Review
Pharmacology & Pharmacy
Cristianne J. F. Rijcken, Federica De Lorenzi, Ilaria Biancacci, Rob G. J. M. Hanssen, Marielle Thewissen, Qizhi Hu, Florence Atrafi, Rob M. J. Liskamp, Ron H. J. Mathijssen, Iris H. C. Miedema, C. Willemien Menke van der Houven van Oordt, Guus A. M. S. van Dongen, Danielle J. Vugts, Matt Timmers, Wim E. Hennik, Twan Lammers
Summary: Nanomedicines, specifically the CCPM based on CriPec (R) technology, improve the efficacy and safety of pharmacotherapeutic interventions through targeted drug delivery. These nanomedicines have prolonged circulation time, high concentrations at pathological sites, and low levels of accumulation in healthy tissues. Preclinical and clinical studies have demonstrated their potential for improved anticancer therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Ilaria Biancacci, Federica De Lorenzi, Benjamin Theek, Xiangyang Bai, Jan-Niklas May, Lorena Consolino, Maike Baues, Diana Moeckel, Felix Gremse, Saskia von Stillfried, Asmaa El Shafei, Karina Benderski, Armin Azadkhah Shalmani, Alec Wang, Jeffrey Momoh, Quim Pena, Eva Miriam Buhl, Johannes Buyel, Wim Hennink, Fabian Kiessling, Josbert Metselaar, Yang Shi, Twan Lammers
Summary: Cancer nanomedicines rely on the EPR effect for efficient target site accumulation. This study longitudinally studied the dynamics of the EPR effect during nanotherapy and found that the extent of nanomedicine tumor accumulation is predictive for therapy outcome. It also showed that the interindividual heterogeneity in EPR-based tumor accumulation significantly increases during treatment, especially for more efficient double-dose nanotaxane therapy. These findings highlight the importance of the EPR effect in nanomedicine treatment.
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Instruments & Instrumentation
Rosario Pignatello, Roberta Corsaro, Angela Bonaccorso, Elide Zingale, Claudia Carbone, Teresa Musumeci
Summary: This study characterized Soluplus(R) nanomicelles to enhance the apparent solubility of drugs in BCS class II. The prepared nanomicelles showed small and stable particle size and could be easily filtered. The freeze-dried powder materials maintained the micelle size upon reconstitution. Additionally, the nanomicelles demonstrated potential applications in topical ocular administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemical Research Methods
Tarun Ojha, Qizhi Hu, Claudio Colombo, Jan Wit, Michiel van Geijn, Mies J. van Steenbergen, Mahsa Bagheri, Hiltrud Koenigs-Werner, Eva Miriam Buhl, Ruchi Bansal, Yang Shi, Wim E. Hennink, Gert Storm, Cristianne J. F. Rijcken, Twan Lammers
Summary: A freeze-drying methodology was developed for drug-containing CCPM, demonstrating that trehalose-protected CPC634 could be rapidly reconstituted with identical critical quality attributes, providing proof-of-concept for future commercialization.
BIOTECHNOLOGY JOURNAL
(2021)
Article
Instruments & Instrumentation
Armin Azadkhah Shalmani, Alec Wang, Zaheer Ahmed, Maryam Sheybanifard, Rahaf Mihyar, Eva Miriam Buhl, Michael Pohl, Wim E. Hennink, Fabian Kiessling, Josbert M. Metselaar, Yang Shi, Twan Lammers, Quim Pena
Summary: Nanomedicine holds promise for enhancing drug combination therapies through co-formulating and co-delivering different drugs. This study developed a size- and release rate-tunable polymeric micelle platform for co-delivery of taxanes and corticosteroids.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Donya Esmaeilpour, Jens Albert Broscheit, Sergey Shityakov
Summary: This article reviews the applications of cyclodextrins (CDs) in personalized medicine. CDs can enhance drug solubility, stability, and bioavailability, as well as enable controlled and targeted delivery of small molecules. The structure of CDs also allows the preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. The addition of protein corona to nanoparticles improves their biodistribution and half-life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Filippo Prencipe, Carlo Diaferia, Filomena Rossi, Luisa Ronga, Diego Tesauro
Summary: Precision medicine relies on innovative management methods for active components, delivering drugs to specific tissues to enhance therapeutic effects and reduce side effects. Utilizing drug-encapsulated micelles for active targeting marks a new frontier in precision medicine. By decorating micelles with targeting bioactive moieties like peptides, it is possible to direct drugs towards a range of molecular targets, particularly on cancer cells and vasculature.
Review
Pharmacology & Pharmacy
Marjolein I. Priester, Timo L. M. ten Hagen
Summary: Significant advancements have been made in the development of solid tumor treatment, particularly through the implementation of nanosystems for drug delivery, which have reduced side effects and improved drug delivery to tumor regions. However, challenges still exist in clinical translation, and the development of smart drug delivery systems that can be actively manipulated to control drug release shows promise as a powerful strategy to improve drug activity at the target site.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Wenqian Yang, Pengwen Chen, Eger Boonstra, Taehun Hong, Horacio Cabral
Summary: Messenger RNA (mRNA) is a promising therapeutic modality, but its fragility and limited intracellular access pose challenges. This study developed pH-responsive cross-linked micelles for stable mRNA delivery and complete release in endosomal pH. The cross-linked micelles increased mRNA delivery efficiency and promoted protein expression.
