Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ramon A. Lujan, Sophia M. Vrba, Heather D. Hickman
Summary: Before the adaptive immune response, innate antiviral cells, including conventional natural killer cells (cNK) and tissue-resident ILCs (ILC1s), respond to a wide range of viruses to limit replication and virus-induced pathology. While cNK cells lyse virus-infected cells, ILC1s respond with the production of antiviral cytokines and can even induce an antiviral state in uninfected tissue. Mounting evidence suggests that ILC1s may have enhanced secondary responses to viral infections.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hobin Seo, Amisha Verma, Megan Kinzel, Qiutong Huang, Douglas J. J. Mahoney, Nicolas Jacquelot
Summary: Reinvigorating the killing function of tumor-infiltrating immune cells through targeting regulatory molecules has improved the prognosis of cancer patients. Recent investigations suggest that tissue-resident innate lymphoid cells (ILCs), in addition to T lymphocytes, can benefit from immunotherapy. This article discusses the expression of immune checkpoint on ILCs and how their effector function is modulated by checkpoint blockade-based therapies, exploring potential to impede tumor growth and disease progression.
Review
Immunology
Zhengzheng Shi, Hiroshi Ohno, Naoko Satoh-Takayama
Summary: Innate lymphoid cells (ILCs) are a group of innate immune cells with significant functions in mediating immune responses, protecting mucosal barrier integrity and maintaining tissue homeostasis. Emerging evidence shows that dietary micronutrients can modulate immune responses through ILCs and affect human health. Micronutrients control the development and proliferation of ILCs and play important roles in resolving local inflammation in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Prakash Sah, Lauren A. Zenewicz
Summary: Innate lymphoid cells (ILCs) play important roles in maintaining tissue homeostasis, regulating inflammation, and immune responses to infections. They respond quickly to environmental cues and are enriched at barrier surfaces, such as the gastrointestinal (GI) tract, where they are critical in eliminating pathogens. Pathogenic bacteria, however, can manipulate these immune responses to their advantage, affecting the host's immune defense and microbiota. This review discusses the recent progress in understanding the role of ILCs during enteric bacterial infections, the mechanisms by which pathogens modulate the immune response, and the implications for developing new therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Urology & Nephrology
Ruifeng Wang, Yiping Wang, David C. H. Harris, Qi Cao
Summary: Innate immune cells, including a newly discovered group of innate lymphoid cells (ILCs), play critical roles in kidney diseases by providing immunomodulatory cytokines and guiding immune responses. Understanding the function of ILCs in normal and diseased kidneys emphasizes the emerging importance of ILC-regulated immunity for future research and therapeutic interventions.
KIDNEY INTERNATIONAL
(2021)
Article
Allergy
Andrzej Eljaszewicz, Fiorella Ruchti, Urszula Radzikowska, Anna Globinska, Tadech Boonpiyathad, Anna Gschwend, Hideaki Morita, Arthur Helbling, Stefania Arasi, Helga Kahlert, Nadine Berek, Andreas Nandy, Mubeccel Akdis, Christoph Willers, Marcin Moniuszko, Cezmi A. Akdis, Milena Sokolowska
Summary: This study found that AIT treatment can induce changes in the composition and heterogeneity of circulating innate immune cells, bringing them to the level observed in healthy individuals. Monitoring of ILCs, monocytes, and DCs during AIT may serve as a novel biomarker strategy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Giacomo Della Camera, Mariusz Madej, Anna Maria Ferretti, Rita La Spina, Yang Li, Annunziata Corteggio, Tommaso Heinzl, Benjamin J. Swartzwelter, Gergo Sipos, Sabrina Gioria, Alessandro Ponti, Diana Boraschi, Paola Italiani
Summary: This study found that nanoparticles used for diagnostic imaging, such as gold and iron oxide nanoparticles, can induce or modulate innate memory in human primary monocytes. The effects on innate memory were found to be donor-dependent, suggesting personalized profiling would be needed to predict the impact of imaging nanoparticles on patients' innate immune reactivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Douglas C. Chung, Nicolas Jacquelot, Maryam Ghaedi, Kathrin Warner, Pamela S. Ohashi
Summary: This review highlights the immunosuppressive roles of innate lymphoid cells (ILCs) in cancer. ILCs inhibit anti-tumour immune response through various mechanisms and impact tumour progression. The review also discusses the history and challenges in defining immunosuppressive ILCs.
