The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation
出版年份 2019 全文链接
标题
The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation
作者
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出版物
Frontiers in Immunology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-12-03
DOI
10.3389/fimmu.2019.02816
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion
- (2019) Kevin C Conlon et al. CLINICAL CANCER RESEARCH
- Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering
- (2019) Olaf Oberschmidt et al. Human Gene Therapy Methods
- Improving Clinical Manufacturing of IL-15 Activated Cytokine-Induced Killer (CIK) Cells
- (2019) Melanie Bremm et al. Frontiers in Immunology
- Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma
- (2018) Toni Illhardt et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Haploidentical allogeneic hematopoietic stem cell transplantation in patients with high-risk soft tissue sarcomas: results of a single-center prospective trial
- (2018) Michael Merker et al. BONE MARROW TRANSPLANTATION
- Selective T cell-depleted haploidentical hematopoietic stem cell transplantation for relapsed/refractory neuroblastoma
- (2018) Anthony P. Y. Liu et al. PEDIATRIC TRANSPLANTATION
- Clinical-scale production of cGMP compliant CD3/CD19 cell-depleted NK cells in the evolution of NK cell immunotherapy at a single institution
- (2018) Shelly M. Williams et al. TRANSFUSION
- Neuroblastoma Cell Lines Are Refractory to Genotoxic Drug-Mediated Induction of Ligands for NK Cell-Activating Receptors
- (2018) Irene Veneziani et al. Journal of Immunology Research
- A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity
- (2018) Hilary Sherman et al. Frontiers in Immunology
- Natural Killer Cells: Development, Maturation, and Clinical Utilization
- (2018) Alex M. Abel et al. Frontiers in Immunology
- Anti-GD2 immunotherapy for neuroblastoma
- (2017) Sameer Sait et al. Expert Review of Anticancer Therapy
- Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells
- (2017) Stephan Klöß et al. HUMAN GENE THERAPY
- CD56bright NK cells exhibit potent antitumor responses following IL-15 priming
- (2017) Julia A. Wagner, Maximillian Rosario, Rizwan Romee, Melissa M. Berrien-Elliott, Stephanie E. Schneider, Jeffrey W. Leong, Ryan P. Sullivan, Brea A. Jewell, Michelle Becker-Hapak, Timothy Schappe, Sara Abdel-Latif, Aaron R. Ireland, Devika Jaishankar, Justin A. King, Ravi Vij, Dennis Clement, Jodie Goodridge, Karl-Johan Malmberg, Hing C. Wong, Todd A. Fehniger JOURNAL OF CLINICAL INVESTIGATION
- Cancer Immunotherapy with Cytokine-Induced Killer Cells
- (2017) Juan J. Mata-Molanes et al. Targeted Oncology
- Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children
- (2017) Michael Merker et al. Oncotarget
- IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities
- (2017) Sigrid Dubois et al. Cancer Immunology Research
- Shaping of Natural Killer Cell Antitumor Activity by Ex Vivo Cultivation
- (2017) Markus Granzin et al. Frontiers in Immunology
- Developmental and Functional Control of Natural Killer Cells by Cytokines
- (2017) Yang Wu et al. Frontiers in Immunology
- A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma
- (2017) Juliane Wagner et al. Frontiers in Immunology
- Preparation of Cytokine-activated NK Cells for Use in Adoptive Cell Therapy in Cancer Patients
- (2016) Monique M. van Ostaijen-ten Dam et al. JOURNAL OF IMMUNOTHERAPY
- Cytotoxic potential of IL-15-activated cytokine-induced killer cells against human neuroblastoma cells
- (2016) Claudia Cappel et al. PEDIATRIC BLOOD & CANCER
- Optimization of individualized graft composition: CD3/CD19 depletion combined with CD34 selection for haploidentical transplantation
- (2016) Sabine Huenecke et al. TRANSFUSION
- Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids
- (2015) Ariane Giannattasio et al. BMC CANCER
