang Zhang, Hong Chu, Peng Du, Aili Li, Libo Liu, Chun Li
Summary: The purpose of this study was to prepare conjugates of casein with pectin or arabinogalactan by the Maillard reaction and investigate the effects on the structural and functional properties of casein. The results showed that the grafting of pectin or arabinogalactan onto casein improved its functional properties. The glycosylation treatment further enhanced the functional properties, such as solubility, foaming property, emulsifying property, thermal stability, and antioxidant activity.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Cell Biology
Anna V. Tsyganova, Nicholas J. Brewin, Viktor E. Tsyganov
Summary: This review discusses the formation and regulation of intracellular infection threads initiated in root hair cells, focusing on the rearrangement of the plant-microbial interface and the growth of infection threads. It also explores the composition of the main polymers of the infection thread wall and matrix, as well as the role of reactive oxygen species in infection thread development.
Article
Engineering, Environmental
LiZhen Wang, KongYuan Wu, ZiQing Liu, ZengFei Li, Jun Shen, ZiHan Wu, Hong Liu, LeXing You, GuiDi Yang, Christopher Rensing, RenWei Feng
Summary: Selenium can reduce the uptake and translocation of cadmium in plants by regulating the synthesis and interactions of cell wall components. The exact molecular mechanisms are still unclear.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Applied
Mariem Hamed, Elisabete Coelho, Rita Bastos, Dmitry Evtuguin, Sonia S. Ferreira, Tania Lima, Manuel Vilanova, Assaad Sila, Manuel A. Coimbra, Ali Bougatef
Summary: This study successfully extracted and purified a novel arabinogalactan from pistachio external hull, which showed potential immunostimulatory activity and could be used in nutraceutical and biomedical applications.
Article
Chemistry, Applied
Minyeong Kim, Seong-Ryeol Kim, Jiye Park, Seo-Hyeon Mun, Myounghai Kwak, Hyun-Jeong Ko, Seung-Hoon Baek
Summary: This study aimed to investigate the structure and anti-enterovirus 71 (EV71) effects of polysaccharides extracted from the roots of Sanguisorba officinalis (SO), traditionally used for infectious diseases. The results showed that the purified polysaccharide (S-a3) significantly inhibited cell death and viral gene expression in EV71-infected cells, and alleviated EV71-induced symptoms in a mouse model. The effective dose of S-a3 was non-toxic. This study demonstrates that polysaccharides from SO can be a safe and effective treatment for EV71 infection.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Rosaria Ciriminna, Alexandra Fidalgo, Antonino Scurria, Laura M. Ilharco, Mario Pagliaro
Summary: Significant progress has been made in the study of pectin polysaccharides and pectin-derived oligosaccharides in the past decade (2010-2020), leading to new applications of pectin beyond its traditional use as a food hydrocolloid. This study provides a comprehensive perspective on the science and technology of pectin and its extraction by-products, as well as insights into future applications and factors influencing pectin production.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Dan Liu, Wei Tang, Xiao-Jun Huang, Jie-Lun Hu, Jun-Qiao Wang, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie
Summary: This study characterized and analyzed the polysaccharide components in Dolichos lablab hull, specifically focusing on the pectin-glucuronoxylan complex. The results revealed the molecular structure of this complex, which consists of pectin and glucuronoxylan regions covalently bound together. The findings provide valuable insights into the composition of polysaccharides in Dolichos lablab hull.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Carlos Frey, Nerea Martinez-Romera, Antonio Encina, Jose L. Acebes
Summary: Immunolocalization highlighted the changes in cell wall components, including homogalacturonan, xyloglucan, and arabinogalactan proteins, and their role in successful graft healing in tomato. The spatiotemporal dynamics of these cell wall changes, which are crucial for grafting, were previously unknown. This study revealed that homogalacturonan synthesis and deposition were observed at the cut edges, specifically in low methyl-esterified form. Galactan side chains of rhamnogalacturonan increased until 8 days after grafting, while xylan and xyloglucan exhibited changes associated with vasculature development and early synthesis at the cut edges, respectively. Arabinogalactan proteins showed asymmetry, with higher levels in the scion, and their increase was observed until 8 days after grafting. The combined changes in these cell wall components contribute to the success of autograft by facilitating adhesion between scion and rootstock tissues.
PLANT MOLECULAR BIOLOGY
(2023)
Article
Biodiversity Conservation
Jason S. Henry, Karen S. Renzaglia
Summary: The study investigated the composition of cell wall polymers in Physcomitrium patens transfer cells using immunogold labeling TEM. The findings showed less pectins and AGPs in transfer cell walls compared to hornwort and liverwort, with similar composition on both sides of the placenta in P. patens. The variability in cell wall composition among bryophytes suggests that function and morphology do not necessarily require a common composition.
Article
Biochemistry & Molecular Biology
Belen Chaves-Arquero, Cecilia Persson, Nekane Merino, Julen Tomas-Cortazar, Adriana L. Rojas, Juan Anguita, Francisco J. Blanco
Summary: Salp15 is a protein found in the saliva of the tick Ixodes scapularis. It interferes with the cellular immune response of the mammalian host by inhibiting the activation of CD4(+) T-lymphocytes. This protein has potential therapeutic applications in immune system disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Evgeny G. Shakhmatov, Elena V. Udoratina, Konstantin V. Atukmaev, Elena N. Makarova
CARBOHYDRATE POLYMERS
(2015)
Article
Chemistry, Applied
Elena N. Makarova, Evgeny G. Shakhmatov, Vladimir A. Belyy
CARBOHYDRATE POLYMERS
(2016)
Article
Chemistry, Applied
Elena N. Makarova, Evgeny G. Shakhmatov, Vladimir A. Belyy
CARBOHYDRATE POLYMERS
(2018)
Article
Chemistry, Applied
Evgeny G. Shakhmatov, Vladimir A. Belyy, Elena N. Makarova
CARBOHYDRATE POLYMERS
(2018)
Article
Biochemistry & Molecular Biology
Evgeny G. Shakhmatov, Elena N. Makarova, Vladimir A. Belyy
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Chemistry, Applied
Evgeny G. Shakhmatov, Philip Toukach, Elena N. Makarova
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Elena N. Makarova, Evgeny G. Shakhmatov
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Evgeny G. Shakhmatov, Vladimir A. Belyy, Elena N. Makarova
CARBOHYDRATE POLYMERS
(2017)
Article
Chemistry, Applied
Elena N. Makarova, Evgeny G. Shakhmatov, Vladimir A. Belyy
CARBOHYDRATE POLYMERS
(2017)
Article
Engineering, Chemical
E. A. Skiba, V. V. Budaeva, O. V. Baibakova, E. V. Udoratina, E. G. Shakhmatov, T. P. Shcherbakova, A. V. Kuchin, G. V. Sakovich
CATALYSIS IN INDUSTRY
(2016)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)