Article
Computer Science, Interdisciplinary Applications
Chuanpeng Wu, Liang Li
Summary: X-ray fluorescence computed tomography (XFCT) is a promising method for imaging the distribution of high-Z elements in a target object. Using a Compton camera for XFCT can overcome the limitations of mechanical collimators and achieve higher photon collection efficiency. In this work, a Compton camera platform is demonstrated for XFCT imaging, showing its potential for handheld XRF imaging and image-guided interventional operation.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Materials Science, Multidisciplinary
Ammar Alhasan, Hairul Anuar Tajuddin, S. F. Abdul Sani, Tammar Hussein Ali, Shameer Hisham, Muhammad Haniff Mokti, Ngie Min Ung, Min Phin Ng, Kae Shin Sim
Summary: In this study, silica-Ag:Mn3O4 hybrid nanoparticles were synthesized and conjugated with a commercial iodine contrast agent (Iohexol) for CT contrast enhancement. The results showed that the absorption intensity of the nanoparticles drastically increased, with higher Hounsfield unit (HU) values compared to Iohexol, indicating the efficiency of the hybrid nanoparticles in CT contrast enhancement.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Ngoc Ton, Una Goncin, Arash Panahifar, Dean Chapman, Sheldon Wiebe, Steven Machtaler
Summary: The study aimed to evaluate the feasibility of ultrasound microbubbles as a contrast agent for X-ray phase contrast imaging. Results suggest that lipid-MBs larger than 4 µm may be candidates for PCI, and a concentration of 5 x 10(6) MBs/ml could be the lowest suitable concentration for generating visible phase contrast in vivo.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Agronomy
Callum P. Scotson, Arjen van Veelen, Katherine A. Williams, Nicolai Koebernick, Dan McKay Fletcher, Tiina Roose
Summary: The aim of the study was to develop an experimental system that allowed the application of iodinated contrast media to intact plant roots in soil and was compatible with time-resolved synchrotron X-ray computed tomography imaging. By using synchrotron X-ray computed tomography and synchrotron X-ray fluorescence mapping, the system was successful in visualizing the translocation of contrast media through root vasculature into the leaves, providing insights into internal fluid transport mechanisms and anatomical features of the plants.
Article
Chemistry, Multidisciplinary
Bo Peng, Yifan Hao, Chao Si, Bo Wang, Chengfeng Luo, Menghao Chen, Cheng Luo, Baijuan Gong, Zhimin Li
Summary: Oral cancer is a common malignant tumor in the oral and maxillofacial region. Radiotherapy is currently a common treatment method, but its effectiveness is limited by the resistance of cancerous tissues to radiation and the side effects on healthy tissues. The use of nanomaterials containing high atomic number elements as radiosensitizers shows promise in improving the effectiveness of radiotherapy while reducing side effects. In this study, Twee-20-modified BiVO4 nanorods were prepared and used in radiotherapy for tongue squamous cell carcinoma, showing enhanced therapeutic effects and precise imaging guidance.
Article
Multidisciplinary Sciences
Hongchang Wang, Kawal Sawhney
Summary: Researchers have successfully generated omnidirectional differential phase images using X-ray differential phase contrast imaging, providing more information for studying complex samples and enabling simultaneous extraction of omnidirectional dark-field images to study ordered scattering structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hongchang Wang, Kawal Sawhney
Summary: This article introduces a method for generating omnidirectional differential phase images by scanning a randomly structured modulator, which provides more information than traditional imaging methods and allows the simultaneous extraction of omnidirectional dark-field images for studying strongly ordered scattering structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Optics
Shaozhou Pu, Yunwen Huang, Ning Zhao, Hui Liu, Yang Zuo, Cheng Zheng, Hangcheng Zhou, Lei Zhu, Yidong Yang
Summary: An in-house dual-modality XFT and XCT system was developed to quantify iodine contrast distribution through the whole tumor volume ex vivo. The vasculature distribution was reflected by the iodine perfusion, which was validated with histology. This technique may open a new, to the best of our knowledge, route to the non-destructive three-dimensional-imaging-based histological analysis of tumor samples.
