Article
Medicine, Research & Experimental
Liu Kai-xin, Cheng Cheng, Li Rui, Shi Zheng-wei, Tan Wen-wen, Xu Peng
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in cancer, with MAGI2-AS3 being a widely expressed lncRNA associated with cancer development and prognosis. Dysregulation of MAGI2-AS3 can affect cancer cell behaviors and treatment responses, making it a potential biomarker and therapeutic target for cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Chen Xue, Ganglei Li, Juan Lu, Jia Luo, Junjun Jia
Summary: MAGI2-AS3, a long non-coding RNA, is aberrantly expressed in solid tumors and has been shown to be correlated with patient clinical characteristics. It regulates multiple biological processes through target-gene regulation, making it a potential diagnostic biomarker and therapeutic target against solid tumors. Understanding the properties of MAGI2-AS3 may provide new insights into the diagnoses and treatments of solid tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Fei Liu, Wenwen Deng, Zhenda Wan, Dajin Xu, Jun Chen, Xin Yang, Jianhua Xu
Summary: This study found that MAGI2-AS3 was significantly downregulated in liver cancer tissues, and its overexpression reduced proliferation, invasion, and migration, while increasing apoptosis in Bel-7402 and Huh-7 cell lines. MAGI2-AS3 might serve as a potential therapeutic target for liver cancer through regulation of the miRNA-23a-3p/PTEN axis.
FOOD SCIENCE & NUTRITION
(2021)
Article
Geriatrics & Gerontology
Jingjing Zhang, Rui Wang
Summary: This study explored the regulatory effects of MAGI2-AS3 and miR-374b-5p on A beta-induced neurotoxicity and neuroinflammation in Alzheimer's disease. The findings suggest that the MAGI2-AS3/miR-374b-5p axis may serve as potential biomarkers and therapeutic targets for AD, as it can attenuate neuronal injury and inflammation. The expression levels of MAGI2-AS3 and miR-374b-5p were negatively correlated in AD patients and correlated with disease severity, highlighting their potential importance in AD pathogenesis.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Lv, Yin Wang, Yu Song, Shu-Sheng Wang, Kai-wen Cheng, Zhi-qing Zhang, Jin Yao, Li-na Zhou, Zhuo-yan Ling, Cong Cao
Summary: PINK1-AS promotes G alpha i1-driven gastric cancer progression by sponging miR-200a, while miR-200a directly silences G alpha i1 to induce anti-gastric cancer activity.
Article
Health Care Sciences & Services
Yiqing Chai, Lili Wang, Yanwen Qu, Zhixia Hu
Summary: This study investigated the functions of MAGI2-AS3 and miR-15b in cervical cancer and found that MAGI2-AS3 inhibits the proliferation and invasion of cervical cancer cells by regulating the expression of miR-15b. These results suggest that MAGI2-AS3 may serve as an important indicator for early diagnosis and prognosis assessment of cervical cancer.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Guo Yang, Ting Li, Jiayu Liu, Zhen Quan, Miao Liu, Yuan Guo, Yingying Wu, Liping Ou, Xiaohou Wu, Yongbo Zheng
Summary: Prostate cancer (PCa) is a common malignant cancer in elderly males in Western countries. Long non-coding RNAs (lncRNAs) are frequently altered in castration-resistant prostate cancer (CRPC) and promote drug resistance to cancer therapy. Elucidating the prospective role of lncRNAs in PCa oncogenesis and progression is of remarkable clinical significance.
