Review
Oncology
Ningxin Jia, Yanan Zhou, Xiaosheng Dong, Meng Ding
Summary: Aerobic exercise is an important non-pharmacological intervention for tumors, involving multiple signaling pathways and cytokine balance. Future research directions include investigating the influence of cytokine subtypes, tailoring exercise prescriptions, studying the effects of exercise time and intensity, and elucidating details of unclear mechanisms.
Article
Clinical Neurology
Cherie L. La Rocque, Raegan Mazurka, Troy J. R. Stuckless, Kyra Pyke, Kate L. Harkness
Summary: The study compared the efficacy of Bikram yoga, aerobic exercise, and a waitlist for depression, finding significantly higher response rates in both the Bikram yoga and aerobic exercise conditions compared to the waitlist. Results suggest that reductions in rumination played a mediating role in the antidepressant effects of both active treatments.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Lu Bai, Zhao-Xu Yang, Peng-Fei Ma, Jian-Shan Liu, De-Sheng Wang, Heng-Chao Yu
Summary: SLC25A51 is overexpressed in hepatocellular carcinoma (HCC) and correlates with clinicopathological characteristics and poor survival in HCC patients. Its overexpression promotes the growth and metastasis of HCC cells through reprogramming glucose metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Bing Bo, Yang Zhou, Qingyun Zheng, Guandong Wang, Ke Zhou, Jianshe Wei
Summary: Aerobic exercise plays a positive role in heart health and regeneration, although current research on its effects is not comprehensive. Complex molecular and cellular mechanisms, along with paracrine factors, transcriptional factors, signaling pathways, and microRNAs, contribute to cardiomyocyte regeneration induced by physical activity.
Article
Cell Biology
Sara E. DiNapoli, Raul Martinez-McFaline, Hao Shen, Ashley S. Doane, Alexendar R. Perez, Akanksha Verma, Amanda Simon, Isabel Nelson, Courtney A. Balgobin, Caitlin T. Bourque, Jun Yao, Renuka Raman, Wendy Beguelin, Jonathan H. Zippin, Olivier Elemento, Ari M. Melnick, Yariv Houvras
Summary: Perturbations to the epigenome are known drivers of tumorigenesis. This study used a melanoma model to demonstrate the critical roles of histone methyltransferases in melanoma formation and innate immune response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Zeyu Xing, Ruojiao Wang, Xin Wang, Jiaqi Liu, Menglu Zhang, Kexin Feng, Xiang Wang
Summary: The study demonstrated that circPDCD11 functions as an oncogene in triple-negative breast cancer (TNBC), promoting metabolic activity and tumor growth. This circRNA serves as a miRNA sponge to upregulate LDHA expression, providing a potential prognostic biomarker for TNBC.
CELL DEATH DISCOVERY
(2021)
Review
Medicine, Research & Experimental
Hongyuan Liang, Lingyun Zhang, Jian Rong
Summary: The incidence and mortality rates of lung cancer (LC) are increasing globally each year. LC is difficult to detect early and easily metastasizes and relapses. Currently, there is no effective cure for advanced metastatic LC, leading to poor prognosis. Exosomes, nano-sized extracellular vesicles produced by healthy or diseased cells, contain various functional molecules and play crucial roles in the occurrence and metastasis of many malignancies, including LC. Understanding the potential roles of exosomes in the initiation, invasion, and metastasis of LC and the underlying molecular mechanisms could contribute to improved early diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Dong Han, Jude N. Owiredu, Bridget M. Healy, Muqing Li, Maryam Labaf, Jocelyn S. Steinfeld, Susan Patalano, Shuai Gao, Mingyu Liu, Jill A. Macoska, Kourosh Zarringhalam, Kellee R. Siegfried, Xin Yuan, Timothy R. Rebbeck, Changmeng Cai
Summary: Prostate cancer affects men of African ancestry disproportionately with higher prevalence and worse outcomes compared to American men of European ancestry. Genetic variations such as SNP, particularly in the NEDD9 gene, may play a crucial role in driving racial disparities in prostate cancer aggressiveness and treatment outcomes. The identified prostate cancer susceptibility SNP in NEDD9 increases NEDD9 expression and promotes tumor growth and metastasis, providing new insights into the genetic mechanisms of prostate cancer disparities.
