Review
Oncology
Azin Aghamajidi, Saman Maleki Vareki
Summary: The gut microbiome plays a crucial role in the development of the immune system and can impact the response to systemic treatments like immunotherapy and chemotherapy. This article provides a comprehensive overview of how the gut microbiome interacts with the immune system and cancer, and how it affects anti-tumor immunity and response to immunotherapy. Understanding these mechanisms can lead to better treatment strategies for cancer patients undergoing systemic therapy.
Article
Oncology
Christine Son, Melissa Y. Y. Moey, Paul R. Walker, Abdul R. Naqash, Matthew Sean Peach, Andrew W. Ju
Summary: In this retrospective study, data was collected on Stage III-IV lung cancer patients who received immune checkpoint inhibitors (ICIs) between 2015 and 2018. The risk of cardiotoxicity was assessed in patients who received thoracic radiotherapy compared to those who did not, and no significant difference was found in the occurrence of cardiotoxicities between the two groups.
FRONTIERS IN ONCOLOGY
(2023)
Review
Engineering, Biomedical
Mengying He, Tao Yang, Yuhan Wang, Mengyuan Wang, Xingye Chen, Dawei Ding, Yiran Zheng, Huabing Chen
Summary: Immune checkpoint blockade therapy has shown potential efficacy in various cancers, but its effectiveness is limited when used alone. Studies have demonstrated that combining ICBT with other treatment modalities such as chemotherapy, radiotherapy, and phototherapy can enhance therapeutic outcomes. However, there are still challenges and potential issues that need to be addressed in the research on ICBT-based synergistic therapies.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Oncology
Meng-Yu Chen, Yue-Can Zeng
Summary: The occurrence of pseudoprogression in lung cancer due to the application of immunotherapy has complicated clinical evaluation and management, highlighting the need for a better understanding of its mechanisms and strategies for differentiation.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Oncology
Vishesh Agrawal, Kimberly Thomas Benjamin, Eric C. Ko
Summary: Recent immunotherapy trials for NSCLC have shown positive results, especially with the approval of drugs like nivolumab and pembrolizumab for metastatic NSCLC. Early trials have also demonstrated the ability of radiation therapy to induce significant tumor immunity. The combination of radiation therapy and immunotherapy holds promise for expanding treatment options for NSCLC, but careful patient selection is needed for optimal therapy outcomes.
CURRENT ONCOLOGY REPORTS
(2021)
Review
Oncology
John H. Heinzerling, Kathryn F. Mileham, Charles B. Simone
Summary: The combination of radiation therapy and immunotherapy has shown positive effects in the treatment of lung cancer, particularly in improving survival rates and reducing toxicity. Immune checkpoint inhibitors have shown new progress in the treatment of metastatic and locally advanced lung cancer.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Oncology
Martina Catalano, Sonia Shabani, Jacopo Venturini, Carlotta Ottanelli, Luca Voltolini, Giandomenico Roviello
Summary: Immunotherapy has revolutionized lung cancer treatment, but only a minority of patients respond to treatment, and there are limitations and adverse events associated with current immune checkpoint inhibitors. Researchers are exploring novel immune targets to improve treatment outcomes.
Review
Oncology
Yuhei Miyasaka, Hiro Sato, Naoko Okano, Nobuteru Kubo, Hidemasa Kawamura, Tatsuya Ohno
Summary: Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy has achieved significant technical advances and is widely used in the management of lung cancer. The anti-tumor effect of radiotherapy is mainly caused by DNA damage in cancer cells. Additionally, radiotherapy induces anti-tumor immune responses, but also suppresses the immune system. Combining radiotherapy with immunotherapy, particularly immune checkpoint inhibitors, shows promise in overcoming immunosuppressive conditions in lung cancer patients. Particle therapy using protons and carbon ions in combination with immunotherapy is also a promising treatment strategy according to evidence outlined in this review.
Review
Immunology
Sijia Ren, Xinxin Xiong, Hua You, Jianfei Shen, Penghui Zhou
Summary: Combining immunotherapy with anti-angiogenesis can transform the tumor microenvironment from immunosuppressive to immune-supportive, increasing the infiltration and activation of immune cells. Therefore, this combination is a promising strategy for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Perla Chami, Youssef Diab, Danny N. Khalil, Hassan Azhari, William R. Jarnagin, Ghassan K. Abou-Alfa, James J. Harding, Joseph Hajj, Jennifer Ma, Maria El Homsi, Marsha Reyngold, Christopher Crane, Carla Hajj
Summary: The liver tumor immune microenvironment plays a crucial role in the development and progression of HCC. While immune checkpoint inhibitors have limited efficacy in HCC, it has been found that radiation therapy can overcome some of these limitations and reshape the liver immune microenvironment. Combining radiation therapy with immune checkpoint inhibitors effectively restores anti-tumor activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Luc Ollivier, Camille Moreau Bachelard, Emmanuelle Renaud, Estelle Dhamelincourt, Francois Lucia
Summary: Despite vaccination and screening, some cases of cervical cancer are discovered at an advanced stage, with limited treatment options and poor prognosis. Immune checkpoint inhibitors (ICIs) and tisotumab vedotin have shown promising results in improving survival rates for these patients. Additionally, the combination of radiation therapy (RT) and ICIs may induce an abscopal effect, enhancing the body's immune response and potentially leading to better outcomes. This review focuses on the potential abscopal effect of immune-radiation therapy in metastatic cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ming Zheng
Summary: This study demonstrates that the neutrophil-to-lymphocyte ratio (NLR) is a valuable indicator for predicting the outcomes of immune checkpoint blockade (ICB) treatment. An NLR range of 2.0 to 3.0 is associated with optimal treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Arthur Mulvey, Emilien Muggeo-Bertin, Dominik R. Berthold, Fernanda G. Herrera
Summary: This article reviews the role of immunotherapy in prostate cancer, discusses opportunities for future development, and explores the potential of synergistic therapeutic strategies with modern radiotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zsofia Dora Drobni, Carlos Gongora, Jana Taron, Giselle A. Suero-Abreu, Julia Karady, Hannah K. Gilman, Sama Supraja, Sofia Nikolaidou, Nicolas Leeper, Bela Merkely, Pal Maurovich-Horvat, Borek Foldyna, Tomas G. Neilan
Summary: This study compared lung cancer patients receiving immune checkpoint inhibitors (ICI) with those not receiving ICI, and found that non-calcified plaque progressed significantly faster in the ICI group, while calcified plaque progressed slower. The findings underscore the importance of further research on the underlying mechanisms of plaque advancement in ICI-treated patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Giandomenico Roviello, Luigi Francesco Iannone, Melissa Bersanelli, Enrico Mini, Martina Catalano
Summary: Immunotherapy has revolutionized cancer treatment, but reliable biomarkers for predicting treatment response are still unknown. Recent studies suggest that the gut microbiota may play a role in modulating the efficacy and toxicity of immunotherapy drugs.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Anthony F. Rullo, Kelly J. Fitzgerald, Viswanathan Muthusamy, Min Liu, Cai Yuan, Mingdong Huang, Minsup Kim, Art E. Cho, David A. Spiegel
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Chemistry, Multidisciplinary
Tina Wang, Eugene F. Douglass, Kelly J. Fitzgerald, David A. Spiegel
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Chemistry, Multidisciplinary
Patrick J. McEnaney, Kelly J. Fitzgerald, Andrew X. Zhang, Eugene F. Douglass, Weifang Shan, Aaron Balog, Mariya D. Koesnikova, David A. Spiegel
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Meeting Abstract
Oncology
K. J. Fitzgerald, J. Flynn, Z. Zhigang, E. F. Gillespie, A. J. Khan, O. Cahlon, B. McCormick, S. N. Powell, L. Z. Braunstein
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Meeting Abstract
Oncology
M. Thor, K. J. Fitzgerald, A. Iyer, A. Apte, J. H. Oh, J. Chaft, A. J. Wu, M. Offin, D. Gelblum, J. O. Deasy, A. Rimner
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Cell Biology
Sadna Budhu, Rachel Giese, Aditi Gupta, Kelly Fitzgerald, Roberta Zappasodi, Sara Schad, Daniel Hirschhorn, Luis Felipe Campesato, Olivier De Henau, Mathieu Gigoux, Cailian Liu, Gregory Mazo, Liang Deng, Christopher A. Barker, Jedd D. Wolchok, Taha Merghoub
Summary: The study showed that targeting PS with antibodies can enhance the efficacy of tumor-directed RT and improve overall survival, while also increasing proinflammatory tumor-associated macrophages. Combining PD-1 blockade with RT further increases anti-tumor efficacy and survival, particularly in patients with metastatic melanoma.
