Article
Oncology
Jody Vykoukal, Johannes F. Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J. Ostrin, Jennifer B. Dennison, Cristina Ivan, Gary E. Goodman, Mark D. Thornquist, Matt J. Barnett, Ziding Feng, George A. Calin, Samir M. Hanash
Summary: Blood-based cancer biomarkers, including miRNA and four protein marker panel, have shown utility in improving the assessment and early detection of lung cancer.
Article
Endocrinology & Metabolism
Jelena Jankovic Miljus, Maria Augusta Guillen-Sacoto, Jennifer Makiadi-Alvarado, Leon Wert-Lamas, Julia Ramirez-Moya, Mercedes Robledo, Pilar Santisteban, Garcilaso Riesco-Eizaguirre
Summary: This study identified two putative novel miRNAs that rise with rhTSH stimulation in the serums of patients with recurrent/persistent thyroid cancer. However, known miRNAs were not found to be circulating markers for thyroid cancer recurrence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Haihua Huang, Zhentian Kai, Yuchen Wang, Xiaomiao Zhang, Jin Wang, Wei Zhang, Qian Xue, Hang Zhang, Hansong Jin, Peize Meng, Shuilong Zhang, Yueyue Yang, Honghua Yang, Wanning Liang, Guangbing Zha, Peng Luo, Yan Xu, Weiwei Shi, Zheng Ruan
Summary: In this study, we evaluated factors influencing the detection sensitivity of circulating tumor DNA (ctDNA) and found that histological subtypes and disease stages played significant roles in ctDNA detection rate. Additionally, we discovered that DNA extracted from bronchoalveolar lavage fluid had higher levels of ctDNA compared to plasma, suggesting its potential as a valuable sample source for tumor detection. Furthermore, tumor cellularity was shown to have a significant impact on the design of personalized ctDNA panels and the overall detection sensitivity.
Article
Clinical Neurology
Gerrit M. Grosse, Anselm A. Derda, Ricarda D. Stauss, Lavinia Neubert, Danny D. Jonigk, Mark P. Kuehnel, Maria M. Gabriel, Ramona Schuppner, Mathias Wilhelmi, Christian Baer, Johann Bauersachs, Claudia Schrimpf, Thomas Thum, Karin Weissenborn
Summary: This study did not find strong associations between specific circulating miRs and symptomatic state in a group of patients with carotid stenosis. Further research is needed to understand the role of circulating miRs as targets in advanced carotid atherosclerosis.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Justyna Raczkowska, Agnieszka Bielska, Adam Kretowski, Magdalena Niemira
Summary: Non-small cell lung cancer (NSCLC) is a malignant condition resistant to advanced-stage treatment and the leading cause of cancer death worldwide. Current diagnostic methods cannot detect the disease at an early stage or predict its development. Micro RNAs (miRNAs) show significant differences in NSCLC tissues and can be easily detected in biofluids without invasive collection techniques. Many studies support the importance of miRNAs as a promising biomarker for detecting and predicting NSCLC. This review discusses the role of biofluid miRNAs as a diagnostic tool in NSCLC and highlights future areas of interest.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Sayuri Herath, Habib Sadeghi Rad, Payar Radfar, Rahul Ladwa, Majid Warkiani, Ken O'Byrne, Arutha Kulasinghe
Summary: Liquid biopsies have emerged as a non-invasive diagnostic approach for screening, early diagnosis, and prognostication of lung cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Anna Niedzwiedz, Milosz Kawa, Ewa Pius-Sadowska, Agnieszka Kuligowska, Alicja Ziontkowska, Dawid Wrzalek, Milosz Parczewski, Krzysztof Safranow, Krzysztof Kozlowski, Boguslaw Machalinski, Anna Machalinska
Summary: This study found that ophthalmic symptoms were not common in COVID-19 patients and did not trigger a strong immune response in the conjunctiva.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Marzia Robotti, Francesca Scebba, Debora Angeloni
Summary: miRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level, and can be detected in cell and tissue extracts, as well as body fluids. The stability of circulating miRNAs in body fluids and their accessibility to sampling make them potential disease biomarkers with diagnostic and prognostic relevance. Saliva, as a representative body fluid, accurately reflects systemic pathophysiological conditions and holds promise as a diagnostic resource for low-cost screening procedures for systemic diseases, including cancer.
