Article
Plant Sciences
Wenshuai Wang, Yaohan Zhang, Zhiying Wang, Jianjun Zhang, Le Jia
Summary: This study investigated the protective effects of Ganoderma lucidum polysaccharides (GLP) on high-fat diet-induced hyperlipidemia and explored the underlying mechanism. The results showed that GLP decreased body weight gain, reduced lipid levels, alleviated tissue injury, and improved oxidative stress and inflammation response. GLP also modulated bile acids synthesis, lipid regulatory factors, and promoted reverse cholesterol transport.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Liyuan Li, Yannan Guo, Qing Huang, Xiaojin Shi, Qingqing Liu, Fang Wang, Qingfei Liu, Kang Yu, Zhao Wang
Summary: The compound GPP, composed of water-soluable Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP), enhances immune function in mice by enhancing macrophage cell function and natural killer (NK) cell activity. GPP also increases the diversity of intestinal microorganisms and has a positive effect on colitis model mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Fisheries
Guixiang Lin, Fan Da, Xiaoju Wan, Yucong Huang, Shiping Yang, Jichang Jian, Shuanghu Cai
Summary: This study found that using APS and GLP as adjuvants for DNA vaccine could significantly enhance the immune response in pearl gentian grouper, including antibody titres and enzyme activities. These adjuvants also up-regulated the expression levels of multiple immune-related genes. After vaccination, the groups with APS and GLP had significantly higher survival rates when challenged with Vibrio harveyi.
JOURNAL OF FISH DISEASES
(2023)
Review
Pharmacology & Pharmacy
M. A. Oke, F. J. Afolabi, O. O. Oyeleke, T. A. Kilani, A. R. Adeosun, A. A. Olanbiwoninu, E. A. Adebayo
Summary: Ganoderma lucidum, also known as Lingzhi, is a medicinal mushroom used in traditional medicine for various health benefits. It contains a wide range of bioactive compounds, including triterpenoids and polysaccharides, which have been shown to possess numerous pharmacological activities. Studies have demonstrated the potential of Ganoderma lucidum in disease prevention and treatment, leading to the development of various formulations and products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Shaodan Chen, Xiaoying Guan, Tianqiao Yong, Xiong Gao, Chun Xiao, Yizhen Xie, Diling Chen, Huiping Hu, Qingping Wu
Summary: In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have a protective effect on liver damage caused by restraint stress in mice by improving oxidative status. Two polysaccharides, including a neutral beta-glucan (GLPB2) and an acidic beta-glucan (GLPC2), were purified from GLP. GLPC2 exhibited a stronger hepatoprotective effect compared to GLPB2. The findings provide a theoretical basis for the potential application of G. lucidum polysaccharides as hepatoprotective agents in the food and pharmaceutical industry.
Article
Biochemistry & Molecular Biology
Jiaqi Jiao, Tianqiao Yong, Longhua Huang, Shaodan Chen, Chun Xiao, Qingping Wu, Huiping Hu, Yizhen Xie, Xiangmin Li, Yuancao Liu, Manjun Cai, Ruifang Zhang, Ting Xie, Rongjie Liu
Summary: In this paper, we revealed the hypoglycemic effect of Ganoderma lucidium polysaccharide F31, which showed efficacies between 45 and 54%, approaching that of liraglutide (52%). F31 reduced body weight gains and food intakes, protected kidney function, promoted apoptosis in epididymal fat, and induced early apoptosis in 3 T3-L1 preadipocyte cells. Molecular docking showed a possible cross-talk between kidney and epididymal fat through the glycerophosphorylcholine-Bax axis. Overall, F31 alleviated hyperglycemia through kidney protection and adipocyte apoptosis in db/db mice, providing novel insights into the hypoglycemic activity of polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Fang Kou, Yunfei Ge, Weihao Wang, Yuxia Mei, Longkui Cao, Xuetuan Wei, Hang Xiao, Xian Wu
Summary: Ganoderma lucidum polysaccharides have unique functional properties and various processing technologies have been used to improve their yield and utilization. This review summarizes the structure and health benefits of G. lucidum polysaccharides, and discusses factors that may affect their quality, including chemical modifications. These modifications improve the physicochemical characteristics and utilization of G. lucidum polysaccharides, making them more stable and suitable for encapsulating active substances. Ultimately, G. lucidum polysaccharide-based nanoparticles are designed to deliver functional ingredients for better health-promoting effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Zhiyuan Chen, Guozhi Xiao
Summary: The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 from Ganoderma lucidum, which possess immune-enhancing activities, were prepared using a one-pot glycan assembly strategy that features orthogonal one-pot glycosylation, one-pot assembly of oligosaccharides, and modular and convergent [4+5+5] assembly of the highly branched tetradecasaccharide.
Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Ming Cai, Hua Mu, Haoyong Xing, Zhenhao Li, Jing Xu, Wei Liu, Kai Yang, Peilong Sun
Summary: The study found that Ganoderma lucidum spores with the sporoderm removed showed stronger metabolic promotion effects and better anti-inflammatory properties after in vitro digestion.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Ming Cai, Haoyong Xing, Baoming Tian, Jing Xu, Zhenhao Li, Hua Zhu, Kai Yang, Peilong Sun
Summary: The study revealed that Ganoderma lucidum polysaccharides can extend swimming time, enhance endurance, and promote fatigue recovery, especially polysaccharides with molecular weights above 10 kDa. These GLPs may reduce the activities of SUN and CK, decrease the levels of MDA and BLA, increase the level of Gly, accelerate fat transformation, and improve the activities of GPx, SOD, and LDH in all treated mice. Therefore, GLPs above 10 kDa could be potential agents with antifatigue activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Li Ren, Jie Zhang, Tiehua Zhang
Summary: Polysaccharides from Ganoderma, as the most abundant bioactive compounds, exhibit unique biological properties such as anti-tumor, anti-inflammatory, and immunomodulatory activities. They can potentially be applied for the modulation of the host immune system, including innate immunity, cellular immunity, and humoral immunity.
Article
Biochemistry & Molecular Biology
Chung-Hsiung Huang, Tzu-Yu Chen, Guo-Jane Tsai
Summary: This study investigated the hypouricemic effects of submerged culture of Ganoderma lucidum. The results demonstrated the stronger hypouricemic effect of the submerged culture's mycelium, as well as the effectiveness of the extracellular polysaccharides in improving renal and hepatic function.
Article
Biochemistry & Molecular Biology
Loreto Robles-Hernandez, Nora A. Salas-Salazar, Ana C. Gonzalez-Franco
Summary: This study aimed to purify and characterize the antibacterial activity against plant pathogenic bacteria from culture fluids of Ganoderma lucidum, revealing that the bioactive compounds are small polysaccharides. This is the first report of such polysaccharides produced by G. lucidum with activity against bacterial plant pathogens.
Review
Biochemistry & Molecular Biology
Emin Cadar, Ticuta Negreanu-Pirjol, Carolina Pascale, Rodica Sirbu, Irina Prasacu, Bogdan-Stefan Negreanu-Pirjol, Cezar Laurentiu Tomescu, Ana-Maria Ionescu
Summary: This review examines the scientific research on the natural bioactive compounds found in extracts of Ganoderma lucidum (G. lucidum) and their potential in cancer treatment. The study reveals that G. lucidum contains important bioactive compounds such as polysaccharides, triterpenoids, and sterols, which have demonstrated multiple anticancer effects including immunomodulatory, anti-proliferative, cytotoxic, and antioxidant actions. However, there is still uncertainty about the effects of G. lucidum bioactive compounds in treating different types of cancer, and further clinical trials are needed to clarify their potential benefits in cancer prevention and treatment.
Article
Environmental Sciences
Fangshu Xie, Qiyu Shi, Huiling Bai, Meiyu Liu, Jingbin Zhang, Meiyun Qi, Jianfeng Zhang, Zhihua Li, Weihuang Zhu
Summary: A Co@ZIF-8/CNTs-CF anode was prepared for peroxymonosulfate (PMS) activation, showing enhanced performance in tetracycline (TC) removal compared to a bare CF anode + PMS system. The enhanced activation was attributed to the high pyrrolic N content and low valence state of Co in the Co@ZIF-8/CNTs-CF anode. Quenching experiments and EPR tests revealed the generation of SO4 center dot-and reactive oxygen-containing reactive species (O2 center dot-and 1O2) during PMS activation by the anode, which contributed to TC removal. The anode for PMS activation provides a reference for wastewater treatment using electrochemical advanced oxidation processes (EAOPs).
