Article
Biotechnology & Applied Microbiology
Cheng Wang, Peng Wang, Feng Li, Yang Li, Minwei Zhao, Hui Feng, Haoye Meng, Junyang Li, Peng Shi, Jiang Peng, Hua Tian
Summary: This study investigated the expression of miRNA-214 in human osteoporotic bone tissue and tested the utility of AAV expressing a miRNA-214 inhibitor in preventing local osteoporosis in a rat model. The results showed that miRNA-214 expression was significantly increased in osteoporotic bone tissue. Moreover, AAV-anti-miRNA-214 promoted osteoblast activity and inhibited osteoclast activity in the femoral condyles of osteoporotic rats, improving bone metabolism and slowing the progression of osteoporosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yoon-Hee Cheon, Chang Hoon Lee, Soojin Kim, Gyeong Do Park, Sung Chul Kwak, Hae Joong Cho, Ju-Young Kim, Myeung Su Lee
Summary: Pitavastatin shows potential as a candidate for treating osteoporosis by enhancing osteoblast differentiation and bone growth, as well as inhibiting osteoclast differentiation and bone resorption. Its mechanisms include inhibiting signaling pathways and downregulating transcription factors to regulate osteoclast activity, and stimulating osteoblast differentiation and mineralization to promote bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Orthopedics
Bo Liu, Feng Gao, Xiaofei Xiu, Tao Wu, Zeming Liu, Bingshi Zhang, Sikai Liu, Yongtai Han
Summary: This study demonstrates that denosumab has a positive effect in preventing femoral head collapse in patients with steroid-induced ONFH. It can improve the Harris hip score, relieve bone marrow edema, increase bone mineral density in the femoral head, and reduce the progression of osteosclerosis. Additionally, the protective mechanism of denosumab may be associated with the inhibition of osteoclasts and their autophagy.
ORTHOPAEDIC SURGERY
(2023)
Article
Multidisciplinary Sciences
Kai Nan, Jun-peng Pei, Li-hong Fan, Yuan-kai Zhang, Xin Zhang, Kang Liu, Zhi-bin Shi, Xiao-qian Dang, Kun-zheng Wang
Summary: Resveratrol can reverse abnormal osteogenesis/osteoclastogenesis activity by upregulating miR-146a and stabilizing osteogenesis/osteoclastogenesis homeostasis through Wnt/FOXO and Sirt1/NF-κB pathways.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Cell Biology
Hyun Jin Kim, Jiae Lee, Gong-Rak Lee, Narae Kim, Hye In Lee, Minjeong Kwon, Nam Young Kim, Jin Ha Park, Ye Hee Kang, Hyeong Ju Song, TaeSoo Kim, Dong Min Shin, Woojin Jeong
Summary: FN inhibits osteoclastogenesis by blocking CaMKIV and calcineurin, reducing the risk of bone diseases like osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Food Science & Technology
Ilandarage Menu Neelaka Molagoda, Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Eui Kyun Park, Yung Hyun Choi, You-Jin Jeon, Gi-Young Kim
Summary: This study evaluated the osteogenic potential of gamma aminobutyric acid-enriched fermented oyster extract (FO) on prednisolone-induced bone resorption. The results showed that FO can restore osteogenic activity and improve osteoblast markers in MC3T3-E1 preosteoblast cells and zebrafish larvae. Additionally, FO also restored vertebral resorption induced by prednisolone in zebrafish larvae, along with downregulation of osteoclastogenic markers. Importantly, FO did not disturb the endocrine system.