Article
Oncology
Yao Wu, Qing Yin, Ya-Ling Zhou, Lei He, Zhi-Qing Zou, Xiao-Yue Dai, Wen Xia
Summary: This study aimed to investigate the potential risk of circulating HPV-DNA in NSCLC and analyze the abnormally expressed miRNAs in circulating HPV-DNA-positive NSCLC. Circulating HPV-DNA was found in 16 NSCLC patients, with higher levels of miR-183, miR-210, and miR-182, and lower levels of miR-144 compared to HPV-DNA-negative patients. Using miR-210 had the highest AUC for identifying circulating HPV-DNA-positive NSCLC patients, and the combination of miR-210 and miR-144 showed the best predictive performance. These findings suggest that circulating HPV-DNA could be a risk factor in NSCLC, and plasma miR-183, miR-210, miR-182, and miR-144 can be reliable biomarkers for identifying circulating HPV-DNA-positive NSCLC.
CANCER BIOLOGY & THERAPY
(2021)
Article
Multidisciplinary Sciences
Sena Ikemoto, Fuminori Sakurai, Sora Tokuoka, Tomoki Yamashita, Kosuke Takayama, Kazuaki Hoshi, Takahiro Okabe, Issei Sumiyoshi, Shinsaku Togo, Kazuhisa Takahashi, Masashi Tachibana, Hiroyuki Mizuguchi
Summary: Circulating tumor cells (CTCs) are present in the blood of cancer patients and are closely correlated with patient prognosis and treatment responses. Therefore, CTCs have been recognized as a novel biomarker for early detection of cancer and monitoring of treatment responses. However, it is crucial to develop an accurate and highly sensitive CTC detection method due to the low abundance of CTCs in patient blood samples. The researchers in this study developed four types of novel GFP-expressing conditionally replicating adenoviruses (rAds) and successfully visualized CTCs in the blood samples of lung cancer patients.
Article
Oncology
Yang Song, Suzhu Zhu, Ning Zhang, Lixin Cheng
Summary: A diagnostic signature consisting of four miRNA pairs was developed for early detection of esophageal cancer. The signature was validated in two independent datasets, demonstrating high performance with accuracy in diagnosing early-stage esophageal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zahra Nashtahosseini, Mahmoud Reza Aghamaali, Farzin Sadeghi, Nadia Heydari, Hadi Parsian
Summary: The study investigated the expression levels of serum miR-660-5p and miR-210-3p in breast cancer patients compared to healthy controls. The results showed significant up-regulation of these microRNAs in breast cancer patients, especially in the early stages, indicating their potential as biomarkers for breast cancer detection with reasonable sensitivity and specificity. Further large-scale studies are needed to confirm these preliminary findings.
JOURNAL OF GENE MEDICINE
(2021)
Review
Oncology
Masahisa Ohtsuka, Kazuya Iwamoto, Atsushi Naito, Mitsunobu Imasato, Satoshi Hyuga, Yujiro Nakahara, Manabu Mikamori, Kenta Furukawa, Jeongho Moon, Tadafumi Asaoka, Kentaro Kishi, Awad Shamma, Hiroki Akamatsu, Tsunekazu Mizushima, Hirofumi Yamamoto
Summary: MicroRNAs (miRNAs) show potential as noninvasive biomarkers for gastrointestinal cancer (GIC) due to their stability in blood and association with GIC status. Research on miRNAs is crucial for early detection and treatment improvement in GIC patients.
Article
Biochemistry & Molecular Biology
Motoki Murata, Yuki Marugame, Shuhei Yamada, Ichian Lin, Shuya Yamashita, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study found that flavonoids can alter the expression of miRNA in plasma, and identified promising plasma miRNAs for assessing the functionality of flavonoids.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Analytical
Cheng Zheng, Xuemei Hu, Shujuan Sun, Lingye Zhu, Ning Wang, Jing Zhang, Guoqiao Huang, Yuzhe Wang, Xiaoying Huang, Liangxing Wang, Zhifa Shen
Summary: In this study, a biosensor is proposed for the specific detection of lung cancer-associated biomarker miRNA-21 through stimuli-induced strand displacement amplification and cascade signal amplification. The sensing system shows good specificity to discriminate coexisting miRNAs and achieves good detection performance in complex human serum samples.
