Article
Cell Biology
Jian Liang, Xing Li, Jian Xu, Guang-Mou Cai, Jian-Xuan Cao, Bo Zhang
Summary: The study identified miR-338-5p as a suppressor of glioma development and predicted that multiple circRNAs could relieve the silencing of IKBIP, potentially affecting glioma progression. This provides new insights for investigating ceRNAs in glioma.
Article
Oncology
Jinxu Zhou, Hongxiang Wang, Fan Hong, Shuai Hu, Xin Su, Juxiang Chen, Junsheng Chu
Summary: Circular RNA circPARP4 is significantly upregulated in glioma and plays a role in promoting glioma cell proliferation and migration through the miR-125a-5p/FUT4 pathway. This suggests circPARP4 could be a potential target for glioma therapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medical Laboratory Technology
Ruixin Li, Zhihao Hu, Zhuoyin Wang, Tianyu Zhu, Guojun Wang, Bulang Gao, Jingtao Wang, Xiumei Deng
Summary: MiR-125a-5p can promote gastric cancer growth and invasion by upregulating the expression of EphA2, TAZ, and TEAD2, while also reversing the EMT process.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cell Biology
Heng Yu, Anchun Xu, Bo Wu, Meng Wang, Zhongjun Chen
Summary: NEAT1 promotes glioma tumorigenesis by acting as a competing endogenous RNA for miR-185-5p to regulate DNMT1/mTOR signaling pathway, inhibiting apoptosis and promoting glioma migration, proliferation, and epithelial-mesenchymal transition. Moreover, NEAT1 knockdown can suppress tumor growth and alter the expression of related genes in vivo, highlighting its potential as a diagnostic and therapeutic target in glioma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Yongyue Dai, Yucheng Zhang, Maolin Hao, Renwu Zhu
Summary: In glioma, high expression of LINC00665 promotes proliferation and invasion of tumor cells by competitively binding to miR-34a-5p to regulate AGTR1 expression.
Article
Oncology
Kebin Zheng, Haipeng Xie, Wensong Wu, Xichao Wen, Zhaomu Zeng, Yanfang Shi
Summary: The study revealed that overexpressed CircPIP5K1A in glioma tissues was associated with tumor volume and histopathological grade. Functional experiments showed that overexpressing CircPIP5K1A significantly promoted glioma cell proliferation, invasion, and epithelial-mesenchymal transition, while inhibiting apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Zekun Wang, Yaming Li, Jingwen Yang, Yiran Liang, Xiaolong Wang, Ning Zhang, Xiaoli Kong, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: This study reveals that circ-TRIO plays a crucial role in TNBC and is associated with the recurrence and prognosis of TNBC patients. The findings demonstrate that knockdown of circ-TRIO inhibits the proliferation, migration, and invasion of TNBC cells, while overexpression of circ-TRIO has the opposite effects. Mechanistically, circ-TRIO interacts with miR-432-5p to regulate the expression of CCDC58.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Su Jung Hwang, Bum Ju Ahn, Min-Wook Shin, Ye-Seul Song, Youngbin Choi, Goo Taeg Oh, Kyu-Won Kim, Hyo-Jong Lee
Summary: Ninj1 plays a critical role in maintaining vascular integrity, while miR-125a-5p acts as a novel regulator in inflammatory diseases and diabetic retinopathy.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Medical Laboratory Technology
Wangzhen Shen, Jiawei Zhang, Yunfeng Pan, Yun Jin
Summary: In this study, it was found that lncRNA MIR4435-2HG promotes the development of neuroglioma by upregulating the TAZ gene, while miR-125a-5p can block this effect.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Ping Zhang, Shenghui Gong, Shuoshuo Li, Zengqiang Yuan
Summary: Endothelial dysfunction is crucial in vascular disease pathogenesis. Long noncoding RNA (lncRNA) and microRNA (miRNA) play significant roles in various cellular processes in vascular endothelial cells (VECs), including cell growth, migration, autophagy, and apoptosis. The present study investigated the role of plasmacytoma variant translocation 1 (PVT1) in regulating autophagy and apoptosis in human umbilical vein endothelial cells (HUVEC). It was found that PVT1 knockdown accelerates apoptosis and suppresses cellular autophagy. PVT1 functions as a competing endogenous RNA (ceRNA) of miR-15b-5p and miR-424-5p, promoting cellular autophagy and down-regulating apoptosis. This study suggests PVT1 as a potential therapeutic target for cardiovascular disease treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Tao Deng, Yang Liu, Yanlong Yang, Leyong Yuan, Fangfang Liu, Xiaobo Wang, Qiuying Zhang, Mingshui Xie
Summary: The study reveals that the high expression of circular RNA circ_0000285 in gliomas promotes tumor growth and invasion by binding to miR-197-3p and silencing CKS1B. This highlights a novel competing endogenous RNA circuit in glioma progression.