Article
Oncology
Ritesh R. Kotecha, Andrea Knezevic, Kanika Arora, Chaitanya Bandlamudi, Fengshen Kuo, Maria I. Carlo, Kelly N. Fitzgerald, Darren R. Feldman, Neil J. Shah, Ed Reznik, A. Ari Hakimi, Jian Carrot-Zhang, Diana Mandelker, Michael Berger, Chung-Han Lee, Robert J. Motzer, Martin H. Voss
Summary: This study examines the differences in clinical and molecular data among different genetic ancestry groups in patients with renal cell carcinoma (RCC). The findings suggest that genetic ancestry may contribute to variations in clinical and molecular characteristics of RCC, and significant differences were identified in angiogenesis and inflammatory pathways. This study highlights the importance of exploring both genetic and nongenetic variables in order to reduce health-related disparities.
Article
Oncology
Kelly Fitzgerald, Jessica Flynn, Zhigang Zhang, Zachary Cost, Boris Mueller, Erin F. Gillespie, Beryl McCormick, Atif Khan, Oren Cahlon, Simon N. Powell, Lior Z. Braunstein
ADVANCES IN RADIATION ONCOLOGY
(2020)
Article
Respiratory System
Kirsten A. Freeman
Summary: As a new surgeon, understanding the transitions and challenges ahead, building a support network, and focusing on clinical competence are key to thriving in the first years of your career.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Keith S. Naunheim, Joseph J. Platz
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Fatima G. Wilder, Jason J. Han
Summary: Mentorship plays a crucial role in a successful career in cardiothoracic surgery, and finding a mentor and establishing a fruitful mentor-mentee relationship requires self-reflection, alignment of goals, open communication, and regular feedback. There are various resources available in the cardiothoracic surgery community to aid members in finding and maintaining successful mentoring relationships.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Jennifer L. Perri, Tom C. Nguyen
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Melanie A. Edwards
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Rachel Kim, Nahush A. Mokadam
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
William A. Baumgartner
Summary: The author enjoys spending time with their family in retirement and emphasizes the importance of staying active and connected. Mentoring, editing, and documenting family history are also meaningful activities for the author. The author misses the interactions with colleagues but believes retirement can be greatly enjoyed with proper preparation.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Sarah Khalil, Anna Olds, Kristine Chin, Cherie P. Erkmen
THORACIC SURGERY CLINICS
(2024)
Editorial Material
Respiratory System
Ourania Preventza
Summary: Making a professional transition during a surgeon's mid-career is challenging. It is a crucial phase where experience, repetition, and judgment are developed through extensive practice. This phase involves deciding one's future, helping others shape theirs, and moving into the senior phase of a career.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Himanshu J. Patel, Stefanie L. Peters, Barbara Hamilton, Andrew C. Chang
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Robert James Cerfolio
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Marko T. Boskovski, Elaine E. Tseng
Summary: The promotion process at academic institutions is clearly defined, and promotion criteria vary based on academic tracks. Promotion packets include multiple components.
THORACIC SURGERY CLINICS
(2024)
Article
Respiratory System
Russell Seth Martins, Kostantinos Poulikidis, Faiz Y. Bhora
Summary: This article emphasizes the importance of financial literacy for new attending surgeons, including establishing a financial team, obtaining appropriate insurance, and planning for retirement. It also reminds surgeons to strike a balance between personal life goals and long-term financial obligations.
THORACIC SURGERY CLINICS
(2024)
