Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome

In a case-control study of patients with Clostridium difficile infection, we found no statistically significant association between the presence of trehalose utilization variants in infecting C. di/cite strains and development of severe infection outcome. These results do not support trehalose utilization conferring enhanced virulence in the context of human C. dcile infections.