Article
Biochemistry & Molecular Biology
Zhiwei Zhang, Yanli Yi, Zai Wang, Haoyun Zhang, Yanchun Zhao, Ruijing He, Yan Luo, Zhiqiang Cui
Summary: Using WGCNA, MEpurple and MEblack modules were found to be significantly negatively correlated with T stage in breast cancer (BRCA) patients. MAGI2-AS3 was identified as one of the differentially expressed (DE) lncRNAs with translational potential in MEblack and MEpurple modules in BRCA. The abundance of MAGI2-AS3 was significantly decreased in invasive BRCA patients and it had high diagnostic and prognostic values.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Toxicology
Tong-tong Zhang, Hai-peng Chen, Su-yang Yu, Shi-peng Zhao
Summary: In this study, HOXC-AS3 was found to be significantly downregulated in colorectal cancer tissues, while TGF-beta 2 was significantly upregulated. Low expression of HOXC-AS3 was closely associated with poor prognosis in CRC patients, and overexpression of HOXC-AS3 inhibited TGF-beta 2-induced CRC cell migration and invasion.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Renbao Hu, Pei Wu, Jianhui Liu
Summary: This study found that MAGI2-AS3 expression is decreased while miR-142-3p expression is increased in prostate cancer. MAGI2-AS3 is considered a diagnostic biomarker for prostate cancer and inhibits cancer progression by targeting miR-142-3p.
HORMONE AND METABOLIC RESEARCH
(2022)
Article
Cell & Tissue Engineering
Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu, Baoshan Wang
Summary: This study found that MAGI2 antisense RNA 3 (MAGI2-AS3) is downregulated in laryngeal squamous cell carcinoma (LSCC) and is associated with tumor stage and lymph node metastasis. The expression of MAGI2-AS3 is regulated by DNA methyltransferase 1 (DNMT1) through hypermethylation of the promoter region, and it inhibits the occurrence and progression of LSCC in an SPT6 binding-dependent manner.
CELL TRANSPLANTATION
(2023)
Article
Biotechnology & Applied Microbiology
Guanbo Wang, Hai Li, Yi Hou
Summary: ccRCC is the most common type of RCC in adults, characterized by hyper-vascularization and metastatic relapse, with surgical resection being the main treatment. This study identified the anti-angiogenic activity of MAGI2-AS3 in ccRCC, which exerts tumor-suppressive activities through modulation of the HEY1/ACY1 pathway.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xin Jun Wang, Si Li, Jiang Fang, Zhi Jian Yan, Guang Cheng Luo
Summary: In this study, it was found that the highly expressed FAM13A-AS1 in RCC patients promotes cell proliferation, migration, and invasion by interacting with miR-141-3p, thus contributing to tumorigenesis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Jiang Yu, Chengjin Li
Summary: In this study, the role of lncRNA MAGI2-AS3 in the pathogenesis of IDD was examined. The results showed that lncRNA MAGI2-AS3 can increase IL-10 expression levels by sponging miR-374b-5p, thereby alleviating decreased NP cell proliferation, increased apoptosis, inflammatory response, and ECM degradation induced by LPS. Therefore, lncRNA MAGI2-AS3 may be a potential therapeutic target for IDD.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Oncology
Huamei Wei, Qianli Tang, Anmin Wang, Ya Zhang, Zebang Qin, Wenchuan Li, Zuoming Xu, Jianchu Wang, Jian Pu
Summary: In this study, MAGI2-AS3 was found to inhibit HCC tumorigenesis through the miR-519c-3p/TXNIP axis both in vitro and in vivo. MAGI2-AS3 overexpression suppressed HCC tumor growth in vivo, highlighting its crucial role in HCC development. Additionally, MAGI2-AS3 serves as a ceRNA of miR-519c-3p to regulate TXNIP in HCC.
JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Juanli Ji, Weiguo Zhen, Yuan Si, Wenjing Ma, Lanlan Zheng, Chen Li, Yonghong Zhang, Shanshan Qin, Te Zhang, Pengfei Liu, Xin Zheng, Ying Liu
Article
Genetics & Heredity
Chen Li, Jia Li, Xiujuan Xiong, Ying Liu, Yanxia Lv, Shanshan Qin, Dandan Liu, Ronghua Wei, Xuzhi Ruan, Jingxuan Zhang, Liang Xu, Xuanbin Wang, Jicheng Chen, Yonghong Zhang, Lanlan Zheng
Article
Oncology
Lan Jin, Yuan Si, Xing Hong, Pengfei Liu, Beibei Zhu, Huiliang Yu, Xinhua Zhao, Shanshan Qin, Mengyuan Xiong, Ying Liu, Zhiguo Luo, Yang Guo
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Oncology
Dandan Li, Ping Cheng, Jingjie Wang, Xuemei Qiu, Xudong Zhang, Li Xu, Ying Liu, Shanshan Qin
FRONTIERS IN ONCOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jingjie Wang, Meixin Zhang, Xinhui Hu, Jiajun She, Ruonan Sun, Shanshan Qin, Dandan Li
Summary: MiR-194 acts as a prognostic biomarker in gastric cancer by targeting CCND1 to suppress cell growth.