Review
Biochemistry & Molecular Biology
Jooske L. Monster, Lars J. S. Kemp, Martijn Gloerich, Rachel S. van der Post
Summary: Gastric cancer is the fourth leading cause of cancer-related deaths worldwide, and patients with diffuse-type gastric cancer have a poor prognosis with limited effectiveness of conventional chemotherapies. However, recent advancements in mouse and organoid models, as well as multi-omic analyses, are shedding light on the mechanisms responsible for DGC initiation and progression, offering potential opportunities for targeted therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Engineering, Environmental
Qi Qin, Bingwei Yang, Jing Liu, Erqun Song, Yang Song
Summary: The exposure of PCB29-pQ was found to promote aerobic glycolysis in breast cancer through the activation of GLUT1 signaling pathway. Inhibition of GLUT1 reversed the effects on migration and invasion of MDA-MB-231 cells induced by PCB29-pQ, and repression of GLUT1 also suppressed breast cancer metastasis in nude mice inoculated with 4T1-luc cells.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Oncology
Jorge Almagro, Hendrik A. Messal, Alberto Elosegui-Artola, Jacco van Rheenen, Axel Behrens
Summary: The 3D architecture of tissues bearing tumors has significant impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. Various forces from cancer cells, host tissue, and the molecular and cellular microenvironment modulate the morphology and malignant potential of the tumor through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have revealed how tissue architecture influences cancer biology and progression.
Article
Engineering, Environmental
Hu Cui, Yang Ou, Lixia Wang, Baixing Yan, Yingxin Li, Meiwen Bao
Summary: The study found that adding zeolite of different grain sizes can significantly reduce the bioavailability of heavy metals during aerobic composting, promoting the passivation of copper, cadmium, and lead through surface adsorption and humification.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Oncology
Hongfei Yu, Chaoyi Chen, Fengyan Han, Jinlong Tang, Mengli Deng, Yumiao Niu, Maode Lai, Honghe Zhang
Summary: In this study, it was found that the depletion of MIR4435-2HG promotes the development of colorectal cancer by increasing tumor-infiltrating PMN-MDSCs and enhancing their immunosuppressive potential. This provides a theoretical basis for further investigating the pathogenesis of colorectal cancer and identifying potential targets for anti-tumor immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Lara F. Tshering, Fu Luo, Savanah Russ, Mariola Szenk, Diana Rubel, Karis Tutuska, James G. Balazsi, Gabor Balazsi, Michael M. Shen, Flaminia Talos
Summary: Understanding the role of the immune microenvironment in modulating intratumor heterogeneity is essential for effective cancer therapies. The study shows that slowly progressing tumors have a well-organized tumor microenvironment with relatively homogeneous subpopulations, while advanced tumors have a disordered microenvironment with competing dominant and minor clones. Immunomodulation of the IFNg pathway can rescue minor clones, and the immune-specific gene signature of minor clones has prognostic value in prostate cancer.
DEVELOPMENTAL CELL
(2023)
Review
Oncology
Roxan F. C. P. A. Helderman, Daan R. Loke, Pieter J. Tanis, Jurriaan B. Tuynman, Wim Ceelen, Ignace H. de Hingh, Kurt van der Speeten, Nicolaas A. P. Franken, Arlene L. Oei, H. Petra Kok, Johannes Crezee
Summary: The efficacy of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) depends on various factors, including patient selection, tumor type, delivery technique, and treatment parameters. Preclinical research plays a crucial role in investigating and potentially improving treatment protocols. This study aims to review the objectives, methods, and clinical relevance of in vivo preclinical HIPEC studies found in the literature, providing recommendations and highlighting possible pitfalls in the experimental design.
Editorial Material
Obstetrics & Gynecology
Tiffany Y. Sia, Allison Betof Warner, Sarah J. Noor, Emeline M. Aviki, Kara Long Roche
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Oncology
Allison Betof Warner, Pippa G. Corrie, Omid Hamid
Summary: Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) has shown durable responses in patients with advanced melanoma, but it is not yet approved by any regulatory agency. TIL therapy involves harvesting patient-specific T cells from tumors, expanding them ex vivo, and re-infusing them back into the patient. Objective response rates of 30% to 50% have been observed in heavily pretreated patients, including those who have progressed after other treatments. Improvements in patient selection, TIL production, and efficacy are currently being explored.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Allison Betof Warner, Ahmad Tarhini, Barinder Kang, Antonio Nakasato, You-Li Ling, Rohan Shah, Jackson Tang, Jeetvan Patel
Summary: The study compares the efficacy of different treatment sequences and lines among advanced melanoma patients with BRAF V600 mutation using real-world data. The results show that there is no significant difference in progression-free survival and overall survival between immunotherapies and targeted therapies, regardless of treatment sequence. However, the efficacy of second-line therapy is worse than first-line therapy. The study provides real-world evidence beyond clinical trials.