Article
Cell Biology
Xuehui Wang, Jiaying Wang, Zihui An, Aifen Yang, Mengsheng Qiu, Zhou Tan
Summary: Mounting evidence suggests that circular RNAs (circRNAs) play important roles in the development and progression of cancers. In this study, researchers identified a specific circRNA, circXPO1, that was significantly upregulated in glioblastomas (GBM). Functional studies demonstrated that circXPO1 promoted GBM cell proliferation, migration, and tumor formation. Further investigation revealed that circXPO1 directly bound to miR-7-5p, which negatively regulated the RAF1 gene expression. These findings suggest that circXPO1 may be a potential therapeutic target for GBM treatment.
Article
Medicine, Research & Experimental
Xuejun Wang, Zijie Cheng, Jia Xu, Mengwen Feng, Hao Zhang, Li Zhang, Lingmei Qian
Summary: This study aimed to investigate the regulatory role of differentially-expressed circular RNAs (circRNAs) in mouse cardiomyocytes during doxorubicin-induced cardiotoxicity. The expression profiles of circRNAs were significantly altered, with circArhgap12 playing a competitive role among endogenous RNAs in regulating cardiotoxicity. Further analysis revealed that circArhgap12 promoted apoptosis and oxidative stress by sponging miR-135a-5p, suggesting a potential therapeutic target in doxorubicin-induced cardiotoxicity.
Letter
Biotechnology & Applied Microbiology
Na Wang, Xiuzhi Xia, Teng Jiang, Lulu Li, Pengcheng Zhang, Lifang Niu, Hongmei Cheng, Kejian Wang, Hao Lin
PLANT BIOTECHNOLOGY JOURNAL
(2022)
Review
Biochemical Research Methods
Jie Xiong, Fengyue Hu, Jun Ren, Yong Huang, Chaolei Liu, Kejian Wang
Summary: This study summarizes recent advances in synthetic apomixis and discusses the limitations of current synthetic apomixis systems and ways to overcome them.
CURRENT OPINION IN BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuhong Zhao, Yingxi Chen, Ling Wei, Jianhua Ran, Kejian Wang, Shujuan Zhu, Qian Liu
Summary: In this study, it was found that p53 inhibits polyamine metabolism by suppressing the urea cycle, which in turn inhibits glioma progression.
METABOLIC BRAIN DISEASE
(2023)
Letter
Biochemistry & Molecular Biology
Xin Wei, Chaolei Liu, Xi Chen, Hongwei Lu, Jian Wang, Shenlin Yang, Kejian Wang
Editorial Material
Plant Sciences
Maria Raffaella Ercolano, Kejian Wang
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chaolei Liu, Zexue He, Yan Zhang, Fengyue Hu, Mengqi Li, Qing Liu, Yong Huang, Jian Wang, Wenli Zhang, Chun Wang, Kejian Wang
Summary: In hybrid plants, heterosis produces high-yielding large plants, but generating hybrid seeds is costly. Apomixis, asexual reproduction via seeds, could revolutionize plant biology. Synthetic apomixis has enabled clonal reproduction of rice hybrids, but the inheritance and stability of the trait remained unclear. This study investigated the genetic and molecular stability of clonal plants for multiple generations, confirming the stable transmission of the synthetic apomixis trait and suggesting the feasibility of using apomixis in the future.
PLANT COMMUNICATIONS
(2023)
Letter
Biochemistry & Molecular Biology
Xin Wei, Qing Liu, Tingting Sun, Xiaozhen Jiao, Chaolei Liu, Yufeng Hua, Xi Chen, Kejian Wang
PLANT COMMUNICATIONS
(2023)
Article
Agronomy
Tingting Sun, Hongwei Lu, Kejian Wang
Summary: In this study, 15 domestication regions (DRs) in the rice genome were identified using wild and cultivated rice accessions. The closely affiliated wild accessions of temperate japonica came mainly from southern China, while those of tropical japonica came from China and India. Similarly, the closely affiliated wild accessions of indica rice came from Southeast Asia, China, and India. The results provide valuable insights into the origin and domestication history of Asian cultivated rice.
