The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro

(2019) Conny Tümmler et al.   Cancers

The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

(2019) Guillermo de Cárcer   Genes

Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk

(2018) Deepshikha Bhardwaj et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin

(2017) Jayshree Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation and isoform use in p120-catenin during development and tumorigenesis

(2016) Ji Yeon Hong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adherens Junction and E-Cadherin complex regulation by epithelial polarity

(2016) Peter Coopman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cadherin tales: Regulation of cadherin function by endocytic membrane trafficking

(2016) Chantel M. Cadwell et al.   TRAFFIC

Syk mediates airway contractility independent of leukocyte function

(2015) X. Wang et al.   ALLERGY

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer

(2015) Mariya O. Krisenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia

(2014) Alexandre Puissant et al.   CANCER CELL

SYK Is a Candidate Kinase Target for the Treatment of Advanced Prostate Cancer

(2014) V. P. S. Ghotra et al.   CANCER RESEARCH

Epigenetic Regulation of EMT: The Snail Story

(2014) Yiwei Lin et al.   CURRENT PHARMACEUTICAL DESIGN

Actin Cytoskeleton Reorganization by Syk Regulates Fcγ Receptor Responsiveness by Increasing Its Lateral Mobility and Clustering

(2014) Valentin Jaumouillé et al.   DEVELOPMENTAL CELL

SYK Allelic Loss and the Role of Syk-Regulated Genes in Breast Cancer Survival

(2014) Jan Blancato et al.   PLoS One

Cell-Cycle Reprogramming for PI3K Inhibition Overrides a Relapse-Specific C481S BTK Mutation Revealed by Longitudinal Functional Genomics in Mantle Cell Lymphoma

(2014) D. Chiron et al.   Cancer Discovery

Transcription Regulation of E-Cadherin by Zinc Finger E-Box Binding Homeobox Proteins in Solid Tumors

(2014) Thian-Sze Wong et al.   Biomed Research International

Syk is low-expressed in non-small-cell lung cancer and inversely correlates with patient's survival

(2012) C. Peng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

(2012) Manjeet Mukherjee et al.   EMBO JOURNAL

Centrosomal targeting of Syk kinase is controlled by its catalytic activity and depends on microtubules and the dynein motor

(2012) Guillaume Fargier et al.   FASEB JOURNAL

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development

(2012) Romain M. Larive et al.   MOLECULAR BIOLOGY OF THE CELL

Competitive Regulation of E-Cadherin JuxtaMembrane Domain Degradation by p120-Catenin Binding and Hakai-Mediated Ubiquitination

(2012) Andrea Hartsock et al.   PLoS One

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Cadherin–actin interactions at adherens junctions

(2011) Shigenobu Yonemura   CURRENT OPINION IN CELL BIOLOGY

Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling

(2011) Buzz Baum et al.   JOURNAL OF CELL BIOLOGY

Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium

(2011) Srikar R Guntaka et al.   LABORATORY INVESTIGATION

Modulation of E-cadherin function and dysfunction by N-glycosylation

(2010) Salomé S. Pinho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Healing the Syk through Kinase Inhibitors

(2010) Juan Rivera et al.   NEW ENGLAND JOURNAL OF MEDICINE

Syk Tyrosine Kinase Acts as a Pancreatic Adenocarcinoma Tumor Suppressor by Regulating Cellular Growth and Invasion

(2009) Tracy Layton et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of Membrane Localization and Aberrant Nuclear E-cadherin Expression Correlates With Invasion in Pancreatic Endocrine Tumors

(2009) Runjan Chetty et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

Proteomic and Genetic Approaches Identify Syk as an AML Target

(2009) Cynthia K. Hahn et al.   CANCER CELL

Junctional trafficking and epithelial morphogenesis

(2009) Frederik Wirtz-Peitz et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nuclear Accumulation of E-Cadherin Correlates with Loss of Cytoplasmic Membrane Staining and Invasion in Pituitary Adenomas

(2009) Marianne S. Elston et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells

(2009) X. Zhang et al.   MOLECULAR CANCER RESEARCH

Phosphoproteomic analysis of Syk kinase signaling in human cancer cells reveals its role in cell–cell adhesion

(2009) R M Larive et al.   ONCOGENE

Tumor Suppressor Function of Syk in Human MCF10A In Vitro and Normal Mouse Mammary Epithelium In Vivo

(2009) You Me Sung et al.   PLoS One

Regulation of cell–cell adhesion by the cadherin–catenin complex

(2008) W. James Nelson   BIOCHEMICAL SOCIETY TRANSACTIONS

The cell-cell adhesion molecule E-cadherin

(2008) F. van Roy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Role for the Cleaved Cytoplasmic Domain of E-cadherin in the Nucleus

(2008) Emma C. Ferber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY