A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep

An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control

(2019) Zhe Zhang et al.   CELL

Whole-animal connectomes of both Caenorhabditis elegans sexes

(2019) Steven J. Cook et al.   NATURE

The Serotonergic Raphe Promote Sleep in Zebrafish and Mice

(2019) Grigorios Oikonomou et al.   NEURON

A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

(2019) Wagner Steuer Costa et al.   Nature Communications

Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep

(2018) Heather L. Bennett et al.   BMC NEUROSCIENCE

Sleep-Active Neurons: Conserved Motors of Sleep

(2018) Henrik Bringmann   GENETICS

Recurrent Circuitry for Balancing Sleep Need and Sleep

(2018) Jeffrey M. Donlea et al.   NEURON

Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans

(2018) Susanne Skora et al.   Cell Reports

Glia Modulate a Neuronal Circuit for Locomotion Suppression during Sleep in C. elegans

(2018) Menachem Katz et al.   Cell Reports

Sleep-Active Neurons: Conserved Motors of Sleep

(2018) Henrik Bringmann   GENETICS

Sleep Counteracts Aging Phenotypes to Survive Starvation-Induced Developmental Arrest in C. elegans

(2018) Yin Wu et al.   CURRENT BIOLOGY

Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans

(2018) Huiyan Huang et al.   GENETICS

High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins

(2018) Mathias Mahn et al.   Nature Communications

Comprehensive single-cell transcriptional profiling of a multicellular organism

(2017) Junyue Cao et al.   SCIENCE

Automatically tracking neurons in a moving and deforming brain

(2017) Jeffrey P. Nguyen et al.   PLoS Computational Biology

Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit

(2016) Sha Liu et al.   CELL

Unraveling the Evolutionary Determinants of Sleep

(2016) William J. Joiner   CURRENT BIOLOGY

Sleep and Development in Genetically Tractable Model Organisms

(2016) Matthew S. Kayser et al.   GENETICS

Circuit-based interrogation of sleep control

(2016) Franz Weber et al.   NATURE

Operation of a homeostatic sleep switch

(2016) Diogo Pimentel et al.   NATURE

Sleep function: Toward elucidating an enigma

(2016) James M. Krueger et al.   SLEEP MEDICINE REVIEWS

Call it Worm Sleep

(2016) Nicholas F. Trojanowski et al.   TRENDS IN NEUROSCIENCES

Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep

(2016) Michal Turek et al.   eLife

Sleep and Development in Genetically Tractable Model Organisms

(2016) Matthew S. Kayser et al.   GENETICS

Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective

(2015) Michael R. Irwin   Annual Review of Psychology

Feedback from Network States Generates Variability in a Probabilistic Olfactory Circuit

(2015) Andrew Gordus et al.   CELL

Global Brain Dynamics Embed the Motor Command Sequence of Caenorhabditis elegans

(2015) Saul Kato et al.   CELL

Whole-brain calcium imaging with cellular resolution in freely behavingCaenorhabditis elegans

(2015) Jeffrey P. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multilevel Modulation of a Sensory Motor Circuit during C. elegans Sleep and Arousal

(2014) Julie Y. Cho et al.   CELL

Neuronal Machinery of Sleep Homeostasis in Drosophila

(2014) Jeffrey M. Donlea et al.   NEURON

Inducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channels

(2014) N. Pokala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep Conservation of Genes Required for Both Drosophila melanogaster and Caenorhabditis elegans Sleep Includes a Role for Dopaminergic Signaling

(2014) Komudi Singh et al.   SLEEP

Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms

(2014) Stanislav Nagy et al.   eLife

Modular Control of Glutamatergic Neuronal Identity in C. elegans by Distinct Homeodomain Proteins

(2013) Esther Serrano-Saiz et al.   CELL

An AP2 Transcription Factor Is Required for a Sleep-Active Neuron to Induce Sleep-like Quiescence in C. elegans

(2013) Michal Turek et al.   CURRENT BIOLOGY

Astroglial regulation of sleep homeostasis

(2013) Marcos G Frank   CURRENT OPINION IN NEUROBIOLOGY

ASI Regulates Satiety Quiescence in C. elegans

(2013) T. Gallagher et al.   JOURNAL OF NEUROSCIENCE

Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light

(2013) Tina Schrödel et al.   NATURE METHODS

Long-Term Imaging of Caenorhabditis elegans Using Nanoparticle-Mediated Immobilization

(2013) Eric Kim et al.   PLoS One

Reduced Sleep-Like Quiescence in Both Hyperactive and Hypoactive Mutants of the Galphaq Gene egl-30 during lethargus in Caenorhabditis elegans

(2013) Juliane Schwarz et al.   PLoS One

Caenorhabditis-in-Drop Array for Monitoring C. elegans Quiescent Behavior

(2013) Samuel J. Belfer et al.   SLEEP

The Microarchitecture of C. elegans Behavior during Lethargus: Homeostatic Bout Dynamics, a Typical Body Posture, and Regulation by a Central Neuron

(2013) Shachar Iwanir et al.   SLEEP

A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by Gαs signaling

(2013) Stanislav Nagy et al.   eLife

Optogenetic Analysis of a Nociceptor Neuron and Network Reveals Ion Channels Acting Downstream of Primary Sensors

(2012) Steven J. Husson et al.   CURRENT BIOLOGY

The neuroethology of C. elegans escape

(2012) Jennifer K Pirri et al.   CURRENT OPINION IN NEUROBIOLOGY

An optogenetic application of proton pump ArchT to C. elegans cells

(2012) Ayako Okazaki et al.   NEUROSCIENCE RESEARCH

The Neural Circuits and Synaptic Mechanisms Underlying Motor Initiation in C. elegans

(2011) Beverly J. Piggott et al.   CELL

Reduced activity of a sensory neuron during a sleep-like state in Caenorhabditis elegans

(2011) Juliane Schwarz et al.   CURRENT BIOLOGY

Agarose hydrogel microcompartments for imaging sleep- and wake-like behavior and nervous system development in Caenorhabditis elegans larvae

(2011) Henrik Bringmann   JOURNAL OF NEUROSCIENCE METHODS

Codon adaptation–based control of protein expression in C. elegans

(2011) Stefanie Redemann et al.   NATURE METHODS

Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans

(2011) Jeffrey N Stirman et al.   NATURE METHODS

An Imbalancing Act: Gap Junctions Reduce the Backward Motor Circuit Activity to Bias C. elegans for Forward Locomotion

(2011) Taizo Kawano et al.   NEURON

The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans

(2011) Wei Li et al.   Nature Communications

Sleep State Switching

(2010) Clifford B. Saper et al.   NEURON

Review of Sleep Disorders

(2009) Lori A. Panossian et al.   MEDICAL CLINICS OF NORTH AMERICA

Optical interrogation of neural circuits in Caenorhabditis elegans

(2009) Zengcai V Guo et al.   NATURE METHODS

Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases

(2009) Manuel Zimmer et al.   NEURON

The Human K-Complex Represents an Isolated Cortical Down-State

(2009) S. S. Cash et al.   SCIENCE

Lethargus is a Caenorhabditis elegans sleep-like state

(2008) David M. Raizen et al.   NATURE

Identification of SLEEPLESS, a Sleep-Promoting Factor

(2008) K. Koh et al.   SCIENCE

Metabolic consequences of sleep and sleep loss

(2008) Eve Van Cauter et al.   SLEEP MEDICINE

Gene Activation Using FLP Recombinase in C. elegans

(2008) M. Wayne Davis et al.   PLoS Genetics