Article
Biochemistry & Molecular Biology
Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Jeong-Tae Koh, Nacksung Kim
Summary: ATF3 regulates the differentiation of various cell types in the bone microenvironment, including osteoblasts, osteoclasts, and adipocytes, by inducing OPG production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
You-Jin Jo, Hye In Lee, Narae Kim, Donghyun Hwang, Jiae Lee, Gong-Rak Lee, Seong-Eun Hong, Hana Lee, Minjeong Kwon, Nam Young Kim, Hyun Jin Kim, Jin Ha Park, Ye Hee Kang, Han Sung Kim, Soo Young Lee, Woojin Jeong
Summary: Studies have shown that Cinchonine inhibits osteoclast differentiation by regulating TAK1 to suppress NFATc1 and PGC1 beta, leading to the suppression of osteoclast differentiation and promotion of osteoblast differentiation. Furthermore, Cinchonine exhibits potential therapeutic effects in mouse models of inflammation-induced bone diseases and postmenopausal osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Jian Zhang, Jiangmei Wu
Summary: This article discusses the role of exosomal miR-214 in bone metastasis of lung adenocarcinoma, suggesting that exosomal miR-214 may disrupt bone homeostasis by enhancing bone resorption, leading to bone metastasis. Furthermore, exosomal miR-214 facilitates intercellular communication between lung adenocarcinoma cells and osteoclasts, promoting the colonization and proliferation of cancer cells in the bone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Orthopedics
Zhen Guo, Jing Li, Jiyong Tan, Sainan Sun, Qing Yan, Hao Qin
Summary: Osteoporosis is a common bone disease that increases the risk of fracture. Through experiments, it has been found that exosomes secreted by senescent osteoblasts can accelerate endothelial cell senescence through the miR-214-3p/L1CAM pathway. This study reveals the role of exosomes in the skeletal microenvironment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
Yan Xie, Jie Zhou, Lijie Tian, Yuan Dong, Hairui Yuan, Endong Zhu, Xiaoxia Li, Baoli Wang
Summary: miR-196b-5p plays a role in various malignancies and has been found to affect bone cells and bone homeostasis by inhibiting osteoblast differentiation and regulating the Wnt/beta-catenin signaling pathway. Inhibition of miR-196b-5p can reduce ovariectomy-induced bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Plant Sciences
Xuanqing Chen, Tingting Xu, Xiangyu Lv, Jingwei Zhang, Shijia Liu
Summary: The study found that Rh2 exhibits potential application value in the treatment of ulcerative colitis (UC), and its mechanism is related to the downregulation of STAT3/miR-214 levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Orthopedics
Zeqing Huang, Taixian Li, Na Lin, Quanjun Cui, Weiheng Chen
Summary: This article introduces a new X-ray scoring system, the Beijing University of Chinese Medicine X-ray evaluation (BUCMXE), which allows for objective evaluation and comparison of radiographic outcomes following joint-preserving treatments for osteonecrosis of the femoral head. The scoring system is based on three domains: femoral head morphology, osteonecrotic lesion, and degree of osteoarthritis, and provides a clear and reproducible means of quantifying and communicating radiographic changes over the course of follow-up.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Critical Care Medicine
Qiang Song, Hai-Ming Yong, LV-Lin Yang, Yu-Qi Liang, Ze-Xin Liu, Dong-Sheng Niu, Zhi-Gang Bai
Summary: The study showed that Lycium barbarum polysaccharide can reduce glucocorticoid-induced osteonecrosis of the femoral head in rats, promote the proliferation and osteoblast differentiation of bone marrow-derived mesenchymal stem cells in a dose-dependent manner, and have therapeutic potential.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Cell Biology
Yangquan Hao, Chao Lu, Baogang Zhang, Zhaochen Xu, Hao Guo, Gaokui Zhang
Summary: The study revealed that CircPVT1 expression is decreased in SIONFH rats and GC-treated BMSCs, while miR-21-5p is up-regulated. Overexpression of CircPVT1 can attenuate GC-induced apoptosis and cell viability inhibition in BMSCs, while upregulation of miR-21-5p has the opposite effects.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Jian Zhang, Wenjing Xu, Chaochao Li, Fanqi Meng, Yanjun Guan, Xiuzhi Liu, Jie Zhao, Jiang Peng, Yu Wang
Summary: Microtissue, formed by the aggregation of seed cells, has characteristics similar to natural tissues and can promote cell proliferation and differentiation. It protects cells from adverse factors, improves cell survival rate, and enhances the therapeutic effect of tissue-engineered grafts. Researchers have made significant progress in tissue engineering microtissues, though practical conditions, advantages, and disadvantages still need further elucidation.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li
Summary: The study reveals that the 3' UTR of Ckip-1 mRNA in cardiomyocytes can independently inhibit cardiac hypertrophy, protect the heart against pathological cardiac hypertrophy by promoting fatty acid metabolism through the AMPK-PPAR alpha-CPT1b axis, and significantly alleviate cardiac hypertrophy and improve heart function through RNA therapy.
