Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE-19) cells

An in vitro protocol to study the effect of hyperglycemia on intracellular redox signaling in human retinal pigment epithelial (ARPE-19) cells

(2019) Arpitha Haranahalli Shivarudrappa et al.   MOLECULAR BIOLOGY REPORTS

β-carotene isolated from the marine red alga, Gracillaria sp. potently attenuates the growth of human hepatocellular carcinoma (HepG2) cells by modulating multiple molecular pathways

(2018) Yogendra Prasad Kavalappa et al.   Journal of Functional Foods

Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells

(2017) Katja Frede et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

β-carotene at physiologically attainable concentration induces apoptosis and down-regulates cell survival and antioxidant markers in human breast cancer (MCF-7) cells

(2017) G. Sowmya Shree et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protective effect of lutein on ARPE-19 cells upon H2O2-induced G2/M arrest

(2017) Huijun Liu et al.   Molecular Medicine Reports

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

(2017) Manuel Matzinger et al.   BIOTECHNOLOGY ADVANCES

Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins

(2016) Sara E. Thomas et al.   JOURNAL OF LIPID RESEARCH

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

(2016) Małgorzata Nita et al.   Oxidative Medicine and Cellular Longevity

Lutein acts via multiple antioxidant pathways in the photo-stressed retina

(2016) Mamoru Kamoshita et al.   Scientific Reports

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early retinal pigment epithelium dysfunction is concomitant with hyperglycemia in mouse models of type 1 and type 2 diabetes

(2015) Ivy S. Samuels et al.   JOURNAL OF NEUROPHYSIOLOGY

Posttranslational modification of mitochondrial transcription factor A in impaired mitochondria biogenesis: Implications in diabetic retinopathy and metabolic memory phenomenon

(2014) Julia M. Santos et al.   EXPERIMENTAL EYE RESEARCH

Nrf2 and Redox Status in Prediabetic and Diabetic Patients

(2014) Angélica Jiménez-Osorio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Heme Oxygenase System Suppresses Perirenal Visceral Adiposity, Abates Renal Inflammation and Ameliorates Diabetic Nephropathy in Zucker Diabetic Fatty Rats

(2014) Joseph Fomusi Ndisang et al.   PLoS One

Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death

(2014) X Zou et al.   Cell Death & Disease

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanisms of Nrf2/Keap1-Dependent Phase II Cytoprotective and Detoxifying Gene Expression and Potential Cellular Targets of Chemopreventive Isothiocyanates

(2013) Biswa Nath Das et al.   Oxidative Medicine and Cellular Longevity

The Role of Lutein in Eye-Related Disease

(2013) Keyvan Koushan et al.   Nutrients

p38MAPK and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y

(2012) Giuseppe Filomeni et al.   BIOCHEMICAL PHARMACOLOGY

An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)–Nrf2–ARE signaling and ROS–PI3K/Akt signaling in an NF-κB-independent mechanism

(2011) Kyoung-jin Min et al.   CELLULAR SIGNALLING

Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy

(2011) Q. Zhong et al.   DIABETES

Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats

(2011) P. V. Prabhakar et al.   JOURNAL OF APPLIED TOXICOLOGY

Muller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

(2010) J. Wang et al.   DIABETES

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

(2010) Rosaria Varì et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Role of Nrf2 and MAPK Pathways in PFOS-Induced Oxidative Stress in Zebrafish Embryos

(2010) Xiongjie Shi et al.   TOXICOLOGICAL SCIENCES

Human retinal pigment epithelium proteome changes in early diabetes

(2008) A. Decanini et al.   DIABETOLOGIA

Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives

(2008) Sally A. Madsen-Bouterse et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS