Article
Oncology
Pernille Lassen, Shao Hui Huang, Jie Su, John Waldron, Maria Andersen, Hanne Primdahl, Jorgen Johansen, Claus Andrup Kristensen, Elo Andersen, Jesper Grau Eriksen, Christian Ronn Hansen, Jan Alsner, Jacob Lilja-Fisher, Scott Bratman, Jolie Ringash, John Kim, Andrew Hope, Anna Spreafico, John de Almeida, Wei Xu, Brian O'Sullivan, Jens Overgaard
Summary: Two large-scale HPV+ OPC cohorts treated contemporaneously with similar approaches demonstrated exemplary outcomes, with concurrent chemotherapy being a strong independent prognostic factor for all endpoints, emphasizing the need for careful de-intensification of treatment.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Review
Otorhinolaryngology
Jason R. Crossley, Lacey L. Nelson, Jiling Chou, Jessica H. Maxwell
Summary: This study systematically reviewed the prevalence of DM among patients with HPV-related OPSCC, and found a pooled DM rate of 7%. T3 or T4 classification disease was associated with a higher risk of DM compared to T1 or T2 classification disease.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Otorhinolaryngology
Joshua D. Smith, Megan L. Ludwig, Apurva D. Bhangale, Collin Brummel, Paul L. Swiecicki, Francis P. Worden, Steven B. Chinn, Chaz L. Stucken, Andrew J. Rosko, Mark E. P. Prince, Kelly M. Malloy, Keith A. Casper, Carol R. Bradford, Douglas B. Chepeha, Jennifer Shah, Caitlin A. Schonewolf, Jonathon B. McHugh, Mukesh K. Nyati, Avraham Eisbruch, Michelle L. Mierzwa, Matthew E. Spector, J. Chad Brenner
Summary: This study characterized the early changes in CD8(+) tumor-infiltrating lymphocytes and tumor transcriptomes after induction cetuximab. It was found that cetuximab can stimulate immune cell and cellular signaling changes within a short period of time.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Oncology
Benjamin R. Roman, Abraham Aragones
Summary: Globally, 4.5% of cancers are caused by HPV, with HPV oropharyngeal cancer now surpassing cervical cancer in the United States. The highest burden of oropharyngeal cancer is seen in middle-aged and older White men. HPV vaccination offers promise in changing disease epidemiology, but current vaccination rates are too low to effectively reduce disease transmission.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Dong-Yun Kim, Hong-Gyun Wu, Jin Ho Kim, Joo Ho Lee, Soon-Hyun Ahn, Eun-Jae Chung, Keun-Yong Eom, Young Ho Jung, Woo-Jin Jeong, Tack-Kyun Kwon, Suzy Kim, Chan Woo Wee
Summary: This study compared the outcomes of primary radiotherapy and surgery in early-stage hpv+OPC patients. The results showed no differences in overall survival, progression-free survival, and locoregional control between upfront radiotherapy and surgery in stage I-II hpv+OPC. However, most early-stage hpv+OPC patients undergoing surgery received adjuvant (concurrent chemo)radiotherapy.
CANCER RESEARCH AND TREATMENT
(2022)
Review
Oncology
Kaveh Zakeri, Lara Dunn, Nancy Lee
Summary: HPV-related oropharynx squamous cell carcinomas are sensitive to radiotherapy and chemotherapy, with treatment de-intensification aiming to reduce toxicity while maintaining efficacy. While substituting cisplatin with cetuximab or omitting chemotherapy have not been successful, Transoral Robotic Surgery with de-intensified adjuvant therapy has shown promise. Personalized approaches utilizing tumor biology and predictive markers on imaging have successfully reduced the intensity of radiotherapy and chemotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Multidisciplinary Sciences
Chrystiano Campos Ferreira
Summary: In 2020, there were 98,421 cases of oropharyngeal squamous cell carcinomas (OPSCC) worldwide, with human papillomavirus (HPV) being recognized as the leading cause. This review conducted a literature review on the relationship between OPSCC and HPV, focusing on the clinical differences, prognosis, and treatment between HPV+ and HPV- OPSCC. It also analyzed various HPV diagnostic methods. By presenting key information in an organized and accessible way, this review helps healthcare professionals gain a better understanding of the HPV-OPSCC relationship and contributes to the prevention of various cancers caused by HPV, including oropharyngeal cancer.
Review
Oncology
Giuseppe Carlo Iorio, Francesca Arcadipane, Stefania Martini, Umberto Ricardi, Pierfrancesco Franco
Summary: The article discusses the potential toxicity burden and de-escalation strategies following standard chemoradiotherapy for HPV-related oropharyngeal squamous cell carcinoma patients. Various approaches to therapy de-escalation are explored, including local and systemic strategies. It is advised not to make any changes in management or deviate from the standard of care outside of clinical trials while awaiting further evidence.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Yong Lu, Zongyu Xie, Ganfeng Luo, Honghong Yan, Han-Zhu Qian, Leiwen Fu, Bingyi Wang, Ruonan Huang, Fei Cao, Hongsheng Lin, Rui You, Liqiang Tan, Tao Yu, Mingyuan Chen, Chunwei Li, Xuekui Liu, Wenbin Lei, Huachun Zou
Summary: This study updates the global burden estimates of oropharyngeal cancer attributable to HPV and estimates the global burden of tonsillar cancer and base of tongue cancer. The study found that the number of cancer cases attributable to HPV is about 4-fold greater in males than females, and the burden of HPV-related cancers is higher in developed countries.
CANCER EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kelvin Okoth, Anuradhaa Subramanian, Joht Singh Chandan, Nicola J. Adderley, G. Neil Thomas, Krishnarajah Nirantharakumar, Christina Antza
Summary: This study found that women with a history of miscarriage have a higher risk of developing diabetes and hypertension compared to women without a record of miscarriage, indicating a higher cardiometabolic risk in women with miscarriage. Regular monitoring of cardiometabolic health may benefit women with a history of miscarriage.
Article
Public, Environmental & Occupational Health
Jacqueline M. Mix, Sameer V. Gopalani, Sarah Simko, Mona Saraiya
Summary: The incidence of vulvar cancer has been rising in recent years, possibly due to increasing exposure to human papillomavirus (HPV). The highest increase in incidence rates was observed among women aged 50 and above, white and black women, and women living in the Midwest, Northeast, and South regions.
PREVENTIVE MEDICINE
(2022)
Article
Immunology
Alpamys Issanov, Mohammad Ehsanul Karim, Gulzhanat Aimagambetova, Trevor J. B. Dummer
Summary: This study aimed to evaluate the association between HPV vaccination and HPV-related cancers among US adults. While no statistically significant association was found, the results suggest that vaccinated adults may have lower odds of developing HPV-related cancers.
Article
Public, Environmental & Occupational Health
Haoyu Wen, Donghui Yang, Cong Xie, Fang Shi, Yan Liu, Jiaming Zhang, Chuanhua Yu
Summary: This study investigated the burden of chronic kidney disease (CKD) in China, Japan, the United Kingdom (U.K.), and the United States (U.S.) from 1990 to 2019, analyzing the patterns and temporal variations. Despite stable incidence rates, the number of CKD cases significantly increased, particularly in the U.S. CKD caused by diabetes and hypertension accounted for a small portion of incidence but a significant portion of deaths, highlighting the need for prevention and control efforts focusing on these causes. Transforming CKD treatment into primary and secondary prevention is urgent considering the high treatment costs.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Hae Chan Park, Hyojin Kim, Ji-Yeong Kim, Hye-Yeon Lee, Jinyi Lee, WonJae Cha, Soon-Hyun Ahn, Woo-Jin Jeong
Summary: PSMD1 has been identified as a potential negative prognostic factor in oropharyngeal squamous cell carcinoma (OPSCC), indicating its potential as a target for targeted therapy.
Review
Oncology
Akshat Malik, John C. Hardman, Yadsan Devabalan, Christopher Nutting, Shreerang Bhide, Kevin Harrington, Clare Schilling, Vinidh Paleri
Summary: A systematic review and meta-analysis was conducted to evaluate occult contralateral nodal metastases (OCM) in patients undergoing bilateral neck dissection for surgically treated oropharyngeal squamous cell carcinoma (OPSCC). The study found that OCM were seen in 9.8% of patients, with a higher rate in cN positive necks compared to cN0 necks. This highlights the importance of considering contralateral neck involvement in the surgical treatment of OPSCC.
