期刊
CHEMISTRYSELECT
卷 4, 期 45, 页码 13347-13355出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201903458
关键词
Acetylcholinesterase; Carbonic Anhydrase; Isoindole; Molecular Docking; Sulfonamide
资金
- Research Fund of Sakarya University [2016-02-04-018]
- Research Fund of Erzincan Binali Yildirim University [FBA-2017-501]
Herein, a series of isoindole-1,3-dione substituted sulfonamide derivatives (3, 4a-k) were designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) and acetylcholinesterase (AChE). CA and AChE inhibitory activities of newly synthesized isoindole-1,3-dione substituted sulfonamides compounds (3, 4a-k) towards the hCA I, II, and AChE were evaluated utilizing the Verpoorte's and Ellman's assays and checked against that of standard inhibitors, acetazolamide (AAZ) and tacrine (TAC). The developed compounds (3, 4a-k) showed the potent hCA isoenzyme inhibitory effect with K-i constants ranging from 7.96 to 48.34 nM, compared to AAZ (K(i)s; 436.20 nM for hCA I and 93.53 nM for hCA II). Among these derivatives; 1,3-dioxo-1,3-dihydroisobenzofuran-5-carbocyclic acid (3) and benzyl-1,3-dioxo-2-(4-sulfomophenyl)isoindoline-5-carboxylate (4i) determined to be effective AChE inhibitors (K(i)s, 103.51 and 108.92 nM, respectively); these compounds were almost as potent to TAC (K-i, 109.75 nM). Furthermore, molecular docking studies of derivatives 3 and 4i were carried out utilizing the crystal structures of hCA I (PDB Code: 4WR7), II (PDB Code: 4HT0) isozymes and AChE (PDB Code: 4EY7) receptors to study their binding interactions.
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