Article
Environmental Sciences
Zhihan Cao, Ping Li, Jinchuang Ru, Xuqian Cao, Xu Wang, Bin Liu, Zhi-Hua Li
Summary: This study evaluated the impact of environmental levels of triphenyltin (TPT) on marine Chlorella sp. It found that TPT had both promoting and inhibitory effects on the growth of marine Chlorella sp. depending on the concentration. The chlorophyll composition changed, and oxidative damage and gene expression alterations were observed. These findings contribute to a better understanding of the ecological toxicity of TPT in marine environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xingshe Liu, Yongjun Liu, Hui Tang, Aining Zhang, Zhe Liu, Zhihua Li
Summary: The study investigated the regulation effect and mechanism of microbial metabolism on the efficient degradation of aromatic compounds in the biochemical treatment process of coal chemical wastewater. The addition of dominant microbial strains that could degrade aromatic compounds significantly increased the removal efficiencies of COD, TOC, phenols, benzenes, N-CHs, and PAHs in the system. The microbial community abundance and diversity, microbial activity, and enzymatic activity were all improved, leading to enhanced performance for aromatic compounds removal and the formation of microbial hydrophobic cell surfaces.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agricultural Engineering
Chi Zhao, Mei Han, Tan Tu, Shanbo Chen, Wen Hu, Ling Dong, Fengju Zhang, Yuejun Zhao, Zhihua Li
Summary: This study comprehensively revealed the differences in sensory and biological activities between red huajiao and green huajiao at the metabolic level using non-targeted and targeted metabolomics. Key bioactive metabolites were identified and potential reasons for the differences were explored through metabolic pathway analysis.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Environmental Sciences
Cong-Cong Tang, Bao-Cai Zhang, Xing-Ye Yao, Thangavel Sangeetha, Ai -Juan Zhou, Wenzong Liu, Yong-Xiang Ren, Zhihua Li, Aijie Wang, Zhang-Wei He
Summary: Anaerobic digestion is a commonly used method for treating waste activated sludge, and natural zeolite has the potential to improve methane production from this process. The optimal dosage of natural zeolite was found to be 0.1 g zeolite/g volatile suspended solids, resulting in a 20.1% increase in methane yield compared to the control. Natural zeolite had a greater effect on protein transfer and conversion than polysaccharides, and it improved the hydrolysis, acidification, and methanogenesis stages of anaerobic digestion. The dosages of natural zeolite also influenced bacterial and archaeal communities in biofilm and suspension.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Physics, Multidisciplinary
Tianxiang Dai, Yutian Ao, Jun Mao, Yan Yang, Yun Zheng, Chonghao Zhai, Yandong Li, Jingze Yuan, Bo Tang, Zhihua Li, Jun Luo, Wenwu Wang, Xiaoyong Hu, Qihuang Gong, Jianwei Wang
Summary: In this work, topologically protected non-Hermitian phase transitions driven by optical nonlinearity were observed. The phase transition occurs at the gain-loss junction induced by nonlinearity at the boundaries of a topological insulator. The transitions occur at speeds of hundreds of picoseconds, retaining topological protections against fabrication imperfections.