Article
Oncology
Kevin J. Harrington, Barbara Burtness, Richard Greil, Denis Soulieres, Makoto Tahara, Gilberto de Castro Jr, Amanda Psyrri, Irene Brana, Neus Baste, Prakash Neupane, Ase Bratland, Thorsten Fuereder, Brett G. M. Hughes, Ricard Mesia, Nuttapong Ngamphaiboon, Tamara Rordorf, Wan Zamaniah Wan Ishak, Jianxin Lin, Burak Gumuscu, Ramona F. Swaby, Danny Rischin
Summary: The study presents a post hoc analysis of the long-term efficacy and progression-free survival in recurrent/metastatic head and neck squamous cell carcinoma patients treated with pembrolizumab and pembrolizumab-chemotherapy as next-line therapy. The results demonstrate favorable clinical efficacy and progression-free survival with pembrolizumab and pembrolizumab-chemotherapy in patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) >= 20, CPS >= 1, and total populations. Subsequent treatments after pembrolizumab-based therapy also showed good efficacy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rona Slator, Lydia Perisanidou, Debbie Sell, Jonathan Sandy, Andrew R. Ness, Andrew K. Wills
Summary: This study found associations between surgical variables and speech outcomes at 5 years of age, but not between surgical variables and dento-facial outcome, nor between surgical variables and secondary speech surgery.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Oncology
Charles M. Rudin, Hardev S. Pandha, Matthew Zibelman, Wallace L. Akerley, Kevin J. Harrington, Daphne Day, Andrew G. Hill, Steven J. O'Day, Timothy D. Clay, Gavin M. Wright, Ross R. Jennens, David E. Gerber, Jonathan E. Rosenberg, Christy Ralph, David C. Campbell, Brendan D. Curti, Jaime R. Merchan, Yixin Ren, Emmett Schmidt, Lisa Guttman, Sumati Gupta
Summary: This study evaluated the efficacy and safety of V937 combined with pembrolizumab in patients with advanced solid tumors. The results showed that the combination therapy had a manageable safety profile, but did not achieve greater efficacy than pembrolizumab monotherapy in non-small cell lung cancer and urothelial cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Genetics & Heredity
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Loic Le Marchand, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Borge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Gronberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Elise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sorensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Geraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Eli Marie Grindedal, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manoli Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, Kim De Ruyck, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Jose Esteban Castelao, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Stephen K. van den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, John S. Witte, Rosalind A. Eeles, Zsofia Kote-Jarai, Stephen Watya, John M. Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Summary: In this study, the predictive ability of several genome-wide polygenic risk score (GW-PRS) approaches was compared to a recently developed PRS of established prostate cancer-risk variants. The findings suggest that the PRS269 developed from multi-ancestry GWASs and fine-mapping has better predictive ability for prostate cancer risk compared to current GW-PRS approaches.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Oncology
Robert I. Haddad, Kevin Harrington, Makoto Tahara, Petr Szturz, Christophe Le Tourneau, Satu Salmio, Marcis Bajars, Nancy Y. Lee
Summary: For the last 20 years, cisplatin-based chemoradiotherapy has been the standard treatment for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) patients at high risk of recurrence. However, many patients are ineligible for this treatment due to various reasons. The criteria for cisplatin ineligibility, including age and renal impairment, are still debated. The proportion of cisplatin ineligible patients with resected LA SCCHN remains unclear. This review discusses cisplatin ineligibility considerations, limited clinical evidence, and ongoing clinical trials for alternative treatment options.
CANCER TREATMENT REVIEWS
(2023)
Review
Otorhinolaryngology
Hisham Mehanna
Summary: The purpose of this article is to provide readers with the latest evidence on the role of trans oral surgery (TOS) in diagnosing carcinoma of unknown primary in the head and neck. Recent findings suggest that tongue base mucosectomy is important in identifying the primary site in patients with negative imaging, PET CT scans, and ipsilateral tonsillectomy. There are still unanswered questions regarding the sequencing of operations and the use of intraoperative frozen section. An evidence-based approach to diagnosis is crucial in order to achieve higher detection rates and minimize morbidity in patients with head and neck carcinoma of unknown primary.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Janet A. Wilson, James O'Hara, Tony Fouweather, Tara Homer, Deborah D. Stocken, Luke Vale, Catherine Haighton, Nikki Rousseau, Rebecca Wilson, Lorraine Mcsweeney, Scott Wilkes, Jill Morrison, Kenneth Mackenzie, Kim Ah-See, Sean Carrie, Claire Hopkins, Nicola Howe, Musheer Hussain, Hisham Mehanna, Christopher Raine, Frank Sullivan, Alexander von Wilamowitz-Moellendorff, M. Dawn Teare
Summary: This study compares the clinical effectiveness and cost-effectiveness of conservative management and tonsillectomy in adults with recurrent acute tonsillitis. The results show that immediate tonsillectomy is more effective in reducing sore throat days and has better cost-effectiveness compared to conservative management.
