Article
Nutrition & Dietetics
Antonio Gazquez, Maria J. Gimenez-Banon, Maria T. Prieto-Sanchez, Carmen Martinez-Gracia, Clara Suarez, Marina Santaella-Pascual, Lina Galdo-Castineira, Carmen Ballesteros-Meseguer, Jesus Vioque, Miriam Martinez-Villanueva, Francisco Aviles-Plaza, Jose A. Noguera-Velasco, Eva Morales, Luis Garcia-Marcos, Elvira Larque
Summary: Maternal supplementation of DHA during pregnancy enhances maternal and fetal DHA levels regardless of pre-pregnancy BMI, but may have a reduced effect in newborns of mothers with GDM.
Article
Nutrition & Dietetics
Ting Zhang, Wen-Rong Jiang, Yin-Yin Xia, Toby Mansell, Richard Saffery, Richard D. Cannon, Jamie De Seymour, Zhen Zou, Ge Xu, Ting-Li Han, Hua Zhang, Philip N. Baker
Summary: The study suggests a relationship between maternal serum fatty acid levels and gestational diabetes mellitus (GDM) subtypes, with different fatty acid levels observed in different GDM subtypes during pregnancy. Specifically, higher levels of ALA and DHA in early pregnancy are associated with an increased risk of fasting plasma glucose (FPG) GDM subtype.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Theresa L. Powell, Kenneth Barentsen, Owen Vaughan, Charis Uhlson, Karin Zemski Berry, Kathryn Erickson, Kelsey Faer, Stephanie S. Chassen, Thomas Jansson
Summary: Reducing the expression of the LPC-DHA transporter MFSD2a specifically in the placenta resulted in reduced fetal brain weight and lower phospholipid DHA content in the fetal brain. These findings provide mechanistic evidence of the critical role of placental MFSD2a in maternal-fetal transfer of LPC-DHA for brain growth.
Article
Nutrition & Dietetics
Melanie Gsoellpointner, Margarita Thanhaeuser, Fabian Eibensteiner, Robin Ristl, Bernd Jilma, Renate Fuiko, Sophia Brandstetter, Angelika Berger, Nadja Haiden
Summary: This study analyzed the intake of polyunsaturated fatty acids (PUFAs) during complementary feeding (CF) in very low birth weight (VLBW) infants and its impact on neurodevelopment. The results showed that higher intake of total PUFAs, docosahexaenoic acid (DHA), and arachidonic acid (AA) was associated with improved cognitive and motor function at 12 months of age. However, the dietary intake of AA and DHA did not meet the recommended levels, highlighting the need to increase PUFA, DHA, and AA intake during CF for better neurodevelopmental outcomes in VLBW infants.
Article
Nutrition & Dietetics
Terue Kawabata, Hideoki Fukuoka, Michiru Harada, Kumiko Shoji, Yoshinori Kubo, Chisato Mori, Kenichi Sakurai, Takeshi Ohkubo, Kyoichi Oshida, Yuichiro Yamashiro
Summary: The increase in fetal requirements of long-chain polyunsaturated fatty acids during pregnancy alters maternal fatty acid metabolism, and FADS gene polymorphisms may change blood fatty acid composition differently. The study investigated the relationship between a FADS1 SNP and maternal serum LCPUFA levels in Japanese pregnant women. The results showed that LCPUFAs significantly decreased as pregnancy progressed and certain fatty acids were significantly associated with the number of minor FADS1 SNP alleles, indicating genotype effects become more obvious later in pregnancy.
