Article
Cell Biology
Yan Yan, Karl N. Krecke, Aditi S. Bapat, Tingyuan Yang, Michael W. Lopresti, Douglas G. Mashek, Ameeta Kelekar
Summary: The study revealed a novel role for PHLPP2 in targeting AMP-activated protein kinase (AMPK) to suppress the survival response of leukemia cells under glucose limitation. Silencing PHLPP2 prolonged the survival of leukemia cells by promoting AMPK-mediated fatty acid oxidation. This discovery could lead to better therapeutic strategies for both cancer and metabolic diseases.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Wang, Xinyi Yu, Tingyu Wang, Wenbin Cai, Tong Hua, Jinjie Duan, Xu Zhang, Yi Zhu, Liu Yao
Summary: Myocardial infarction (MI) is a fatal manifestation of coronary heart disease, and lipid metabolism plays a crucial role in its development. In this study, we found that myocardial glycerophospholipids (GPLs) were significantly changed after MI, while plasma GPLs remained largely unchanged. Decreased phosphatidylserine (PS) levels in the heart tissues were associated with the inhibition of phosphatidylserine synthase 1 (PSS1).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Atsuko K. Kimura, Tomohiro Kimura
Summary: This article discusses the crucial role of phosphatidylserine (PS) in lipid homeostasis in cells, focusing on recent discoveries about the two enzymes involved in PS synthesis and their roles in membrane structure and PS synthesis.
Article
Multidisciplinary Sciences
Valentina Botero, Bethany A. Stanhope, Elizabeth B. Brown, Eliza C. Grenci, Tamara Boto, Scarlet J. Park, Lanikea B. King, Keith R. Murphy, Kenneth J. Colodner, James A. Walker, Alex C. Keene, William W. Ja, Seth M. Tomchik
Summary: Neurofibromatosis type 1 is a genetic disorder that affects metabolic homeostasis through a discrete neuronal circuit, leading to increased metabolic rate, feeding, and alterations in lipid stores and turnover kinetics.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, Ernest R. Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lu, Komal S. Keerthy, Chloe E. Booth, Christopher B. Newgard, Mukesh K. Jain
Summary: The skeletal muscle Kruppel-like factor 15 (KLF15) plays a critical role in coordinating pathways central to systemic lipid homeostasis, regulating lipid uptake, mitochondrial transport, and utilization. Deletion of skeletal muscle-specific KLF15 leads to elevated circulating lipids, insulin resistance/glucose intolerance, and increased lipid deposition in white adipose tissue and liver, which can be ameliorated by a diet rich in short-chain fatty acids.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Adam De Jesus, Farnaz Keyhani-Nejad, Carolina M. Pusec, Lauren Goodman, Justin A. Geier, Joshua S. Stoolman, Paulina J. Stanczyk, Tivoli Nguyen, Kai Xu, Krishna V. Suresh, Yihan Chen, Arianne E. Rodriguez, Jason S. Shapiro, Hsiang-Chun Chang, Chunlei Chen, Kriti P. Shah, Issam Ben-Sahra, Brian T. Layden, Navdeep S. Chandel, Samuel E. Weinberg, Hossein Ardehali
Summary: The product of hexokinase enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative metabolic routes. The presence of N-terminal mitochondrial binding domain (MBD) in HK1 alters glucose metabolism through regulation of GAPDH.
Article
Multidisciplinary Sciences
Xiaoyu Tracy Cai, Hongjie Li, Martin Borch Jensen, Elie Maksoud, Jovencio Borneo, Yuxin Liang, Stephen R. Quake, Liqun Luo, Pejmun Haghighi, Heinrich Jasper
Summary: Glial metabolic reprogramming by gut-derived cytokines in Drosophila results in lasting changes in the sensory system of an ageing organism. This metabolic reprogramming is transient in young flies but becomes constitutive in old flies, contributing to an age-related decline in sensory discrimination.
Editorial Material
Biochemistry & Molecular Biology
Emma Burbridge, Colin Adrain
Summary: This article discusses the importance and mechanisms of maintaining organelle homeostasis in cells, providing a comprehensive perspective on the functions and interactions of various organelles. It also introduces some lesser-known organelles.
Article
Oncology
Takahiro Anzai, Shinji Saijou, Yoshitsugu Ohnuki, Hiroshi Kurosawa, Masahiro Yasunaga, Yasuhiro Matsumura
Summary: Preliminary results suggest that TMEM180 may promote colon cancer growth, without significant effects on oxygen consumption or phosphorylated protein expression. However, glycolysis differs significantly between SW480 cells and TMEM180-knockdown cells. NGS analysis indicates that TMEM180 promotes enzyme expression in the nitric oxide synthesis system, potentially contributing to glucose and glutamine metabolism and cancer growth. Further basic studies of the TMEM180 molecule are warranted based on these findings.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gokhan Unlu, Benjamin Prizer, Ranya Erdal, Hsi-Wen Yeh, Erol C. Bayraktar, Kivanc Birsoy
Summary: This study identifies SLCO2B1 as a plasma membrane heme importer predominantly expressed in microglia, which plays a vital role in iron utilization under restriction conditions. SLCO2B1 mediates heme analog import to provide sufficient iron for cell proliferation through heme oxygenases. The study also highlights the metabolic limitations under stress conditions and provides a genetic platform for further exploration.