Article
Oncology
Thomas M. Atkinson, Jennifer L. Hay, Soo Young Kim, Elizabeth Schofield, Michael A. Postow, Parisa Momtaz, Allison Betof Warner, Alexander N. Shoushtari, Margaret K. Callahan, Jedd D. Wolchok, Yuelin Li, Paul B. Chapman
Summary: This pilot study examined the factors influencing patients' decision on undergoing adjuvant anti-PD1 immunotherapy and their satisfaction with the decision. The study found that when provided with comprehensive quantitative information about the risks and benefits, 59% of patients chose observation while 41% opted for adjuvant immunotherapy. Patients choosing adjuvant immunotherapy had higher social well-being, more positive attitudes towards the treatment, and perceived their physician's preference for adjuvant therapy. They had lower decisional regret and higher satisfaction, even with poorer treatment outcomes.
Article
Biochemistry & Molecular Biology
Daniel Hirschhorn, Sadna Budhu, Lukas Kraehenbuehl, Mathieu Gigoux, David Schroder, Andrew Chow, Jacob M. Ricca, Billel Gasmi, Olivier De Henau, Levi Mark B. Mangarin, Yanyun Li, Linda Hamadene, Anne-Laure Flamar, Hyejin Choi, Czrina A. Cortez, Cailian Liu, Aliya Holland, Sara Schad, Isabell Schulze, Allison Betof Warner, Travis J. Hollmann, Arshi Arora, Katherine S. Panageas, Gabrielle A. Rizzuto, Rebekka Duhen, Andrew D. Weinberg, Christine N. Spencer, David Ng, Xue-Yan He, Jean Albrengues, David Redmond, Mikala Egeblad, Jedd D. Wolchok, Taha Merghoub
Summary: Cancer immunotherapies can be ineffective due to tumor evolution and antigen-loss-variant clones. However, a combination of melanoma-specific CD4+ T cell therapy with OX40 co-stimulation or CTLA-4 blockade can eradicate melanomas containing antigen escape variants. The study reveals the importance of early recognition of melanoma antigens by tumor-specific CD4+ T cells and the role of neutrophils and inducible nitric oxide synthase in tumor eradication.
Correction
Multidisciplinary Sciences
Rodabe N. Amaria, Michael Postow, Elizabeth M. Burton, Michael T. Tetzlaff, Merrick I. Ross, Carlos Torres-Cabala, Isabella C. Glitza, Fei Duan, Denai R. Milton, Klaus Busam, Lauren Simpson, Jennifer L. McQuade, Michael K. Wong, Jeffrey E. Gershenwald, Jeffrey E. Lee, Ryan P. Goepfert, Emily Z. Keung, Sarah B. Fisher, Allison Betof-Warner, Alexander N. Shoushtari, Margaret Callahan, Daniel Coit, Edmund K. Bartlett, Danielle Bello, Parisa Momtaz, Courtney Nicholas, Aidi Gu, Xuejun Zhang, Brinda Rao Korivi, Madhavi Patnana, Sapna P. Patel, Adi Diab, Anthony Lucci, Victor G. Prieto, Michael A. Davies, James P. Allison, Padmanee Sharma, Jennifer A. Wargo, Charlotte Ariyan, Hussein A. Tawbi
Article
Public, Environmental & Occupational Health
Sejin Lee, Antonia V. Bennett, Xi Zhou, Allison Betof Warner, Justin G. Trogdon, Erin E. Kent, Jennifer L. Lund
Summary: This study examined treatment patterns, sequence and outcomes for older adults with advanced melanoma who received first line immunotherapy or targeted therapy. The use of immunotherapy has increased steadily, with PD-1 inhibitors becoming the dominant treatment option since 2015. First line immunotherapy showed longer overall survival and time to treatment failure compared to targeted therapy. The most common treatment switch pattern involved transitioning from a first line CTLA-4 inhibitor to a second line PD-1 inhibitor. These findings provide valuable insights into the treatment patterns of immunotherapies and targeted therapies in older adults with advanced melanoma.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Oncology
Kimberly Loo, Hannah L. L. Kalvin, Katherine S. Panageas, Margaret K. K. Callahan, Paul B. B. Chapman, Parisa Momtaz, Alexander N. N. Shoushtari, Jedd D. D. Wolchok, Michael A. A. Postow, Allison Betof Warner