Review
Chemistry, Multidisciplinary
Guan-Meng Zhang, Shao-Chen Nie, Zhao-Yuan Xu, Ya-Ru Fan, Mai-Ning Jiao, He-Jing Miao, Su-Xia Liang, Ying-Bin Yan
Summary: Oral cancer is a common tumor that poses a threat to human life and health. Current clinical diagnostic methods often fail to achieve early diagnosis, resulting in most patients being at an advanced stage when oral cancer is detected. Polymer nanoagents in nanomedicine show great potential in the early accurate diagnosis and treatment of oral cancer due to their stability and high drug loading.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhijian Chang, Jia-Hai Ye, Fen Qi, Hongbao Fang, Fuyan Lin, Shuai Wang, Cancan Mu, Wenchao Zhang, Weijiang He
Summary: The study developed a novel chemo-photodynamic combined therapeutic self-assembly polymeric platform that can efficiently encapsulate drugs and exhibit time/dose-dependent cytotoxicity, while generating singlet oxygen under light irradiation, potential for synchronized therapy.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Phuoc Vinh Nguyen, Katel Herve-Aubert, Igor Chourpa, Emilie Allard-Vannier
Summary: EGFR has emerged as a promising oncomarker for active targeting nanomedicines in cancer therapy. Many novel EGFR-targeted nanomedicines have shown encouraging results in both in vitro and in vivo studies. The review highlights the various applications of these medicines in oncology, emphasizing the contribution of EGFR-targeting ligands to therapy efficacy and addressing current challenges and potential solutions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Natalia Lopuszynska, Wladyslaw P. Weglarz
Summary: Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, improve its solubility and stability, enhance distribution and targeting, ensure sustained release, and reduce drug resistance. Nanotechnology enables the combination of therapeutics with biomedical imaging agents to overcome the challenges of disease diagnosis and therapy. This paper presents scientific reports on polymeric nanocarriers for MRI-guided drug delivery, focusing on their contrasting properties and categorizing them into three main groups based on the type of contrast agents.
Review
Chemistry, Multidisciplinary
Xue Zheng, Jizhen Xie, Xing Zhang, Weiting Sun, Heyang Zhao, Yantuan Li, Cheng Wang
Summary: Polymeric nanomedicine, especially polymeric micelles (PM) with nanoscale size, shows promising physical and biological advantages such as excellent solubility, pharmacokinetics, efficacy, and lower toxicity. PM has garnered increasing interest in research and clinical applications, with good clinical outcomes but also facing challenges.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hiroyuki Chaya, Mitsuru Naito, Masaru Cho, Kazuko Toh, Kotaro Hayashi, Shigeto Fukushima, Yuichi Yamasaki, Kazunori Kataoka, Kanjiro Miyata
Summary: The study investigated how the polymerization degree of lysine affected the stability of uPICs in the bloodstream. A smaller polymerization degree resulted in a decreased association constant and prolonged blood retention of free bPEG-PLys. Therefore, the lysine polymerization degree can influence the dynamic stability of uPICs.
Article
Engineering, Biomedical
Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka
Summary: The study successfully stabilized Polyplex micelles (PMs) by developing RNA oligonucleotide (OligoRNA) derivatives to bridge mRNA and polycation, improving their stability against polyion exchange reaction and ribonuclease attack. This bridging strategy provides a new approach for mRNA delivery by enhancing the efficiency of mRNA introduction in cultured cells and mouse lungs after intratracheal administration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Editorial Material
Chemistry, Multidisciplinary
Nicholas A. Kotov, Deji Akinwande, C. Jeffrey Brinker, Jillian M. Buriak, Warren C. W. Chan, Xiaodong Chen, Manish Chhowalla, William Chueh, Sharon C. Glotzer, Yury Gogotsi, Mark C. Hersam, Dean Ho, Tony Hu, Ali Javey, Cherie R. Kagan, Kazunori Kataoka, Il-Doo Kim, Shuit-Tong Lee, Young Hee Lee, Luis M. Liz-Marzan, Jill E. Millstone, Paul Mulvaney, Andre E. Nel, Peter Nordlander, Wolfgang J. Parak, Reginald M. Penner, Andrey L. Rogach, Mathieu Salanne, Raymond E. Schaak, Ajay K. Sood, Molly Stevens, Vladimir Tsukruk, Andrew T. S. Wee, Ilja Voets, Tanja Weil, Paul S. Weiss
Review
Pharmacology & Pharmacy
Sabina Quader, Kazunori Kataoka, Horacio Cabral
Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Takuya Miyazaki, Shaoyi Chen, Stelios Florinas, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Ze-Qi Xu, Herren Wu, Changshou Gao, Kazunori Kataoka, R. James Christie, Horacio Cabral
Summary: This study presents a Hoechst-based reporter system that can monitor the release and engagement of drugs from nanoparticle delivery systems. The system allows the visualization of drug distribution and binding to subcellular targets, providing insights into the effects of drug-linker and nanoparticle properties on target-bound drug distribution. The findings from this study were applied to develop highly potent, targeted anticancer nanoparticles with optimized drug-linker design, resulting in effective tumor growth inhibition without severe toxicity.
