Article
Biochemistry & Molecular Biology
Jin Wook Hwang, Won-Jong Park, Younho Han
Summary: Asarylaldehyde is proposed for osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) to prevent bone loss. It promotes osteogenic differentiation of hPDLSCs by increasing the expression of osteoblast-specific markers through regulating the p38/ERK signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shunyi Tong, Sanhua Fang, Kangjie Ying, Weiwei Chen
Summary: Metallic implants have significant applications in clinical orthopedics but wear out over time due to mechanical loading, leading to complications such as wear debris formation and aseptic loosening. This study focuses on the influence of titanium particles, commonly used in clinical practice, on the osteogenic differentiation of mesenchymal stem cells. Results showed that titanium particles significantly inhibit osteogenic differentiation in a dose-dependent manner. Further exploration revealed that the MAPK signaling pathway, specifically the phosphorylation of ERK1/2, is involved in this inhibition.
Article
Cell Biology
Yan Deng, Ling Li, Jia-Hui Zhu, Pei-Pei Li, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Bai-Cheng He, Yuxi Su
Summary: This study demonstrates that overexpression of COX-2 enhances BMP9's osteogenic ability through upregulation of TGF-beta 1, resulting in the activation of p38 signaling pathway in MSCs.
Article
Cell & Tissue Engineering
Jing Li, Haoran Du, Xin Ji, Yihan Chen, Yishuai Li, Boon Chin Heng, Jianguang Xu
Summary: This study demonstrated that overexpression of ETV2 significantly enhanced osteogenic markers expression, ALP activity, and matrix mineralization of hDPSCs. The mechanisms involved ERK/MAPK and PI3K-Akt signaling pathways, which were partially reversed by inhibitors of these pathways. In vivo studies also showed improved bone healing and ectopic bone formation due to ETV2 overexpression in animal models.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Orthopedics
Qi Wang, Wei Shi, Shaozhan Lin, Hanxue Wang
Summary: This study analyzed the molecular mechanisms that affect the osteogenic differentiation of periodontal ligament stem cells (PDLSCs). The findings showed that FOXO1 activates the PI3K/AKT signaling pathway by transcriptionally activating METTL3, promoting the osteogenic differentiation of PDLSCs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yongxiang Xu, Shichun Chen, Linxuan Huang, Weichao Han, Yingying Shao, Minyi Chen, Yusheng Zhang, Ruirong He, Baocheng Xie
Summary: In this research, the protective impacts of epimedin C on the osteogenic inhibition impact of MC3T3-E1 cells and zebrafish larvae mediated by DEX were examined. The results showed that epimedin C could alleviate the suppressive impact of DEX on the osteogenesis of MC3T3-E1 cells and zebrafish larvae by triggering the PI3K and AKT signaling pathways. This suggests that epimedin C has significant potential in the development of innovative drugs for the treatment of glucocorticoid-mediated osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Deao Gu, Hanxiao Liu, Xinyi Qiu, Yijun Yu, Xuna Tang, Chao Liu, Leiying Miao
Summary: This study found that erythropoietin can enhance the odontoblastic differentiation of human-derived pulp stem cells and promote the formation of tertiary dentin. This effect is mediated by the EphB4-mediated MAPK signaling pathway, and can be attenuated by EphB4 inhibitors.
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Cell & Tissue Engineering
Yi-Lin Zhang, Fen Liu, Zhi-Bang Li, Xiao-Tao He, Xuan Li, Rui-Xin Wu, Hai-Hua Sun, Shao-Hua Ge, Fa-Ming Chen, Ying An
Summary: Metformin may enhance the osteogenic differentiation of PDLSCs under high glucose by downregulating NPR3 expression and inhibiting the downstream MAPK pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Xiang Gao, Guanhao Hong, Weiqiang Zhan, Tianfeng Liu, Shouquan Yan, Mingzhu Deng, Chenlin Tu, Peng Li
Summary: This study found that DPA can promote the osteogenic differentiation of hBMSCs through the miR-9-5p/ERK/ALP signaling pathway. This provides a potential therapeutic strategy for patients with bone loss.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Anatomy & Morphology
Kai Wang, Zhiping Zhao, Xiangyu Wang, Yongtao Zhang
Summary: BRD4 plays a role in the osteogenic differentiation of BMSCs through the Wnt/beta-catenin signaling pathway. This finding contributes to a better understanding of the mechanism behind BMSC osteogenic differentiation.
Article
Immunology
Zhihui Kuang, Xiaowei Yang, Zhiyou Cao, Yanhua Li, Jiawei Hu, Xin Hong, Bo Li, Changjian Wu, Qihua Qi, Xuqiang Liu, Min Dai
Summary: Surfactin, a highly effective biosurfactant, inhibits osteoclastogenesis and promotes osteogenic differentiation, suggesting its potential as a treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying Xing, Mi-Shuai Zhang, Jian-Hui Xiao, Ru-Ming Liu
Summary: This study found that galangin can promote the osteogenic differentiation of human amniotic mesenchymal stem cells (hAMSCs) through the JAK2/STAT3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jingyuan Wen, Zhengsheng Bao, Lunxin Li, Yingquan Liu, Bing Wei, Xiaoang Ye, Huihui Xu, Longkang Cui, Xuefei Li, Gaobo Shen, Yuan Fang, Hanbing Zeng, Zhe Shen, Enping Guo, Hongting Jin, Lianguo Wu
Summary: Through network pharmacological analysis, this study found that Qiangguyin (QGY) can reduce fat accumulation in the chondro-osseous junction by activating the mitogen-activated protein kinase (MAPK) signaling pathway, thereby reducing decreased bone density and increased bone fragility in postmenopausal osteoporosis (PMOP) patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Jing He, Nihui Zhang, Yue Zhu, Rongrong Jin, Fang Wu
Summary: Integration of neurogenesis into nerve repair materials should consider anti-inflammatory function, using MSC spheroids-loaded collagen hydrogels demonstrated superior anti-inflammatory efficacy and neurogenic activity, modulated by spheroid size. MSC spheroids promoted secretion of trophic factors, ECM, cytokines, and immunomodulatory factors, activating neuroactive ligand-receptor interaction for neuronal differentiation via PI3K-Akt pathway.