Protective Effect of Stachydrine Against Cerebral Ischemia-Reperfusion Injury by Reducing Inflammation and Apoptosis Through P65 and JAK2/STAT3 Signaling Pathway

Stachydrine prevents LPS‐induced bone loss by inhibiting osteoclastogenesis via NF‐κB and Akt signalling

(2019) Jiahong Meng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Atractylenolide III ameliorates cerebral ischemic injury and neuroinflammation associated with inhibiting JAK2/STAT3/Drp1-dependent mitochondrial fission in microglia

(2019) Kecheng Zhou et al.   PHYTOMEDICINE

The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury

(2019) Tom Leech et al.   PHARMACOLOGICAL RESEARCH

Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine

(2018) Xinya Xie et al.   MOLECULAR MEDICINE

Study on the mechanism of JAK2/STAT3 signaling pathway-mediated inflammatory reaction after cerebral ischemia

(2018) Yuquan Wu et al.   Molecular Medicine Reports

Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation

(2018) Eman M. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phytochemistry and pharmacology of the genus Leonurus : The herb to benefit the mothers and more

(2018) Rui-Han Zhang et al.   PHYTOCHEMISTRY

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

(2018) Renxu Chang et al.   Nature Communications

Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats

(2017) Lingling Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The role of succinate and ROS in reperfusion injury – A critical appraisal

(2017) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NF-κB and JAK–STAT Pathway

(2017) Qasim Alhadidi et al.   MOLECULAR NEUROBIOLOGY

The influence of stachydrine hydrochloride on the reperfusion model of mice with repetitive cerebral ischemia

(2017) Mingsan Miao et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Very Early versus Delayed Rehabilitation for Acute Ischemic Stroke Patients with Intravenous Recombinant Tissue Plasminogen Activator: A Nationwide Retrospective Cohort Study

(2016) Ryo Momosaki et al.   CEREBROVASCULAR DISEASES

MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2

(2016) Qiuzhen Zhu et al.   PLoS One

ROS act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain

(2015) Xue Wei et al.   NEUROTOXICOLOGY

Animal models of ischemic stroke and their application in clinical research

(2015) Christoph Kleinschnitz et al.   Drug Design Development and Therapy

Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling

(2014) Xi Kuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin Inhibits TLR2/4-NF-κB Signaling Pathway and Attenuates Brain Damage in Permanent Focal Cerebral Ischemia in Rats

(2014) Xian-kun Tu et al.   INFLAMMATION

An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: Up-regulation of Bcl-2 and down-regulation of Bax and caspase-3

(2014) Guo-Hua Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

SH2B1  Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation

(2014) Y.-J. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Behavior outcome after ischemic and hemorrhagic stroke, with similar brain damage, in rats

(2013) Régis Gemerasca Mestriner et al.   BEHAVIOURAL BRAIN RESEARCH

Executive Summary: Heart Disease and Stroke Statistics—2013 Update

(2013) Alan S. Go et al.   CIRCULATION

Stachydrine ameliorates high-glucose induced endothelial cell senescence and SIRT1 downregulation

(2013) Luigi Servillo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed Tissue Plasminogen Activator Treatment in a Mouse Thromboembolic Model

(2013) Francisco Campos et al.   STROKE

Chinese Medicine Neuroaid Efficacy on Stroke Recovery: A Double-Blind, Placebo-Controlled, Randomized Study

(2013) C. L. H. Chen et al.   STROKE

The Role of TNF-α 308G>A Polymorphism in the Risk for Ischemic Stroke

(2012) Lian Gu et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Loss of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling during Elevated Activity Causes Vulnerability in Hippocampal Neurons

(2012) S. Murase et al.   JOURNAL OF NEUROSCIENCE

A Pentapeptide Monocyte Locomotion Inhibitory Factor Protects Brain Ischemia Injury by Targeting the eEF1A1/Endothelial Nitric Oxide Synthase Pathway

(2012) Yuefan Zhang et al.   STROKE

Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases

(2011) Xin H Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemical shift sodium imaging in a mouse model of thromboembolic stroke at 9.4 T

(2011) Patrick M. Heiler et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation

(2011) Hongyi Qi et al.   NEUROPHARMACOLOGY

Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells

(2010) Manush Saydmohammed et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Leonurine Protects Middle Cerebral Artery Occluded Rats Through Antioxidant Effect and Regulation of Mitochondrial Function

(2010) Kok Poh Loh et al.   STROKE

Cerebral protection of purified Herba Leonuri extract on middle cerebral artery occluded rats

(2009) Kok Poh Loh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL