期刊
ADVANCED OPTICAL MATERIALS
卷 8, 期 14, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adom.201902027
关键词
aggregation-induced emission; bacteria imaging; excited-state intramolecular proton transfer; lipid droplets imaging; salicylaldehyde
资金
- National Natural Science Foundation of China [21672135, 21975149, 21402115, 51403122]
- Natural Science Foundation of Shaanxi Province [2018JM5086]
- Academic Leaders and Academic Backbones, Shaanxi Normal University [18QNGG007]
- Fundamental Research Funds for the Central Universities [GK201902006]
Aggregation-induced emission luminogens (AIEgens) with excited-state intramolecular proton transfer (ESIPT) process have attracted significant attention in bioimaging applications owing to their high solid-state emission efficiencies and large Stokes shifts. Herein, a series of simple AIEgens with ESIPT process, referred to as triphenylamine salicylaldehyde (TS) derivatives, are designed and synthesized by a rational hybridization of triphenylamine and salicylaldehyde units as the intramolecular rotor and ESIPT generator, respectively. Owing to the AIE and ESIPT effects, TS derivatives exhibit intense emission and large Stokes shifts (>140 nm) in the aggregated state. By altering the substituents in the triphenylamine units, their solid-state emission varies from 490 to 590 nm. Owing to their excellent biocompatibilities and suitable lipophilicities, the TS derivatives are able to specifically and rapidly (<5 min) stain the lipid droplets in the cells in a wash-free manner and successfully image the lipid-rich tissue in vivo. Moreover, owing to their suitable hydrophilicity, TS and methoxyl substituted TS (TS-OMe) are shown to stain gram-positive bacteria with high selectivity.
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