Article
Endocrinology & Metabolism
Xiaoxin Wang, Ya Zhang, Wei Zheng, Jia Wang, Yuanyuan Wang, Wei Song, Shengnan Liang, Cuimei Guo, Xu Ma, Guanghui Li
Summary: This study explores the changes of branched-chain amino acids (BCAAs) during pregnancy and identifies potential early biomarkers for gestational diabetes mellitus (GDM). The results show that serum levels of valine (Val), isoleucine (Ile), and leucine (Leu) are higher in GDM patients during the first trimester, but decrease in the second trimester. Ile combined with advanced maternal age and overweight can be used for the early prediction of GDM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Xiao-Man Sun, Ying-Shuang Xu, He Huang
Summary: Thraustochytrids can accumulate high biomass and lipid content, exhibit broad substrate utilization capacity and effective metabolic pathways without genetic modification, showing great promise for future development.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Mia Stravik, Klara Gustin, Malin Barman, Michael Levi, Anna Sandin, Agnes E. Wold, Ann-Sofie Sandberg, Maria Kippler, Marie Vahter
Summary: This study assessed biomarkers in the blood and urine of 549 pregnant women to investigate the effects of fish and seafood intake on fetal development. The results showed that erythrocyte mercury and urinary arsenobetaine are reliable indicators of seafood intake.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Aleix Sala-Vila, Nathan Tintle, Jason Westra, William S. Harris
Summary: Dietary omega-3 fatty acids are inversely related to the risk of dementia, particularly in men and individuals aged 60 and above.
Article
Endocrinology & Metabolism
Xingjun Meng, Bo Zhu, Yan Liu, Lei Fang, Binbin Yin, Yanni Sun, Mengni Ma, Yuli Huang, Yuning Zhu, Yunlong Zhang
Summary: The study revealed disordered unsaturated fatty acid metabolism in GDM, and a selected combination of metabolites improved the diagnostic sensitivity and specificity. The new biomarkers contribute to precise diagnosis of GDM, and the findings provide critical insights into the pathological and biological mechanisms of GDM.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Nutrition & Dietetics
Wenqian Lu, Mingjuan Luo, Xiangnan Fang, Rong Zhang, Shanshan Li, Mengyang Tang, Xiangtian Yu, Cheng Hu
Summary: This study identified metabolic differences between healthy pregnant women and GDM patients, identified trimester-specific GDM metabolite biomarkers using machine learning approaches, established logistic regression models to evaluate predictive efficiency, and found significant associations between metabolites/biomarkers and GDM-related indices, providing insights into the pathology of GDM.
NUTRITION & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Nikita P. Joshi, Shweta D. Madiwale, Deepali P. Sundrani, Sadhana R. Joshi
Summary: Gestational diabetes mellitus (GDM) is a metabolic disorder in pregnancy with increasing prevalence. Inflammation and fatty acids are associated with maternal GDM, but studies on inflammatory markers and angiogenic factors in GDM are limited and inconsistent. Understanding the role of inflammation and angiogenesis in GDM is important for better management of pregnancies complicated by GDM.
Article
Multidisciplinary Sciences
Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Velez-Vega, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: Maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters were characterized, revealing potential biomarkers for pregnancy outcomes. Fine omics-scale analysis of the maternal lipidome may offer more informative insights compared to whole class level lipid analysis.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Zhuo Sun, Zequn Deng, Xiaohui Wei, Na Wang, Jiaqi Yang, Wenyun Li, Min Wu, Yuwei Liu, Gengsheng He
Summary: This study investigates the association between plasma saturated fatty acids (SFAs) and gestational diabetes mellitus (GDM) through a cross-sectional study and a meta-analysis. The results indicate that certain plasma SFAs are positively associated with GDM, while others are negatively associated.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yueqi Fu, Ya Yang, Liyuan Zhu, Jing Chen, Ningning Yu, Mei Zhao
