Review
Chemistry, Multidisciplinary
Young Geon Kim, Yunjung Lee, Nohyun Lee, Min Soh, Dokyoon Kim, Taeghwan Hyeon
Summary: The field of nanocatalytic therapy, which employs catalytic reactions mediated by nanomaterials to intervene in disease-critical biomolecular processes, has gained increasing interest in the last 20 years. Ceria nanoparticles have shown unique scavenging properties against biologically noxious free radicals, making them potential candidates for self-regenerating antioxidative and anti-inflammatory agents in disease therapy. This review provides an overview of the characteristics of ceria nanoparticles, their scavenging mechanisms, and recent therapeutic applications, as well as the challenges and future research directions.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Ruizhen Tian, Jiayun Xu, Quan Luo, Chunxi Hou, Junqiu Liu
Summary: Nanozyme, a type of nanostructured material with intrinsic enzyme mimicking activity, has been increasingly studied in the biological field. It offers advantages such as higher stability, design flexibility, and economical production costs compared to natural enzymes, making it an attractive option for antioxidant therapy in various diseases.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Gwang-Bum Im, Young Geon Kim, Tae Yong Yoo, Yeong Hwan Kim, Kang Kim, Jiyu Hyun, Min Soh, Taeghwan Hyeon, Suk Ho Bhang
Summary: Copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects and therapeutic performance through the upregulation of specific biological factors, scavenging reactive oxygen species, and promoting anti-inflammation and M2 polarization of macrophages. In ischemic vascular diseases, CuCe NPs afford increased perfusion and alleviate tissue damage.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Feng Gao, Tianyi Shao, Yunpeng Yu, Yujie Xiong, Lihua Yang
Summary: The study shows that nanozymes that generate surface-bound ROS can selectively kill bacteria without harming mammalian cells, offering great potential for antimicrobial applications.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Matyas Jelinek, Michal Jurajda, Kamil Duris
Summary: Oxidative stress, caused by an imbalance between free radical production and elimination, plays a crucial role in brain pathologies, particularly in conditions like stroke.
Article
Chemistry, Physical
Dolores Bourbiaux, Yu Xu, Laurence Burel, Firat Goc, Pascal Fongarland, Regis Philippe, Guillaume Aubert, Cyril Aymonier, Franck Rataboul, Laurent Djakovitch
Summary: Lignin is a major component of lignocellulosic biomass and can be depolymerized under mild oxidizing conditions with the Pd catalyst to produce oxygenated aromatic compounds. The richness of functional groups in lignin makes it an attractive precursor for a wide variety of aromatic compounds. Differences in selectivity in aromatic monomers may arise depending on the catalyst nature and synthetic methods used.
Article
Chemistry, Multidisciplinary
Chunyu Zhou, Liang Zhang, Zhongsheng Xu, Tao Sun, Mingfu Gong, Yun Liu, Dong Zhang
Summary: A self-propelled nanoparticle, SAuPTB, is designed to scavenge excessive reactive oxygen species (ROS) and regulate inflammation, effectively alleviating drug-induced liver injury.
Article
Chemistry, Multidisciplinary
Antoine Lancien, Egon Heuson, Franck Dumeignil, Ivaldo Itabaiana, Renato Froidevaux, Robert Wojcieszak
Summary: The study utilized a Pt/SiO2 nanozyme for oxidative deamination reactions, demonstrating its high catalytic activity and selectivity in converting HMFA and glutamic acid to target products.
Article
Biochemistry & Molecular Biology
Katarina Siposova, Veronika Huntosova, Ivana Garcarova, Yuliia Shlapa, Illia Timashkov, Anatolii Belous, Andrey Musatov
Summary: Oxidative stress is associated with amyloid-related diseases, and understanding the interplay between them is crucial for aging and age-related neurodegenerative diseases. Cerium dioxide nanoparticles show potential in studying oxidative stress and amyloid-related diseases, as their antioxidative effects and bioactivity depend on the size and valence of the nanoparticles.