Article
Rehabilitation
Lucia Gassner, Peter Dabnichki, Rochus Pokan, Michaela Schmoeger, Ulrike Willinger, Walter Maetzler, Hermann Moser, Heidemarie Zach
Summary: This study investigated the effects of therapeutic climbing (TC) on individuals with Parkinson's disease (PwP) and found that TC can improve the overall physical and psychosocial health status of PwP, including strength, balance, and social interaction.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Medicine, Research & Experimental
Agnes Langer, Lara Lucke-Paulig, Lucia Gassner, Rejko Krueger, Daniel Weiss, Alireza Gharabaghi, Heidemarie Zach, Walter Maetzler, Markus A. Hobert
Summary: This study compared the effects of deep brain stimulation and dopaminergic medication on gait parameters in patients with advanced Parkinson disease. The results showed that dopaminergic medication had larger additional effects on gait parameters under both single-tasking and dual-tasking conditions, while deep brain stimulation only improved specific gait parameters.
Article
Geriatrics & Gerontology
Laura Delgado-Ortiz, Ashley Polhemus, Alison Keogh, Norman Sutton, Werner Remmele, Clint Hansen, Felix Kluge, Basil Sharrack, Clemens Becker, Thierry Troosters, Walter Maetzler, Lynn Rochester, Anja Frei, Milo A. Puhan, Judith Garcia-Aymerich
Summary: This study examined the personal experiences of individuals living with walking impairment and identified seven themes describing the walking experience across different health conditions. A novel conceptual framework was proposed to guide patient-centered clinical practice, research, and public health.
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Cell Biology
Caroline Diener, Martin Hart, Tim Kehl, Anouck Becker-Dorison, Tanja Taenzer, David Schub, Lena Krammes, Martina Sester, Andreas Keller, Marcus Unger, Barbara Walch-Rueckheim, Hans-Peter Lenhof, Eckart Meese
Summary: Parkinson's disease is a complex and multifactorial disease in which dysregulated T cells play a central role in the pathogenesis. This study used time-resolved RNA expression analysis of peripheral CD4+ T cells to uncover changes in cellular signaling during different stages of Parkinson's disease. The findings revealed altered expression of specific genes and highlighted the involvement of the IL-17 pathway, including an increased prevalence of Th17 cells and a specific subtype of IL-17 producing gamma delta-T cells.
CELL DEATH DISCOVERY
(2023)
Article
Engineering, Biomedical
Sebastian Mang, Lena Reichert, Ralf M. Muellenbach, Jonathan Riesner, Christopher Lotz, Alexander Supady, Haitham Mutlak, Robert Bals, Torben M. Rixecker, Andre P. Becker, Maximilian Leitner, Carsten Zeiner, Guy Danziger, Patrick Meybohm, Frederik Seiler, Philipp M. Lepper
Summary: This study compared the outcomes of COVID-19 patients transported by mobile ECMO teams with those cannulated in experienced ECMO centers. The results showed that COVID-19 patients transported by mobile ECMO teams had no excess risk compared to those receiving VV-ECMO in experienced ECMO centers.
