Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Review
Multidisciplinary Sciences
Qi Sun, Tianhao Zhang, Jiayun Liu, Yong Cui, Wenfei Tan
Summary: By conducting a bibliometric analysis of publications related to postoperative pulmonary complications (PPCs) over the past 20 years, it was found that the number of publications in this field has been increasing, with a majority of them published in the last five years. The United States has the highest number of articles, and the University of Genoa has the highest number of publications among institutions. The focus of research has shifted over time, with current attention on enhanced recovery, prehabilitation, driving pressure, and sugammadex. More large-scale studies and institutional collaboration are needed to provide robust evidence for individualized prevention of PPCs.
Article
Biochemistry & Molecular Biology
Hui-Chuan Chang, Shih-Feng Liu, Ying-Chun Li, Ho-Chang Kuo, Yun-Chyn Tsai, Min-Hui Chen
Summary: The study demonstrates that influenza vaccination is more effective in reducing hospital and emergency department utilization, as well as respiratory failure, in COPD patients with moderate, severe, and very severe airflow obstruction compared to those with mild obstruction.
Article
Cardiac & Cardiovascular Systems
Yun Seok Kim, Yong Il Hwang, Jae Ha Lee, Yong Bum Park, Cheon Woong Choi, Ki-Suck Jung, Kwang Ha Yoo, Seong Yong Lim, Ju Sang Kim, Joon Young Choi
Summary: This study compared the clinical features and prognosis of patients with FEV1/FVC<0.70 at baseline, based on the normalized airflow obstruction status during follow-up. The results showed that transient airflow obstruction in the normalized obstruction group may represent an early manifestation of COPD. Monitoring is needed for such patients to ensure early detection and management.
RESPIRATORY MEDICINE
(2023)
Article
Infectious Diseases
Hye Jung Park, Min Kwang Byun, Jaeuk Lee, Chi Young Kim, Sojung Shin, Youlim Kim, Chin Kook Rhee, Ki Suck Jung, Kwang Ha Yoo
Summary: Pulmonary tuberculosis is a risk factor for airflow obstruction and chronic obstructive pulmonary disease. Even if there are no TB sequelae observed on chest X-ray, TB patients may still develop airway obstruction and COPD.
INFECTIOUS DISEASES
(2023)
Article
Anesthesiology
Gen Li, Robert E. Freundlich, Rajnish K. Gupta, Christina J. Hayhurst, Chi H. Le, Barbara J. Martin, Matthew S. Shotwell, Jonathan P. Wanderer
Summary: This study conducted an observational cohort study on patients at Vanderbilt University Medical Center, finding that changing neuromuscular blockade reversal agents was not associated with the occurrence of postoperative pulmonary complications.
Article
Critical Care Medicine
Surya P. Bhatt, Arie Nakhmani, Spyridon Fortis, Matthew J. Strand, Edwin K. Silverman, Frank C. Sciurba, Sandeep Bodduluri
Summary: The study tested a new severity classification scheme for COPD based on airflow obstruction measurement, and found that this scheme can better differentiate patients' symptoms, disease burden, and prognosis, and is less sensitive to race/ethnicity and other demographic characteristics.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Vasiliy V. Polosukhin, Sergey S. Gutor, Rui-Hong Du, Bradley W. Richmond, Pierre P. Massion, Pingsheng Wu, Justin M. Cates, Kim L. Sandler, Stephen Rennard, Timothy S. Blackwell
Summary: In patients with COPD, thickening of epithelial and subepithelial tissue, mucus plugging, reduced collagen density in the airway wall, and loss of radial alveolar attachments were associated with airflow limitation. The major determinant of airflow limitation related to small airways was found to be the loss of alveolar attachments, which may be mediated by neutrophilic inflammation. Additionally, quantitative analysis of CT scans found an association between the extent of emphysema and loss of alveolar attachments.
Article
Medicine, General & Internal
Chalerm Liwsrisakun, Warawut Chaiwong, Chaicharn Pothirat
Summary: This study compares spirometry and impulse oscillometry (IOS) for the detection and prevalence of small airway dysfunction (SAD) in COPD and asthma patients. The results demonstrate that IOS is more sensitive in detecting SAD in asthma patients without fixed airflow obstruction (FAO), whereas spirometry is more sensitive in COPD and asthma patients with FAO.