Article
Biochemistry & Molecular Biology
Dandan Li, Jiajun She, Xinhui Hu, Meixin Zhang, Ruonan Sun, Shanshan Qin
Summary: The overexpression of lncRNA UBE2CP3 in gastric cancer promotes tumor progression through modulation of the miR-138-5p/ITGA2 axis. This suggests that UBE2CP3 may serve as a potential therapeutic target in gastric cancer.
Article
Cell Biology
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin
Summary: The abnormal expression of NR2F1-AS1 in gastric cancer is related to its correlation with NR2F1 expression, as well as their response to epithelial-to-mesenchymal transition signaling. NR2F1-AS1 modulates the miR-29a-3p/VAMP7 axis and plays a crucial role in the progression of gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Shanshan Qin, Zidi Wang, Congcong Huang, Pan Huang, Dandan Li
Summary: In this study, it was found that the serine protease PRSS23 promotes tumor-associated macrophage infiltration in gastric cancer by regulating the expression and secretion of FGF2, resulting in a poor prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Dandan Li, Li Shen, Xudong Zhang, Zhen Chen, Pan Huang, Congcong Huang, Shanshan Qin
Summary: This study reveals the SNAI2-ELF3-AS1 feedback loop that regulates the expression of ELF3 at transcriptional and post-transcriptional levels, driving gastric cancer metastasis by maintaining SNAI2 overexpression. Additionally, the study provides direct evidence that head-to-head antisense lncRNAs can share promoters with neighboring coding genes, resulting in high co-expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin
Summary: We found that IGFBP7 enhances the stability of oncogenic lncRNA UBE2CP3 by RNA-RNA interaction in gastric cancer. Clinical analysis demonstrated that IGFBP7 is associated with poor prognosis and macrophage infiltration in gastric cancer. Mechanistically, IGFBP7 promotes gastric cancer progression by regulating tumor-associated macrophage polarization through the FGF2/FGFR1/PI3K/AKT axis.
CELL DEATH DISCOVERY
(2023)
Review
Cell Biology
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin
Summary: Epithelial-mesenchymal transition (EMT) or mesenchymal-epithelial transition (MET) is important in cancer metastasis, and recent studies have shown that EMT is a heterogeneous and dynamic process with intermediary or partial EMT states. Multiple double-negative feedback loops involving EMT-related transcription factors (EMT-TFs) have been identified to regulate the EMT transition state of the cell. This review summarizes the characteristics, biomarkers, and molecular mechanisms of different EMT transition states, as well as the role of EMT transition state in tumor metastasis, with a focus on gastric cancer.
CELL PROLIFERATION
(2023)
Correction
Biochemistry & Molecular Biology
Dandan Li, Jiajun She, Xinhui Hu, Meixin Zhang, Ruonan Sun, Shanshan Qin
Article
Biochemistry & Molecular Biology
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin
Summary: In this study, PRSS56, a testis-specific serine protease, was identified as a novel cancer/testis antigen. PRSS56 was frequently overexpressed in various cancers, especially in gastrointestinal cancer. The expression of PRSS56 was associated with DNA methylation levels, and its decreased methylation led to overexpression in GC and CRC. Furthermore, PRSS56 activated the oncogenic PI3K/AKT signaling pathway in GC and CRC.
CELL AND BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Lingyun Xia, Tianshu Zhang, Juncheng Yao, Kaitian Lu, Ziqiu Hu, Xinsheng Gu, Yongji Chen, Shanshan Qin, Weidong Leng
Summary: Accumulating evidence suggests that overexpression of fibromodulin (FMOD) in oral squamous cell carcinoma promotes cancer cell proliferation and metastasis through activation of EGFR signaling pathway.