Article
Health Care Sciences & Services
Edoardo Bianchini, Elke Warmerdam, Robbin Romijnders, Klarissa Hanja Stuerner, Ralf Baron, Sebastian Heinzel, Francesco Ernesto Pontieri, Clint Hansen, Walter Maetzler
Summary: Using a smartphone while walking can lead to en bloc turning, increasing the risk of falls. This turning behavior is particularly dangerous for individuals with Parkinson disease and may be used to differentiate individuals with lower-back pain and early Parkinson disease.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Letter
Immunology
Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary, Eunsil Hahm, Sarah Triem, Mira Klug, Stefan J. Schunk, David Schmit, Rafael Kramann, Christina Koerbel, Emmanuel Ampofo, Matthias W. Laschke, Simina-Ramona Selejan, Anna Paschen, Tobias Herter, Susanne Gaul, Guenther Silbernagel, Martina Sester, Urban Sester, Gunter Assmann, Robert Bals, Gerhard Kostner, Willi Jahnen-Dechent, Michael D. Menger, Lucia Rohrer, Winfried Maerz, Michael Boehm, Joachim Jankowski, Manfred Kopf, Eicke Latz, Barbara A. Niemeyer, Danilo Fliser, Ulrich Laufs, Thimoteus Speer
Article
Biochemistry & Molecular Biology
Ernesto Aparicio-Puerta, Pascal Hirsch, Georges P. Schmartz, Fabian Kern, Tobias Fehlmann, Andreas Keller
Summary: miEAA is a flexible and comprehensive miRNA enrichment analysis tool based on direct and indirect miRNA annotation. It includes 19 miRNA repositories, covering 10 different organisms and 139,399 functional categories. miEAA has added information on the cellular context of miRNAs, isomiRs, and high-confidence miRNAs to improve the accuracy of results. It also improves the representation of aggregated results, including interactive Upset plots. Finally, miEAA demonstrates its functionality in the context of ageing and emphasizes the importance of carefully considering the miRNA input list. miEAA is free to use and publicly available.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Analytical
Johannes Hoffmann, Sebastian Roldan-Vasco, Karolin Krueger, Florian Niekiel, Clint Hansen, Walter Maetzler, Juan Rafael Orozco-Arroyave, Gerhard Schmidt
Summary: This study presents a novel approach for evaluating swallowing using magnetic sensors and actuators. The results show the detection capability of swallowing-related movements and suggest the potential for dysphagia screening and biofeedback-based therapies.
Article
Nutrition & Dietetics
Jacqueline Rehner, Georges P. Schmartz, Tabea Kramer, Verena Keller, Andreas Keller, Soeren L. Becker
Summary: Researchers conducted a study on the human gut microbiome of healthy volunteers following the Planetary Health diet and found a slight increase in probiotic-associated bacteria after 4 weeks.
Article
Neurosciences
Odette Fruendt, Anne-Marie Hanff, Annika Moehl, Tobias Mai, Christiane Kirchner, Ali Amouzandeh, Carsten Buhmann, Rejko Kruger, Martin Suedmeyer
Summary: Data on the use of device-aided therapies (DATs) in people with Parkinson's disease (PwP) are scarce. German DAT application rate is rather low, indicating a need for precise identification of symptoms and implementation in future treatment strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Burak Kocak, Bettina Baessler, Renato Cuocolo, Nathaniel Mercaldo, Daniel Pinto dos Santos
Summary: The study conducted a comprehensive bibliometric analysis of artificial intelligence (AI) and radiomics in Radiology, Nuclear Medicine, and Medical Imaging (RNMMI) using Web of Science data. The results showed that RNMMI was the most prominent category in medicine, and the USA and China were the most productive and collaborative countries. The study also found that AI and machine learning in RNMMI demonstrated exponential growth, with deep learning-based research showing the most prominent growth pattern.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemical Research Methods
Sanjay K. Srikakulam, Sebastian Keller, Fawaz Dabbaghie, Robert Bals, Olga Kalinina
Summary: MetaProFi is a Bloom filter-based tool that allows rapid searches in large sequence datasets. It is the first tool that can build indexes of amino acid sequences and query them with both amino acid and nucleotide sequences, bringing sequence comparison to the biologically relevant protein level.
Article
Respiratory System
Kathrin Kahnert, Rudolf A. Joerres, Hans-Ulrich Kauczor, Peter Alter, Franziska C. Trudzinski, Felix Herth, Bertram Jobst, Oliver Weinheimer, Sebastian Nauck, Pontus Mertsch, Diego Kauffmann-Guerrero, Juergen Behr, Robert Bals, Henrik Watz, Klaus F. Rabe, Tobias Welte, Claus F. Vogelmeier, Juergen Biederer
Summary: This study aimed to evaluate the association of Pi10, a measure of standardized airway wall thickness on CT, with exacerbations, mortality, and response to triple therapy in patients with COPD. The results showed that Pi10 was associated with COPD severity, comorbidities, lung function, respiratory therapy, and mortality, and it had some predictive ability.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)