FRONTIERS IN MEDICINE
(2023)
Article
Anesthesiology
Douglas A. Colquhoun, Michelle T. Vaughn, Lori D. Bash, Allison Janda, Nirav Shah, Amir Ghaferi, Michael Sjoding, Graciela Mentz, Sachin Kheterpal
Summary: In this retrospective cohort study, the association between neuromuscular blocking agent reversal agent and postoperative pulmonary complications was assessed. The use of sugammadex was independently associated with a reduced risk of subsequent development of pneumonia or respiratory failure compared to neostigmine.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Thomas Ledowski, Zoltan Szabo-Maak, Pui San Loh, Berwin A. Turlach, Hong Seuk Yang, Hans D. de Boer, Laszlo Asztalos, Ina Ismiarti Shariffuddin, Lucy Chan, Bela Fulesdi
Summary: In high-risk older patients, reversing rocuronium neuromuscular block with sugammadex may result in a reduced risk of postoperative pulmonary complications on Day 7.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Anesthesiology
Yu Fu, Yan-Wei Zhang, Jie Gao, Hui-Min Fu, Ling Si, Yong-Tao Gao
Summary: The study suggests that in moderate-risk patients, lung-protective ventilation strategy can reduce the incidence and severity of postoperative pulmonary complications, as well as shorten the postoperative hospital stay.
MINERVA ANESTESIOLOGICA
(2021)
Article
Medicine, General & Internal
Alejandro A. Diaz, Jose L. Orejas, Scott Grumley, Hrudaya P. Nath, Wei Wang, Wojciech R. Dolliver, Andrew Yen, Seth J. Kligerman, Kathleen Jacobs, Padma P. Manapragada, Mostafa Abozeed, Muhammad Usman Aziz, Mohd Zahid, Asmaa N. Ahmed, Nina L. Terry, Ruben San Jose Estepar, Victor Kim, Barry J. Make, MeiLan K. Han, Sushilkumar Sonavane, George R. Washko, Michael Cho, Raul San Jose Estepar
Summary: The presence of mucus plugs in patients with COPD is associated with increased all-cause mortality, as observed in this study.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Critical Care Medicine
Chun Lin, Wen-Cheng Chao, Kai-Chih Pai, Tsung-Ying Yang, Chieh-Liang Wu, Ming-Cheng Chan
Summary: This retrospective analysis found that prolonged use of neuromuscular blockade agents (NMBAs) was associated with an increased risk of long-term mortality in critically ill patients requiring mechanical ventilation, particularly in patients with multiple comorbidities. Further studies are needed to validate these findings.
JOURNAL OF INTENSIVE CARE
(2023)
Review
Medicine, General & Internal
Tim Raveling, Judith Vonk, Fransien M. Struik, Roger Goldstein, Huib A. M. Kerstjens, Peter J. Wijkstra, Marieke L. Duiverman
Summary: Chronic non-invasive ventilation (NIV) can improve arterial blood gases and health-related quality of life in stable COPD patients, while also benefiting post-exacerbation COPD patients in terms of blood gases and admission-free survival. However, the overall impact on exercise capacity and mortality remains uncertain across both populations.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Critical Care Medicine
Hyung-Jun Kim, Nakwon Kwak, Hyunsook Hong, Noeul Kang, Yunjoo Im, Byung Woo Jhun, Jae-Joon Yim
Summary: A novel scoring system named BACES was developed to accurately predict mortality among patients with nontuberculous mycobacterial pulmonary disease caused by M. avium, M. intracellulare, M. abscessus subsp. abscessus, or M. abscessus subsp. massiliense. The BACES score showed excellent discrimination performance with a Harrell's C-index of 0.812 in the derivation cohort and 0.854 in the validation cohort. The estimated 5-year risk of mortality ranged from 1.2% to 82.9% based on the BACES score.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sae Byol Kim, Won-Yeon Lee, Ji-Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Sang-Ha Kim, Young Uh, Soon-Hee Jung, Beomsu Shin
Article
Multidisciplinary Sciences
Sun Hye Shin, Sumin Shin, Yunjoo Im, Genehee Lee, Byeong-Ho Jeong, Kyungjong Lee, Sang-Won Um, Hojoong Kim, O. Jung Kwon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Juhee Cho, Danbee Kang, Hye Yun Park
Summary: Bronchodilator therapy during the perioperative period was effective in preserving lung function in COPD patients undergoing surgery for non-small cell lung cancer, with no significant difference in postoperative complications between patients treated with and without bronchodilators.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Hongseok Yoo, Yunjoo Im, Ryoung-Eun Ko, Jin Young Lee, Junseon Park, Kyeongman Jeon
Summary: The study revealed that plasma HMGB1 levels were associated with the severity and mortality of sepsis, and showed positive correlations with necroptosis-related proteins like RIPK3 and MLKL. This suggests a potential connection between HMGB1 and necroptosis.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Yeonseok Choi, Sun Hye Shin, Hyun Lee, Hyun Kyu Cho, Yunjoo Im, Noeul Kang, Hye Sook Choi, Hye Yun Park
Summary: Bronchiectasis patients with chronic airflow obstruction (CAO) may benefit more from long-term azithromycin treatment compared to COPD patients without bronchiectasis.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Infectious Diseases
Yunjoo Im, Byung Woo Jhun, Eun-Suk Kang, Won-Jung Koh, Kyeongman Jeon
Summary: For patients with chronic pulmonary aspergillosis (CPA), extending antifungal therapy beyond 12 months can significantly reduce the recurrence rate.
