A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

(2018) Paul A. Parcon et al.   Alzheimers & Dementia

NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

(2018) Caixia Zhang et al.   Frontiers in Aging Neuroscience

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells

(2018) Venumadhav Janganati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2

(2018) Meenakshisundaram Balasubramaniam et al.   Scientific Reports

Behavioral Phenotyping of a Transgenic Caenorhabditis Elegans Expressing Neuronal Amyloid-β

(2017) Laura E. Dosanjh et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls

(2016) Srinivas Ayyadevara et al.   AGING CELL

Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans

(2016) Srinivas Ayyadevara et al.   Aging-US

GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions

(2016) Martina Moeton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic ProfilesNovelty and Significance

(2016) Srinivas Ayyadevara et al.   HYPERTENSION

HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational protein–ligand docking and virtual drug screening with the AutoDock suite

(2016) Stefano Forli et al.   Nature Protocols

Neuron–microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

(2016) Makoto Tsuda et al.   NEUROPHARMACOLOGY

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans

(2016) Srinivas Ayyadevara et al.   Oncotarget

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

New Insights into the Mechanism of Action of Aspirin in the Prevention of Colorectal Neoplasia

(2015) Luigia Francesco et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4

(2015) Nikhil R. Madadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration

(2015) Aiko Ishiki et al.   JOURNAL OF NEUROCHEMISTRY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

(2015) Zhihui Yang et al.   TRENDS IN NEUROSCIENCES

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

(2014) Srinivas Ayyadevara et al.   AGING CELL

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Global Epidemiology of Dementia: Alzheimer’s and Vascular Types

(2014) Liara Rizzi et al.   Biomed Research International

Neuron-Microglia Interaction in Neuroinflammation

(2013) Akio Suzumura   CURRENT PROTEIN & PEPTIDE SCIENCE

Low-dose aspirin in primary prevention: cardioprotection, chemoprevention, both, or neither?

(2013) C. Patrono   EUROPEAN HEART JOURNAL

Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants

(2013) Puneet Bharill et al.   Frontiers in Genetics

Physical and Cognitive Stimulation in Alzheimer Disease. The GAIA Project

(2012) Tiziana Maci et al.   American Journal of Alzheimers Disease and Other Dementias

Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans

(2012) Srinivas Ayyadevara et al.   ANTIOXIDANTS & REDOX SIGNALING

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Discovery of Anti-Alzheimer Agents: Current Ligand-Based Approaches toward the Design of Acetylcholinesterase Inhibitors

(2012) A. Speck-Planche et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Protein Homeostasis, Aging and Alzheimer’s Disease

(2012) Tobias Morawe et al.   MOLECULAR NEUROBIOLOGY

Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model

(2012) Yoshikazu Tasaki et al.   NEUROSCIENCE LETTERS

A Randomized Controlled Trial of an Activity Specific Exercise Program for Individuals With Alzheimer Disease in Long-term Care Settings

(2011) Kathryn E. Roach et al.   Journal of Geriatric Physical Therapy

Tau protein and tau aggregation inhibitors

(2010) Bruno Bulic et al.   NEUROPHARMACOLOGY

Coordination of Autophagy and the Proteasome in Resolving Endoplasmic Reticulum Stress

(2010) X. Chen et al.   VETERINARY PATHOLOGY

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

(2010) Vishantie Dostal et al.   Jove-Journal of Visualized Experiments

Inhibitors of protein aggregation and toxicity

(2009) Hozefa Amijee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay

(2009) Alison Rinderspacher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Phase I Trial of Radioimmunotherapy with 131I-A5B7 Anti-CEA Antibody in Combination with Combretastatin-A4-Phosphate in Advanced Gastrointestinal Carcinomas

(2009) T. Meyer et al.   CLINICAL CANCER RESEARCH

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

(2009) Nicholas H. Varvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2

(2008) Catarina Figueiredo et al.   JOURNAL OF NEUROCHEMISTRY

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY