Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Endocrinology & Metabolism
Panagiotis Anagnostis, Kalliopi Lampropoulou-Adamidou, Julia K. Bosdou, Georgios Trovas, Petros Galanis, Efstathios Chronopoulos, Dimitrios G. Goulis, Symeon Tournis
Summary: The optimal management of pregnancy and lactation-associated osteoporosis (PLO) has not been determined. Existing studies have found that calcium/vitamin D, bisphosphonates, and teriparatide can improve bone mineral density, with teriparatide showing better efficacy. However, due to heterogeneity and lack of robust comparative data, safe conclusions cannot be drawn regarding the optimal therapeutic intervention in women with PLO.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Chia-Hsien Chen, Wei-Cheng Lo, Ping-Jen Hu, Hsiu-Chen Chan, Wan-Chen Shen, Mai-Szu Wu, Mei-Yi Wu
Summary: From network meta-analysis, it was found that teriparatide and denosumab appear to be the most effective treatments for preventing bone loss and reducing the risk of fracture in patients with CKD or a history of kidney transplantation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Orthopedics
Filippo Migliorini, Nicola Maffulli, Giorgia Colarossi, Joerg Eschweiler, Markus Tingart, Marcel Betsch
Summary: This study found that Denosumab has a higher impact on spine bone mineral density in selected postmenopausal women, and has the highest influence on hip and femur bone mineral density.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Plant Sciences
Bin Wu, Xiu-Fang Zhu, Xiao-Qiang Yang, Wei-Yi Wang, Jian-Hua Lu
Summary: The active compound osthole derived from Cnidium monnieri Cusson has shown to be effective in treating osteoporosis in rats, promoting bone formation and inhibiting bone absorption.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Geriatrics & Gerontology
Charlotte Beaudart, Celine Demonceau, Shaun Sabico, Nicola Veronese, Cyrus Cooper, Nicholas Harvey, Nicholas Fuggle, Olivier Bruyere, Rene Rizzoli, Jean-Yves Reginster
Summary: This systematic review and meta-analysis aimed to evaluate the efficacy of pharmacological treatments in men with osteoporosis. The analysis showed that treatment improved bone mineral density and reduced the incidence of fractures in men with osteoporosis.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
H. Xie, N. Wang, H. He, Z. Yang, J. Wu, T. Yang, Y. Wang
Summary: In this meta-analysis, the association between selenium status and bone health indicators was investigated. The results demonstrate a positive correlation between selenium intake and bone mineral density, as well as an inverse relationship with osteoporosis and hip fracture risk.
BONE & JOINT RESEARCH
(2023)
Review
Environmental Sciences
Seyed Rohallah Mousavibaygei, Amir Bisadi, Fariba ZareSakhvidi
Summary: This study systematically reviewed the evidence on the association between exposure to air pollution and osteoporosis-related outcomes. The findings suggest that PM2.5, PM10, and nitrogen dioxide may be associated with decreased bone density, osteoporotic fractures, and osteoporosis. However, due to limitations in the number of studies, heterogeneity, and publication bias, caution should be exercised in interpreting the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Pharmacology & Pharmacy
Peiyu Zhang, Liu Yang, Qingwen Xu, Yidi Zeng, Yipin Yu, Qinghua Peng, Hao Liang
Summary: This study found that low bone mineral density is associated with a higher prevalence and severity of coronary arterial calcification, especially in postmenopausal women. However, this association is not significant after adjusting for age and other confounding variables. Bone mineral density and coronary arterial calcification may be two independent processes with aging. More large-scale studies with high-quality design are needed to further understand the relationship between them.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Salma, Syed Sufian Ahmad, Shahid Karim, Ibrahim M. Ibrahim, Huda M. Alkreathy, Mohammed Alsieni, Mohammad Ahmed Khan
Summary: Adequate intake of Vitamin K is associated with improved skeletal health and decreased fracture risk. However, there is insufficient evidence regarding the significant impact of Vitamin K on femoral neck bone density.
