Review
Pharmacology & Pharmacy
Maram Suresh Gupta, Tegginamath Pramod Kumar, Robert Davidson, Guruprasad Rao Kuppu, Kamla Pathak, Devegowda Vishakante Gowda
Summary: Orodispersible film (ODF) formulations are promising and progressive drug delivery systems, with printed orodispersible films (POFs) being a modern and rapidly developing method. The review provides an overview of printing methods for fabricating POFs, highlighting patenting trends and future market potential.
Article
Pharmacology & Pharmacy
Erna Turkovic, Ivana Vasiljevic, Milica Draskovic, Natasa Obradovic, Dragana Vasiljevic, Jelena Parojcic
Summary: Inkjet printing in drug manufacturing allows precise dispensing of drug ink onto substrates. Various substrates, including single-polymer films and structured templates, can be used, each with its own advantages and disadvantages in terms of drug load and printability. The study contributes to understanding the substrate properties that influence printability and provides insights into the use of different materials as printing substrates.
Review
Pharmacology & Pharmacy
Maram Suresh Gupta, Devegowda Vishakante Gowda, Tegginamath Pramod Kumar, Jessica M. Rosenholm
Summary: This review provides an overview of patented technologies for fabricating orodispersible films (ODFs) in the past two decades. The solvent casting method (SCM) is identified as the most popular method, while electrospinning is considered a recent and upcoming method for ODF fabrication.
Article
Pharmacology & Pharmacy
Chak Hin Tam, Matthew Alexander, Peter Belton, Sheng Qi
Summary: In this study, the feasibility of using a micro-dispensing jet system to fabricate substrate-free ODFs was evaluated, and compared with cast films. The results showed that MD printing achieves high precision in dosing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Ju-Hyun Lee, Chulhun Park, In-OK Song, Beom-Jin Lee, Chin-Yang Kang, Jun-Bom Park
Summary: The objective of this study was to design and evaluate an orodispersible film (ODF) composed of aripiprazole, prepared using a conventional solvent casting technique, and to fuse a three-dimensional (3D) printing technique with a hot-melt extrusion filament. The study showed that the 3D-printed films had faster dissolution and disintegration compared to solvent-cast films. The combination of polymer selection and 3D printing technology could innovatively design ODFs composed of aripiprazole to meet the unmet medical needs of psychiatric patients.
Article
Chemistry, Medicinal
Garba M. Khalid, Umberto M. Musazzi, Francesca Selmin, Silvia Franze, Paola Minghetti, Francesco Cilurzo
Summary: The potential application of hot-melt ram extrusion printing for producing diclofenac orodispersible films (ODF) made of maltodextrin was studied, focusing on the effects of taste-masking agents and an opacifier. The study demonstrated the feasibility of printing ODF loaded with a thermosensitive drug using hot-melt technologies, showing improved tensile properties and disintegration time. The addition of diclofenac significantly enhanced the ODF tensile strength, while titanium dioxide played a role in reducing peel forces and improving detachment from packaging material.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Olga Kiefer, Bjoern Fischer, Joerg Breitkreutz
Summary: Individualized medicine is gaining attention in pharmaceutical research, requiring new concepts and manufacturing technologies. The combination of orodispersible films and inkjet printing technology provides precise and acceptable doses of MPT for pediatric use. Uniform dosages can be achieved, but considerations are needed for implementation of inkjet printing in pharmaceutical production due to nozzle aging affecting printed quantity.
Article
Pharmacology & Pharmacy
Ewelina Lyszczarz, Witold Brniak, Joanna Szafraniec-Szczesny, Tomasz M. Majka, Dorota Majda, Marta Zych, Krzysztof Pielichowski, Renata Jachowicz
Summary: Orodispersible films (ODFs) are a drug dosage form for pediatric, geriatric patients, and those with swallowing difficulties. This study compared ODFs made using different methods and found that electrospun ODFs had faster disintegration but were sensitive to storage conditions, affecting stability. Nevertheless, they showed promising mechanical properties for future use in treating patients with swallowing difficulties.