JOURNAL OF INFECTION
(2021)
Article
Multidisciplinary Sciences
Myoung Kyu Lee, Sae Byol Kim, Beomsu Shin
Summary: The study investigated the clinical characteristics of patients with chronic pulmonary aspergillosis based on spirometric patterns, revealing differences in features between restrictive and obstructive patterns. Further research is needed to explore the clinical significance of these findings.
Article
Multidisciplinary Sciences
Yunjoo Im, Hongseok Yoo, Ryoung-Eun Ko, Jin Young Lee, Junseon Park, Kyeongman Jeon
Summary: Elevated levels of exosomal CD63 are positively correlated with the severity of organ failure and mortality in critically ill patients with sepsis, indicating a potential for predicting patient outcomes.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Kyung Soo Lee, Yunjoo Im
Letter
Infectious Diseases
Si-Ho Kim, Hyun Kyu Cho, Chun-Hoo Jeon, Hye Sung Ock, Beomsu Shin, Yu Mi Wi
JOURNAL OF INFECTION
(2022)
Article
Dermatology
Yoojin Nam, Seong Mi Moon, Beomsu Shin, Nak Gyeong Ko, Junho An, Yu Mi Wi, Kyung Soo Lee
Summary: This study investigated the clinical and CT findings of CCPA patients receiving antifungal therapy. The results showed that cavity wall thickness decreased with antifungal therapy. Additionally, the initial cavity size and concurrent NTM infection were found to be related to poor response to antifungal therapy.
Article
Medicine, General & Internal
Jae Ni Jang, Soyoon Park, Ji-Hoon Park, Yumin Song, Sooil Choi, Young Uk Kim, Sukhee Park
Summary: This study aims to compare the effectiveness of high-voltage (60V) and standard-voltage (45V) pulsed radiofrequency (PRF) in treating lumbar radicular pain. Twenty patients will be recruited for this prospective, double-blind randomized controlled study. The results will help determine the optimal voltage for PRF in treating lumbar radicular pain and provide a basis for further trials.
Article
Oncology
Hanmil Choi, Yunjoo Im, Byeong-Ho Jeong, Kyungjong Lee, Hojoong Kim, Sang-Won Um
Summary: This study aimed to evaluate the clinical characteristics and survival of miliary pulmonary metastases (MPM) in non-small cell lung cancer (NSCLC) patients. The results showed a significant association between MPM and EGFR gene mutation and the survival rate of MPM group was not inferior to that of non-miliary pulmonary metastases (NMPM) group. Therefore, the presence of EGFR mutations should be thoroughly evaluated in NSCLC patients with initial presentation of MPM.
Article
Clinical Neurology
Sukhee Park, Joohyun Park, Ji Won Choi, Yu Jeong Bang, Eun Jung Oh, Jiyeon Park, Kwan Young Hong, Woo Seog Sim
Summary: The study found that erector spinae plane block reduces postoperative opioid consumption and increases patient satisfaction during immediate breast reconstruction, without significant complications.
KOREAN JOURNAL OF PAIN
(2021)