Article
Cell Biology
Dong Mei Xie, Yang Chen, Yan Liao, Wanwen Lin, Gang Dai, Di Han Lu, Shuanghua Zhu, Ke Yang, Bingyuan Wu, Zhihong Chen, Chaoquan Peng, Mei Hua Jiang
Summary: The study found that CD51 can serve as a marker for resident cardiac MSCs, and CD51(+)cMSC therapy enhances cardiac repair through promoting angiogenesis and a mechanism mediated by SCF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Alireza Hosseinpour, Fatemeh Kheshti, Asma Kazemi, Armin Attar
Summary: This study compared the effects of transplantation of bone-marrow mononuclear cells (BM-MNCs) and mesenchymal stem cells (MSCs) on ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). The results showed that both types of cells significantly improved LVEF in the short term, with MSCs being more effective according to the ICEMAN criteria. The effect was even more pronounced in patients who received stem cell transplantation in the early course after AMI.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Endocrinology & Metabolism
Benedetta Maria Bonora, Mattia Albiero, Mario Luca Morieri, Roberta Cappellari, Francesco Ivan Amendolagine, Marta Mazzucato, Alberto Zambon, Elisabetta Iori, Angelo Avogaro, Gian Paolo Fadini
Summary: This study aimed to investigate the effect of fenofibrate on circulating haematopoietic stem/progenitor cells (HSPCs) in patients with diabetic retinopathy. The results showed that fenofibrate significantly increased the levels of HSPCs expressing CD34 and/or CD133, potentially explaining its role in reducing retinopathy progression.
Article
Multidisciplinary Sciences
Cheng Su, Xiao Zheng, Yanjin He, Li Long, Wenchuan Chen
Summary: This study identified aberrant expression of circRNAs in hUCMSCs during osteogenic differentiation, constructed competing endogenous RNA networks using bioinformatics tools, elucidated underlying mechanisms, and validated the osteogenic-promoting effect of a specific circRNA.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Hanne Belien, Lize Evens, Marc Hendrikx, Virginie Bito, Annelies Bronckaers
Summary: Myocardial infarction, the leading cause of heart failure worldwide, has sparked interest in stem cell therapy for cardiac repair. While some successful results have been achieved in animal models, the overall outcome of clinical trials has been disappointing, mainly due to limited stem cell survival and retention. Combinational use of stem cells and various priming strategies may hold promise for improving regenerative cell therapy efficacy.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Sheng Xing, Jin-Ze Tian, Shu-Hua Yang, Xue-Ting Huang, Yan-Fu Ding, Qian-Yun Lu, Jin-Shu Yang, Wei-Jun Yang
Summary: Blood vessels in adult mammals are highly organized and stable, but in cases of ischemic heart, c-Kit(+) cells play a crucial role in the development and homeostasis of cardiac endothelial cells. Setd4-expressing quiescent c-Kit(+) cells can regulate vascular endothelial cells and improve cardiac function in myocardial infarction injured mice. This suggests the potential for targeted treatments for cardiac ischemic injury by controlling the quiescence of c-Kit(+) cells through epigenetic mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Andrew J. Smith, Prashant Ruchaya, Robert Walmsley, Kathleen E. Wright, Fiona C. Lewis-McDougall, Jacquelyn Bond, Georgina M. Ellison-Hughes
Summary: Receptor tyrosine kinase inhibitors have detrimental effects on human cardiac progenitor cells' viability, proliferation, differentiation, and reparative growth factor expression.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Qianqian Zhu, Shengluan Tang, Yanwen Zhu, Di Chen, Jialyu Huang, Jiaying Lin
Summary: The study demonstrated that CTF1-modified BMSCs-exo could enhance neovascularization and improve endometrial receptivity through promoting endothelial cell proliferation, migration, and tube formation, leading to tissue regeneration, neovascularization, and localized tissue fibrosis suppression in a rat model with endometrial thinning. The upregulation of the JAK/PI3K/mTOR/STAT3 signaling pathways may be responsible for the proangiogenic effects of CTF1 in endometrial regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Tina B. Marvasti, Faisal J. Alibhai, Lukasz Wlodarek, Anne Fu, Shu-Hong Li, Jun Wu, Richard D. Weisel, Robert J. Cusimano, Maral Ouzounian, Terrence Yau, Ren-Ke Li
Summary: This study investigated the impact of aging on human bone marrow cell responses post-myocardial infarction. The findings revealed that younger patient cells had greater repopulation capacity and lymphoid cell production, while the age of CD34(+) cells influenced donor and host cellular responses following MI.
Article
Biochemistry & Molecular Biology
Woo-Sup Sim, Bong-Woo Park, Kiwon Ban, Hun-Jun Park
Summary: The study explored a novel therapeutic platform called in situ preconditioning to enhance the therapeutic potential of BM-MSCs in a rat myocardial infarction model. Results showed that this approach significantly improved the survival and retention of BM-MSCs in the heart, leading to enhanced cardiac function and repair in myocardial infarction hearts. This suggests that in situ preconditioning could be an effective strategy for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Theresa Dolejsi, Murilo Delgobo, Thomas Schuetz, Luigi Tortola, Katrin G. Heinze, Ulrich Hofmann, Stefan Frantz, Axel Bauer, Frank Ruschitzka, Josef M. Penninger, Gustavo Campos Ramos, Bernhard J. Haubner
Summary: Newborn mice and humans have temporary cardiac regenerative potential that declines rapidly as they age. Transfer of adult T-cells into neonatal mice after myocardial infarction leads to impaired cardiac regeneration, increased fibrosis, and dysfunction, demonstrating a trade-off between regenerative potential and T-cell development.