Article
Nanoscience & Nanotechnology
Mohamed F. Attia, Roman Akasov, Nancy M. Elbaz, Tyler C. Owens, Evan C. Curtis, Soham Panda, Ralph Santos-Oliveira, Frank Alexis, Forrest M. Kievit, Daniel C. Whitehead
Summary: We report the synthesis of hybrid iodinated silica-lipid nanoemulsions for ultrasound and X-ray imaging. The nanoemulsions showed excellent biocompatibility and significant contrast-enhancing properties, suggesting their potential as dual-modality clinical agents.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Quanjie Lv, Yili Zhang, Ruihao Yang, Yingfan Dai, Yu Lin, Kang Sun, Hong Xu, Ke Tao
Summary: This study introduces a noninvasive imaging method using photoacoustic imaging and nanoparticles as contrast agents for deep-seated endometriosis lesions. The method is proven to be accurate and effective through animal experiments and in vivo assessments. Moreover, it provides real-time monitoring of drug therapy effects and eliminates the need for sacrificing experimental animals.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Computer Science, Information Systems
Sandun Jayarathna, Md Foiez Ahmed, Liam O'ryan, Hem Moktan, Yonggang Cui, Sang Hyun Cho
Summary: Pixelated semi-conductor detector HEXITEC was characterized for its performance in benchtop XFCT system, demonstrating the necessity for application-specific detector characterization and highlighting the characteristics of HEXITEC under different working conditions. The investigation also showed the potential of high energy resolution in parallel acquisition of XRF signals using HEXITEC.
Article
Chemistry, Multidisciplinary
Giovanni M. Saladino, Carmen Vogt, Yuyang Li, Kian Shaker, Bertha Brodin, Martin Svenda, Hans M. Hertz, Muhammet S. Toprak
Summary: This study introduces core-shell nanoparticles with combined optical and X-ray fluorescence properties as bioimaging contrast agents. The SiO2 coating method is shown to be applicable to both metallic and ceramic nanoparticles. In vitro studies demonstrate the improved biocompatibility of SiO2 coated nanoparticles.
Article
Energy & Fuels
Patrick Kin Man Tung, Amalia Yunita Halim, Huixin Wang, Anne Rich, Christopher Marjo, Klaus Regenauer-Lieb
Summary: Quantitative characterisation through mineral liberation analysis is essential in minerals processing. The combination of X-ray microcomputed tomography and micro-X-ray fluorescence offers a new opportunity for robust 3D mineral liberation analysis.
Article
Medicine, General & Internal
Simone Fantoni, Ilenia Gabucci, Paolo Cardarelli, Gianfranco Paterno, Angelo Taibi, Virginia Cristofori, Claudio Trapella, Armando Bazzani, Marta Assenza, Alice Zanna Bonacorsi, Daniele Conti, Fabio Baruffaldi
Summary: This study assessed a new cationic contrast agent, CA4+, in the spatial distribution and saturation time in bovine cartilage. The results showed that CA4+ was distributed in three distinct layers in the cartilage and had a longer saturation time. Clinical CT results confirmed the contrast enhancement effect of CA4+ in the cartilage, with different regions showing different degrees of contrast enhancement. In addition, partial washout of the cartilage was observed.
Article
Chemistry, Multidisciplinary
Alessandra Gianoncelli, Valentina Bonanni, Gianluca Gariani, Francesco Guzzi, Lorella Pascolo, Roberto Borghes, Fulvio Bille, George Kourousias
Summary: Progress in nanotechnology requires high sensitivity and resolution material probing techniques, with soft X-ray microscopy being one of the most powerful tools in medicine and the life sciences for studying complex biological processes at micrometric and sub-micrometric length scales. The TwinMic soft X-ray microscopy end-station at the Elettra synchrotron demonstrates capabilities in medical and biological imaging, along with novel uses and developments.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Yong Du, Zhenzhen Kong, Muhammet S. Toprak, Guilei Wang, Yuanhao Miao, Buqing Xu, Jiahan Yu, Ben Li, Hongxiao Lin, Jianghao Han, Yan Dong, Wenwu Wang, Henry H. Radamson
Summary: This study successfully grows high-quality Ge epitaxial layers on Si substrates using RPCVD, systematically investigating the morphology and crystal quality of Ge layers under different conditions. The results demonstrate the key factors influencing the quality of Ge layers and highlight the importance of strain and defect formation in the Ge buffer layer.
