期刊
MINERALS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/min10020172
关键词
hydrotalcite; nanohybrids; layered double hydroxide; biomedical; therapy; bio-imaging
资金
- National Research Foundation of Korea (NRF) - the Korean government (MSIT) [NRF-2019R1G1A1006582]
- National Research Foundation of Korea [21A20130011104] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Biocompatible hydrotalcite nanohybrids, i.e., layered double hydroxide (LDH) based nanohybrids have attracted significant attention for biomedical functions. Benefiting from good biocompatibility, tailored drug incorporation, high drug loading capacity, targeted cellular delivery and natural pH-responsive biodegradability, hydrotalcite nanohybrids have shown great potential in drug/gene delivery, cancer therapy and bio-imaging. This review aims to summarize recent progress of hydrotalcite nanohybrids, including the history of the hydrotalcite-like compounds for application in the medical field, synthesis, functionalization, physicochemical properties, cytotoxicity, cellular uptake mechanism, as well as their related applications in biomedicine. The potential and challenges will also be discussed for further development of LDHs both as drug delivery carriers and diagnostic agents.
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