Editorial Material
Cell Biology
Odeta Mece, Diede Houbaert, Patrizia Agostinis
Summary: Lymphatic endothelial cells (LECs) rely on fatty acid oxidation (FAO) and the transcription factor PROX1 for growth and maintaining their identity. The loss of ATG5 in LECs prevents injury-induced lymphangiogenesis by impairing the degradation of lipid droplets (LDs) and disrupting mitochondrial fitness. This leads to reduced mitochondrial FAO and acetyl-CoA levels, affecting PROX1-mediated epigenetic regulation and key lymphatic markers. Supplementing with acetate, a fatty acid precursor, rescues defective inflammation-driven lymphangiogenesis in LEC-specific atg5 knockout mice.
Article
Nutrition & Dietetics
Kaho Nakamura, Eri Tajiri, Yoichi Hatamoto, Takafumi Ando, Seiya Shimoda, Eiichi Yoshimura
Summary: The study showed that mild early time-restricted eating (dinner at 18:00) has a positive effect on blood glucose levels and postprandial lipid metabolism in healthy adults compared to eating dinner late (at 21:00), despite only a 3-hour difference.
Article
Medicine, Research & Experimental
Jinchao Hou, Jue Zhang, Ping Cui, Yingyue Zhou, Can Liu, Xiaoliang Wu, Yun Ji, Sicong Wang, Baoli Cheng, Hui Ye, Liqi Shu, Kai Zhang, Di Wang, Jielin Xu, Qiang Shu, Marco Colonna, Xiangming Fang
Summary: NAFLD serves as an independent risk factor for sepsis, with a link to hepatic mitochondria and energetic metabolism dysfunction. Trem2 plays a crucial role in the metabolic coordination between hepatocytes and liver macrophages, affecting the progression and treatment of NAFLD-associated sepsis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Nutrition & Dietetics
Rachel A. Tinius, Maire M. Blankenship, Karen E. Furgal, W. Todd Cade, Cathryn Duchette, Kevin J. Pearson, Jill M. Maples
Summary: The study identified correlations between maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy with neonatal adiposity. This is the first study to link these factors to neonatal adiposity at parturition.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Mai Kuwahara, Yu Tahara, Takahiko Suiko, Yuki Nagamori, Shigenobu Shibata
Summary: This study examined the influence of different breakfast styles on eating habits among Japanese workers and found that a traditional Japanese food breakfast is effective for developing good eating habits, such as avoiding irregular amounts of food, snacking, and consuming sweet juices, and maintaining a balanced diet.
Article
Biochemistry & Molecular Biology
Bao Yang, Maoyin Li, Anne Phillips, Long Li, Usman Ali, Qing Li, Shaoping Lu, Yueyun Hong, Xuemin Wang, Liang Guo
Summary: Phosphate is essential for plant growth, and NPC4 enzyme plays a positive role in root growth by hydrolyzing and remodeling sphingolipids during phosphate deficiency in Arabidopsis.
Article
Cell Biology
Nina Vujovic, Matthew J. Piron, Jingyi Qian, Sarah L. Chellappa, Arlet Nedeltcheva, David Barr, Su Wei Heng, Kayla Kerlin, Suhina Srivastav, Wei Wang, Brent Shoji, Marta Garaulet, Matthew J. Brady, Frank A. J. L. Scheer
Summary: Late eating is associated with increased risk of obesity, possibly due to increased hunger, altered appetite-regulating hormones, disrupted energy balance, and enhanced adipogenesis.
Article
Biochemistry & Molecular Biology
Kelly C. Allison, Christina M. Hopkins, Madelyn Ruggieri, Andrea M. Spaeth, Rexford S. Ahima, Zhe Zhang, Deanne M. Taylor, Namni Goel
Summary: This study investigates the effects of delayed eating schedule compared to daytime eating schedule on weight and metabolism in adults. The results suggest that a daytime eating schedule promotes weight loss and improvements in energy metabolism and insulin levels, highlighting the efficacy of this eating pattern for real-world conditions.
Article
Nutrition & Dietetics
Peggy Ober, Carolin Sobek, Nancy Stein, Ulrike Spielau, Sarah Abel, Wieland Kiess, Christof Meigen, Tanja Poulain, Ulrike Igel, Tobias Lipek, Mandy Vogel
Summary: The study found that there is a correlation between school meal patterns and weight status in children, with having breakfast associated with lower BMI and overweight risk, while skipping breakfast linked to higher BMI and overweight risk. These associations were independent of parental SES and weight status.
Review
Biochemistry & Molecular Biology
Ignacio Gutierrez-del-Rio, Sara Lopez-Ibanez, Patricia Magadan-Corpas, Luis Fernandez-Calleja, Alvaro Perez-Valero, Mateo Tunon-Granda, Elisa M. Miguelez, Claudio J. Villar, Felipe Lombo
Summary: Synthetic antioxidant food additives like BHA, BHT and TBHQ are facing challenges due to negative consumer perception, prompting food manufacturers to seek safer natural alternatives. Terpenoids and polyphenols, widely distributed in fruits and vegetables, show broad antioxidant effects and have the potential to replace synthetic antioxidants in food preservation, particularly in preventing lipid oxidation in high fat-containing foods.