Article
Chemistry, Multidisciplinary
Bejan Hamawandi, Hazal Batili, Moon Paul, Sedat Ballikaya, Nuzhet I. Kilic, Rafal Szukiewicz, Maciej Kuchowicz, Mats Johnsson, Muhammet S. Toprak
Summary: This study presents rapid and effective methods for synthesizing nanostructured bismuth telluride materials with promising TE performance using microwave volume heating in a short reaction time. The use of water as a solvent is as effective as ethylene glycol, providing a greener reaction medium. Characterization techniques, including XRD, SEM/TEM, XPS and zeta potential, were used to evaluate crystal structure, morphology, crystallinity, microstructure and surface chemistry of the materials. The low thermal conductivity values and high ZT values demonstrate the potential impact of these materials, developed with energy and time efficiency, in advancing TE technology with minimal environmental impact.
Article
Chemistry, Multidisciplinary
Giovanni M. Saladino, Nuzhet I. Kilic, Bertha Brodin, Bejan Hamawandi, Idris Yazgan, Hans M. Hertz, Muhammet S. Toprak
Summary: A hybrid material combining optical and X-ray fluorescence properties was presented as a bioimaging contrast agent. Rhodium core NPs were synthesized using a microwave-assisted hydrothermal method, showing potential as X-ray Fluorescence Computed Tomography (XFCT) contrast agents.
Article
Materials Science, Multidisciplinary
M. A. Almessiere, B. Unal, Y. Slimani, H. Gungunes, M. S. Toprak, N. Tashkandi, A. Baykal, M. Sertkol, A. Trukhanov, A. Yildiz, A. Manikandan
Summary: Ce-Dy co-doping has significant effects on the crystal structure, optical, and magnetic properties of Ni-Co spinel ferrite microspheres. Increasing Ce3+-Dy3+ content enhances the magnetic capabilities of the ferrite microspheres. The AC conductivity and dielectric properties are also influenced by the Ce-Dy content, with the dielectric properties strongly depending on the frequency.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Pharmacology & Pharmacy
Ahmed Raslan, Jesus Ciriza, Ana Maria Ochoa de Retana, Maria Luisa Sanjuan, Muhammet S. Toprak, Patricia Galvez-Martin, Laura Saenz-del-Burgo, Jose Luis Pedraz
Summary: The study focused on the impact of protein-coated reduced graphene oxide on the conductivity of hydrogels, with results indicating that collagen had better adsorption capacity and enhanced conductivity.
Editorial Material
Materials Science, Multidisciplinary
Muhammet S. Toprak, Sedat Ballikaya, Emrah Celik
FRONTIERS IN MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jose F. Serrano-Claumarchirant, Bejan Hamawandi, Adem B. Ergul, Andres Cantarero, Clara M. Gomez, Pankaj Priyadarshi, Neophytos Neophytou, Muhammet S. Toprak
Summary: This study focuses on the development of large-area thermoelectric films using hybrid materials. By blending TE materials with polymers and using a specific solvent, durable polymer, and additive in the ink formulation, the researchers successfully fabricated large-area homogeneous hybrid TE films with improved conductivity and TE power factor.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Y. Slimani, M. A. Almessiere, A. Demir Korkmaz, A. Baykal, A. Manikandan, H. Gungunes, M. S. Toprak
Summary: This study focused on the impact of Ga-Gd co-substitution on the structural, magnetic features and hyperfine interactions of nanosized NiCuZn spinel ferrites. The results showed that the substitution of Ga and Gd influenced the crystallite and particle sizes, as well as the cation distribution, of the spinel ferrites. Magnetometry measurements revealed changes in coercivity and saturation magnetization with the substitution of Ga and Gd. Superparamagnetic-to-ferromagnetic transition was observed below the blocking temperature.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
Z. Lalegani, S. A. Seyyed Ebrahimi, B. Hamawandi, L. La Spada, H. Batili, M. S. Toprak
Summary: An epsilon-negative metamaterial (ENM) with core@shell nanoparticles was designed. The optimal performance was achieved by growing a 10 nm SiO2 shell on 54 nm Ag nanoparticles.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Physical
Hazal Batili, Bejan Hamawandi, Adem Bjorn Ergul, Muhammet Sadaka Toprak