EUROPEAN HEART JOURNAL
(2021)
Article
Engineering, Biomedical
Qi Quan, Lei Hong, Yu Wang, Rui Li, Xin Yin, Xiaoqing Cheng, Guangbo Liu, He Tang, Haoye Meng, Shuyun Liu, Quanyi Guo, Biqin Lai, Qing Zhao, Min Wei, Jiang Peng, Peifu Tang
Summary: Hypoxia in damaged tissues may play a key role in stimulating macrophages, promoting endothelial-to-mesenchymal transition, and driving the migration of endothelial cells to the injured region to form regenerative bridge tissue. The final nerve defect repair outcomes were similar with autografts after intervention by this material, challenging the view that hypoxia is exclusively involved in peripheral nerve regeneration.
Article
Cell & Tissue Engineering
Yanjun Guan, Boyao Yang, Wenjing Xu, Dongdong Li, Sidong Wang, Zhiqi Ren, Jian Zhang, Tieyuan Zhang, Xiuzhi Liu, Junyang Li, Chaochao Li, Fanqi Meng, Feng Han, Tong Wu, Yu Wang, Jiang Peng
Summary: The involvement of cell-derived extracellular matrix (CDM) in tissue engineering scaffolds shows great potential. CDM provides an ideal microenvironment for stem cell culture and differentiation. In addition, CDM-assembled tissue engineering scaffolds have comprehensive applications in disease simulation and tissue organ repair.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Cell & Tissue Engineering
Jian Zhang, Chaochao Li, Fanqi Meng, Yanjun Guan, Tieyuan Zhang, Boyao Yang, Zhiqi Ren, Xiuzhi Liu, Dongdong Li, Jinjuan Zhao, Jie Zhao, Yu Wang, Jiang Peng
Summary: The study found that tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. Microtissues can secrete more nerve regeneration related cytokines to promote cell proliferation and axon growth, and can effectively repair nerve defects.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Weimin Guo, Mingxue Chen, Zhenyong Wang, Yue Tian, Jinxuan Zheng, Shuang Gao, Yangyang Li, Yufeng Zheng, Xu Li, Jingxiang Huang, Wei Niu, Shuangpeng Jiang, Chunxiang Hao, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Zehao Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Libo Hao, Xifu Zheng, Shuyun Liu, Quanyi Guo
Summary: By utilizing decellularized meniscal extracellular matrix and 3D-printed polycaprolactone scaffolds, meniscus regeneration can be promoted effectively, as evidenced by promising results in rabbit and sheep models, indicating potential clinical applications.
BIOACTIVE MATERIALS
(2021)
Article
Orthopedics
Yuxuan Zhang, Tao Lin, Haoye Meng, Xueting Wang, Hong Peng, Guangbo Liu, Shuai Wei, Qiang Lu, Yu Wang, Aiyuan Wang, Wenjing Xu, Huiping Shao, Jiang Peng
Summary: This study successfully prepared a 3D gel-printed DCPD-coated porous magnesium scaffold and evaluated its biocompatibility, degradation rate, and osteogenic ability in vitro and in vivo. The results showed that the scaffold has great potential as a bone graft alternative.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Review
Cell Biology
Junhao Deng, Fanqi Meng, Kexue Zhang, Jianpeng Gao, Zhongyang Liu, Ming Li, Xiao Liu, Jiantao Li, Yu Wang, Licheng Zhang, Peifu Tang
Summary: Microglia play a crucial role in the pathophysiological process of spinal cord injury, acting as both protectors and potential exacerbators. The effects of microglia depletion on spinal cord injury repair are still unclear, and the strategies and timing of microglia depletion greatly impact outcomes. Short-term depletion seems to promote tissue repair and functional improvement, while sustained microglial depletion worsens injury and hampers recovery.
Article
Neurosciences
Xiangling Li, Tieyuan Zhang, Chaochao Li, Wenjing Xu, Yanjun Guan, Xiaoya Li, Haofeng Cheng, Shengfeng Chen, Boyao Yang, Yuli Liu, Zhiqi Ren, Xiangyu Song, Zhibo Jia, Yu Wang, Jinshu Tang
Summary: Low-frequency electrical stimulation (ES) promotes nerve regeneration by accelerating Wallerian degeneration (WD) and upregulating the expression of neurotrophic factors, leading to accelerated early axonal and vascular regeneration while delaying muscle atrophy.
