Article
Medicine, Research & Experimental
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Pragya Bradu, Aarthi Sukumar, Megha Patil, Kaviyarasi Renu, Abhijit Dey, Balachandar Vellingiri, Alex George, Raja Ganesan
Summary: This review provides a detailed study on pancreatic cancer and its association with different types of cancer related to diabetes. It discusses the combination of anti-diabetic drugs with other anti-cancer drugs and phytochemicals for the prevention and treatment of the disease. The migration and development of pancreatic cancer stem cells (CSCs) are also discussed. Additionally, it explores the mechanisms of diabetes development that enhance the proliferation of pancreatic CSCs, such as increased IGF factor levels, epigenetic modifications, DNA damage, and lifestyle factors like obesity and inflammation.
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, Yuanjie Pang, Iona Millwood, Ling Yang, Yu Guo, Robin Walters, Jun Lv, Michael Hill, Canqing Yu, Yiping Chen, Xiaofang Chen, Eric O'Neill, Junshi Chen, Ruth C. Travis, Robert Clarke, Liming Li, Zhengming Chen, Michael Holmes
Summary: Several plasma proteins were found to be associated with the risk of subsequent diagnosis of pancreatic cancer, potentially serving as biomarkers for early detection and prediction. While there was only a small increase in discrimination for long-term risk, the clinical utility of these proteins warrants further investigation.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yasuhiro Fujiwara, Ryouichi Tsunedomi, Kiyoshi Yoshimura, Satoshi Matsukuma, Nobuyuki Fujiwara, Mitsuo Nishiyama, Shinsuke Kanekiyo, Hiroto Matsui, Yoshitaro Shindo, Yukio Tokumitsu, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Tatsuya Ioka, Shoichi Hazama, Hiroaki Nagano
Summary: The study found that CALR is highly expressed in P-CSLCs, which exhibit increased tumor incidence and sphere-forming ability.
Article
Biochemistry & Molecular Biology
Esther Imperlini, Claudia Corbo
Summary: The eradication of cancer stem cells (CSCs) is a major challenge in cancer research. These cells are crucial for tumor initiation, growth, and maintenance. This study aimed to identify specific biomarkers for osteosarcoma (OS) stem cells by comparing their proteomic profile to non-stem counterparts. Using the cell lines 3AB-OS (stem-like) and MG63 (parental), 63 proteins exclusively expressed in 3AB-OS cells were discovered. Analyzing their functions, we found a potential correlation between the IGF2BPs signaling pathway and the tumorigenic and stemness features of 3AB-OS cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tong Lei, Jian Wang, Yanyan Liu, Peng Chen, Zhihui Zhang, Xiaoshuang Zhang, Xiao Wang, Quanhai Li, Hongwu Du
Summary: The study compared the protein abundance profiles of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSCs) using proteomic techniques, revealing differences at the protein level. Specific markers proposed to distinguish the two cell types were identified through functional and pathway analysis of differentially abundant proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Olga Pershina, Natalia Ermakova, Angelina Pakhomova, Darius Widera, Edgar Pan, Mariia Zhukova, Elena Slonimskaya, Sergey G. Morozov, Aslan Kubatiev, Alexander Dygai, Evgenii G. Skurikhin
Summary: This study found that breast cancer patients can be divided into two groups based on the frequency of ALDH1 cells, corresponding to different types of stem cells. Additionally, epithelial precursors associated with a positive effect of chemotherapy and remission in breast cancer patients were found in normal breast tissue.
Article
Pharmacology & Pharmacy
Hongyu Zhou, Licheng Tan, Beilei Liu, Xin-Yuan Guan
Summary: Tumors consist of malignant components that generate abnormal tissues through self-renewal and differentiation. Cancer stem cells (CSCs) play a fundamental role in maintaining tumor heterogeneity and remodeling the tumor microenvironment. Recent advances in technology have allowed for better understanding of CSC characteristics, markers, mechanisms, and their interactions with other cells in the tumor microenvironment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alberto Nicoletti, Marcantonio Negri, Mattia Paratore, Federica Vitale, Maria Elena Ainora, Enrico Celestino Nista, Antonio Gasbarrini, Maria Assunta Zocco, Lorenzo Zileri Dal Verme
Summary: Pancreatic cancer is highly aggressive and has a poor prognosis due to difficulties in detection and limited effectiveness of current treatments. Extracellular vesicles, such as exosomes and microvesicles, may play a crucial role in the progression and resistance to chemotherapy of pancreatic cancer. They also have the potential to be used as biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roman Bubin, Romans Uljanovs, Ilze Strumfa
Summary: The discovery of cancer stem cells (CSCs) in leukemia has led to active research on stemness in neoplastic tissues. CSCs are a subpopulation of malignant cells with unique properties, including a dedifferentiated state, self-renewal, pluripotency, resistance to therapy, epigenetic alterations, and higher tumorigenicity. CSCs have been confirmed in various malignancies, including pancreatic ductal adenocarcinoma, which has a poor prognosis. This review aims to summarize the current knowledge on the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options for their elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Akihiro Yoneda, Kenjiro Minomi, Yasuaki Tamura
Summary: Disruption of heat shock protein 47 (HSP47) enhances the efficacy of gemcitabine for PDAC cells by promoting the interaction of CALR with Ca2+ ATPase 2 and IRE1 alpha with inositol 1,4,5-triphosphate receptor, resulting in increased intracellular Ca2+ levels prone to oxidative stimuli induced cell death. Ablation of HSP47 also promotes gemcitabine-induced suppression of tumor growth in PDAC cell-bearing mice, suggesting that targeting HSP47 may improve chemotherapy efficacy for PDAC patients.