Summary: The aim of this study was to investigate the relationship between dietary n-6: n-3 poly-unsaturated fatty acids (PUFA) ratio and the risk of developing gestational diabetes mellitus (GDM). The results showed that a higher dietary n-6: n-3 PUFA ratio was associated with higher odds of GDM.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Sanchez-Campillo, Maria Teresa Pastor-Fajardo, Maria Sabater-Molina, Maria Jose Lopez-Andreo, Elvira Larque
Summary: This study investigates the critical steps of non-invasive methods for analyzing human gut cell gene expression in stool samples by examining prokaryote contamination in each step of different procedures and the influence of fecal sampling collection process. The results show that the least bacterial contamination is found when using RNA amplified with oligo dT from the GeneChip 3' IVT Pico Reagent Kit or using RNA purified by both Oligotex (R) + oligo dT.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Lucia Yepes-Molina, Maria Isabel Perez-Jimenez, Maria Martinez-Esparza, Jose A. Teruel, Antonio J. Ruiz-Alcaraz, Pilar Garcia-Penarrubia, Micaela Carvajal
Summary: There is a growing interest in finding new non-toxic anti-inflammatory drugs, and this study investigates the potential of sulforaphane, a compound derived from Brassica plants, loaded into membrane vesicles from broccoli plants. The results show that the sulforaphane-loaded vesicles exhibit anti-inflammatory properties and the vesicles themselves also have anti-inflammatory effects, indicating potential for further research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Eva Morales, Maria Alcantara-Lopez, Juan Cabezas-Herrera, Teresa de Diego, Trinidad Hernandez-Caselles, Pedro Jimenez-Guerrero, Elvira Larque, Concepcion Lopez-Soler, Carmen Martinez-Gracia, Antonela Martinez-Torres, Elena Martin-Orozco, Jaime Mendiola, Anibal Nieto-Diaz, Jose A. Noguera, Virginia Perez-Fernandez, M. Teresa Prieto-Sanchez, Carme Salvador-Garcia, Manuel Sanchez-Solis, Marina Santaella-Pascual, Rosa A. Sola-Martinez, Alberto Torres-Cantero, Genoveva Yague-Guirao, Matilde Zornoza-Moreno, Luis Garcia-Marcos
Summary: The NELA cohort study aims to unravel the developmental origins of asthma by investigating the impact of maternal obesity, nutrition, air pollution, endocrine disruptors, and maternal psychological stress on asthma susceptibility, using biological samples to assess potential mechanisms.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Javier Sanchez-Romero, Jesus Lopez-Perez, Ana Belen Flores-Munoz, Maria Josefa Mendez-Martinez, Fernando Araico-Rodriguez, Jaime Mendiola-Olivares, Jose Eliseo Blanco-Carnero, Luis Falcon-Arana, Anibal Nieto-Diaz, Maria Luisa Sanchez-Ferrer
Summary: This study evaluated the outcomes of external cephalic version (ECV) using propofol and found that the results were similar to those with other anesthetic adjuncts, suggesting that propofol sedation could be a suitable option for ECV.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Claudia Terezia Socol, Alexandra Chira, Maria Antonia Martinez-Sanchez, Maria Angeles Nunez-Sanchez, Cristina Maria Maerescu, Daniel Mierlita, Alexandru Vasile Rusu, Antonio Jose Ruiz-Alcaraz, Monica Trif, Bruno Ramos-Molina
Summary: Obesity and colorectal cancer are major diseases causing deaths worldwide, with complex pathology. Leptin, an important adipokine related to obesity, plays a significant role in the development of colorectal cancer. However, the current data on the relationship between leptin and obesity and colorectal cancer are inconsistent and insufficient, calling for further research to better understand this association.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Antonio Gazquez, Maria Sanchez-Campillo, Alejandro Barranco, Ricardo Rueda, Jia P. Chan, Matthew J. Kuchan, Elvira Larque
Summary: Oral 25-OH-D3 provides better vitamin D availability for both mother and fetus during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcomes were observed. The effects of 25-OH-D3 on the expression of VDR and GAD67 in fetal brain require further investigation.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Eva Morales, Azahara M. Garcia-Serna, Elvira Larque, Maria Sanchez-Campillo, Ana Serrano-Munera, Carmen Martinez-Gracia, Marina Santaella-Pascual, Clara Suarez-Martinez, Jesus Vioque, Jose A. Noguera-Velasco, Francisco V. Aviles-Plaza, Miriam Martinez-Villanueva, Carmen Ballesteros-Meseguer, Lina Galdo-Castineira, Luis Garcia-Marcos
