期刊
BIOTECHNOLOGY ADVANCES
卷 33, 期 5, 页码 394-411出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2015.03.010
关键词
Chemo- and multi-enzymatic processes; Polyethers; Polypeptide alkaloids; Piperidines and pyrrolidines; Oxidoreductases; Hydrolases; Cyclases; Transaminases; Imine reductases
资金
- Petrobras (ANP) [0050.0076286.12.9, 0050.0022707.06.4]
- CNPq [472145/2012-6, 307885/2013-5]
- FAPESP [2010/51278-0, 2013/12598-8]
- FAPESP/VALE [2011/10378-5]
Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases. (C) 2015 Elsevier Inc. All rights reserved.
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