Article
Pharmacology & Pharmacy
Giuseppe Francesco Racaniello, Monica Pistone, Chiara Meazzini, Angela Lopedota, Ilaria Arduino, Rosanna Rizzi, Antonio Lopalco, Umberto M. Musazzi, Francesco Cilurzo, Nunzio Denora
Summary: The aim of this study is to develop and produce novel oral mucoadhesive films delivering Clobetasol propionate (CBS) through Direct Powder Extrusion (DPE) 3D printing technique for paediatric treatment of Oral Lichen Planus (OLP). Different polymeric materials, such as hydroxypropylmethylcellulose or polyethylene oxide blended with chitosan (CS), were tested to obtain suitable mucoadhesive films. Hydroxypropyl-& beta;-cyclodextrin was added to enhance CBS solubility. The DPE-printed films showed strong adhesion, improved drug characteristics, and significant drug exposure time on the mucosa.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Maram Suresh Gupta, Tegginamath Pramod Kumar, Devegowda Vishkante Gowda, Jessica M. Rosenholm
Summary: Orodispersible films (ODFs) are a unique pharmaceutical dosage form that can improve patient compliance and convenience, particularly for pediatric and geriatric populations. They have the potential to serve as carriers for drugs, herbal extracts, probiotics, and vaccines, while also aiding in drug loading, taste masking, and stability enhancement.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Elisabetta Ravasi, Alice Melocchi, Alessia Arrigoni, Arianna Chiappa, Chiara Grazia Milena Gennari, Marco Uboldi, Chiara Bertarelli, Lucia Zema, Francesco Briatico Vangosa
Summary: The feasibility of using electrospinning to manufacture sildenafil-containing orodispersible films (ODFs) for pediatric patients was evaluated. A water-based formulation using pullulan as the fiber-forming agent was chosen. The electrospinning parameters for producing defect-free nanofibers at a high rate were determined and the resulting non-woven films were evaluated for their morphology, micro-structure, drug content, and interaction with aqueous fluids. The disintegration process of the electrospun ODFs was found to be the fastest, making them promising for enhancing sildenafil bioavailability and lowering dosages.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Takeru Kaneko, Yi-Fei Wang, Mayuka Hori, Tomohito Sekine, Ayako Yoshida, Yasunori Takeda, Daisuke Kumaki, Shizuo Tokito
Summary: A liquid metal (LM) soft sensor has been developed for strain monitoring and self-powered tactile detection in soft robotics. The sensor is fabricated through printing a bilayer of oxidized LM paste and bare LM on a soft substrate. This bilayer design overcomes the challenges in scalable printing of liquid metal and shows exceptional electromechanical performance. Employing a single electrode triboelectric effect, the sensor achieves self-powered tactile sensing. Integrated into a soft pneumatic actuator, the sensor demonstrates its ability to perceive gestures, motion, and grasping. This work highlights the potential of LM-based soft sensors in advancing the field of soft sensing and soft robotics.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Denise Steiner, Jakob F. Emmendoerffer, Heike Bunjes
Summary: This study aimed to investigate the suitability of using HPMC film matrix as a delivery platform for solid lipid nanoparticles, showing that lipid contents of up to 54 wt.% could be achieved in the film matrix without affecting the nanoparticle state and mechanical properties of the films. Additionally, processing lipid suspension into solid dosage form led to reduced transformation of lipid particles, which could be beneficial for APIs loaded lipid particles.
Article
Chemistry, Analytical
Supatinee Kongkaew, Suowarot Tubtimtong, Panote Thavarungkul, Proespichaya Kanatharana, Kah Haw Chang, Ahmad Fahmi Lim Abdullah, Warakorn Limbut
Summary: Multichannel graphite electrodes (MGrEs) were designed and fabricated in this study using a template cutting and ink application technique. The precision and reliability of the MGrEs were evaluated, and the sensitivity was found to be comparable to a single channel electrode. The potential applications of the MGrEs were demonstrated by detecting nitrite in milk and tap water samples.