Review
Materials Science, Biomaterials
Yifan Lai, Jingyu Wang, Ning Yue, Qiaochu Zhang, Jiangjiexing Wu, Wei Qi, Rongxin Su
Summary: GPx-like nanozymes, which catalytically reduce H2O2/organic hydroperoxides to H2O/alcohols, have attracted significant attention due to their powerful antioxidant properties. They find broad applications in cytoprotection, anti-inflammation, neuroprotection, tumor therapy, and anti-aging. This review aims to summarize recent advances on GPx-like nanozymes, including their mechanism, classification, and bioapplication, while also discussing future prospects for their design and application.
BIOMATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Giovanna Petrucci, Alessandro Rizzi, Duaa Hatem, Giulia Tosti, Bianca Rocca, Dario Pitocco
Summary: Oxidative stress caused by the imbalance between reactive oxygen species formation and antioxidant scavenger system's activity plays a significant role in the development and complications of atherosclerotic cardiovascular diseases (ASCVD). Overexpression of ROS-generating enzymes and uncontrolled ROS formation are associated with accelerated atherosclerosis in animal models, while overexpression of ROS scavenger systems reduces or stabilizes atherosclerotic lesions. Circulating biomarkers derived from lipid and protein oxidation have been identified as independent predictors of ASCVD in humans. Antioxidant supplementation in animal models reduces ROS and attenuates atherosclerotic lesions, but large human trials or prospective studies have failed to show athero-protective effects of antioxidant supplementation. However, long-term consumption of antioxidant-rich diets has been shown to reduce ASCVD in humans.
Article
Biochemistry & Molecular Biology
Mireya Viviana Belloso Daza, Anna Scarsi, Francesca Gatto, Gabriele Rocchetti, Pier Paolo Pompa, Pier Sandro Cocconcelli
Summary: This study investigated the oxidative stress response of Salmonella enterica serovar Typhimurium cells when exposed to 5 nm citrate coated platinum nanoparticles, revealing their mechanism as antimicrobial agents. The platinum nanoparticles mainly exerted their antibacterial effect through their oxidase-like properties, with stronger action on mutant strains under aerobic conditions. Additionally, the platinum nanoparticles demonstrated protective ROS scavenging action due to their efficient peroxidase mimicking activity.
Article
Chemistry, Multidisciplinary
Joanna Korpanty, Lucas R. Parent, Nathan C. Gianneschi
Summary: In the study, the radiolytic environment experienced by a polymer in water during LCTEM was examined, showing the significant mitigation effect of IPA on polymer damage and the enhancement effect of GNPs. The combination of experiments and simulations provided a generalizable strategy for assessing radiolysis mitigation or enhancement. The study highlights the caution needed for LCTEM experiments involving inorganic nanoparticles and suggests an increased use of scavengers for various LCTEM studies.
Review
Biochemistry & Molecular Biology
Rekha Thiruvengadam, Baskar Venkidasamy, Ramkumar Samynathan, Rajakumar Govindasamy, Muthu Thiruvengadam, Jin Hee Kim
Summary: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular antioxidant defense. It can be activated by oxidative stress and various factors and modifications. Keap1/Nrf2/ARE signaling is a target for treating diseases. Nanomaterials have unique properties and can be used in various biological applications. This review discusses the combined therapy of nanoparticles and Nrf2 and their significance in diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Nanoscience & Nanotechnology
Surabhi, Digvijay Sah, Javaid Shabir, Padmini Gupta, Subho Mozumdar
Summary: A novel and efficient catalyst for the oxidative amidation of aldehydes has been developed in this study. The successful preparation of the catalyst was confirmed through various physicochemical characterization techniques, demonstrating its superior catalytic performance and recyclability.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Andrea Perrelli, Chiara Ferraris, Elisa Berni, Angela J. Glading, Saverio Francesco Retta
Summary: This review explores the role of KRIT1 in the redox mechanisms that influence endothelial cell adhesion and barrier function. It proposes that redox signaling forms the common link between CCM disease, its pathogenetic mechanisms, and therapeutic approaches.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Chemistry, Analytical
Isma Haq, Alvaro Garcia Cruz, Sabrina Di Masi, Todd Cowen, Natalie S. Allcock, Cosimino Malitesta, Adnan Mujahid, Tajamal Hussain, Elena Piletska, Sergey A. Piletsky
Summary: Smart artificial nano-actuators, developed using electroactive acrylamide polymer nanoparticles by molecular imprinting, can mimic the specificity of antibodies and replace enzymes in traditional biosensors for highly sensitive and selective monitoring. These nano-actuators, which operate through a swelling mechanism in response to an electrochemical stimulus, allow extremely sensitive monitoring of Metformin in human plasma, with no cross-reactivity observed against potential interferences. This technology has the potential to be used for rapid point-of-care testing, reducing the time and cost of analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Polymer Science
Antonio Turco, Anna Grazia Monteduro, Francesco Montagna, Elisabetta Primiceri, Mariaenrica Frigione, Giuseppe Maruccio
Summary: Carbon nanotube polymeric composites have been widely developed in piezoresistive sensors, but they are less sensitive and cannot be tuned to adapt to different applications compared to carbon aerogels. By modifying solvent dilution, we fabricated porous piezoresistive nanocomposites with different detection limits, working ranges, and sensitivities.