EUROPEAN HEART JOURNAL
(2022)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Anatomy & Morphology
Christian Klopsch, Ralf Gaebel, Heiko Lemcke, Martin Beyer, Praveen Vasudevan, Hsin-Yu Fang, Michael Quante, Brigitte Vollmar, Anna Skorska, Robert David, Gustav Steinhoff
CELLS TISSUES ORGANS
(2018)
Review
Cardiac & Cardiovascular Systems
Kamal S. Ayyat, Ahmed Argawi, Meinhard Mende, Gustav Steinhoff, Michael A. Borger, Ahmed M. Deebis, Kenneth R. McCurry, Jens Garbade
ANNALS OF THORACIC SURGERY
(2019)
Article
Cell Biology
Haval Sadraddin, Ralf Gaebel, Anna Skorska, Cornelia Aquilina Lux, Sarah Sasse, Beschan Ahmad, Praveen Vasudevan, Gustav Steinhoff, Robert David
Article
Cell Biology
Praveen Vasudevan, Ralf Gaebel, Piet Doering, Paula Mueller, Heiko Lemcke, Jan Stenzel, Tobias Lindner, Jens Kurth, Gustav Steinhoff, Brigitte Vollmar, Bernd Joachim Krause, Hueseyin Ince, Robert David, Cajetan Immanuel Lang
Article
Cell Biology
Cajetan Immanuel Lang, Piet Doering, Ralf Gaebel, Praveen Vasudevan, Heiko Lemcke, Paula Mueller, Jan Stenzel, Tobias Lindner, Markus Joksch, Jens Kurth, Carina Bergner, Hans-Juergen Wester, Hueseyin Ince, Gustav Steinhoff, Brigitte Vollmar, Robert David, Bernd Joachim Krause
Article
Medicine, General & Internal
Markus Wolfien, Denise Klatt, Amankeldi A. Salybekov, Masaaki Ii, Miki Komatsu-Horii, Ralf Gaebel, Julia Philippou-Massier, Eric Schrinner, Hiroshi Akimaru, Erika Akimaru, Robert David, Jens Garbade, Jan Gummert, Axel Haverich, Holger Hennig, Hiroto Iwasaki, Alexander Kaminski, Atsuhiko Kawamoto, Christian Klopsch, Johannes T. Kowallick, Stefan Krebs, Julia Nesteruk, Hermann Reichenspurner, Christian Ritter, Christof Stamm, Ayumi Tani-Yokoyama, Helmut Blum, Olaf Wolkenhauer, Axel Schambach, Takayuki Asahara, Gustav Steinhoff
Article
Cell Biology
Praveen Vasudevan, Markus Wolfien, Heiko Lemcke, Cajetan Immanuel Lang, Anna Skorska, Ralf Gaebel, Dirk Koczan, Tobias Lindner, Robby Engelmann, Brigitte Vollmar, Bernd Joachim Krause, Olaf Wolkenhauer, Hermann Lang, Gustav Steinhoff, Robert David
Article
Biochemistry & Molecular Biology
Nicole Zarniko, Anna Skorska, Gustav Steinhoff, Robert David, Ralf Gaebel
Editorial Material
Cell Biology
Gustav Steinhoff
Article
Multidisciplinary Sciences
Cajetan Immanuel Lang, Praveen Vasudevan, Piet Doering, Ralf Gaebel, Heiko Lemcke, Tobias Lindner, Gustav Steinhoff, Bernd Joachim Krause, Brigitte Vollmar, Felix G. Meinel, Seyrani Yuecel, Alper Oener, Hueseyin Ince, Robert David
Summary: This study investigated post-infarct remodeling after acute myocardial infarction using mouse models and magnetic resonance imaging. The results showed differences in cardiac remodeling between the permanent ligation (PL) and ischemia reperfusion (I/R) models. Different methods of analysis revealed that PL resulted in significant left ventricle dilation and decreased contractile function, while the effects were less pronounced in the I/R model.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Amankeldi A. Salybekov, Markus Wolfien, Shuzo Kobayashi, Gustav Steinhoff, Takayuki Asahara
Summary: Stem/progenitor cell transplantation is a potential therapy for inducing angiogenesis in ischemic tissue and preventing major amputation in patients with advanced PAD. However, clinical studies have shown varying responses among patients, suggesting the influence of unidentified risk factors. Personalized stem cell-based therapy by analyzing individual risk factors may improve treatment efficacy, but integrating complex approaches for patient identification before therapy remains a significant challenge.
Article
Biochemistry & Molecular Biology
Beschan Ahmad, Anna Skorska, Markus Wolfien, Haval Sadraddin, Heiko Lemcke, Praveen Vasudevan, Olaf Wolkenhauer, Gustav Steinhoff, Robert David, Ralf Gaebel
Summary: This study investigated the effects of mesenchymal stem cell (MSC) injection on post-infarction arrhythmias. The results showed that MSC therapy after double infarction significantly reduced simple and complex arrhythmias. RNA sequencing analysis also revealed a decline in arrhythmias and reduced inflammatory pathways. Additionally, the study identified highly expressed genes linked to lowering the risk of heart failure, cardiomyopathy, and sudden cardiac death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Stephan C. Knipp, Torulv Holst, Konstantinos Bilbilis, Otgonzul von Velsen, Claudia Ose, Hans-Christoph Diener, Heinz Jakob, Arjang Ruhparwar, Karl-Heinz Joeckel, Christian Weimar
Summary: In patients with coronary artery disease and asymptomatic severe carotid stenosis, the risk of stroke or death is higher following combined CABG+CEA compared with CABG alone. However, there is no significant difference in long-term outcomes after 5 years.
Review
Biochemistry & Molecular Biology
Yanli Liu, Rongcheng Niu, Wenzhong Li, Juntang Lin, Christof Stamm, Gustav Steinhoff, Nan Ma
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)