Article
Pharmacology & Pharmacy
Maram Suresh Gupta, Tegginamath Pramod Kumar, Dinesh Reddy, Kamla Pathak, Devegowda Vishakante Gowda, A. V. Naresh Babu, Alhussain H. Aodah, El-Sayed Khafagy, Hadil Faris Alotaibi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussin
Summary: Iron deficiency is a major health problem, especially during pregnancy. This study developed and characterized pullulan-based iron-loaded orodispersible films (i-ODFs) which showed good physicochemical properties, excellent disintegration time, and optimal stability at specified storage conditions.
Article
Chemistry, Applied
P. A. Fuaad, Agne Swerin, Fredrik Lundell, Martti Toivakka
Summary: Bio-based nanocellulosic materials are suitable for sustainable food packaging, but the complex fluid dynamics and wall slip phenomenon need to be considered during slot coating. Modeling the particle-depleted boundary layer can predict the coating effects under different conditions.
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2022)
Article
Materials Science, Biomaterials
Ruoyu Cheng, Shiqi Wang, Karina Moslova, Ermei Maekilae, Jarno Salonen, Jiachen Li, Jouni Hirvonen, Bing Xia, Helder A. Santos
Summary: In this study, we proposed an optimized solution to quantify the functionalization groups on porous silicon (PSi) using nuclear magnetic resonance (NMR) method. By combining hydrolysis with 1H NMR experiments, we successfully optimized the hydrolysis conditions and NMR parameters for quantitative analysis of surficial modification characterization of PSi.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Applied
Qingbo Wang, Wenyang Xu, Rajesh Koppolu, Bas van Bochove, Jukka Seppala, Leena Hupa, Stefan Willfor, Chunlin Xu, Xiaoju Wang
Summary: The study introduces an injectable nanocomposite hydrogel cured by light-induced thiol-ene addition, with features of faster crosslinking, more stable mechanics, and higher bioactivity, suitable for fabrication of digitally designed hydrogel constructs.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Physical
Henri Kivela, Mikko Salomaki, Petteri Vainikka, Ermei Makila, Fabrizio Poletti, Stefano Ruggeri, Fabio Terzi, Jukka Lukkari
Summary: Deep eutectic solvents (DESs) formed by hydrogen bond donors and acceptors can be affected by the presence of water, leading to changes in physical properties such as phase separation, viscosity, self-diffusion, and conductivity. Water interferes with the hydrogen bonding network, enhancing ion pair formation. These water-induced changes have both beneficial and potentially negative effects on DESs.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Applied
Irina L. Simakova, Zuzana Vajglova, Paivi Maki-Arvela, Kari Eranen, Leena Hupa, Markus Peurla, Ermei M. Makila, Johan Warna, Dmitry Yu Murzin
Summary: A one-pot continuous synthesis of menthols from citral was achieved with high selectivity under specific conditions. Catalyst deactivation over time resulted in a decrease in the selectivity to menthols and an increase in the selectivity to isopulegols. A kinetic model was developed to describe the reaction, taking into account both metal and acid site deactivation, and showed good agreement with the experimental data.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Correction
Chemistry, Physical
Henri Kivela, Mikko Salomaki, Petteri Vainikka, Ermei Makila, Fabrizio Poletti, Stefano Ruggeri, Fabio Terzi, Jukka Lukkari
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Applied
Liqiu Hu, Wenyang Xu, Jan Gustafsson, Rajesh Koppolu, Qingbo Wang, Emil Rosqvist, Anna Sundberg, Jouko Peltonen, Stefan Willfor, Martti Toivakka, Chunlin Xu
Summary: This study establishes a method of water-redispersible nanocellulose production by adding water-soluble polysaccharides, which saves energy consumption. The addition of carboxymethylated-galactoglucomannan improves fiber fibrillation and enhances the water redispersibility and film properties of nanocellulose.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Kyudeok Oh, Sunhyung Kim, Zhenghui Shen, Min Hwan Jeong, Martti Toivakka, Hak Lae Lee
Summary: This study investigated the effect of polymers on the cracking of particulate coating layers. The addition of polymers increased the drying stress in the layers, leading to cracking. However, different polymer additives had varying effects on the critical cracking thickness, indicating that the properties of the particulate layers varied depending on the polymer. The study also found a strong positive correlation between toughness and the critical cracking thickness of the layers.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Materials Science, Multidisciplinary
Amit Tewari, Hugo Huerta, Gary Chinga-Carrasco, Leif Kare Hindersland, Samuli Ranta, Fredrik Pettersson, Ronald Osterbacka, Martti Toivakka
Summary: This study clarifies the sensitivity response behavior of three low-cost dielectric materials and demonstrates their potential applications in low-pressure and high-pressure monitoring. The devices fabricated in the form of a metal-insulator-metal structure show both steady-state and transient response, which can be further improved by minimizing interference between different pixels. Additionally, progress has been made in the application of floor sensors.