- Generation and flow cytometric quality control of clinical-scale TCRαβ/CD19-depleted grafts
- (2015) Melanie Bremm et al. CYTOMETRY PART B-CLINICAL CYTOMETRY
- Challenges of cancer therapy with natural killer cells
- (2015) Hans Klingemann CYTOTHERAPY
- IL-15 Superagonist–Mediated Immunotoxicity: Role of NK Cells and IFN-γ
- (2015) Yin Guo et al. JOURNAL OF IMMUNOLOGY
- Advances in clinical NK cell studies: Donor selection, manufacturing and quality control
- (2015) U. Koehl et al. OncoImmunology
- Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
- (2014) Rasheena Edmondson et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Donor-Derived Natural Killer Cells Infused after Human Leukocyte Antigen–Haploidentical Hematopoietic Cell Transplantation: A Dose-Escalation Study
- (2014) Inpyo Choi et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion
- (2014) Eva Rettinger et al. CYTOTHERAPY
- Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA
- (2014) M. Kloss et al. JOURNAL OF IMMUNOLOGY
- Feasibility of IL-15-activated cytokine-induced killer cell infusions after haploidentical stem cell transplantation
- (2013) E Rettinger et al. BONE MARROW TRANSPLANTATION
- Current and Future Strategies for Relapsed Neuroblastoma
- (2013) Daniel A. Morgenstern et al. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- New prospects on the NKG2D/NKG2DL system for oncology
- (2013) Evelyn Ullrich et al. OncoImmunology
- Clinical Grade Purification and Expansion of NK Cell Products for an Optimized Manufacturing Protocol
- (2013) Ulrike Koehl et al. Frontiers in Oncology
- Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers
- (2012) M Stern et al. BONE MARROW TRANSPLANTATION
- Natural killer cells can exert a graft-vs-tumor effect in haploidentical stem cell transplantation for pediatric solid tumors
- (2012) Antonio Pérez-Martínez et al. EXPERIMENTAL HEMATOLOGY
- NK cytotoxicity and alloreactivity against neuroblastoma cell lines in vitro: Comparison of Europium fluorometry assay and quantification by RT-PCR
- (2012) C. Paillard et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Natural killer cells: a review of manufacturing and clinical utility
- (2012) Scott A. Koepsell et al. TRANSFUSION
- Rapid immune recovery and low TRM in haploidentical stem cell transplantation in children and adolescence using CD3/CD19-depleted stem cells
- (2011) Peter Bader et al. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells
- (2011) Eva Rettinger et al. CYTOTHERAPY
- NK Cell immunotherapy for high-risk neuroblastoma relapse after haploidentical HSCT
- (2011) Justyna Kanold et al. PEDIATRIC BLOOD & CANCER
- IL-2 Stimulated but Not Unstimulated NK Cells Induce Selective Disappearance of Peripheral Blood Cells: Concomitant Results to a Phase I/II Study
- (2011) Claudia Brehm et al. PLoS One
- NF- B, and not MYCN, Regulates MHC Class I and Endoplasmic Reticulum Aminopeptidases in Human Neuroblastoma Cells
- (2010) M. Forloni et al. CANCER RESEARCH
- Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation
- (2010) S. Kuci et al. HAEMATOLOGICA
- IL-2−driven Regulation of NK Cell Receptors With Regard to the Distribution of CD16+ and CD16− Subpopulations and In Vivo Influence After Haploidentical NK Cell Infusion
- (2010) Sabine Huenecke et al. JOURNAL OF IMMUNOTHERAPY
- Recent Advances in Neuroblastoma
- (2010) John M. Maris NEW ENGLAND JOURNAL OF MEDICINE
- The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report
- (2008) Susan L. Cohn et al. JOURNAL OF CLINICAL ONCOLOGY
- IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
- (2008) Nicholas D. Huntington et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Natural killer cell–directed therapies: moving from unexpected results to successful strategies
- (2008) Magali Terme et al. NATURE IMMUNOLOGY
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