Article
Oncology
Young Eun Kim, Eun-Kyung Kim, Min-Jeong Song, Tae-Young Kim, Ho Hee Jang, Dukjin Kang
Summary: Resistance to oxaliplatin is a challenge in pancreatic cancer therapy, and the molecular mechanisms underlying this resistance remain unclear. This study aimed to identify changes in proteins associated with oxaliplatin resistance in pancreatic cancer cells. The findings revealed enrichment of multiple biological processes and highlighted the potential involvement of WLS and MARCKS in oxaliplatin resistance.
Article
Oncology
Yoseop Kim, Injoon Yeo, Iksoo Huh, Jaenyeon Kim, Dohyun Han, Jin-Young Jang, Youngsoo Kim
Summary: The study developed a multi-marker panel containing 14 proteins for improved pancreatic ductal adenocarcinoma detection. The panel achieved high AUC values in both the training and validation sets. Compared to CA 19-9 alone, the multi-marker panel showed significant improvements in diagnostic performance.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Young Hoon Choi, Tae Ho Hong, Seung Bae Yoon, In Seok Lee, Myung Ah Lee, Ho Joong Choi, Moon Hyung Choi, Eun Sun Jung
Summary: Portal venous circulating tumor cells (CTCs) can serve as a biomarker for early recurrence and poor prognosis in patients with resectable pancreatic cancer. The number of CTCs is associated with stage and regional lymph node metastasis, and low portal venous CTCs are associated with better overall and recurrence-free survival.
Article
Medicine, General & Internal
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan
Summary: This study identified potential biomarkers for bladder cancer diagnosis and disease progression using aptamer screening and systems biology analysis. Urine d-dimer showed high sensitivity (97%) for bladder cancer diagnosis, while urine IL-8 and IgA were associated with disease progression. These biomarkers could be used for initial triage and patient follow-up, reducing the need for invasive cystoscopy-based diagnostic methods.
Review
Cell Biology
Aaron Galindo-Vega, Vilma Maldonado-Lagunas, Irma B. Mitre-Aguilar, Jorge Melendez-Zajgla
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy due to a complex tumor microenvironment and the presence of cancer stem cells, which contribute to therapy resistance and tumor relapse. Understanding and targeting the tumor microenvironment and cancer stem cells may be crucial for effective PDAC therapies. This review summarizes recent advances in the role of tumor microenvironment in pancreatic neoplastic progression.