Article
Biochemistry & Molecular Biology
Chiara Pastorio, Sara Torres-Rusillo, Juan Ortega-Vidal, M. Carmen Jimenez-Lopez, Inmaculada Ianez, Sofia Salido, Manuel Santamaria, Joaquin Altarejos, Ignacio J. Molina
Summary: Olive oil contains (-)-oleocanthal (OLC), which has been found to have anti-inflammatory, antioxidant, and antitumor activities. This study examined the effects of OLC on various cell lines and found that it inhibits cell proliferation and induces apoptotic death. Hematopoietic tumor cell lines were the most sensitive to OLC treatment. The mechanisms of OLC-mediated cell death involve caspase-dependent and independent pathways.
Review
Biochemistry & Molecular Biology
Julia Kallenbach, Golnaz Atri Roozbahani, Mehdi Heidari Horestani, Aria Baniahmad
Summary: This review analyzes the mechanisms of therapy-induced senescence (TIS) in PCa and finds that different molecular pathways are used by cancer cells for TIS. Understanding the complexity and underlying mechanisms of cellular senescence is critical for tumorigenesis.
CELL AND BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Wenfeng Li, Rui Qing, Haojie Zhang, Ziwei Wang, Yuhan Yuan, Lili Wang, Jia Deng, Bochu Wang, Shilei Hao
Summary: The study demonstrates the significant promise of trichocyte keratins in promoting wound healing, with distinct behaviors and advantages observed among different types. Transcriptomic analysis reveals the regulatory mechanisms of keratins in cell proliferation, migration, and blood vessel generation. These findings can contribute to the development and precision application of keratins.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Marion Weber-Boyvat, Jana Kroll, Thorsten Trimbuch, Vesa M. Olkkonen, Christian Rosenmund
Summary: This research identified a dual function of ORP2, serving as a physiological regulator of synaptic cholesterol content and a regulator of neuronal exocytosis.
Article
Biochemistry & Molecular Biology
Wenhao Zhang, Leilei Yu, Fang Wang, Minjie Chen, Hui Li
Summary: Bioactive constituents from Rhodiola rosea L. has therapeutic effects on osteoporosis by inhibiting osteoclast viability and promoting osteoblast viability. The HDAC1/EEF2 axis is identified as an important axis for the action of Rosavin.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Correction
Multidisciplinary Sciences
Hongri Gong, Yan Gao, Xiaoting Zhou, Yu Xiao, Weiwei Wang, Yanting Tang, Shan Zhou, Yuying Zhang, Wenxin Ji, Lu Yu, Changlin Tian, Sin Man Lam, Guanghou Shui, Luke W. Guddat, Luet-Lok Wong, Quan Wang, Zihe Rao
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui
Summary: This study found that the natural non-nutritive sweetener Reb A can extend the lifespan and healthspan of C. elegans by reducing cellular reactive oxygen species levels and attenuating neutral lipid accumulation with aging. Reb A acts as an effective cellular antioxidant and lowers the ectopic accumulation of neutral lipids, which contributes to its anti-aging effects.
Article
Biology
Qianqian Pang, Chunyi Liu, Yulong Qiao, Jian Zhao, Sin Man Lam, Mei Mei, Guanghou Shui, Shilai Bao, Qiuling Li
Summary: Deletion of the GM130 gene disrupts the Golgi structure, impairing the secretion of lung surfactant proteins and lipids. This leads to an enlargement of alveolar airspace and increased alveolar epithelial autophagy, which can be partially rescued by surfactant repletion in GM130-deficient mice.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Plant Sciences
Yingchun Wang, Jianan Zhai, Zhenyu Qi, Wanping Liu, Jipeng Cui, Xi Zhang, Sulan Bai, Li Li, Guanghou Shui, Suxia Cui
Summary: Physcomitrella patens, an early terrestrial plant, has short-term desiccation resistance, with membrane integrity maintenance related to its specific glycerolipid composition and key genes for lipid metabolism. Phospholipids and glycolipids dominate its lipid composition, with phospholipids accounting for 61.7% and glycolipids for 26.5%. The study sheds light on lipid evolution of early terrestrial plants in adverse terrestrial environments.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Oncology
Mingjun Cao, Shaohua Zhang, Sin Man Lam, Guanghou Shui
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ying Yu, Bin Liu, Xiaolin Liu, Xuan Zhang, Wenhui Zhang, He Tian, Guanghou Shui, Wenzhao Wang, Moshi Song, Jun Wang
Summary: The gut-liver axis refers to the complex connection and interaction between the gut microbiome and the liver, which affects the host metabolism. The hepatic portal vein is considered to be the main route for metabolite transportation in the gut-liver axis, but the existence and importance of other routes are still unclear. By comparing the metabolites in the blood circulation and mesenteric lymph systems, significant shifts in metabolites in serum and mesentery are identified. The study reveals that the lymph system has the potential to regulate liver metabolism by transporting certain metabolites independently.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Review
Endocrinology & Metabolism
Sin Man Lam, Xun Huang, Guanghou Shui
Summary: This review discusses the connection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and systemic lipid couriers, such as high-density lipoproteins (HDLs) and exosomes, in relation to the neurological aspects of the infection. It is found that SARS-CoV-2 primarily targets lipid-producing cells and utilizes host cell lipid metabolism for efficient replication and systemic spreading. Additionally, certain lipid particles have the ability to traverse the blood-brain barrier (BBB) and contribute to the neurotropism of SARS-CoV-2.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Chemistry, Physical
He Tian, Zhen Ni, Sin Man Lam, Wenxi Jiang, Fengjuan Li, Jie Du, Yuan Wang, Guanghou Shui
Summary: This study develops a robust metabolomics approach for accurate quantitation and precise profiling of metabolomes. By introducing isotope-labeled standards (ISs) and refining the selection of appropriate ISs, this approach successfully reduces COVs and facilitates the identification of additional metabolites. The approach reveals perturbations in various metabolic pathways across aging, providing clues for the prevention and treatment of age-related diseases.