Article
Behavioral Sciences
Ege Bicaker, Sarah E. Schell, Sarah E. Racine
Summary: Studies suggest that experiencing interpersonal rejection leads to negative affect and unhealthy eating behaviors. Cultivating self-compassion can attenuate the negative impact of rejection experiences on emotions and unhealthy eating behaviors.
Article
Nutrition & Dietetics
Ulrike A. Gisch, Margaux Robert, Noemi Berlin, Antoine Nebout, Fabrice Etile, Sabrina Teyssier, Valentina A. Andreeva, Serge Hercberg, Mathilde Touvier, Sandrine Peneau
Summary: This study assessed the relationship between mastery and weight status, food intake, snacking, and eating disorder symptoms. The results showed that individuals with higher levels of mastery were more likely to have a healthy weight status, consume healthier foods, have lower snacking frequency, and experience fewer eating disorder symptoms.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Cheen Fei Chin, Dwight L. A. Galam, Liang Gao, Bryan C. Tan, Bernice H. Wong, Geok-Lin Chua, Randy Y. J. Loke, Yen Ching Lim, Markus R. Wenk, Miao-Shan Lim, Wei-Qiang Leow, George B. B. Goh, Federico Torta, David L. Silver
Summary: This study reveals the critical role of the lysophosphatidylcholine transporter Mfsd2a in maintaining hepatic phospholipid pools. Deficiency of Mfsd2a leads to a NASH-like phenotype and reduced hepatic phospholipids. LPCs containing polyunsaturated fatty acids promote hepatic lipid droplet formation and suppress lipogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Public, Environmental & Occupational Health
Wei-Jie Gong, Daniel Yee-Tak Fong, Man-Ping Wang, Tai-Hing Lam, Thomas Wai-Hung Chung, Sai-Yin Ho
Summary: Skipping breakfast, especially eating breakfast away from home, is associated with adolescent emotional/behavioral problems, particularly in younger and underweight children. Increasing home breakfast may reduce emotional/behavioral problems and improve psychosocial health if the associations are causal.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xueyun Liu, Man Hu, Chen Ye, Lihong Liao, Chang Ding, Lijuan Sun, Jichao Liang, Yong Chen
Summary: This study found that isosilybin can inhibit lipid synthesis and activate lipid oxidation through the AMPK signaling pathway, thus reducing lipid accumulation in hepatocytes. Furthermore, the diastereoisomer B of isosilybin is the active substance responsible for these effects.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Analytical
Nadia Ayala-Lopez, Layla Aref, Jennifer M. Colby, Jacob J. Hughey
Summary: The study utilized electronic health record data to identify medications causing false positives on urine drug screening (UDS) assays and discovered multiple compounds that can lead to presumptive positives. Although the adapted approach showed slightly diminished ability to detect interfering medications compared to the method requiring confirmation data, it can still be used to uncover potential interfering medications.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Michael C. Tackenberg, Jacob J. Hughey
Summary: The study identifies a major source of inaccuracy in the chi-square periodogram and introduces a revised version, the greedy CSP, which still falls short of the accuracy of the Lomb-Scargle periodogram. Better estimates of biological rhythms period can be obtained through alternative methods.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
J. Dustin Tracy, Thomas Donnelly, Evan C. Sommer, William J. Heerman, Shari L. Barkin, Maciej S. Buchowski
Summary: The study aimed to adapt and validate a decision tree for identifying bedrest in preschool children, which showed high accuracy in children after parameter optimization. Results indicated that the decision tree outperformed other sleep detection algorithms and identified less bedrest time compared to parental surveys.
Article
Multidisciplinary Sciences
Joshua L. Schoenbachler, Jacob J. Hughey
Summary: pmparser and PMDB allow for large-scale, reproducible, and transparent analyses of biomedical literature.
Article
Biochemistry & Molecular Biology
Cody N. Heiser, Victoria M. Wang, Bob Chen, Jacob J. Hughey, Ken S. Lau
Summary: dropkick is a fully automated software tool for quality control and filtering of single-cell RNA sequencing data, which outperforms conventional thresholding approaches and EmptyDrops in recovering rare cell types and excluding uninformative barcodes. It provides a fast and reproducible solution for cell identification critical to downstream analysis, compatible with popular single-cell Python packages.
Article
Biochemistry & Molecular Biology
Vincent Careau, Lewis G. Halsey, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, John J. Reilly, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjodin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Amy H. Luke, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, William W. Wong, Yosuke Yamada, John R. Speakman
Summary: Understanding the impacts of activity on energy balance is crucial, as increasing activity levels may lead to diminishing returns in energy expenditure. Only a portion of the extra calories burned from additional activity are actually burned that day, with the rest being compensated for by reduced basal energy expenditure. The degree of energy compensation varies among individuals based on their body composition, which may influence the accumulation of body fat and the difficulty of losing weight.