Summary: This retrospective cohort study investigated the long-term outcomes of patients with advanced nonuveal melanoma treated with anti-PD-1 therapy off clinical trials. The study found that patients who survived at least 5 years following their first anti-PD-1 dose had excellent overall survival and melanoma-specific survival rates.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Letter
Oncology
Marie E. Portuallo, David Y. Lu, Gretchen M. Alicea, Joel Bolling, Rebecca Lee, Jennifer McQuade, Allison Betof Warner, Michael Davies, Ashani Weeraratna, Jessie Villanueva, Vito W. Rebecca
Summary: The inaugural Diversity and Inclusion in Science Session discussed the need for diversity, equity, and inclusion in the melanoma research community and identified issues of inequity, bias, and harassment based on gender, ethnicity, and geographic location. The session revealed significant reports of discrimination, sexual harassment, and limited opportunities, highlighting the importance of creating an academic workplace culture that promotes mutual respect, fair access, and equal opportunities for all scientists in the field.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Editorial Material
Oncology
Allison Betof Warner, Jason J. Luke
Summary: This article discusses the potential of tumor-infiltrating lymphocyte therapy to overcome immune checkpoint inhibitor resistance through CD4(+)-mediated and MHC-II-dependent killing. Validating these results from human tumors has the potential to improve the clinical application of adoptive cellular transfer in advanced cancers.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Paolo A. Ascierto, Sanjiv S. Agarwala, Allison Betof Warner, Marc S. Ernstoff, Bernard A. Fox, Thomas F. Gajewski, Jerome Galon, Claus Garbe, Brian R. Gastman, Jeffrey E. Gershenwald, Pawel Kalinski, Michelle Krogsgaard, Rom S. Leidner, Roger S. Lo, Alexander M. Menzies, Olivier Michielin, Poulikos I. Poulikakos, Jeffrey S. Weber, Corrado Caraco, Iman Osman, Igor Puzanov, Magdalena Thurin
Summary: Outcomes for melanoma patients have improved with the development of immunotherapies targeting immune checkpoint receptors and molecularly targeted therapies. Combinations of these treatments have shown improved prognosis compared to monotherapy. The search for biomarkers to guide treatment decisions and optimize therapies is still ongoing.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Allison Betof Warner
Summary: A study found that aerobic exercise improves tumor vasculature, enhances T-cell and myeloid-cell infiltration of the tumor through an ERK5-dependent mechanism, thus boosting the efficacy of immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Oncology
Ashlyn G. Rickard, Husam Mikati, Antoine Mansourati, Daniel Stevenson, Marlee Krieger, Daniel Rocke, Ramon Esclamado, Mark W. Dewhirst, Nirmala Ramanujam, Walter T. Lee, Gregory M. Palmer
Summary: Diffuse reflectance spectroscopy (DRS) is a powerful tool for quantifying optical and physiological tissue properties. In this clinical study, a pressure-sensing and automatic self-calibration DRS was assessed and validated in patients with head and neck squamous cell carcinoma (HNSCC). The results showed that cancerous tissues have a significantly lower hemoglobin saturation compared to normal tissues, suggesting tumor hypoxia. The study also demonstrated the feasibility of conducting optical spectroscopy measurements on intact lesions prior to removal during HNSCC procedures.
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Clinical Neurology
Rachna Malani, Ankush Bhatia, Allison Betof Warner, Jonathan T. Yang
Summary: Leptomeningeal metastases/diseases (LMDs) are a late-stage complication of solid tumor or hematologic malignancies. It is a disseminated disease which significantly affects the neurological system. Our understanding of its pathophysiology is currently lacking, but treatment strategies are constantly improving.
SEMINARS IN NEUROLOGY
(2023)