Article
Multidisciplinary Sciences
Hua Yan, Comzit Opachaloemphan, Francisco Carmona-Aldana, Giacomo Mancini, Jakub Mlejnek, Nicolas Descostes, Bogdan Sieriebriennikov, Alexandra Leibholz, Xiaofan Zhou, Long Ding, Maria Traficante, Claude Desplan, Danny Reinberg
Summary: Reproduction is correlated with shorter life span in most organisms. However, in Harpegnathos ants, workers can switch to reproductive pseudo-queens and exhibit a prolonged life span. Increased insulin expression in the gamergate brain leads to increased lipid synthesis and vitellogenin production in the fat body, extending their longevity. The anti-insulin Imp-L2 in the gamergate developing ovary decreases signaling in the fat body, consistent with their extended life span.
Article
Cell Biology
Xinyu Bao, Xiaogen Ma, Rongfeng Huang, Jianghui Chen, Haoran Xin, Meiyu Zhou, Lihua Li, Shifei Tong, Qian Zhang, Guanghou Shui, Fang Deng, Liqing Yu, Min-Dian Li, Zhihui Zhang
Summary: This study demonstrates that inhibiting Plin3 in hepatocytes is sufficient to alleviate hepatic steatosis and steatohepatitis caused by CGI-58 deficiency.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Hematology
Jing-gang Xia, Bowen Li, Hao Zhang, Qin-xue Li, Sin Man Lam, Chun-lin Yin, He Tian, Guanghou Shui
Summary: This study used quantitative metabolomics to investigate the metabolic differences in acute myocardial infarction (AMI) patients with and without diabetes. The findings revealed that diabetes-AMI patients had more severe metabolic dysregulation, involving multiple pathways such as carbohydrate metabolism, lipid metabolism, glycolysis, tricarboxylic acid cycle, and amino acid metabolism. The key functional metabolites N-lactoyl-phenylalanine and lysophosphatidylcholines were identified, which were associated with mitochondrial dysfunction, glucose utilization, and inflammation, suggesting their potential as therapeutic targets for diabetes-AMI.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinglin Zhu, Wei Meng, Sin Man Lam, Guanghou Shui, Xun Huang
Summary: By regulating lysosomal activity, the protein SPIN-4 ensures the synthesis of B12-associated PC, which is essential for germline development and fertility in Caenorhabditis elegans. Sterility resulting from PC deficiency can be rescued by reducing levels of polyunsaturated fatty acids, reactive oxygen species, and redox-active iron, indicating that it is mediated by germline ferroptosis. These findings highlight the critical role of PC homeostasis in ferroptosis susceptibility and provide a new target for pharmacological interventions.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Review
Chemistry, Analytical
Zehua Wang, Mingjun Cao, Sin Man Lam, Guanghou Shui
Summary: Technological innovations have revolutionized the way scientists approach biological and clinical questions, shifting the focus from conventional bulk assays to the measurement of single molecules in individual cells. Single-cell lipidomics has emerged as a promising technique to provide unique insights into the lipid composition of individual cells. This review summarizes the current progress and challenges in single-cell lipidomics, particularly emphasizing the importance of accurate lipid identification and quantification, and discusses its potential applications in biology and clinical medicine.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Cen Yan, Xiaojuan Ma, Sin Man Lam, Yuejie Zhang, Yu Cao, Yuan Dong, Li Su, Guanghou Shui, Yingmei Feng
Summary: GLP-1 RAs can control blood sugar and inhibit inflammation and plaque development. The study shows that Ex-4 can inhibit skewed myelopoiesis caused by hypercholesteremia, reducing the risk of atherosclerosis.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)