Review
Endocrinology & Metabolism
Ying-Hao Su, Kuo-Liong Chien, Shu-Hua Yang, Wei-Tso Chia, Jen-Hau Chen, Yen-Ching Chen
Summary: This systematic review and meta-analysis found that nonalcoholic fatty liver disease (NAFLD) is associated with decreased bone mineral density (BMD) and increased risks of osteoporosis and osteoporotic fractures in adults. Male sex and the BMD of the femoral neck and total hip are potential risk factors for decreased BMD in adults with NAFLD. Ethnic disparities exist between Asian and non-Asian populations regarding BMD and osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Xiaodan Ou, Mingguang Chen, Lizhen Xu, Wei Lin, Huibin Huang, Gang Chen, Junping Wen
Summary: Bariatric surgery has a certain impact on bone density, especially in patients over 40 years of age and individuals with a postsurgical time of greater than 12 months. It is important for these patients to pay attention to bone density screening and osteoporosis prevention. Further research is needed to analyze longer-term changes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Hematology
Ibadete Bytyci, Rafik Shenouda, Per Wester, Michael Y. Henein
Summary: The meta-analysis revealed a linear relationship between coronary and carotid atherosclerosis, with carotid plaque features associated with coronary artery disease. Moderate correlations were found between carotid intima-media thickness and the severity of CAD, as well as carotid and coronary stenosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Integrative & Complementary Medicine
Qiu-Yan Zhang, Hao Liang, Hou-Wu Gong, Hui-yong Huang, Xiao-qing Zhou, Xiang Sun
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Review
Medicine, General & Internal
Hao Liang, Lan Wu, Yingchen Li, Yidi Zeng, Zhixi Hu, Xinchun Li, Xiang Sun, Qiuyan Zhang, Xiaoqing Zhou
Article
Cardiac & Cardiovascular Systems
Jiaze Wu, Hao Liang, Changsong Ding, Xindi Huang, Jianhua Huang, Qinghua Peng
Summary: By investigating determinants for blood pressure classification accuracy, a new algorithm based on photoplethysmography (PPG) and deep learning was established with high predictive accuracy. The Cgau1 wavelet and segment length of 300 showed superior performance in achieving a high accuracy rate.
INTERNATIONAL JOURNAL OF HYPERTENSION
(2021)
Article
Oncology
Yipin Yu, Duoting Tan, Can Liao, Pei Yang, Zhixi Hu, Hao Liang
Summary: This meta-analysis revealed that elevated NLR before and after SBRT were independently associated with poorer survival in patients with cancer who received SBRT. Prospective studies showed more significant heterogeneity compared to retrospective studies and overall analysis.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Pei Yang, Yu Zhao, Hao Liang, Guanzhi Zhou, Bassem Youssef, Hesham Elhalawani, Meizhen Li, Fengbo Tan, Yi Jin, Hekun Jin, Hong Zhu, Abdallah Sherif Radwan Mohamed, Nantavithya Chonnipa, Danita Kannarunimit, Yingrui Shi, Hui Wang, Clifton David Fuller
Summary: The NLR trend can independently predict the prognosis of patients with nasopharyngeal carcinoma receiving radiotherapy, and the combination of NLR trend and pretreatment NLR is more precise than pretreatment NLR alone in predicting prognosis. A high NLR trend may be indicative of a positive immune response to radiotherapy in patients with nasopharyngeal carcinoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2022)
Article
Medicine, General & Internal
Dan Sheng, Duo Yang, Wanqin Xie, Mojiang Li, Liqin Zhong, Shuangxi Zhao, Hao Liang
Summary: This study reports the clinical and genetic findings of a two-generation Chinese family affected by congenital cataract. A novel PAX6 mutation (c.221G>A) was found to be associated with congenital cataract, and the WFS1 mutation (c.2070_2079del) may interactively aggravate this process. These findings may increase our understanding of the genetic etiology of congenital cataract.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Peiyu Zhang, Liu Yang, Qingwen Xu, Yidi Zeng, Yipin Yu, Qinghua Peng, Hao Liang
Summary: This study found that low bone mineral density is associated with a higher prevalence and severity of coronary arterial calcification, especially in postmenopausal women. However, this association is not significant after adjusting for age and other confounding variables. Bone mineral density and coronary arterial calcification may be two independent processes with aging. More large-scale studies with high-quality design are needed to further understand the relationship between them.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Plant Sciences
Qing Du, Dan He, Hong-Liang Zeng, Jian Liu, Hui Yang, Lin-Ben Xu, Hao Liang, Dan Wan, Chun-Yu Tang, Ping Cai, Jian-hua Huang, Shui-han Zhang
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Cheng-Long Yang, Yi-Di Zeng, Zhi-Xi Hu, Hao Liang
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2020)
Article
Medicine, Research & Experimental
Yao Zhou, Senjie Zhong, Siyuan Hu, Wenbo Dong, Tao Yao, Hao Liang, Lin Li, Zhixi Hu
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2018)