Article
Biochemistry & Molecular Biology
Xinxin Ma, Shuhua Li, Bodi Zheng, Lei Hu, Huijing Liu, Zheng Wang, Zhaoxia Wang, Haibo Chen, Wen Su
Summary: This study investigated retinal structure changes in patients with Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and controls. The results showed that spectral domain optical coherence tomography (SD-OCT) can be used for differential diagnosis and progression evaluation of parkinsonian syndrome. PD and atypical parkinsonism were found to correlate with specific patterns of retina alterations, and OCT parameters were negatively correlated with disease duration in all three conditions.
Article
Clinical Neurology
Young Hee Sung, Suk Yun Kang
Summary: The present study investigated the characteristics of pain in Parkinson's disease (PD) and other parkinsonian disorders. The results suggest that pain can be a pre-motor symptom in PD, multiple system atrophy (MSA), and vascular parkinsonism (VP), but not in progressive supranuclear palsy (PSP). The study also found that the location of pain differed among the different disorders.
NEUROLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Amina Nasri, Mouna Ben Djebara, Ikram Sghaier, Saloua Mrabet, Sabrina Zidi, Amina Gargouri, Imen Kacem, Riadh Gouider
Summary: This study explored the epidemiological features of atypical parkinsonian syndromes (APS) in a Tunisian population, showing a hospital prevalence of 20.6% with dementia with Lewy bodies (DLB) as the most common subtype. Age of onset proved to be a decisive factor for differential diagnosis, with males predominating in all subgroups except for multiple system atrophy (MSA).
BRAIN AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Cinzia Tiloca, Stefano Goldwurm, Narghes Calcagno, Federico Verde, Silvia Peverelli, Daniela Calini, Anna Lena Zecchinelli, Davide Sangalli, Antonia Ratti, Gianni Pezzoli, Vincenzo Silani, Nicola Ticozzi
Summary: This study provides further insight into the clinical phenotypic heterogeneity associated with TARDBP mutations, extending beyond ALS and FTD diseases to include PD and atypical parkinsonism. However, the mutational frequency is low and varies considerably in different Caucasian populations.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Gary Cheung, Edith To, Claudia Rivera-Rodriguez, Etuini Ma'u, Amy Hai Yan Chan, Brigid Ryan, Sarah Cullum
Summary: This study estimated the prevalence of dementia in New Zealand using health data and found higher prevalence among Maori and Pacific Islanders. However, the study was limited to diagnosed dementia individuals in seven data sets, highlighting the need for a nationwide community-based study to validate these findings.
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Talyta Grippe, Alfonso Fasano, Robert Chen
Summary: This article describes an unusual case involving a combination of slow orthostatic tremor, orthostatic myoclonus, and parkinsonism. The case highlights the importance of utilizing electrophysiology for precise characterization of physical findings in order to establish a diagnosis.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Arnaud Lapostolle, Marion Houot, Marie Mongin, Bertrand Degos
Summary: Botulinum neurotoxin (BoNT) is effective in treating dystonia associated with Parkinson's disease and atypical parkinsonism. The degree of improvement is similar across different localizations of dystonia, but the duration of effect is longer in Parkinson's disease compared to atypical parkinsonism. Patients' demographic and clinical characteristics do not influence the effectiveness of BoNT.
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Arjun Krishnan, Louise M. Waite, Fiona F. Stanaway
Summary: This study aims to systematically investigate and quantify the representation of racial and ethnic minority populations in dementia risk factor research, in order to understand the causes of racial and ethnic inequalities.
Article
Biochemistry & Molecular Biology
Meerakhan Pathan, Junfang Wu, Hans-ake Lakso, Lars Forsgren, Anders oehman
Summary: By utilizing metabolomics techniques, researchers successfully identified significant differences in plasma metabolite concentrations between different disease groups and controls, discovering potential plasma metabolite markers for Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy, enabling differentiation between these disorders.
Article
Medicine, General & Internal
Alexander P. Seiffert, Adolfo Gomez-Grande, Laura Alonso-Gomez, Antonio Mendez-Guerrero, Alberto Villarejo-Galende, Enrique J. Gomez, Patricia Sanchez-Gonzalez
Summary: Neurodegenerative parkinsonisms, including PD and atypical parkinsonisms, show different metabolic uptake patterns in the striatum, as evaluated using [F-18]FDG PET. Striatal hypermetabolism is found in PD patients, while atypical parkinsonisms show hypometabolism compared to the control group. Hemispherical and caudate-putamen differences are observed in CBD, MSA, and DLB. These findings support the differential diagnosis of these syndromes.
