期刊
OPEN BIOLOGY
卷 9, 期 12, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.190229
关键词
phylogenetic lineage reconstruction; dynamic barcoding; CRISPR; Cas9; scRNA-Seq; genetic switch
资金
- Howard Hughes Medical Institute
The first meeting exclusively dedicated to the 'High-throughput dense reconstruction of cell lineages' took place at Janelia Research Campus (Howard Hughes Medical Institute) from 14 to 18 April 2019. Organized by Tzumin Lee, Connie Cepko, Jorge Garcia-Marques and Isabel Espinosa-Medina, this meeting echoed the recent eruption of new tools that allow the reconstruction of lineages based on the phylogenetic analysis of DNA mutations induced during development. Combined with single-cell RNA sequencing, these tools promise to solve the lineage of complex model organisms at single-cell resolution. Here, we compile the conference consensus on the technological and computational challenges emerging from the use of the new strategies, as well as potential solutions.
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