GENETIC RESOURCES AND CROP EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Tian Yan, Ke-Jian Wang, Xiu-Ying Zhao, Yang-Yang Gao
Summary: There has been limited research on the influence of vulcanized characteristics, especially cross-linking density, on the dynamic shear behavior of vulcanized rubber. This study uses molecular dynamics simulations to investigate the impact of different cross-linking densities on the dynamic shear behavior of styrene-butadiene rubber (SBR). The results show a significant drop in the storage modulus when the strain amplitude exceeds 0.1, attributed to polymer bond fractures and decreased molecular chain flexibility. Higher cross-linking densities impede molecular chain motion and increase the storage modulus of SBR. The results are verified through comparisons with existing literature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Han Fang, Qi Sun, Jin Zhou, Huijuan Zhang, Qiong Song, Hua Zhang, Guohua Yu, Ying Guo, Chengyu Huang, Yakui Mou, Chuanliang Jia, Yingjian Song, Aina Liu, Kaiyu Song, Congxian Lu, Ruxian Tian, Shizhuang Wei, Dengfeng Yang, Yixuan Chen, Ting Li, Kejian Wang, Yilan Yu, Yufeng Lv, Ke Mo, Ping Sun, Xiaofeng Yu, Xicheng Song
Summary: This study investigated the molecular mechanisms of metastasis in lung adenocarcinoma (LUAD) using single-cell transcriptomics. A specific cell subpopulation, LUAD_IGF2BP2, was found to promote angiogenesis and metastasis in LUAD by activating the PI3K-Akt signaling pathway. These findings provide new insights into the multicellular ecosystems of LUAD and potential targets for antiangiogenic therapy.
Article
Chemistry, Multidisciplinary
Lin Li, Yaojian Zhang, Naifang Hu, Kejian Wang, Yuehui Liu, Xiaogang Wang, Xinhong Zhou, Jun Ma, Guanglei Cui
Summary: In this study, carbonized polymer dots (CPDs) were successfully introduced onto the surface of LiNi0.8Co0.1Mn0.1O2 (NCM811) cathodes to improve their interfacial stability and cycling performance. The CPDs formed strong covalent bonds with transition metal ions at the NCM811 surface, preventing surface structure degradation and transition metal ion dissolution. As a result, the NCM811@1 wt% CPDs exhibited enhanced cycling performance with a capacity retention of 89.77% after 100 cycles at 0.5 C compared to 55.39% of the bare NCM811. This facile and effective surface decoration strategy provides valuable guidance for improving the stability and cycling performance of Ni-rich cathodes.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Neurosciences
Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong He
Summary: This study investigates the role of MKP-1 in regulating microglia phenotype and inflammatory factor release in Alzheimer's disease (AD). The findings suggest that MKP-1 can modulate microglia phenotype and inflammatory factor release in AD through the p38 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Mei-Zhen Hu, Zhi-Zheng Dai, Hong-Yu Ji, An-Qi Zheng, Hang Liang, Mei-Mei Shen, Jun-Nan Liu, Kai-Fu Tang, Shu-Juan Zhu, Ke-Jian Wang
Summary: FAM50A is upregulated in multiple types of common cancer tissues and its elevated expression is associated with poor prognosis and immune cell infiltration. Promoter hypomethylation may contribute to FAM50A upregulation. Inhibition of FAM50A expression leads to DNA damage, induction of interferon beta and interleukin-6 expression, and suppression of cancer cell proliferation, invasion, and migration.
Article
Spectroscopy
Zhao Ting-ting, Wang Ke-jian, Si Yong-sheng, Shu Ying, He Zhen-xue, Wang Chao, Zhang Zhi-sheng
Summary: This paper proposes an improved feature wavelength variable selection method based on an information vector and exponential decay function of the ordered predictive selection method (AW-OPS). The experiments show that the AW-OPS method outperforms the OPS method and full-spectrum method in terms of test accuracy.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Tian Yan, Xiuying Zhao, Kejian Wang, Hao Song
Summary: A new composite acoustic structure is proposed and its impact on sound-absorbing performance is studied through numerical simulation. The optimized structure shows a 6.3% increase in absorption property compared to the original structure, and exhibits better efficiency and accuracy.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