Letter
Clinical Neurology
Laurens A. van Kleef, Tian Xiao, M. Arfan Ikram, Kamran Ikram, Robert J. de Knegt
Summary: A study involving 8,848 elderly European individuals found no association between fatty liver disease and Parkinsonism or Parkinson's disease, regardless of gender. This association remained consistent when non-alcoholic fatty liver disease (NAFLD) or metabolic-dysfunction associated fatty liver disease (MAFLD) were used as exposures, defined by either fatty liver index (FLI) or ultrasound.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
Miriam H. Terkelsen, Victor S. Hvingelby, Nicola Pavese
Summary: This review discusses the latest literature on GABAergic alterations in parkinsonian disorders, highlighting its role in motor symptoms, gait disturbances, cognition, and hallucinations. The review suggests potential research strategies for future neuroimaging studies on GABAergic changes in these disorders.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Geriatrics & Gerontology
Hailing Liu, Zifeng Huang, Bin Deng, Zihan Chang, Xiaohua Yang, Xingfang Guo, Feilan Yuan, Qin Yang, Liming Wang, Haiqiang Zou, Mengyan Li, Zhaohua Zhu, Kunlin Jin, Qing Wang
Summary: This study used QEEG to examine the nonmotor symptoms in PD and AP, and found that PSP patients had more severe nonmotor symptoms compared to PD and MSA patients. The QEEG patterns also differed among the three groups in different brain regions.
Article
Clinical Neurology
Ana Rodriguez M. Salgado, Isaac Acosta, Dani J. Kim, Jenny Zitser, Ana Luisa Sosa, Daisy Acosta, Ivonne Z. Jimenez-Velasquez, Mariella Guerra, Aquiles Salas, Adolfo Valvuerdi, Juan C. Llibre-Guerra, Christine Jeyachandran, Ricardo Lopez Contreras, Heike Hesse, Caroline Tanner, JuanJ. Llibre J. Rodriguez, Matthew Prina, Jorge J. Llibre-Guerra
Summary: Neuropsychiatric symptoms (NPSs) are highly prevalent in Hispanic populations with neurodegenerative diseases, particularly in patients with parkinsonism, dementia, and PPD. The most common NPSs include depression, sleep disorders, irritability, and agitation. These symptoms significantly impact caregivers' burden.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Mario Cornejo-Olivas, Lesley Wu, Alastair Noyce
MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Brook Huxford, Tahrina Haque, Aaron Ben Joseph, Cristina Simonet, David Gallagher, Caroline Budu, Ruth Dobson, Alastair J. Noyce
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Hui Liu, Mohammad Dehestani, Cornelis Blauwendraat, Mary B. Makarious, Hampton Leonard, Jonggeol J. Kim, Claudia Schulte, Alastair Noyce, Benjamin M. Jacobs, Isabelle Foote, Manu Sharma, Mike Nalls, Andrew Singleton, Thomas Gasser, Sara Bandres-Ciga
Summary: This study aims to understand why some individuals with high genetic risk do not develop Parkinson's disease (PD). Using large datasets of genetic data, the study found that a higher genetic resilience score was associated with a lower risk for PD. The study also identified potential genes and pathways related to resilience against PD.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Danah Alothman, Charles R. Marshall, Edward Tyrrell, Sarah Lewis, Timothy Card, Andrew Fogarty
Summary: This study examined the suicide risk in patients with Huntington's disease (HD). The results showed a significantly elevated suicide risk in HD patients, especially in younger individuals. Therefore, implementing suicide risk assessment in these patients may improve survival rates.
JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Benjamin Meir Jacobs, Cameron Watson, Charles Marshall, Alastair Noyce, Ruth Dobson
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Alexandra Zirra, Shilpa C. Rao, Jonathan Bestwick, Rajasumi Rajalingam, Connie Marras, Cornelis Blauwendraat, Ignacio Mata, Alastair J. Noyce
Summary: The objective of this systematic review and meta-analysis was to update the overall male/female prevalence ratios (OPR) of Parkinson's disease (PD). The analysis included 19 new articles and 13 articles from a previous meta-analysis. The results showed that the OPR was 1.18, indicating that the gender differences in PD prevalence may not be as significant as previously thought.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Primary Health Care
S. Bramich, K. Verdi, K. Salmon, A. Noyce, J. Alty
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Clinical Neurology
Cristina Simonet, Philipp Mahlknecht, Kathrin Marini, Klaus Seppi, Aneet Gill, Jonathan P. Bestwick, Andrew J. Lees, Gavin Giovannoni, Anette Schrag, Alastair J. Noyce
Summary: The PREDICT-PD study utilized a risk algorithm to stratify individuals for future Parkinson's disease and found an association between risk scores and sub-threshold parkinsonism. The algorithm was able to identify individuals with motor decline over time.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Laura Perez-Carbonell, Cristina Simonet, Harneek Chohan, Aneet Gill, Guy Leschziner, Anette Schrag, Alastair J. Noyce
Summary: This study investigated the experiences and views of risk disclosure in patients with isolated rapid eye movement sleep behavior disorder (iRBD). One-third of the patients reported they were not informed about the link between iRBD and other conditions at diagnosis. Most patients wanted to receive information about the potential implications of iRBD when the diagnosis was made.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Konstantin Senkevich, Paria Alipour, Ekaterina Chernyavskaya, Eric Yu, Alastair J. Noyce, Ziv Gan-Or
Summary: This study used genetic and epidemiological methods and found a potential genetic link between type 1 diabetes (T1D) and Parkinson's disease (PD), suggesting a potentially protective role of T1D in PD risk and progression.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Xinyi Wang, Rebecca J. St George, Aidan D. Bindoff, Alastair J. Noyce, Katherine Lawler, Eddy Roccati, Larissa Bartlett, Son N. Tran, James C. Vickers, Quan Bai, Jane Alty
Summary: This study found that online keyboard tapping tests can predict cognitive abilities, particularly episodic memory. These tests provide a low-cost method for early detection of Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Danielle Newby, Vasiliki Orgeta, Charles R. Marshall, Ilianna Lourida, Christopher P. Albertyn, Stefano Tamburin, Vanessa Raymont, Michele Veldsman, Ivan Koychev, Sarah Bauermeister, David Weisman, Isabelle F. Foote, Magda Bucholc, Anja K. Leist, Eugene Y. H. Tang, Xin You Tai, David J. Llewellyn, Janice M. Ranson
Summary: There is ongoing debate and uncertainty surrounding the risk factors for dementia and how they can be utilized in clinical trials and drug development. Artificial intelligence and machine learning have the potential to enhance understanding and improve precision in dementia prevention.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Christopher R. S. Belder, Charles R. Marshall, Jessica Jiang, Salvatore Mazzeo, Anthipa Chokesuwattanaskul, Jonathan D. Rohrer, Anna Volkmer, Chris J. D. Hardy, Jason D. Warren
Summary: This article reviews recent progress in the diagnosis and management of primary progressive aphasia, the language-led dementias. It poses six key unanswered questions and suggests that linking proteinopathies to phenotypes may help resolve the clinical complexity of this disease.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Benjamin M. Jacobs, Pooja Tank, Jonathan P. Bestwick, Alastair J. Noyce, Charles R. Marshall, Rohini Mathur, Gavin Giovannoni, Ruth Dobson
Summary: This study aimed to determine whether modifiable risk factors for multiple sclerosis have similar effects across diverse ethnic backgrounds. The study found that established modifiable risk factors such as smoking, obesity, infectious mononucleosis, low vitamin D levels, and head injury were consistently associated with multiple sclerosis in the Black and South Asian cohorts.
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Phazha L. K. Bothongo, Mark Jitlal, Eve Parry, Sheena Waters, Isabelle F. Foote, Cameron J. Watson, Jack Cuzick, Gavin Giovannoni, Ruth Dobson, Alastair J. Noyce, Naaheed Mukadam, Jonathan P. Bestwick, Charles R. Marshall
Summary: This study investigates the association between ethnicity, area-level socioeconomic deprivation, and the risk of dementia in East London. The study finds that ethnicity and deprivation are independently associated with dementia risk, and this association may not be attributable to known risk factors.
LANCET REGIONAL HEALTH-EUROPE
(2022)