Article
Nursing
Kozue Okano, Kazuki Shitamoto, Minako Araki, Chie Kawamoto, Reo Kawano, Hiroshi Nogaki
NURSING & HEALTH SCIENCES
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
N. Tanaka, Y. Kunihiro, M. Kubo, R. Kawano, K. Oishi, K. Ueda, T. Gondo
CLINICAL RADIOLOGY
(2018)
Article
Oncology
Issei Saeki, Takahiro Yamasaki, Masaki Maeda, Reo Kawano, Takuro Hisanaga, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida
Article
Clinical Neurology
Kazutaka Sugimoto, Sadahiro Nomura, Satoshi Shirao, Takao Inoue, Hideyuki Ishihara, Reo Kawano, Akiko Kawano, Fumiaki Oka, Eiichi Suehiro, Hirokazu Sadahiro, Mizuya Shinoyama, Takayuki Oku, Yuichi Maruta, Yuya Hirayama, Koichiro Hiyoshi, Miwa Kiyohira, Hiroshi Yoneda, Koki Okazaki, Jens P. Dreier, Michiyasu Suzuki
ANNALS OF NEUROLOGY
(2018)
Article
Clinical Neurology
Hideyuki Ishihara, Fumiaki Oka, Hisaharu Goto, Takuma Nishimoto, Koki Okazaki, Hirokazu Sadahiro, Reo Kawano, Michiyasu Suzuki
WORLD NEUROSURGERY
(2019)
Article
Multidisciplinary Sciences
Tomoe Kimura, Toshinori Ueno, Shigehiro Doi, Ayumu Nakashima, Toshiki Doi, Aki Ashitani, Reo Kawano, Kiminori Yamane, Takao Masaki
Article
Medical Laboratory Technology
Anwar Borai, Kiyoshi Ichihara, Abdulaziz Masaud, Waleed Tamimi, Suhad Bahijri, David Armbruster, Reo Kawano, Ziad Baarmah, Faris Joatar, Mohammed Almohammadi
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2020)
Article
Oncology
Issei Saeki, Takahiro Yamasaki, Yurika Yamauchi, Taro Takami, Tomokazu Kawaoka, Shinsuke Uchikawa, Akira Hiramatsu, Hiroshi Aikata, Reo Kawano, Kazufumi Kobayashi, Takayuki Kondo, Sadahisa Ogasawara, Tetsuhiro Chiba, Kazuaki Chayama, Naoya Kato, Isao Sakaida
Summary: Skeletal muscle volume is a significant prognostic factor for hepatocellular carcinoma patients receiving sorafenib, predicting overall survival and post-progression survival. Patients with higher muscle volume have longer survival times and post-progression survival times.
Article
Clinical Neurology
Kota Kagawa, Akira Hashizume, Masaya Katagiri, Go Seyama, Akitake Okamura, Reo Kawano, Koji Iida
Summary: In terms of postoperative seizure outcomes and activities of daily living recovery period, one-stage TCC is preferred over ACC for adolescent and young adults with severe mental retardation.
Article
Gastroenterology & Hepatology
Tatsuaki Sumiyoshi, Kenichiro Uemura, Gaku Aoki, Reo Kawano, Hiroki Kitagawa, Naru Kondo, Kenjiro Okada, Shingo Seo, Hiroyuki Otsuka, Shinya Takahashi
Summary: Preoperative biliary tract infection and chemotherapy are independently associated with postoperative clostridium difficile infection in pancreatic ductal adenocarcinoma patients.
Article
Pediatrics
K. A. T. M. Ehsanul Huq, Michiko Moriyama, Ryota Matsuyama, Md Moshiur Rahman, Reo Kawano, Mohammod Jobayer Chisti, Md Tariqujjaman, Nur Haque Alam
Summary: The study found that in urban hospitals in Bangladesh, the length of hospital stay for under-five children with severe pneumonia was associated with the number of household family members, humidity variation, and rainfall variation. Additionally, there were negative associations with children's age, well-nourishment, and average rainfall.
Article
Nursing
Mio Ozawa, Kotomi Yamashita, Reo Kawano
Summary: This study aimed to test a comprehensive virtual program for using pain scales to manage neonatal pain and evaluate its effectiveness in improving nurses' knowledge and skill. The results indicated that the e-learning program significantly improved nurses' neonatal pain knowledge and pain-measurement skills compared to no training.
PAIN MANAGEMENT NURSING
(2022)
Article
Gastroenterology & Hepatology
Naru Kondo, Kenichiro Uemura, Tatsuaki Sumiyoshi, Kenjiro Okada, Shingo Seo, Hiroyuki Otsuka, Reo Kawano, Yoshiaki Murakami, Shinya Takahashi
Summary: The study identified preoperative CA19-9 (≥100 U/mL) as the most reliable predictive factor for poor survival in patients with resectable PDAC treated with upfront surgery. Further clinical trials are needed to investigate the efficacy of neoadjuvant therapy targeting patients with elevated preoperative CA19-9 levels, indicating a high risk of poor prognosis.
Article
Obstetrics & Gynecology
Reiko Shiba, Masayuki Kinutani, Shinichiro Okano, Reo Kawano, Yuko Kikkawa
REPRODUCTIVE MEDICINE AND BIOLOGY
(2020)
Meeting Abstract
Gastroenterology & Hepatology
K. Watanabe, R. Kawano, M. Nishishita, F. Shimamoto, T. Fukuchi, M. Esaki, Y. Okamoto, Y. Maehata, S. Oka, S. Nishiyama, S. Fujii, F. Hirai, T. Matsui, K. Kakimoto, T. Okada, T. Inoue, N. Hida, R. Nozaki, T. Sakurai, H. Kashida, K. Takeuchi, N. Ohmiya, M. Saruta, S. Saito, Y. Saito, S. Nakamura, S. Tanaka, Y. Suzuki, Y. Ajioka, H. Tajiri
JOURNAL OF CROHNS & COLITIS
(2018)