Article
Engineering, Biomedical
Iriczalli Cruz-Maya, Simona Zuppolini, Mauro Zarrelli, Elisabetta Mazzotta, Anna Borriello, Cosimino Malitesta, Vincenzo Guarino
Summary: In this study, core-shell microgels were produced by self-polymerization of dopamine and in situ precipitation of polydopamine onto alginate microbeads. The presence of polydopamine was confirmed by morphological and chemical analyses. The polydopamine coating improved the biomechanical properties of the microgel surfaces, leading to increased adhesion and cell proliferation, making core-shell microgels a promising model for studying in vitro cell interactions.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Environmental Sciences
Silvia Fraissinet, Daniele Arduini, Olaya Vidal, Antonio Pennetta, Giuseppe Egidio De Benedetto, Cosimino Malitesta, Adriana Giangrande, Sergio Rossi
Summary: Microplastics pose a serious threat to the marine environment, impacting ecosystem functioning and biodiversity. While there is a vast literature on the uptake of microplastics in different trophic levels, there is limited knowledge on potential strategies to mitigate microplastic pollution. Bioremediation, specifically focusing on three species (Sabella spallanzanii, Mytilus galloprovincialis, Phallusia mammillata), has shown promise in effectively removing microplastics.
MARINE POLLUTION BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Diana Nelli, Valentina Mastronardi, Rosaria Brescia, Pier Paolo Pompa, Mauro Moglianetti, Riccardo Ferrando
Summary: The growth of pyramidal platinum nanocrystals is caused by the adsorption of hydrogen on {100} facets, which results in a peculiar type of symmetry breaking. The size-dependent adsorption energies of hydrogen atoms on {100} facets hinder the growth of pyramidal shapes only when they are sufficiently large. The absence of pyramidal nanocrystals in experiments without hydrogen confirms the crucial role of hydrogen adsorption.
Article
Chemistry, Analytical
Marco Costa, Sabrina Di Masi, Alvaro Garcia-Cruz, Sergey A. Piletsky, Cosimino Malitesta
Summary: Cadmium, a highly toxic heavy metal, accumulates in the body and causes a variety of acute and chronic effects including cancer. To address this, a portable and user-friendly electrochemical sensor for Cd(II) detection was developed using ion-imprinted polymer film. The sensor exhibited a sensitivity 5 orders of magnitude higher than the control experiments in a concentration range of 10 to 1200 nM of Cd (II). This technology has potential applications in water quality control and monitoring of heavy metals.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Tiziano Di Giulio, Amilcare Barca, Tiziano Verri, Marco De Gennaro, Gabriele Giancane, Elisabetta Mazzotta, Cosimino Malitesta
Summary: We report the electrosynthesis of a metallo-porphyrin-based molecularly imprinted polymer (MIP) as a new receptor for carnosine recognition. The MIP was designed to utilize the metal-ion mediated recognition through the chelation of carnosine with Zn(II) ions. The MIP showed high response specificity, stability, and selectivity in the detection of carnosine and other histidine-bearing molecules.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Elisabetta Mazzotta, Tiziano Di Giulio, Stefano Mariani, Martina Corsi, Cosimino Malitesta, Giuseppe Barillaro
Summary: Molecularly imprinted polymers (MIPs) have been synthesized in liquid phase, but their application in nanostructured materials is challenging due to limited diffusion of monomers. This study reports the vapor-phase synthesis of MIPs in nanostructures, utilizing a higher diffusion coefficient in vapor phase to overcome the diffusion limitations. As proof-of-concept, a vapor-phase deposited MIP-based optical sensor in nanostructured porous silicon oxide (PSiO2) is successfully demonstrated for label-free detection of human hemoglobin (HHb). The proposed vapor-phase synthesis of MIPs can be easily applied to other nanomaterials, proteins, and transducers.
