期刊
CANCER MANAGEMENT AND RESEARCH
卷 12, 期 -, 页码 695-702出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S242329
关键词
berberine; anti-tumor; traditional Chinese medicine; cancer
类别
资金
- Provincial Natural Science Foundation of Hubei [2015BCA270]
- Joint Fund of Wuhan Union Hospital [02.03.2019-95]
Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.
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