Article
Biochemistry & Molecular Biology
Masaya Sano, Daisuke Akagi, Mitsuru Naito, Katsuyuki Hoshina, Kanjiro Miyata, Kazunori Kataoka, Soichiro Ishihara
Summary: This study used nanomedicine to deliver miR146a-5p in a rat carotid artery balloon injury model and found that it can inhibit inflammatory response and vascular smooth muscle cell migration, as well as reduce reactive oxygen species production and proinflammatory cytokine gene expression. In a rat model, miR146a-5p attenuated NIH and vessel remodeling by reducing proinflammatory cytokine gene expression in injured arteries and monocyte/macrophage infiltration into the vascular wall.
Editorial Material
Chemistry, Multidisciplinary
Luis M. Liz-Marzan, Andre E. Nel, C. Jeffrey Brinker, Warren C. W. Chan, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Nicholas A. Kotov, Wolfgang J. Parak, Molly M. Stevens
Article
Engineering, Biomedical
Pengwen Chen, Wenqian Yang, Taehun Hong, Takuya Miyazaki, Anjaneyulu Dirisala, Kazunori Kataoka, Horacio Cabral
Summary: Intracellular protein delivery is an effective approach for developing innovative therapeutics. Nanocarriers have the potential to deliver proteins inside cells by promoting cellular uptake and overcoming degradation. Controlling the ability of nanocarriers to escape from the endo/lysosomal compartments can enhance delivery precision.
Article
Chemistry, Multidisciplinary
Yuto Honda, Sayaka Onodera, Hiroyasu Takemoto, Noor Faizah Che Harun, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Yudi Sun, Yutaka Miura, Nobuhiro Nishiyama
Summary: This study aims to develop a technology to control the activity of small interfering RNA (siRNA) in a thermo-responsive manner, even at temperatures close to body temperature. By conjugating siRNA with a thermally responsive copolymer, the activity of siRNA can be enhanced based on temperature changes. This technique offers a promising approach to selectively induce therapeutic effects of siRNA in vivo.
PHARMACEUTICAL RESEARCH
(2023)
Editorial Material
Chemistry, Multidisciplinary
Tony Hu, C. Jeffrey Brinker, Warren C. W. Chan, Chunying Chen, Xiaodong Chen, Dean Ho, Kazunori Kataoka, Nicholas A. Kotov, Luis M. Liz-Marzan, Andre E. Nel, Wolfgang J. Parak, Molly Stevens
Article
Engineering, Biomedical
Haochen Guo, Wen Xu, Takahiro Nomoto, Kaito Kanamori, Yan Ming Voon, Yuto Honda, Naoki Yamada, Hiroyasu Takemoto, Makoto Matsui, Nobuhiro Nishiyama
Summary: Cancer cells overexpress LAT1 to take up neutral amino acids, and targeting LAT1 with drug delivery systems has promising potential for cancer diagnosis and therapy. This study developed polymers with Met or Cys structures to test their affinity with LAT1. The Met-modified polymers exhibited higher cellular uptake efficiency in an LAT1-selective manner and showed tumor-selective accumulation in vivo, suggesting their potential for LAT1-targeting drug delivery systems.
Article
Oncology
Takahiro Nomoto, Kana Komoto, Tomoya Nagano, Takuya Ishii, Haochen Guo, Yuto Honda, Shun-ichiro Ogura, Masahiro Ishizuka, Nobuhiro Nishiyama
Summary: This study suggests that the use of a polymeric iron chelator can enhance the effectiveness of 5-ALA-induced photodynamic therapy by modulating the intratumoral iron levels. The polymeric iron chelator effectively deactivates intracellular labile iron and increases the accumulation of PpIX, improving the cytotoxicity upon photoirradiation.
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Article
Pharmacology & Pharmacy
Hsi-Kai Tsou, Cheng-Hsin Wu, Long Yi Chan, Kazunori Kataoka, Nanae Itokazu, Minoru Tsuzuki, Hsuan Hu, Guan-Yu Zhuo, Keiji Itaka, Chin-Yu Lin
Summary: Large-area craniofacial defects pose a challenge for orthopaedists. In order to develop a safe and effective tissue engineering strategy, cytokines and chemokines can be utilized to attract endogenous stem cells for bone regeneration. The combination of BMP2 and TGF-beta3 mRNA nanomedicine promotes bone formation and provides an alternative cell-free tissue engineering method for craniofacial defect healing.
Meeting Abstract
Oncology
Hiroaki Kinoh, Sabina Quader, Horacio Cabral, Kazunori Kataoka