Article
Oncology
Wang Zeng, Shuchen Gu, Yi Yu, Yili Feng, Mu Xiao, Xin-Hua Feng
Summary: EMT is a crucial biological process, and ZNF451 plays a role in promoting EMT by regulating TWIST2 through SUMOylation to increase TWIST2 protein levels in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chie-Hong Wang, Hsuan-Cheng Wu, Chen-Wei Hsu, Yun-Wei Chang, Chiung-Yuan Ko, Tsung- Hsu, Jian-Ying Chuang, Tsui-Hwa Tseng, Shao-Ming Wang
Summary: The expression of MZF1 is elevated in GBM and is associated with a worse prognosis. CTD exhibits strong anti-proliferative effects on GBM cells by suppressing MZF1 expression. This study suggests that CTD may be a promising therapeutic agent for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Liang Lyu, Haiyan Li, Kefeng Lu, Shu Jiang, Huihui Li
Summary: This study demonstrates that FRAX486, a potent PAK2 inhibitor, suppresses TNBC metastasis by blocking autophagy. Mechanistically, FRAX486 inhibits autophagy in TNBC cells by targeting PAK2, resulting in the ubiquitination and proteasomal degradation of STX17, which mediates autophagosome-lysosome fusion. Inhibition of autophagy by FRAX486 leads to upregulation of E-cadherin and consequently suppresses TNBC cell migration and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Linyuan Feng, Wanwei Li, Xiaowen Li, Xiaotian Li, Yanhong Ran, Xiaoping Yang, Zemin Deng, Hongjian Li
Summary: Signaling desensitization plays a crucial role in limiting the duration and intensity of signal transduction. This study demonstrates that NMI enhances STAT1 phosphorylation and IFNγ-induced immune responses by sequestering UBC9 and blocking STAT1 sumoylation. NMI also facilitates the translocation of UBC9 from the nucleus to the cytoplasm, inhibiting STAT1 sumoylation. This research reveals the importance of NMI in modulating IFNγ signaling through a desensitization mechanism.
Article
Social Sciences, Interdisciplinary
Wang Zeng, Shuchen Gu, Yi Yu, Yili Feng, Mu Xiao, Xin-Hua Feng
Summary: ZNF451 has been identified as a novel regulator of TWIST2 in promoting its stability through SUMOylation, thereby playing a vital role in EMT.
COGENT SOCIAL SCIENCES
(2021)
Review
Plant Sciences
Jibril Lubega, Saima Umbreen, Gary J. Loake
Summary: S-nitrosylation is a key regulatory post-translational modification controlling the plant immune response by regulating the activities of proteins such as GSNO and GSNOR1, thereby affecting processes like antioxidant defense and selective autophagy.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Medicine, Research & Experimental
Alhomidi Almotiri, Hamed Alzahrani, Juan Bautista Menendez-Gonzalez, Ali Abdelfattah, Badi Alotaibi, Lubaid Saleh, Adelle Greene, Mia Georgiou, Alex Gibbs, Amani Alsayari, Sarab Taha, Leigh-anne Thomas, Dhruv Shah, Sarah Edkins, Peter Giles, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Ashleigh S. Boyd, Florian A. Siebzehnrubl, Neil P. Rodrigues
Summary: The study suggests that loss of Zeb1 in adult stem cells leads to significant defects in stem cell renewal and differentiation, which are associated with leukemia signaling. Therefore, Zeb1 plays a crucial role as a transcriptional regulator in hematopoiesis, coordinating HSC self-renewal and differentiation to suppress the potential development of AML.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Qianwen Zhao, Tinghui Shao, Yuwen Zhu, Gengjie Zong, Junjie Zhang, Shifan Tang, Yanshan Lin, Hongzhen Ma, Zhifan Jiang, Yong Xu, Xiaoyan Wu, Tao Zhang
Summary: This study found that myofibroblasts play an important role in renal fibrosis. By deleting myocardin-related transcription factor A (MRTF-A), the researchers discovered that MRTF-A promotes renal fibrosis by activating the transcription of Zeb1 and IRF9. These findings reveal a potential pathway for treating renal fibrosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Review
Multidisciplinary Sciences
Ehsan Razmara, Amirreza Bitaraf, Behnaz Karimi, Sadegh Babashah
Summary: The review discusses the roles of SNAIs in the development of mature osteocytes from chondrocytes, including the regulation of chondro- and osteogenesis, involvement in programmed cell death, and the contribution of epigenetic factors. It also examines genotype-phenotype correlations in different animal models to better understand the importance of the SNAI family in bone development. Additionally, potential applications for therapeutic goals are considered.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Shuye Lin, Hanli Xu, Lin Qin, Mengdi Pang, Ziyu Wang, Meng Gu, Lishu Zhang, Cong Zhao, Xuefeng Hao, Zhiyun Zhang, Weimin Ding, Jianke Ren, Jiaqiang Huang
Summary: This study found that PRSS3 transcripts and their isoforms were divergently expressed in lung cancer, exhibiting opposing functions and clinical outcomes. Epigenetic silencing of PRSS3-V3 through site-specific iCpGI methylation was associated with early clinical progression in lung cancer. This research provides new theoretical basis for early detection and targeted therapy of lung cancer.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Plant Sciences
Xiaofei Liang, Bingxuan Li, Xuemei Zhao, Liqiang Yao, Yuanyuan Kong, Wenkui Liu, Rong Zhang, Guangyu Sun
Summary: In this study, the researchers identified and characterized two zinc finger transcription factors (TFs) that are involved in the regulation of 1,8-dihydroxynaphthalene (DHN) melanin biosynthesis in the phytopathogen Colletotrichum fructicola. They found that these TFs are not only important for melanin production, but also regulate perithecial development in the fungus. The study expands our understanding of DHN melanin regulation and reveals a new function for melanin in sex regulation.
Article
Multidisciplinary Sciences
Jianwen Song, Lele Shang, Changxing Li, Wenqian Wang, Xin Wang, Chunli Zhang, Guo Ai, Jie Ye, Changxian Yang, Hanxia Li, Zonglie Hong, Robert M. Larkin, Zhibiao Ye, Junhong Zhang
Summary: This study identified the molecular mechanism underlying fruit tip development in tomato and elucidated the role of the PT gene in this process, revealing the functional differences between the PTH and PTR alleles.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
Norbert Bollier, Nathalie Gonzalez, Christian Chevalier, Michel Hernould
Summary: The ZHD/MIF protein family is a plant-specific family of transcription factors that play important roles in plant growth and development, as well as in response to environmental stresses. Despite limited information on their functions, various studies have shown their diverse roles in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Jing Zhang, Miao Tian, Kai Chen, Guanxiong Yan, Jie Xiong, Wei Miao
Summary: Meiosis, an important process in eukaryotic sexual reproduction, is initiated by diverse mechanisms involving transcription factors in many species. This study reveals that a putative Cys2His2 zinc finger-containing transcription factor, encoded by the ZFP1 gene, is specifically expressed during sexual reproduction in Tetrahymena thermophila. Cells lacking ZFP1 fail to initiate meiosis, and transcriptome analysis indicates that Zfp1 is required for the expression of meiosis-specific genes. These findings suggest that Zfp1 may act as a transcriptional activator for meiosis initiation in T. thermophila.
Review
Oncology
Xinxin Li, Mengzhen Han, Hongwei Zhang, Furong Liu, Yonglong Pan, Jinghan Zhu, Zhibin Liao, Xiaoping Chen, Bixiang Zhang
Summary: Zinc finger proteins, characterized by their different DNA binding motifs, play a significant role in gene regulation. In hepatocellular carcinoma (HCC), zinc finger proteins exhibit diverse functions in tumorigenesis and progression, and they are also of great significance in HCC diagnosis and prognostic evaluation.
BIOMARKER RESEARCH
(2022)