Article
Neurosciences
Michael C. Tackenberg, Jacob J. Hughey, Douglas G. McMahon
Summary: The research shows that selective activation of VIPergic SCN neurons induces photoperiodic network plasticity in the SCN, underlying photoperiodic entrainment of behavior.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Hendrik J. P. van der Zande, Joost M. Lambooij, Vivien Chavanelle, Anna Zawistowska-Deniziak, Yolanda Otero, Frank Otto, Louise Lantier, Owen P. McGuinness, Florian Le Joubioux, Martin Giera, Thierry Maugard, Sebastien L. Peltier, Pascal Sirvent, Bruno Guigas
Summary: Totum-63 reduces body weight and fat mass in obese mice, improves whole-body insulin sensitivity and glucose uptake, decreases inflammation, and reduces hepatic steatosis.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Endocrinology & Metabolism
Ashley H. Shoemaker, Heidi J. Silver, Maciej Buchowski, James C. Slaughter, Jack A. Yanovski, Clinton Elfers, Christian L. Roth, M. Jennifer Abuzzahab
Summary: Treatment with a GLP1RA can decrease food intake but also lead to a disproportionate decrease in total energy expenditure compared to changes in body composition.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Clinical Neurology
Jacob A. Kaslow, Andrew G. Sokolow, Thomas Donnelly, Maciej S. Buchowski, Bruce M. Damon, Larry W. Markham, W. Bryan Burnette, Jonathan H. Soslow
Summary: Duchenne muscular dystrophy (DMD) is a progressive muscle disease that affects heart and lung function. This study aimed to investigate the relationship between cardiac magnetic resonance imaging (CMR) and functional assessments such as quantitative muscle testing (QMT), spirometry, and accelerometry in patients with DMD. The results showed that imaging of the upper extremity muscles had the strongest correlations with accelerometry, QMT, and spirometry.
NEUROMUSCULAR DISORDERS
(2022)
Article
Biochemical Research Methods
Layla Aref, Lisa Bastarache, Jacob J. Hughey
Summary: The linking of electronic health record (EHR) data to DNA biobanks provides a valuable resource for studying the effects of genetic variation on human phenotypes. The phenotype risk score (PheRS) approach has been developed to identify associations between Mendelian disease-like phenotypes and rare genetic variants, as well as to identify undiagnosed Mendelian disease in patients. To improve the usability of the PheRS approach, the researchers have developed the phers R package, which includes functions and maps for performing PheRS-based analysis on linked clinical and genetic data. This package will enhance our understanding of the relationship between rare genetic variants and clinically meaningful human phenotypes.
Article
Oncology
Yan Sun, Jie Wu, Hyung-Suk Yoon, Maciej S. Buchowski, Hui Cai, Stephen A. Deppen, Mark D. Steinwandel, Wei Zheng, Xiao-Ou Shu, William J. Blot, Qiuyin Cai
Summary: This study examined the associations between dietary intake of carotenoids and vitamin A and lung cancer risk among low-income African Americans and European Americans. The results showed a positive association between dietary vitamin A intake and lung cancer risk among current smokers, as well as racial-specific associations with adenocarcinoma risk among African Americans. This study contributes to understanding the role of nutrient intake and lung cancer risk among underrepresented populations.
Article
Biology
Dora Obodo, Elliot H. Outland, Jacob J. Hughey
Summary: Biomedical research on mammals has traditionally neglected females, resulting in potential lack of generalizability of scientific findings. In the context of circadian genomics, our study found significant underrepresentation of females in publicly available transcriptome studies on daily rhythms. Furthermore, studies including both sexes tended to have more samples from males than from females, and this trend has not changed over time.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Pediatrics
Jacob A. Kaslow, Andrew G. Sokolow, Thomas Donnelly, Maciej S. Buchowski, Larry W. Markham, William Bryan Burnette, Jonathan. H. Soslow
Summary: Current studies have mainly focused on respiratory decline and loss of ambulation as indicators of skeletal muscle strength loss in Duchenne muscular dystrophy (DMD). However, this study found that measures of lung function, specifically forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), showed a strong correlation with functional muscle assessments such as accelerometry and quantitative muscle testing (QMT). Maximal expiratory pressure (MEP) and FVC demonstrated the most robust correlations with total QMT.
PEDIATRIC PULMONOLOGY
(2023)
Article
Multidisciplinary Sciences
Joshua L. Schoenbachler, Jacob J. Hughey
Summary: Transcriptome data is crucial for studying biological systems, but processing and analyzing such data involves multiple steps and software programs. To simplify this process, we have developed an R package called seeker, which provides a unified interface and detailed logging.