Article
Nanoscience & Nanotechnology
Yu Wei, Xing Yun, Yanjun Guan, Shunze Cao, Xiangling Li, Yu Wang, Haoye Meng, Yujie Liu, Qi Quan, Min Wei
Summary: This study developed a biodegradable polycaprolactone scaffold with Wnt3a protein delivery to improve tendon healing in a rat model of Achilles tendon defect. The results showed that the Wnt3a scaffold promoted the polarization of M2 macrophages, increased their recruitment and proportion, and improved tendon function and mechanical properties. This work highlights the beneficial role of local delivery of biological factors in directing inflammatory responses toward regenerative strategies in tendon healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xueying Huang, Hanqing Hou, Bingbing Yu, Jun Bai, Yanjun Guan, Liu Wang, Kuntao Chen, Xibo Wang, Pengcheng Sun, Yuping Deng, Shangbin Liu, Xue Cai, Yu Wang, Jiang Peng, Xing Sheng, Wei Xiong, Lan Yin
Summary: This article proposes a fully biodegradable primary zinc-molybdenum (Zn-Mo) battery system with a prolonged functional lifetime of up to 19 days and desirable energy capacity and output voltage compared with reported primary Zn biobatteries. The Zn-Mo battery system has excellent biocompatibility and biodegradability and can significantly promote Schwann cell proliferation and the axonal growth of dorsal root ganglia. This research is of great importance for the development of high-performance biodegradable primary batteries to achieve a fully bioresorbable electronic platform for innovative medical treatments.
Article
Biochemistry & Molecular Biology
Shuai Wei, Yu Wang, Yu Sun, Leilei Gong, Xiu Dai, Haoye Meng, Wenjing Xu, Jianxiong Ma, Qian Hu, Xinlong Ma, Jiang Peng, Xiaosong Gu
Summary: Compared with most nondegradable or slowly degradable bone repair materials, bioactive biodegradable porous scaffolds with certain mechanical strengths can promote the regeneration of both new bone and vasculature while the cavity created by their degradation can be replaced by the infiltration of new bone tissue. A three-dimensional porous biomimetic composite scaffold with a two-component SF-MC system was constructed based on the advantages of mineralized collagen (MC) and silk fibroin (SF). The SF-MC scaffold showed good osteogenic induction and cell proliferation abilities, and in vivo experiments confirmed its efficacy in stimulating vascular and bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Yanjun Guan, Zhiqi Ren, Boyao Yang, Wenjing Xu, Wenjun Wu, Xiangling Li, Tieyuan Zhang, Dongdong Li, Shengfeng Chen, Jun Bai, Xiangyu Song, Zhibo Jia, Xing Xiong, Songlin He, Chaochao Li, Fanqi Meng, Tong Wu, Jian Zhang, Xiuzhi Liu, Haoye Meng, Jiang Peng, Yu Wang
Summary: Autologous nerve grafting is the gold standard treatment for peripheral nerve defects, but its limited availability and donor area destruction restrict its widespread use. Tissue-engineered neural regeneration materials have been developed, and in this study, a modified poly-caprolactone/silk fibroin material with extracellular matrix (ECM) derived from human umbilical cord mesenchymal stem cells (hUMSCs) was successfully fabricated. The biomimetic material showed excellent biological properties, supporting Schwann cell anchorage, axon regeneration, and angiogenesis processes. Additionally, the dual-bionic material bridged peripheral nerve defects in rats similarly to autologous nerve transplantation. This study provides a new concept for designing neural regeneration materials with potential clinical applications.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Shuai Wei, Qian Hu, Jianxiong Ma, Xiu Dai, Yu Sun, Gonghai Han, Haoye Meng, Wenjing Xu, Lei Zhang, Xinlong Ma, Jiang Peng, Yu Wang
Summary: Compared to conventional artificial nerve guide conduits, acellular nerve grafts derived from natural nerves have natural advantages. In this study, a composite technology based on supercritical carbon dioxide was used to process the peripheral nerve of a large mammal and obtain acellular nerve xenografts. The extracted grafts showed improved cell adhesion and proliferation, reduced inflammatory response, and promoted nerve regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Xiao-Qing Cheng, Wen-Jing Xu, Xiao Ding, Gong-Hai Han, Shuai Wei, Ping Liu, Hao-Ye Meng, Ai-Jia Shang, Yu Wang, Ai-Yuan Wang
Summary: This study investigated the dynamic expression of cytokines in the distal nerve stumps after peripheral nerve injury using protein microarray analysis, revealing distinct patterns between proximal and distal nerve stumps. Distal stumps showed increased expression of interleukins and proteins related to inflammatory and apoptotic responses, while proximal stumps mainly upregulated growth factors. The findings suggest potential therapeutic targets and may advance clinical treatments for peripheral nerve injury.
NEURAL REGENERATION RESEARCH
(2021)