FLEXIBLE AND PRINTED ELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Lauri Marttila, Mikko Salomaki, Henri Kivela, Jukka Hassinen, Sari Granroth, Ermei Makila, Johan Nyman, Jukka Lukkari
Summary: This study investigates the film formation process of oxidative layer-by-layer multilayers, and shows that polyphosphate (PP) plays a crucial role in the stability and function of the multilayers. Low pH and long deposition times are beneficial for the formation of high-quality redox-active polymer films, while improving the electrical connection to the substrate and increasing film conductivity can make melanin films promising components for biodegradable supercapacitors.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Paper & Wood
Rajesh Koppolu, Johanna Lahti, Tiffany Abitbol, Christian Aulin, Jurkka Kuusipalo, Martti Toivakka
Summary: A multilayer barrier paperboard was produced using nanocellulose and biodegradable thermoplastics in a roll-to-roll process. Hyperplaty kaolin pigments were blended into the nanocellulose and a plasticizer (glycerol) was added to improve the barrier properties. The results provide insight into the role of these elements in the barrier properties and pave the way for sustainable packaging production.
Article
Chemistry, Multidisciplinary
Luyao Wang, Qingbo Wang, Emil Rosqvist, Jan-Henrik Smatt, Qiwen Yong, Lippo Lassila, Jouko Peltonen, Thomas Rosenau, Martti Toivakka, Stefan Willfoer, Patrik Eklund, Chunlin Xu, Xiaoju Wang
Summary: Fabricating bio-latex colloids with core-shell nanostructure is an effective method for obtaining films with enhanced mechanical characteristics. Nano-sized lignin is rising as a class of sustainable nanomaterials that can be incorporated into latex colloids. The correlation between surface chemistry of lignin nanoparticles (LNPs) and integration efficiency in latex colloids and from it thermally processed latex films is explored.
Article
Materials Science, Paper & Wood
Daniel Varney, Martti Toivakka, Douglas W. Bousfield
Summary: This study used the discrete element method to simulate the bending and tension deformations of a coating layer and investigated the impact of particle size distribution on its mechanical properties. The model predicted the conditions for crack formation and calculated the modulus, maximum stress, and strain-to-failure of the coating layer. The results were compared to experimental data, showing reasonable predictions for different latex-starch ratios and binder concentrations in both tensile and bending. The study also reported the influence of particle packing density on the mechanical properties.
Article
Materials Science, Paper & Wood
Watti Lehtimaki, Andreas Schroder, Vesa Kukkamo, Martti Toivakka
Summary: This study aims to understand the impact of different rheological additives on the extensional viscosity of barrier coating dispersions, and to examine the role of extensional viscosity in stabilizing a liquid curtain. The findings reveal that extensional viscosity plays a crucial role in stabilizing the liquid curtain, as it slows down hole expansion and prevents impurities and disturbances from causing holes. Additionally, the study shows that by adding suitable rheological additives, the extensional viscosity of the dispersions can be significantly increased without increasing the shear viscosity beyond the typical processable range.