Article
Chemistry, Physical
Giulia Siciliano, Antonio Turco, Anna Grazia Monteduro, Elisabetta Fanizza, Alessandra Quarta, Roberto Comparelli, Elisabetta Primiceri, M. Lucia Curri, Nicoletta Depalo, Giuseppe Maruccio
Summary: The removal of pollutants from water remains a challenge. Adsorption-based techniques, specifically polydopamine-coated magnetic nanoparticles, have shown promise for the removal of heavy metals. In this study, polydopamine-coated Super Paramagnetic Iron Oxide Nanoparticles (PDA@SPIONs) were synthesized and evaluated for their ability to bind and remove Cu2+ ions from water by applying a magnetic field. The results indicate that these nanostructures hold great potential for future bioremediation applications.
Article
Biochemistry & Molecular Biology
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta
Summary: This study investigated the therapeutic effects of multidrug-loaded lipid nanoemulsions in rescuing the pathological phenotype of CCM disease. The results showed that drug-loaded lipid nanoemulsions can rescue antioxidant responses, reactivate autophagy, and reduce the effect of pro-angiogenic factors better than the free drugs. This highlights the importance of developing a combinatorial preventive and therapeutic approach for CCM.
Article
Chemistry, Multidisciplinary
Francesco Rinaldi, Fabrizio Schipani, Beatrice Balboni, Federico Catalano, Roberto Marotta, Samuel H. Myers, Viola Previtali, Marina Veronesi, Luigi Scietti, Valentina Cecatiello, Sebastiano Pasqualato, Jose Antonio Ortega, Stefania Girotto, Andrea Cavalli
Summary: This study successfully developed a monomeric recombinant form of human RAD51 and identified the most suitable conditions to stabilize the monomer using different buffers. The monomer of human RAD51 provides a crucial biological tool for investigating RAD51-mediated homologous recombination and paves the way for more reliable studies on structure, mechanism, and drug discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Electrochemistry
Marilena Isabella Zappia, Valentina Mastronardi, Sebastiano Bellani, Yong Zuo, Gabriele Bianca, Luca Gabatel, Matteo Gentile, Ahmad Bagheri, Hossein Beydaghi, Filippo Drago, Michele Ferri, Mauro Moglianetti, Pier Paolo Pompa, Liberato Manna, Francesco Bonaccorso
Summary: Efficient and cost-effective water splitting electrolyzers are crucial for achieving climate neutrality. This study explores Pt-based nanostructured cathodes with graphene as a nanocatalyst support. The Pt/graphene catalysts outperform traditional Pt/C catalysts in terms of hydrogen evolution reaction (HER) activity and performance durability. This study demonstrates the potential of graphene as a conductive support for nanostructured cathodes and highlights the improved performance of alkaline electrolyzers.
ELECTROCHIMICA ACTA
(2023)
Article
Marine & Freshwater Biology
Gayatri Udayan, Maria Elena Giordano, Patrizia Pagliara, Maria Giulia Lionetto
Summary: This study aimed to investigate the effects of pharmaceuticals released into the environment on marine biota, specifically focusing on the effect of paracetamol on the motility of hemocytes in Mytilus galloprovincialis. The research found that paracetamol affected the motility behavior of hemocytes and the effects were specific to different cell types.
AQUATIC TOXICOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Edoardo Ragusa, Valentina Mastronardi, Deborah Pedone, Mauro Moglianetti, Pier Paolo Pompa, Rodolfo Zunino, Paolo Gastaldo
Summary: The introduction of POC devices is revolutionizing diagnostics, but their accuracy falls short compared to traditional laboratory-based methods. Automated readout using machine learning can significantly enhance the quality of POC analysis while maintaining portability and real-time results. This paper proposes the use of random-based neural networks to accurately assess salivary antioxidant levels and demonstrates their superiority through experiments.
ADVANCES IN SYSTEM-INTEGRATED INTELLIGENCE, SYSINT 2022
(2023)