Article
Immunology
Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Domenico Mallardo, Marilena Tuffanelli, Vito Vanella, Marta Greco, Daniela Patrizia Foti, Giuseppe Viglietto, Paolo Antonio Ascierto, Hergen Spits, Ennio Carbone
Summary: Monoclonal antibodies targeting immune checkpoints have shown improved clinical outcomes for patients with malignant melanoma, but the underlying mechanisms are not fully understood. This study investigated the effects of immune checkpoint inhibitors on innate lymphoid cells (ILCs) and the impact of melanoma cells on ILC functions. The findings suggest that PD-1 blockade can affect the proportions and functions of ILCs in melanoma patients, and specific subpopulations are associated with treatment response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Laurence S. C. Lok, Jennifer A. Walker, Helen E. Jolin, Seth T. Scanlon, Masaru Ishii, Padraic G. Fallon, Andrew N. J. McKenzie, Menna R. Clatworthy
Summary: ILC2s are crucial early effectors of mucosal type 2 immunity, producing IL-13 in lymphoid organs. In vivo imaging showed that ILC2s increase in size and movement after helminth infection, with increased interactions with T cells in the intestinal mucosa.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Nicolas Jacquelot, Maryam Ghaedi, Kathrin Warner, Douglas C. Chung, Sarah Q. Crome, Pamela S. Ohashi
Summary: Immune checkpoints play a crucial role in regulating the immune system and are targeted in antibody-based therapies for improving T cell cytotoxic function in malignancies. These checkpoints are also expressed on innate lymphoid cells, leading to interest in understanding their function and potential for immunotherapy in anti-tumor immunity. Additional research focuses on the specificities and migration potential of ILC at different tissue sites, as well as strategies for modulating ILC as part of anti-cancer treatment.
Review
Immunology
Bernd Heinrich, Firouzeh Korangy
Summary: Innate lymphoid cells (ILCs) are a heterogeneous population of the innate immune system that play a crucial role in maintaining immune homeostasis. They exhibit high plasticity, allowing them to quickly respond to changes in their microenvironment. ILCs can transdifferentiate into different subsets in the tumor microenvironment, influencing the immune response and tumor therapy. This review summarizes the functional and plastic heterogeneity of ILCs in homeostasis and disease, with a focus on tumor-driven plasticity and the impact of ILC-induced inflammation on the tumor microenvironment and anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Leonore Mensching, Angelique Hoelzemer
Summary: This article discusses the role of NK cells and monocytes/macrophages in HIV-1 infection, as well as aspects of innate immune crosstalk in viral infections relevant to HIV-1 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anna Guiomar Ferrete-Bonastre, Josefina Cortes-Hernandez, Esteban Ballestar
Summary: Multiple studies have established the presence of epigenetic alterations, specifically DNA methylation changes, in lupus over the past twenty years. These changes may have varying contributions in pediatric and adult-onset lupus. Although DNA methylation alterations related to disease activity, different lupus subtypes, and drug responses have been identified, practical applications in clinical settings are still lacking.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Octavio Morante-Palacios, Laura Ciudad, Raphael Micheroli, Carlos de la Calle-Fabregat, Tianlu Li, Gisela Barbisan, Miranda Houtman, Sam G. Edalat, Mojca Frank-Bertoncelj, Caroline Ospelt, Esteban Ballestar
Summary: The study revealed that MAFB plays a critical role in the acquisition of tolerogenic properties in DCs in synergy with GR. MAFB interacts with TET2 and binds to genomic loci involved in the demethylation process in tolDCs. Knockdown of MAFB abolishes the tolerogenic properties of tolDCs, reversing the specific DNA demethylation and gene upregulation.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Neurosciences
Ricardo Martins-Ferreira, Barbara Leal, Joao Chaves, Tianlu Li, Laura Ciudad, Rui Rangel, Agostinho Santos, Antonio Martins da Silva, Paulo Pinho Costa, Esteban Ballestar
Summary: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common focal epilepsy in adults, characterized by high rates of drug resistance. Epileptogenesis in MTLE-HS is associated with epigenetic alterations, with previous studies mainly focused on the hippocampus. This study examines DNA methylation profiles in both the hippocampus and anterior temporal neocortex of MTLE-HS patients, showing altered DNA methylation patterns in multiple pathways related to epileptogenesis. The neocortex, which has less histopathological damage, also shows significant DNA methylation changes, suggesting its involvement in epilepsy development. These findings suggest a progressive wave of epigenetic dysregulation associated with inflammation-related genes in MTLE-HS.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Cell Biology
Francesc Catala-Moll, Anna G. Ferrete-Bonastre, Gerard Godoy-Tena, Octavio Morante-Palacios, Laura Ciudad, Laura Barbera, Federico Fondelli, Eva M. Martinez-Caceres, Javier Rodriguez-Ubreva, Tianlu Li, Esteban Ballestar
Summary: Vitamin D induces a tolerogenic phenotype in dendritic cells through the interaction of VDR, STAT3, and TET2, providing possibilities for modulating DC immunogenic properties.
