4.3 Article

Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise

出版社

MDPI
DOI: 10.3390/ijerph17051618

关键词

sex hormones; creatine kinase; inflammation; female

资金

  1. Ministerio de Economia y Competitividad, Convocatoria de ayudas I + D [DEP2016-75387-P]
  2. Universidad Politecnica de Madrid

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The aim of this study was to evaluate whether the menstrual cycle and its underlying hormonal fluctuations affect muscle damage and inflammation in well-trained females following an eccentric exercise. Nineteen eumenorrheic women performed an eccentric squat-based exercise in the early follicular phase, late follicular phase and mid-luteal phase of their menstrual cycle. Sex hormones and blood markers of muscle damage and inflammation -creatine kinase, myoglobin, lactate dehydrogenase, interleukin-6, tumoral necrosis factor-alpha, and C reactive protein- were analyzed in each phase. No effect of menstrual cycle phase was observed (p > 0.05), while an interaction for interleukin-6 was shown (p = 0.047). Accordingly, a moderate effect size [0.68 (0.53)-0.84 (0.74)], indicated that interleukin-6 values 2 h post-trial (2.07 +/- 1.26 pg/mL) were likely to be higher than baseline (1.59 +/- 0.33 pg/mL), 24 h (1.50 +/- 0.01 pg/mL) and 48 h (1.54 +/- 0.13 pg/mL) in the mid-luteal phase. Blood markers of muscle damage and inflammation were not affected by the menstrual cycle in well-trained women. The eccentric exercise barely triggered muscle damage and hence, no inflammation was observed, possibly due to participants training status. The mid-luteal phase was the only phase reflecting a possible inflammatory response in terms of interleukin-6, although further factors than sex hormones seem to be responsible for this finding.

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