FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

Fibroblast Growth Factors in Depression

(2019) Zheng Deng et al.   Frontiers in Pharmacology

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

(2019) Tahir Muhammad et al.   Nutrients

Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice

(2019) E.H. Taniguti et al.   BRAIN RESEARCH BULLETIN

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

(2019) Li-Ting Guo et al.   Journal of Neuroinflammation

Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain

(2019) Yanbo Zhang et al.   Frontiers in Pharmacology

Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer’s disease

(2019) Song Chen et al.   Redox Biology

Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors

(2019) Yun Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant-Like Activity of Myelophil via Attenuation of Microglial-Mediated Neuroinflammation in Mice Undergoing Unpredictable Chronic Mild Stress

(2019) Jin-Seok Lee et al.   Frontiers in Pharmacology

Fibroblast growth factor 21 secretion enhances glucose uptake in mono(2-ethylhexyl)phthalate-treated adipocytes

(2019) Jhih-Wei Hsu et al.   TOXICOLOGY IN VITRO

The FGF metabolic axis

(2019) Xiaokun Li   Frontiers of Medicine

Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats

(2019) Wen Zheng et al.   EXPERIMENTAL NEUROLOGY

Polymorphisms in the BDNF and BDNFOS genes are associated with hypothalamus-pituitary axis regulation in major depression

(2019) Johannes M. Hennings et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Design and Evaluation of Lyophilized Fibroblast Growth Factor 21 and Its Protection against Ischemia Cerebral Injury

(2018) Xuanxin Yang et al.   BIOCONJUGATE CHEMISTRY

FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice

(2018) Xuebo Pan et al.   Cell Metabolism

Peiminine Protects Dopaminergic Neurons from Inflammation-Induced Cell Death by Inhibiting the ERK1/2 and NF-κB Signalling Pathways

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FGF21 Protects the Blood–Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury

(2018) Jun Chen et al.   JOURNAL OF NEUROTRAUMA

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

(2018) Adam K. Walker et al.   MOLECULAR PSYCHIATRY

Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta1–42-Induced Toxicity in SH-SY5Y Cells

(2018) Mona Amiri et al.   NEUROTOXICITY RESEARCH

Dl-3-n-Butylphthalide improves lipopolysaccharide-induced depressive-like behavior in rats: involvement of Nrf2 and NF-κB pathways

(2018) Mengqi Yang et al.   PSYCHOPHARMACOLOGY

Selanylimidazopyridine Prevents Lipopolysaccharide-Induced Depressive-Like Behavior in Mice by Targeting Neurotrophins and Inflammatory/Oxidative Mediators

(2018) Micaela Domingues et al.   Frontiers in Neuroscience

Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

(2018) Kathryn M. Lenz et al.   Frontiers in Immunology

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions

(2018) Xiaoshan Min et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response

(2018) Shariful A. Syed et al.   NEURON

Fibroblast Growth Factor 2 Modulates Hippocampal Microglia Activation in a Neuroinflammation Induced Model of Depression

(2018) Ming-ming Tang et al.   Frontiers in Cellular Neuroscience

Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages

(2018) Nan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

(2018) Yun Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

Endocrine Regulator rFGF21 (Recombinant Human Fibroblast Growth Factor 21) Improves Neurological Outcomes Following Focal Ischemic Stroke of Type 2 Diabetes Mellitus Male Mice

(2018) Yinghua Jiang et al.   STROKE

Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice

(2018) Xu-Ben Yu et al.   JOURNAL OF AFFECTIVE DISORDERS

Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal-regulated kinase 1/2 signaling pathway

(2017) Pingping Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

FGF21 Is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate

(2017) Hui Hua Chang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Characteristics of primary rat microglia isolated from mixed cultures using two different methods

(2017) Li Lin et al.   Journal of Neuroinflammation

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

(2017) Qingzhi Wang et al.   MOLECULAR NEUROBIOLOGY

Negative correlation between cerebrospinal fluid FGF21 levels and BDI scores in male Chinese subjects

(2017) Yanlong Liu et al.   PSYCHIATRY RESEARCH

Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice

(2016) Aislinn J. Williams et al.   BEHAVIOURAL BRAIN RESEARCH

Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy

(2016) Gavin Rush et al.   JOURNAL OF AFFECTIVE DISORDERS

The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β

(2015) Miroslav Adzic et al.   BEHAVIOURAL BRAIN RESEARCH

Fibroblast growth factor 9 is a novel modulator of negative affect

(2015) Elyse L. Aurbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice

(2014) V.S. Tomaz et al.   NEUROSCIENCE

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1

(2014) Johanna Mäkelä et al.   SpringerPlus

Chronic Administration of Infliximab (TNF-α Inhibitor) Decreases Depression and Anxiety-like Behaviour in Rat Model of Chronic Mild Stress

(2013) Ayşe Karson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Activation of Spinal NF-κB/p65 Contributes to Peripheral Inflammation and Hyperalgesia in Rat Adjuvant-Induced Arthritis

(2013) Jian-Gang Luo et al.   Arthritis & Rheumatology

Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression

(2012) Maha Elsayed et al.   BIOLOGICAL PSYCHIATRY

Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice

(2012) M N Silverman et al.   MOLECULAR PSYCHIATRY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment

(2011) Bun-Hee Lee et al.   Psychiatry Investigation

High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli

(2010) Huiyan Wang et al.   BMC BIOTECHNOLOGY

Imbalance between Pro- and Anti-inflammatory Cytokines, and between Th1 and Th2 Cytokines in Depressed Patients: The Effect of Electroacupuncture or Fluoxetine Treatment

(2009) C. Song et al.   PHARMACOPSYCHIATRY

Antidepressant-like effects of intracerebroventricular FGF2 in rats

(2008) Cortney A. Turner et al.   BRAIN RESEARCH

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES