期刊
CARBOHYDRATE POLYMERS
卷 143, 期 -, 页码 35-43出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.02.008
关键词
Polyelectrolyte multilayers; Chitosan; Hyaluronic acid; Poly(ethylene terephthalate) aminolysis
资金
- Government of Basque Country [IT718-13]
Polyelectrolytic multilayers (PEMs) with enhanced antibacterial properties were built up onto commercial poly(ethylene terephthalate) (PET) films based on the layer by layer assembling of bacterial contact killing chitosan and bacterial repelling highly hydrated hyaluronic acid. The optimization of the aminolysis modification reaction of PET was carried out by the study of the mechanical properties and the surface characterization of the modified polymers. The layer by layer assembly was successfully monitored by TEM microscopy, surface zeta-potential, contact angle measurements and, after labeling with fluorescein isothiocyanate (FTIC) by absorption spectroscopy and confocal fluorescent microscopy. Beside, the stability of the PEMs was studied at physiological conditions in absence and in the presence of lysozyme and hyaluronidase enzymes. Antibacterial properties of the obtained PEMs against Escherichia coli were compared with original commercial PET. (C) 2016 Elsevier Ltd. All rights reserved.
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