Summary: This study aimed to assemble thermoelectric films with pre-defined morphology and surface chemistry on non-conductive substrates using electrophoretic deposition (EPD). Bi2Te3 nanoparticles were synthesized and used for the deposition of thermoelectric films on glass substrates. The addition of a molecular linker helped reduce resistance and improve the performance of the films. The measured Seebeck coefficient and power factor indicated the potential application of this technology to large area thermoelectric films.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Materials Science, Multidisciplinary
Huseyin Tombuloglu, Yassine Slimani, Sultan Akhtar, Moneerah Alsaeed, Guzin Tombuloglu, Munirah A. Almessiere, Muhammet S. Toprak, Huseyin Sozeri, Abdulhadi Baykal, Ismail Ercan
Summary: This study investigated the translocation of four different sizes of iron oxide nanoparticles in pumpkins. Only the 30-50 nm nanoparticles were significantly translocated to the leaves, showing size-dependent translocation.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Giovanni Marco Saladino, Carmen Vogt, Bertha Brodin, Kian Shaker, Nuzhet Inci Kilic, Kenth Andersson, Marie Arsenian-Henriksson, Muhammet Sadaka Toprak, Hans Martin Hertz
Summary: In this study, hybrid ruthenium-decorated superparamagnetic iron oxide nanoparticles were designed as contrast agents for both magnetic resonance imaging (MRI) and X-ray fluorescence computed tomography (XFCT). These nanoparticles were synthesized through a one-pot polyol hot injection method. In vivo preclinical studies showed the possibility of correlative bioimaging using these contrast agents. The complementary nature of MRI and XFCT allowed for accurate localization and high specificity and resolution in nanoparticle detection, suggesting potential applications for early tumor diagnosis, improved long-term treatment monitoring, and enhanced radiotherapy planning.
Article
Biotechnology & Applied Microbiology
Govind Gupta, Bejan Hamawandi, Daniel J. Sheward, Ben Murrell, Leo Hanke, Gerald McInerney, Magda Blosi, Anna L. Costa, Muhammet S. Toprak, Bengt Fadeel
Summary: Silver nanoparticles (Ag NPs) have been found to effectively inhibit SARS-CoV-2 infection, particularly the unmodified nanoparticles. This study also showed that the Ag NPs retained their antiviral properties even after pre-incubation with pulmonary surfactant. Additionally, the Ag NPs disrupted the secondary structure of the spike protein of SARS-CoV-2, while ionic control (AgNO3) and TiO2 nanoparticles did not have the same effect. Moreover, the Ag NPs were non-cytotoxic to human lung epithelial cells and nasal epithelial cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Giovanni Marco Saladino, Ronak Kakadiya, Shaquib Rahman Ansari, Alexandra Teleki, Muhammet Sadaka Toprak
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) play a dominant role in various biomedical applications, including magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. In this study, superparamagnetic nanoclusters (SP-NCs) with high unit magnetization and diameters up to 400 nm were synthesized using conventional or microwave-assisted solvothermal methods. The choice of synthesis route and capping agent significantly influenced the particle size, SP-NC size, surface chemistry, and magnetic properties. The SP-NCs were then coated with a silica shell doped with a fluorophore to provide fluorescence properties and high stability. The heating efficiency studies demonstrated the potential of these synthesized SP-NCs in hyperthermia treatment. The enhanced magnetically-active content, fluorescence, magnetic property, and heating efficiency of SP-NCs offer promising opportunities for biomedical applications.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Anna Luisa Costa, Magda Blosi, Andrea Brigliadori, Ilaria Zanoni, Simona Ortelli, Felice Carlo Simeone, Serena Delbue, Sarah D'Alessandro, Silvia Parapini, Claudia Vineis, Alessio Varesano, Muhammet S. Toprak, Bejan Hamawandi, Davide Gardini
Summary: This study explores the antiviral and antibacterial properties of quaternized hydroxyethyl cellulose-stabilized silver nanoparticles (Ag-HEC) in different environments. The results show the potential application of Ag-HEC in protective clothing and nasal masks, providing a broad-spectrum antimicrobial solution.
ENVIRONMENTAL SCIENCE-NANO
(2022)