Article
Oncology
Hisham Mehanna, Miren Taberna, Christian von Buchwald, Sara Tous, Jill Brooks, Marisa Mena, Francisca Morey, Christian Gronhoj, Jacob Hoygaard Rasmussen, Martin Garset-Zamani, Laia Bruni, Nikolaos Batis, Ruud H. Brakenhoff, C. Rene Leemans, Robert J. Baatenburg de Jong, Jens Peter Klussmann, Nora Wuerdemann, Steffen Wagner, Tina Dalianis, Linda Marklund, Haitham Mirghani, Andrew Schache, Jaqueline A. James, Shao Hui Huang, Brian O'Sullivan, Paul Nankivell, Martina A. Broglie, Markus Hoffmann, Elgar Susanne Quabius, Laia Alemany
Summary: The study aimed to quantify the discordance between p16 expression and HPV status in oropharyngeal cancer and evaluate its prognostic implications. The results showed that patients with p16-/HPV+ or p16+/HPV- had worse prognosis compared to p16+/HPV+ or p16-/HPV- patients. HPV testing should be mandatory in clinical trials and recommended in patient care settings where HPV status may have an impact.
Review
Oncology
Janine Dretzke, Ava Lorenc, Ada Adriano, Clare Herd, Hisham Mehanna, Paul Nankivell, David J. Moore
Summary: The current follow-up models in cancer are seen as unsustainable and inflexible. Patient-initiated follow-up (PIFU) is gaining interest as an alternative model, and it is important to determine its acceptability to patients and healthcare professionals (HCPs). The findings show that most women treated for breast or endometrial cancer and HCPs support PIFU, but further research is needed.
Article
Oncology
P. Martin, Z. Tsourti, J. Ribeiro, L. Castelo-Branco, E. de Azambuja, S. Gennatas, J. Rogado, M. Sekacheva, S. Susnjal, D. Vinal, R. Lee, S. Khallaf, G. Dimopoulou, S. Pradervand, J. Whisenant, T. K. Choueiri, D. Arnold, K. Harrington, K. Punie, J. Oliveira, O. Michielin, U. Dafni, S. Peters, G. Pentheroudakis, E. Romano
Summary: This paragraph summarizes the results of a study analyzing COVID-19 patients, which found that factors such as symptomatic patients, males, older age, ethnicity other than Asian/Caucasian, Eastern Cooperative Oncology Group performance status >2, body mass index <25, hematological malignancy, progressive disease versus no evident disease, and advanced cancer stage significantly affect COVID-19 outcomes.
Article
Oncology
Alexandra J. Rose, Mercedes M. Fleming, Jeffrey C. Francis, Jian Ning, Anton Patrikeev, Ritika Chauhan, Kevin J. Harrington, Amanda Swain
Summary: This study established patient-derived xenograft (PDX) lines and tumor organoid models for salivary gland adenoid cystic carcinoma (ACC), and demonstrated the inhibitory effect of dBET6 on ACC cells. Molecular studies revealed a decrease in BRD4 and MYB protein levels and target gene expression with dBET6 treatment. In vivo experiments showed that dBET6 altered the relative composition of ACC cell types and inhibited their progenitor function.
JOURNAL OF PATHOLOGY
(2023)
Article
Otorhinolaryngology
Joseph Califano, Andrew Yousef, Heba Mostafa, Alexandra Valsamakis, Xinlian Zhang, Nikolaos Batis, Christy Varghese, Joanna Parish, Michael Forman, Junko Jarrett, Karen Messer, Hisham Mehanna
Summary: The objective of this study was to identify low-risk HPV-related oropharyngeal cancer (HPVOPC) patients at risk of recurrence by detecting HPV16 DNA in plasma and salivary rinses. The combined plasma and salivary HPV DNA assays showed a sensitivity of 65% and a specificity of 87% in detecting recurrence, with a median lead time of 19 days. Therefore, the presence of HPV DNA in post-treatment plasma and salivary rinses is associated with recurrence, providing a potential opportunity for earlier detection.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ashwin Algudkar, Kevin Harrington, Cyrus Kerawala, Izhar Bagwan, Derfel Ap Dafydd
Summary: This study summarizes the imaging recommendations and characteristics of head and neck mucosal melanoma (HNMM), and provides revised guidelines to guide the investigation and management of this rare and aggressive cancer.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2023)
Article
Oncology
K. J. Harrington, E. E. W. Cohen, D. Soulieres, J. Dinis, L. Licitra, M. -j. Ahn, A. Soria, J. -p. Machiels, N. Mach, R. Mehra, B. Burtness, R. F. Swaby, J. Lin, J. Ge, N. Lerman, C. Le Tourneau
Summary: Through a study on patients with HNSCC, it was found that pembrolizumab provided longer overall survival and durable responses in all subgroups of recurrence patterns, regardless of previous treatment.