Article
Multidisciplinary Sciences
Javier Rodriguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucia Del Pino-Molina, Stephen J. Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-Francois Handfield, Laura Ciudad, Eduardo Andres-Leon, Felix Krueger, Francesc Catala-Moll, Virginia C. Rodriguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu Kiselev, Maria T. Martinez-Saavedra, Holger Heyn, Javier Martin, Klaus Warnatz, Eduardo Lopez-Granados, Carlos Rodriguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Summary: In this study, single-cell omics analyses were performed in CVID-discordant monozygotic twins, revealing epigenetic and transcriptional alterations associated with activation in memory B cells. These findings provide valuable insights into the diagnosis and treatment of CVID patients.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Gerard Godoy-Tena, Esteban Ballestar
Summary: Dendritic cells (DCs) are professional antigen-presenting cells that can be improved in cancer immunotherapy by epigenetic regulation.
Article
Biochemistry & Molecular Biology
Octavio Morante-Palacios, Gerard Godoy-Tena, Josep Calafell-Segura, Laura Ciudad, Eva M. Martinez-Caceres, Jose Luis Sardina, Esteban Ballestar
Summary: This study investigates the epigenomic and transcriptomic reprogramming induced by vitamin C in monocyte-derived dendritic cell (DC) differentiation and maturation. Vitamin C triggers extensive demethylation and upregulation of antigen-presentation and immune response-related genes during DC maturation. It also enhances TNF beta production in DCs and improves their ability to stimulate antigen-specific T cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Genetics & Heredity
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-fabregat, Ricardo Martins-Ferreira, Anna G. Ferrete-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartin, Monica Martinez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodriguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Summary: Peripheral blood monocytes in severe COVID-19 patients undergo epigenetic and transcriptional reprogramming during hyperinflammatory responses, which may be associated with the release of aberrant immune cells, increased systemic levels of pro-inflammatory cytokines, and changes in immune cell crosstalk.
Article
Immunology
Anis Barmada, Louis-Francois Handfield, Gerard Godoy-Tena, Carlos de la Calle-Fabregat, Laura Ciudad, Anna Arutyunyan, Eduardo Andres-Leon, Regina Hoo, Tarryn Porter, Agnes Oszlanczi, Laura Richardson, Fernando J. Calero-Nieto, Nicola K. Wilson, Domenica Marchese, Carmen Sancho-Serra, Jorge Carrillo, Silvia Presas-Rodriguez, Cristina Ramo-Tello, Adolfo Ruiz-Sanmartin, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Monica Martinez-Gallo, Monica Munera-Campos, Jose Manuel Carrascosa, Berthold Gottgens, Holger Heyn, Elena Prigmore, Ivette Casafont-Sole, Xavier Solanich, Ildefonso Sanchez-Cerrillo, Isidoro Gonzalez-Alvaro, Maria Gabriella Raimondo, Andreas Ramming, Javier Martin, Eva Martinez-Caceres, Esteban Ballestar, Roser Vento-Tormo, Javier Rodriguez-Ubreva
Summary: In COVID-19, patients with pre-existing autoimmune conditions experience disturbed immune responses to SARS-CoV-2 infection, which have important implications for disease treatment and follow-up.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Javier Rodriguez-Ubreva, Celia L. Calvillo, Lisa R. Forbes Satter, Esteban Ballestar
Summary: This article discusses inborn errors of immunity (IEIs) with mutations in transcription factors that interact with epigenetic enzymes. Epigenetic alterations can occur through the activation of cellular pathways and genetic-associated changes, affecting epigenetic enzymes or their interactors, along with genetic defects, as the etiology of the disease. This study provides insights into the genetic and epigenetic mechanisms in IEIs.
TRENDS IN IMMUNOLOGY
(2023)
Review
Immunology
Fan Xiao, Ke Rui, Xiaofei Shi, Haijing Wu, Xiaoyan Cai, Kathy O. Lui, Qianjin Lu, Esteban Ballestar, Jie Tian, Hejian Zou, Liwei Lu
Summary: B cells play a crucial role in autoimmune diseases, and epigenetic research has revealed new mechanisms leading to B cell hyperactivation. Dysregulation of epigenetic mechanisms may contribute to the pathogenesis of autoimmune diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Rheumatology
Elkyn Estupinan-Moreno, Lourdes Ortiz-Fernandez, Tianlu Li, Jose Hernandez-Rodriguez, Laura Ciudad, Eduardo Andres-Leon, Laura Carmen Terron-Camero, Sergio Prieto-Gonzalez, Georgina Espigol-Frigole, Maria Cinta Cid, Ana Marquez, Esteban Ballestar, Javier Martin
Summary: This study analyzed the methylation and transcriptome of monocytes from GCA patients, revealing global dysregulation in methylation and gene expression in GCA monocytes. Active patients showed a more proinflammatory phenotype, and a new pathway involving IL-11 response was identified as potentially implicated in GCA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)