Article
Food Science & Technology
Zhangqi Huang, Xiaodong Zhai, Litao Yin, Jiyong Shi, Xiaobo Zou, Zhihua Li, Xiaowei Huang, Xingdan Ma, Megan Povey
Summary: A bilayer film with antibacterial activity and indicating ability was developed for preserving and monitoring the freshness of fish. It showed strong antibacterial activity against foodborne bacteria and could extend the shelf life of fish by 24 hours. The film was also sensitive to NH3 and exhibited a color change to indicate the freshness of fish.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Environmental Sciences
Hui Tang, Yongjun Liu, Xingshe Liu, Aining Zhang, Rushuo Yang, Yulu Han, Pan Liu, Hao bo He, Zhihua Li
Summary: A combination regulation method of co-substrate metabolism and predominant flora enhancement was constructed to improve the degradation of aromatics in coal chemical wastewater (CCW). The method increased the antioxidant enzyme activity of microorganisms and enhanced their resistance to adverse environments. The abundance of aromatics degradation bacteria was also increased.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Engineering, Environmental
Yizhou Feng, Meiyu Liu, Qiyu Shi, Yunan Song, Luni Yang, Jianfeng Zhang, Zhihua Li, Weihuang Zhu
Summary: In this study, sludge-derived biochar (BS900) was prepared as an effective peroxymonosulfate (PMS) activator, which demonstrated remarkable capability in removing tetracycline (TC). The presence of zero-valent iron (Fe0), elevated Fe2+/Fe3+ ratio, and the increased content of graphitic N were identified as the main factors contributing to the high PMS activation performance of BS900. The study provides a new perspective on the characteristics and mechanism of PMS-based advanced oxidation processes catalyzed by sludge-derived biochar.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Yong-Peng Huang, Xin Wang, Ruo-Lan Wang, Jin-Tao He, Yuan Huang, Zhen-Yu Hang, Xi Chen, Zhi-Hua Li
Summary: This study investigates the relationships between granule stability, diameter, biomass retention capacity, and denitrification efficiency in Aerobic Granular Sludge (AGS) technology. The results indicate that granule diameter is not a reliable indicator of stability or biomass retention capacity. Promoting simultaneous nitrification and denitrification is found to improve granule stability. Ensuring coordination between diameter and denitrification control is crucial for AGS stability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Chemistry, Applied
Chuang Li, Jiyong Shi, Zhou Chenguang, Xiaowei Huang, Xiaodong Zhai, Zhikun Yang, Zhihua Li, Xuetao Hu, Yanxiao Li, Jianbo Xiao, Xiaobo Zou
Summary: In this study, the effects of different low-sodium salt substitutes on the properties, texture, sensory attributes, volatile compounds, microstructure, and safety of cured and aged beef were investigated. The results showed that substituting sodium chloride with potassium chloride maintained acceptable sensory and safety profiles for beef consumption.
Article
Chemistry, Applied
Yongqiang Shi, Wenting Li, Xuetao Hu, Xinai Zhang, Xiaowei Huang, Zhihua Li, Xiaodong Zhai, Tingting Shen, Jiyong Shi, Yong He, Xiaobo Zou
Summary: In this study, a ratiometric fluorescent probe was developed for the sensitive detection of salicylic acid in rice. The probe showed low detection limit and superior performance, making it a promising tool for environmental monitoring.
Article
Chemistry, Applied
Wenjun Song, Xiaodong Zhai, Jiyong Shi, Xiaobo Zou, Yuhong Xue, Yue Sun, Wei Sun, Junjun Zhang, Xiaowei Huang, Zhihua Li, Tingting Shen, Yanxiao Li, Chenguang Zhou, Melvin Holmes, Yunyun Gong, Megan Povey
Summary: A ratiometric fluorescence sensor based on dual-emission carbon quantum dots (CQD) was developed for real-time monitoring of food spoilage. The sensor, comprised of hydrophobic electrospun fluorescent films made from PVDF and CQD, exhibited excellent stability and high sensitivity in detecting volatile amines generated from various types of meat. This non-destructive sensing platform provides a simple and robust solution for intelligent food packaging.
Article
Urology & Nephrology
Wenzhi Gao, Lei Zhang, Yuhui He, Tai Tian, Zhihua Li, Liangliang Bai, Ying Shen, Chen Huang, Bing Wang, Peng Zhang, Ninghan Feng, Xuechao Li, Yuexian Guo, Xuesong Li
Summary: This study compared the efficacy of secondary pyeloplasty and balloon dilation in patients with recurrent UPJO and found that secondary pyeloplasty may provide better benefit. Ureteral stricture length and operative time were identified as risk factors for surgical failure.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Shubo Fan, Zhihua Li, Chang Meng, Yicen Ying, Guanpeng Han, Jingjing Gao, Xinfei Li, Jie Wang, Changwei Yuan, Shengwei Xiong, Peng Zhang, Kunlin Yang, Ninghan Feng, Hongjian Zhu, Xuesong Li
Summary: Robotic and laparoscopic ureteroplasty using a lingual mucosa graft (RU-LMG and LU-LMG, respectively) are both feasible, effective, and safe for repairing complex ureteral strictures. RU-LMG has a shorter operative time and length of post-operative stay, but incurs higher hospital costs.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