Summary: The study found that adherence to a healthy dietary pattern during pregnancy may help reduce DNA damage and lipid oxidation in mothers and offspring.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Maria A. Nunez-Sanchez, Silvia Melgar, Keith O'Donoghue, Maria A. Martinez-Sanchez, Virgina E. Fernandez-Ruiz, Mercedes Ferrer-Gomez, Antonio J. Ruiz-Alcaraz, Bruno Ramos-Molina
Summary: Crohn's disease (CD) is a complex and disabling disorder with unknown etiology. The gut microbiota plays a crucial role in CD development, and dietary strategies may impact the composition and functionality of the gut microbiota. This review provides an overview of host-microbe interactions in CD pathogenesis and severity, and discusses the latest information on modulating gut microbiota through nutritional strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Antonio Gazquez, Maria Sabater-Molina, Ines Dominguez-Lopez, Maria Sanchez-Campillo, Neus Torrento, Joan Tibau, Jose A. Moreno-Munoz, Maria Rodriguez-Palmero, Maria C. Lopez-Sabater, Elvira Larque
Summary: Adding MFGM and milk fat to infant formulas can increase the availability of DHA and promote gut development.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Paula Garcia-Ibanez, Maria A. Nunez-Sanchez, Alba Oliva-Bolarin, Maria A. Martinez-Sanchez, Bruno Ramos-Molina, Antonio J. Ruiz-Alcaraz, Diego A. Moreno
Summary: Digestates from red cabbage sprouts and red radish sprouts, which are derived from cruciferous vegetables, have anti-inflammatory effects and could be used as dietary coadjuvants in the treatment of chronic inflammation. These findings were observed in an in vitro model, where the bioaccessible compounds from the sprouts significantly decreased the production of pro-inflammatory cytokines in stimulated cells.
Article
Pharmacology & Pharmacy
Antonio Jose Ruiz-Alcaraz, Maria Angeles Nunez-Sanchez, Maria Alejandra Asensio Ruiz, Maria Antonia Martinez-Sanchez, Alba Oliva-Bolarin, Teresa Martinez Martinez, Jose Julian Perez Cuadrado, Bruno Ramos-Molina, Antonio Abel Lozano-Perez
Summary: Silk fibroin nanoparticles (SFN) have excellent physicochemical characteristics and can enhance the antioxidant and anti-inflammatory effects of polyphenols in macrophages. In this study, we developed a reproducible and scalable method for the production of SFN using direct precipitation of non-dialyzed silk fibroin solutions. We also improved the loading efficiency of natural polyphenols in SFN using propylene glycol as a solvent. The loaded nanoparticles were fully characterized and demonstrated significant anti-inflammatory effects in human macrophage cells.
Review
Nutrition & Dietetics
Julia Nino-Narvion, Marina Idalia Rojo-Lopez, Patricia Martinez-Santos, Joana Rossell, Antonio J. Ruiz-Alcaraz, Nuria Alonso, Bruno Ramos-Molina, Didac Mauricio, Josep Julve
Summary: NAD+ is crucial for cellular metabolism and plays a critical role in maintaining the integrity of the gut barrier. Its deficiency is associated with gut inflammation, leakage, and dysbiosis. NAD+-increasing therapies may protect against intestinal inflammation, potentially by modulating the composition of the intestinal microbiota. However, the mechanisms underlying these effects are not well understood.
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Maria Sanchez-Campillo, Antonio Gazquez, Ana Serrano-Munera, Marino B. Arnao, Francisco Aviles-Plaza, Azahara M. Garcia-Serna, Jose A. Noguera-Velasco, Ana Martinez-Lopez de Castro, Carmen Martinez-Gracia, Clara Suarez-Martinez, Marina Santaella-Pascual, Jesus Vioque, Carmen Montoya-Hernandez, Carmen Ballesteros-Meseguer, Marisa Sanchez-Ferrer, Virginia Perez-Fernandez, Eva Morales, Luis Garcia-Marcos, Elvira Larque
Summary: Most pregnant women do not meet the recommended intake of vitamins A and E. However, higher levels of these vitamins in maternal serum during mid-pregnancy are associated with a higher antioxidant status in both the mother and the newborn. Gestational diabetes mellitus is negatively associated with maternal serum vitamin A levels, but no association with oxidative stress parameters was found.
ANNALS OF NUTRITION AND METABOLISM
(2023)